ACR Meeting Abstracts

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Abstracts tagged "autoimmune diseases"

  • Abstract Number: 183 • 2017 ACR/ARHP Annual Meeting

    Allele-Dependent Binding of a Viral Protein to Autoimmune Disease-Associated Genetic Variants

    Matthew Weirauch1, Daniel Miller2, Leah C. Kottyan3, Ignacio Ibarra4, Arthur Lynch2, Sayeed Syed5, Xiaoting Chen2, Erin Zoller2, Connor Schroeder2, Josh Lee2, Albert Magnusen6, Ally Yang7, Timothy R. Hughes7, Joo-Seop Park8, Charles Vinson5 and John B. Harley2,9, 1Center for Autoimmune Genomics and Etiology (CAGE) and Divisions of Biomedical Informatics and Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 3Center for Autoimmune Genomics and Etiology (CAGE), Division of Allergy and Immunology, Cincinnati Children's Hospital, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 4Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany, 5NCI, Bethesda, MD, 6Center of Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 7University of Toronto, Toronto, ON, Canada, 8Divisions of Urology and Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 9US Department of Veterans Affairs Medical Center, Cincinnati, OH

    Background/Purpose: Risk factors are known for many diseases, but the etiologies of most autoimmune diseases remain unknown and are idiopathic. Pathogenesis of disease likely involves…
  • Abstract Number: 1747 • 2017 ACR/ARHP Annual Meeting

    Human C-C Chemokine Receptor-6 (CCR6)+ Th Memory Cells, Including Th17 and Th17.1 Cells, Change into Anti-Inflammatory Cells with Regulatory Capacity upon Exposure to Vitamin D

    Wendy Dankers1, Nadine Davelaar2, Jan Piet van Hamburg3, Patrick Asmawidjaja2, Hoyan Wen2, Johannes van Leeuwen4, Edgar Colin5 and Erik Lubberts2, 1Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 2Rheumatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 3Rheumatology, Erasmus MC, Rotterdam, Netherlands, 4Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 5ZGT Almelo, Deventer, Netherlands

    Background/Purpose: Autoimmune diseases such as RA are driven by an aberrantly activated immune system and an imbalance between pro- and anti-inflammatory cells, resulting in tissue…
  • Abstract Number: 184 • 2017 ACR/ARHP Annual Meeting

    An Epigenome-Guided Approach to Causal Variant Discovery in Autoimmune Disease

    Richard C. Pelikan1, Jennifer A. Kelly2, Yao Fu2, Caleb Lareau3, Graham B. Wiley1, Stuart Glenn1, Martin Aryee3,4, Courtney Montgomery5 and Patrick Gaffney2, 1Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Department of Biostatistics, Harvard T.H. Chan School of Public Health, Charlestown, MA, 4Department of Pathology, Harvard Medical School, Boston, MA, 5Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Genome-wide association studies have identified thousands of genetic associations with complex human diseases and traits. However, establishing the truly causal regions of risk haplotypes…
  • Abstract Number: 1786 • 2017 ACR/ARHP Annual Meeting

    Lupus Nephritis Is Linked to Immunity to an Intestinal Commensal Lachnospiracaea Species

    Gregg J. Silverman1, Doua F. Azzouz2, Hanane El Bannoudi2, Aidana Omarbekova3, Brad H. Rovin4, Roberto Caricchio5, Alexander Alekseyenko6 and Jill P. Buyon2, 1Department of Medicine, New York University School of Medicine, New York, NY, 2Medicine, New York University School of Medicine, New York, NY, 3New York University School of Medicine, New York, NY, 4Ohio State University Medical Center, Columbus, OH, 5Medicine/Rheumatology, Temple University, Philadelphia, PA, 6Medical University of South Carolina, Charleston, SC

    Background/Purpose: A transmissible agent has long been suspected in the pathogenesis of SLE, yet the potential contribution of members of the intestinal microbiome to the…
  • Abstract Number: 210 • 2017 ACR/ARHP Annual Meeting

    Pharmacovigilance Surveillance of Autoimmune Diseases Induced By Biological Agents: A Review of 12013 Cases (aeBIOGEAS-SEMI Registry)

    Soledad Retamozo1,2,3, Manuel Ramos-Casals4,5, Marta Pérez de Lis6, Alejandra Flores-Chavez7,8,9, Sofia Arteaga10,11, Celeste Galcerán-Chaves12, Belchin Kostov13, Roberto Pérez-Alvarez6 and Pilar Brito-Zerón2,14, 1Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Córdoba, Consejo Nacional de Investigaciones Científicas y Técnicas (INICSA-UNC-CONICET), Cordoba, Argentina, 2Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Barcelona, Spain, 3Rheumatology Unit, Hospital Privado Universitario de Córdoba, Institute University of Biomedical Sciences University of Córdoba (IUCBC), Cordoba, Argentina, 4Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Spain, Barcelona, Spain, 5Department of Medicine, University of Barcelona, Barcelona, Spain., Barcelona, Spain, 6Department of Internal Medicine, Hospital Alvaro Cunqueiro, Vigo, Vigo, Spain, 7Department of Autoimmune Diseases, ICMiD, Hospital Clínic Barcelona, Spain., Barcelona, Spain, 8Unidad de Investigación Biomédica 02 (Unidad de Investigación en Epidemiología Clínica), UMAE, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Jalisco, Mexico, 9Programa de Doctorado en Ciencias Médicas, Centro Universitario de Investigaciones Biomédicas (CUIB), Universidad de Colima, Colima, Mexico, Mexico, Mexico, 10Residente de Reumatologia II año, Universidad de Antioquia, Medellin, Colombia, Medellin, Colombia, 11d) Department of Autoimmune Diseases, ICMiD, Hospital Clínic Barcelona, Spain., Barcelona, Spain, 12Neuroscience Clinical Institute, Hospital Clínic, Barcelona, Spain, Barcelona, Spain, 13Primary Care Research Group, IDIBAPS, Centre d’Assistència Primària ABS Les Corts, CAPSE, Barcelona, Barcelona, Spain, 14Autoimmune Diseases Unit, Department of Medicine, Hospital CIMA- Sanitas, Barcelona., Bacelona, Spain

    Background/Purpose: The increasing use of biological agents has been linked with the paradoxical development of autoimmune processes. The scenario has dramatically change in recent years…
  • Abstract Number: 1792 • 2017 ACR/ARHP Annual Meeting

    Distinct and Overlapping Activities of IL-17A and TNF on the Expression of Proinflammatory Cytokines and MMPs in Psoriatic Arthritis: Rationale for Anti-IL-17A/Anti-Tnfalpha Combination Therapy?

    Xiaofei Xu1, Nadine Davelaar2, Anne-Marie Otten-Mus3, Patrick Asmawidjaja2, J.M.W. Hazes4, Dominique Baeten5, Marijn Vis6, Radjesh Bisoendial1 and Erik Lubberts2, 1Rheumatology, Erasmus MC, Rotterdam, Netherlands, 2Rheumatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 3Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 4Department of Rheumatology, Erasmus University Medical Centre, Rotterdam, Netherlands, 5Clinical Immunology and Rheumatology/Experimental immunology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 6Rheumatology, Erasmus Medical Centre, Rotterdam, Netherlands

    Background/Purpose: TNF and IL-17A are proinflammatory cytokines critically involved in the pathogenesis of psoriatic arthritis (PsA). Currently, targeting TNF is the first choice of a…
  • Abstract Number: 284 • 2017 ACR/ARHP Annual Meeting

    Metabolic Activity Sustains Macrophage Cytokine Production in Rheumatoid Arthritis and Coronary Artery Disease

    Cornelia M. Weyand1, Markus Zeisbrich1, Lukas Brosig2, Barbara Wallis1, Niall Roche3, Janice Lin1 and Jorg Goronzy4, 1Medicine: Immunology and Rheumatology, Stanford University, Stanford, CA, 2Medicine: Immunology and Rheumatology, Stanford University, Stanfod, CA, 3The Arthritis Center, Pleasanton, CA, 4Medicine/Division of Immunology & Rheumatology, Stanford University School of Medicine, Stanford, CA

    Background/Purpose: Accelerated atherosclerosis has become increasingly recognized as a complication of chronic inflammatory disease, such as in patients with rheumatoid arthritis (RA). RA patients have…
  • Abstract Number: 1999 • 2017 ACR/ARHP Annual Meeting

    Magnetic Resonance Imaging of Skeletal Muscles in Patients with Dermatomyositis and Polymyositis: Novel and Distinctive Characteristic Findings

    Taro Ukichi1, Ken Yoshida1, Satoshi Matsushima2, Go Kawakami2, Kentaro Noda1, Kazuhiro Furuya1 and Daitaro Kurosaka1, 1Division of Rheumatology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan, 2Department of Radiology, Jikei University School of Medicine, Tokyo, Japan

    Background/Purpose: Radiological studies to distinguish between dermatomyositis (DM) and polymyositis (PM) are few. We predicted that the magnetic resonance imaging (MRI) findings of skeletal muscle…
  • Abstract Number: 900 • 2017 ACR/ARHP Annual Meeting

    Choroid Plexus Tertiary Lymphoid Structures in Lupus: A Novel Neuro-Immune Interface

    Ariel Stock1, Evan Der2, Sivan Gelb3, Ayal Ben-Zvi3 and Chaim Putterman4, 1Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, 2Albert Einstein College of Medicine, Bronx, NY, 3Hebrew University, Jerusalem, Israel, 4Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, USA, Bronx, NY

    Background/Purpose: The central nervous system (CNS) manifestations of SLE remain poorly understood. Although potentially neuropathic autoantibodies have been identified in the serum, lupus patients show…
  • Abstract Number: 2111 • 2017 ACR/ARHP Annual Meeting

    Anti-N-Methyl-D-Aspartate Receptor Encephalitis – Expanding Our Understanding of the Clinical Needs of Pediatric Patients with This Complex Disorder

    Katherine A. Battisti1, Tobias J. Tsai2, Angela Pickersgill3 and Sheetal S. Vora4, 1Emergency Medicine, Nationwide Children's Hospital, Columbus, OH, 2Physical Medicine and Rehabilitation, Levine Children's Hospital/Carolinas Medical Center, Charlotte, NC, 3Pediatrics, Levine Children's Hospital, Charlotte, NC, 4Pediatric Rheumatology, Levine Children's Hospital, Charlotte, NC

    Background/Purpose: Although recognized only 10 years ago, anti-N-Methyl-D-Aspartate receptor encephalitis (anti-NMDAR encephalitis) has become a leading cause of encephalitis with an identifiable etiology in pediatric…
  • Abstract Number: 152 • 2017 Pediatric Rheumatology Symposium

    Characteristics of Patients With Juvenile Idiopathic Arthritis in a US Healthcare Claims Database

    TA Simon1, A Baheti2, N Ray2, S Kelly1 and Z Guo1, 1Bristol-Myers Squibb, Princeton, NJ, 2Mu Sigma, Bangalore, India

    Background/Purpose: Abatacept, the first selective co-stimulation modulator approved and used for the treatment of juvenile idiopathic arthritis (JIA), has a mechanism of action that is…
  • Abstract Number: 147 • 2017 Pediatric Rheumatology Symposium

    Epigenetic and Transcriptomic Profiling of Primary Juvenile Idiopathic Arthritis Patient Cells: Better Understanding of Disease Pathogenesis

    Lucas Picavet1, Janneke Peeters2, Sandra Coenen3, Arjan Boltjes4, Femke van Wijk5, Paul Coffer2, Bas Vastert6 and Jorg van Loosdregt7, 1Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht, Netherlands, 2Center for Molecular Medicine and Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht, Netherlands, 3University Medical Center Utrecht, Utrecht, Netherlands, 4Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 5Laboratory for Translational Immunity, University Medical Center Utrecht, Utrecht, Netherlands, 6Division of Pediatric Rheumatology, University Medical Center Utrecht, Utrecht, Netherlands, 7Division of Pediatrics, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: For many autoimmune diseases, including Juvenile Idiopathic Arthritis (JIA), the molecular mechanisms remain elusive. JIA can be used as a model to study autoimmune…
  • Abstract Number: 12L • 2016 ACR/ARHP Annual Meeting

    Efficacy and Safety of Atacicept in Patients with Systemic Lupus Erythematosus: Results of a 24-Week Randomized, Placebo-Controlled, Phase IIb Study

    Joan T. Merrill1, Daniel J. Wallace2, Stephen Wax3, Amy Kao4, Patricia Fraser4, Wai Chin4 and David A. Isenberg5, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2University of California Los Angeles, Los Angeles, CA, 3EMD Serono, BIllerica, MA, 4EMD Serono, Billerica, MA, 5University College Hospital, London, London, United Kingdom

    Background/Purpose: Atacicept targets B-cell stimulating factors BLyS and APRIL. In the APRIL-SLE trial, atacicept 150 mg was associated with reduced SLE flares in post-hoc analyses.1Methods:…
  • Abstract Number: 2175 • 2016 ACR/ARHP Annual Meeting

    Comparisons of Patients Prescribed Biosimilars or BIO-Originators for Autoimmune Diseases in Germany

    Sumesh Kachroo1, Christopher Black1, Emma Sullivan2, John Waller2 and James Piercy2, 1CORE, Merck & Co., Inc., Kenilworth, NJ, 2Adelphi Real World, Manchester, United Kingdom

    Background/Purpose: To compare the characteristics of patients who receive biosimilars against patients receiving bio-originators. Methods: The Adelphi Biosimilars Programme 2016 is a cross-sectional survey of…
  • Abstract Number: 2428 • 2016 ACR/ARHP Annual Meeting

    Autoantibody Diversity in Pediatric Patients Undergoing Evaluation for Autoimmune Encephalitis: A Retrospective Investigation

    Anne E Tebo1, Thomas Haven2, Aimee O. Hersh3 and Eyal Muscal4, 1Pathology, University of Utah School of Medicine and ARUP Laboratories, Salt Lake City, UT, 2Department of Pathology, University of Utah, ARUP Institute of Clinical and Experimental Pathology, Salt Lake City, UT, 3Pediatrics/Rheumatology, University of Utah, Salt Lake City, UT, 4Immunology, allergy and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX

    Background/Purpose:  Antibodies directed against N-methyl-D-aspartate type glutamate receptor (NMDAR), voltage-gated potassium channel (VGKC) or glutamic acid decarboxylase (GAD65) are frequently associated with autoimmune encephalitis (AE)…
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