ACR Meeting Abstracts

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Abstracts tagged "autoimmune diseases"

  • Abstract Number: L04 • ACR Convergence 2022

    Psoriatic Arthritis Disease Subtypes Mediated by CD8 T Cells Are Phenocopied in a Novel Humanized Murine Model of Psoriasis and Arthritis

    Maria de la Luz Garcia-Hernandez1, Javier Rangel-Moreno1, Ananta Paine2, Soumyaroop Bhattacharya3, Jeffrey Fox4, Ernest Meyer5, Brian Isett5, Riyue Bao6, Tullia Bruno6 and Christopher Ritchlin7, 1University of Rochester, Rochester, NY, 2ORNA Tx, Southborough, MA, 3Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, 4CMSR, University of Rochester Medical Center, Rochester, NY, 5UPMC Hillman Cancer Center, Pittsburgh, PA, 6University of Pittsburgh, Pittsburgh, PA, 7University of Rochester Medical Center, Rochester, NY

    Background/Purpose: A pivotal clinical characteristic of psoriatic arthritis (PsA) is disease manifestations in several domains (skin, entheses, joints, spine) and multiple domain involvement is prevalent,…
  • Abstract Number: L10 • ACR Convergence 2022

    Efgartigimod Prevents Necrosis and Allows for Muscle Fiber Regeneration in a Humanized Mouse Model of Immune-mediated Necrotizing Myopathy (IMNM)

    Sarah Julien1, Emma Briand1, Bas van der Woning2, Leentje de ceuninck3, Rachid zoubari1, olivier benveniste4, laurent drouot1 and olivier boyer5, 1INSERM U1234, PAn’THER FOCIS Center of Excellence, Rouen, France, 2argenx, Boston, MA, 3argenx, Ghent, Belgium, 4AP-HP, Pitié-Salpêtrière University Hospital, Department of Internal Medicine and Clinical Immunology, Paris, France, 5INSERM U1234, PAn’THER FOCIS Center of Excellence; Rouen University Hospital, Department of Immunology and Biotherapy, Rouen, France

    Background/Purpose: Immune-mediated necrotizing myopathy (IMNM) is a severe form of myositis characterized by muscle weakness and elevated creatine kinase levels in serum. The most frequent…
  • Abstract Number: 0083 • ACR Convergence 2022

    COVID-19 Vaccine Uptake and Reasons for Hesitancy in a Large Rheumatology Practice Network

    Amy Mudano1, Fenglong Xie1, Patrick Stewart2, Lesley Jackson3, Maria Danila3, Kelly Gavigan4, William Benjamin Nowell5, Shilpa Venkatachalam6 and Jeffrey Curtis7, 1Illumination Health, Hoover, AL, 2Bendcare, Boca Raton, FL, 3University of Alabama at Birmingham, Birmingham, AL, 4Global Healthy Living Foundation, Upper Nyack, NY, 5Global Healthy Living Foundation, Nyack, NY, 6Global Healthy Living Foundation, New York, NY, 7Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Sub-optimal COVID-19 vaccine uptake by patients with autoimmune conditions is an area of concern to many rheumatologists and other providers. It is important to…
  • Abstract Number: 0202 • ACR Convergence 2022

    Learning Needs Assessment for Patients with Cancer and a Pre-Existing Autoimmune Disease Who Are Candidates to Receive Immune Checkpoint Inhibitors

    Maria A. Lopez-Olivo1, Johncy Kachira2, Maryam Buni3, Sang Taek Kim4, Huifang Lu4, Gabrielle Duhon4, Juan Ruiz4, Clifton O. Bingham III5, Cassandra Calabrese6, Robert J. volk4 and Maria Suarez-Almazor7, 1The University of Texas, MD Anderson Cancer Center, Houston, TX, 2The University of Texas MD Anderson Cancer Center, Texas, TX, 3MD Anderson Cancer Center, Bellaire, TX, 4The University of Texas MD Anderson Cancer Center, Houston, TX, 5Johns Hopkins University, Baltimore, MD, 6Cleveland Clinic Foundation, Cleveland Heights, OH, 7MD Anderson Cancer Center, Houston, TX

    Background/Purpose: Immune checkpoint inhibitors (ICI) have been extremely successful in the treatment of various malignancies. Patients with pre-existing autoimmune disorders and cancer are at risk…
  • Abstract Number: 0578 • ACR Convergence 2022

    Interleukin-6 Trans-Signaling Induces Synovial Fibroblast Invasiveness by Utilizing Ets2 Protein

    Anil Singh, Paul Panipinto, Farheen Sultan Shaikh and Salahuddin Ahmed, Washington State university, Spokane, WA

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease with a complex interplay of synovial cells and soluble factors that create the signatures of chronic inflammation…
  • Abstract Number: 0669 • ACR Convergence 2022

    Understanding How Type I Interferon Modulates Langerhans Cell ADAM17 to Promote Photosensitivity in Lupus

    Thomas Li1, Ethan Seltzer1, Victoria Zyulina1, Keila Veiga2, Noa Schwartz3, Yurii Chinenov1, David Oliver1, Jose Lora4, Ali Jabbari5, Yong Liu1, Hafsa Munir1, William Shipman1, Marvin Sandoval1, Isabel Sollohub1, william ambler1, Bikash Mishra4, sarah taber1, karen onel1, Mehdi Rashighi6, james krueger7, Niroshana Anandasabapathy4, Carl Blobel1 and theresa Lu1, 1Hospital for Special Surgery, New York, NY, 2Maria Fareri Children's Hospital, New York, NY, 3Albert Einstein College of Medicine, New York, NY, 4Weill Cornell Medicine, New York, NY, 5University of Iowa, Iowa City, IA, 6University of Massachusetts Medical School, Worcester, MA, 7Rockefeller University, New York, NY

    Background/Purpose: Photosensitivity is a hallmark symptom of lupus erythematosus (LE), in which patients develop inflammatory skin lesions in response to ultraviolet radiation (UVR). In examining…
  • Abstract Number: 0750 • ACR Convergence 2022

    Quality Improvement Project to Increase the Rate of Vaccination with Pneumococcal Vaccines (PCV13 prime-PPSV23 Boost Strategy) Among Adult Patients with Autoimmune Inflammatory Rheumatic Diseases (AIIRD) Within Nationwide Health Organization

    Victoria Furer, Hagit Sarbagil-Maman and Ori Elkayam, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel

    Background/Purpose: Patients with autoimmune inflammatory rheumatic diseases (AIIRD) are susceptible for pneumococcal disease. Two vaccines against S. pneumoniae are currently recommended for use: a 23-valent…
  • Abstract Number: 0805 • ACR Convergence 2022

    Rheumatic Fever and Streptococcal Cutaneous Infection: A Case-control Study in the Loyalty Islands, New Caledonia

    Quentin AMIC-DESVAUD1, Olivier MAILLARD2, Sylvia IACOBELLI3, Thomas BARDIN4 and Yves-Marie DUCROT5, 1Province des îles Loyauté, Lifou, New Caledonia, 2Centre Hospitalier Universitaire de la Reunion, Saint-Denis, France, 3Centre Hospitalier Universitaire, Saint Dénis de la Réunion, France, 4Université de Paris, Paris, France, 5Province des îles Loyauté, We, Lifou Island, New Caledonia

    Background/Purpose: Acute Rheumatic Fever (ARF) and Rheumatic Heart Disease (RHD) remain major public health problems in the South Pacific. Triggering by group A beta hemolytic…
  • Abstract Number: 1049 • ACR Convergence 2022

    Risk Stratification of Patients with Systemic Sclerosis-associated Pulmonary Arterial Hypertension in EUSTAR Using the Current and New Proposed Criteria

    Hilde Jenssen Bjørkekjær1, cosimo bruni2, PATRICIA E CARREIRA3, Paolo Airò4, CARMEN PILAR SIMEON5, Marie-Elise Truchetet6, Alessandro Giollo7, Alexandra Balbir-Gurman8, Mickaël MARTIN9, Chris Denton10, Armando Gabrielli11, Håvard Fretheim12, Imon Barua12, Helle Bitter13, Øyvind Midtvedt12, Kaspar Broch14, Arne Andreassen12, Yoshiya Tanaka15, Gabriela Riemekasten16, Ulf Müller-Ladner17, Marco Matucci-Cerinic2, Ivan Castellvi18, Elise Siegert19, Eric Hachulla20, Oliver Distler21 and Anna-Maria Hoffmann-Vold12, 1Department of Rheumatology, Hospital of Southern Norway, Kristiansand, Norway, Kristiansand, Norway, 2University of Florence, Florence, Italy, 3HOSPITAL 12 DE OCTUBRE, Madrid, Spain, 4Rheumatology and Clinical Immunology Unit, ASST Spedali Civili, Brescia, Italy, 5Hospital Vall D'Hebron, Barcelona, Spain, 6CHU de Bordeaux, Bordeaux, France, 7Rheumatology Section, Department of Medicine, University of Verona, Italy, Verona, Italy, 8Rheumatology Institute, Rambam Health Care Campus, Haifa, Israel, 9Poitiers's Universatory Hospital, Department of Internal Medicine, Poitiers, France, Mignaloux-Beauvoir, France, 10University College London, London, United Kingdom, 11Università Politecnica delle Marche, Ancona, Italy, 12Oslo University Hospital, Oslo, Norway, 13Sorlandet sykehus, Kristiansand, Norway, 14Oslo University Hospital, Rikshospitalet, Department of Cardiology, Oslo, Norway, Oslo, Norway, 15University of Occupational and Environmental Health, Kitakyusyu Fukuoka, Japan, 16University Clinic Schleswit-Holstein (UKSH), Luebeck, Germany, 17JLU Campus KK, Bad Nauheim, Germany, 18Hospital Universitari de la Santa Creu i Sant Pau, Vilafranca del Pened, Spain, 19Charité Hospital, Berlin, Germany, 20University of Lille, LILLE, France, 21Department of Rheumatology, University Hospital Zurich, University of Zurich, Zürich, Switzerland

    Background/Purpose: Pulmonary arterial hypertension (PAH) is a major clinical challenge in systemic sclerosis (SSc). A new definition for precapillary PH is proposed. Risk stratification is…
  • Abstract Number: 1217 • ACR Convergence 2022

    The Problem of Pain in Rheumatology: Clinical Profiles Associated with Concomitant Diagnoses with Chronic Overlapping Pain Conditions

    Titilola Falasinnu1, Yashaar Chaichian2 and Julia Simard3, 1Stanford School of Medicine, Stanford, CA, 2Stanford University, Stanford, CA, 3Stanford University School of Medicine, Palo Alto, CA

    Background/Purpose: The chronification of pain is heterogeneous in rheumatology. Chronic overlapping pain conditions (COPCs) such as fibromyalgia, endometriosis, migraine, and back pain may co-occur with…
  • Abstract Number: 1455 • ACR Convergence 2022

    Immune Thrombocytopenic Purpura and Subsequent Development of Systemic Lupus Erythematosus

    Gelsomina Alle1, Marina Scolnik1, VALERIA SCAGLIONI1, John Fredy Jaramillo Gallego1, Mayra Alejandra Tobar Jaramillo1, Rodolfo Alvarado1, Enrique R Soriano2 and Javier Eduardo Rosa1, 1Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 2Rheumatology Unit and University Institute, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

    Background/Purpose: The aim of this study is to assess the incidence of Systemic Lupus Erythematosus (SLE) in a cohort of patients with Immune Thrombocytopenic Purpura…
  • Abstract Number: 1700 • ACR Convergence 2022

    IL-21/STAT3 Pathway Mediated Th2-like Vδ2 T Cells Promote Plasmablasts Differentiation in IgG4-Related Disease

    Jieqiong Li1 and Wen Zhang2, 1Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China, 2Peking Union Medical College Hospital, Beijing, China

    Background/Purpose: To explore the phenotype and role of gamma delta (γδ) T cells in the pathogenesis of IgG4-related disease (IgG4-RD), focusing on the effect on…
  • Abstract Number: 1985 • ACR Convergence 2022

    The BEGIN Study: A Double-blind, Multi-center, Two-part, Randomized, Placebo-controlled Study of the Safety, Tolerability, and Efficacy of 4 Weeks of Treatment with AP1189 in Early Rheumatoid Arthritis (RA) Patients with Active Joint Disease

    Thomas Jonassen1, Irene Sandholdt2, Birgitte Telmer2 and Ellen-Margrethe Hauge3, 1SynAct Pharma, Holte, Denmark, 2CroxxMed, Hørsholm, Denmark, 3Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark

    Background/Purpose: Melanocortin (MC) type 1 and type 3 receptor stimulation is associated with anti-inflammatory activity and the promotion of inflammatory resolution. AP1189 is novel biased…
  • Abstract Number: 2237 • ACR Convergence 2022

    Randomized Placebo-Controlled Trial to Evaluate Efficacy and Safety of Subcutaneous Abatacept in Adults with Active Idiopathic Inflammatory Myopathy: Results of the 24-Week Double-Blind and 28-Week Open-Label Periods

    Rohit Aggarwal1, Ingrid Lundberg2, Yeong-Wook Song3, Aziz Shaibani4, Victoria Werth5 and Michael Maldonado6, 1Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 2Karolinska Universitetssjukhuset, Karolinska Institutet, Stockholm, Sweden, 3Seoul National University, Seoul, Republic of Korea, 4Nerve and Muscle Center of Texas, Houston, TX, 5Philadelphia VAMC, Philadelphia, PA, USA and Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, 6Bristol Myers Squibb, Princeton, NJ

    Background/Purpose: A 52-week (wk), randomized, placebo (PBO)-controlled phase 3 trial of subcutaneous (SC) abatacept (ABA) and standard of care (SOC) was performed in patients (pts)…
  • Abstract Number: 0084 • ACR Convergence 2022

    Facilitators and Barriers of Vaccine Uptake in Patients with Chronic Inflammatory Rheumatic Disease: A Scoping Review

    Silke Neusser1, Anja Neumann1, Christian Speckemeier1, Pauline zur NIeden1, Sarah Schlierenkamp1, Anke Walendzik1, Ute Karbach2, Ioana Andreica3, Kristina Vaupel4, Xenofon Baraliakos5 and Uta Kiltz4, 1Essener Forschungsinstitut für Medizinmanagement, Essen, Germany, 2Institute of Medical Sociology, Health Services Research and Rehabilitation Science (IMVR), Cologne, Germany, 3Rheumazentrum Ruhrgebiet, Ruhr-Universität-Bochum, Herne, Germany, 4Rheumazentrum Ruhrgebiet, Herne, Germany, 5Rheumazentrum Ruhrgebiet Herne, Herne, Germany

    Background/Purpose: Patients with chronic inflammatory rheumatic diseases (CIRD) remain underrepresented in receiving vaccinations despite being disproportionately affected by infectious complications. The aim of our study…
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