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Abstract Number: 1089

Clinical Associations of Anti-Ro52 Antibodies in Patients with Systemic Autoimmune Rheumatic Diseases

Diana Prieto-Peña1, Belén Atienza-Mateo2, Miguel Ángel gonzalez-Gay3 and Ricardo Blanco4, 1Hospital Universitario Marqués de Valdecilla, santander, Spain, 2Group "Research in genetic epidemiology and atherosclerosis of systemic diseases and in bone metabolic diseases of the locomotor system", IDIVAL; and Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 3Research group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla; School of Medicine, Universidad de Cantabria, Santander, Spain. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa, 4Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain

Meeting: ACR Convergence 2021

Keywords: Autoantibody(ies), autoimmune diseases

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Session Information

Date: Monday, November 8, 2021

Session Title: Miscellaneous Rheumatic & Inflammatory Diseases Poster II: Clinical Features & Diagnostics (1083–1117)

Session Type: Poster Session C

Session Time: 8:30AM-10:30AM

Background/Purpose: Anti-SSA/Ro antibodies (Abs) can target Ro60 and Ro52 antigens. The presence of anti-Ro60 Abs has been widely described in patients with systemic autoimmune rheumatic diseases (SARDs). However, the clinical implication of anti-Ro52 Abs for the diagnosis and management of SARDs remains unclear. We aimed to assess the clinical associations of anti-Ro52 antibodies in patients with high clinical suspicion of SARDs.

Methods: We retrieved the clinical records of all patients with positive anti-Ro52 Abs tested in our hospital between November 2017 and September 2020. Patients were divided into 3 groups: 1) anti-Ro52+Ro60+ 2) antiRo52+Ro60- 3) antiRo52+Ro60+ with other Abs. A comparative study between groups was performed.

Results: 57 patients (43 women/14 men; mean age 62.1±13.6 years) with antiRo52+ Abs were identified. Final diagnosis were: undifferentiated connective tissue disease (UCTD) (n=13), anti-synthetase/overlap myositis (n=12), Sjögren’s syndrome (n=7), interstitial pneumonia with autoimmune features (IPAF) (n=6), scleroderma (n=4), systemic lupus erythematosus (n=2), dermatomyositis (n=2), other systemic inflammatory diseases (n=3). In 8 (14%) patients the diagnosis of inflammatory diseases was finally ruled out. 27 patients were classified in the Ro52+Ro60+ group, 11 in the Ro52+Ro60- group and 19 Ro52+ with other Abs. Patients with Ro52+Ro60- were younger and more often women than patients with Ro52+Ro60+.Interstitial lung disease (ILD) was less frequent in patients with Ro52+Ro60-(Table). Isolated Ro52 Abs were more frequently associated with UCTD, while IPAF was more commonly found in patients with anti-Ro52+Ro60+ Abs (TABLE and FIGURE).

Conclusion: Anti Ro52 Abs determination has clinical implications in the diagnosis of SARDs

TABLE

FIGURE


Disclosures: D. Prieto-Peña, None; B. Atienza-Mateo, None; M. gonzalez-Gay, None; R. Blanco, Brystol Myers Squibb, 6.

To cite this abstract in AMA style:

Prieto-Peña D, Atienza-Mateo B, gonzalez-Gay M, Blanco R. Clinical Associations of Anti-Ro52 Antibodies in Patients with Systemic Autoimmune Rheumatic Diseases [abstract]. Arthritis Rheumatol. 2021; 73 (suppl 9). https://acrabstracts.org/abstract/clinical-associations-of-anti-ro52-antibodies-in-patients-with-systemic-autoimmune-rheumatic-diseases/. Accessed January 30, 2023.
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