ACR Meeting Abstracts

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Abstracts tagged "Autoantibody(ies)"

  • Abstract Number: 1848 • ACR Convergence 2020

    Identification of Native and Citrullinated Autoantibodies to Psoriasis Related-antigen PsoP27 in Synovial Fluids of Patients with Psoriatic Arthritis

    Marina Slobodkin1, Smadar Gertel1, Ari Polachek2, Victoria Furer3 and Ori Elkayam4, 1Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel, 2Tel Aviv Sourasky Medical Center, Petah-Tikva, Israel, 3Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 4Tel Aviv Sourasky Medical Center,, Tel aviv, Israel

    Background/Purpose: Psoriatic arthritis (PsA) is an inflammatory joint disease with no serological biomarkers, hence diagnosis is based on clinical evaluation alone. PsA is closely associated…
  • Abstract Number: 0769 • ACR Convergence 2020

    Does the Autoantibody-Response Mature Between Presentation with Arthralgia and Development of Rheumatoid Arthritis? – a Longitudinal Serological Study

    Fenne Wouters1, Ellis Niemantsverdriet1, Nazike Salioska1, Annemarie Dorjée1, René Toes1 and Annette van der Helm - van Mil2, 1Leiden University Medical Center, Leiden, Netherlands, 2Leiden University Medical Center, Erasmus Medical Center, Leiden, Netherlands

    Background/Purpose: Auto-antibodies in rheumatoid arthritis (RA) are often present years before disease onset but their mere presence does not seem enough to induce RA. Several…
  • Abstract Number: 1075 • ACR Convergence 2020

    Diagnostic Utility of Myositis Antibodies in HyperCKemia: A University Affiliated Single Center Retrospective Study

    Sandeepkumar Gupta1, Debendra Pattanaik2, Tulio Bertorini2 and Amado Afreire3, 1Medical College Of Georgia at Augusta University Medical Center, Augusta, GA, 2University of Tennessee Health Science Center, Memphis, TN, 3University of Tennessee Health Science Cente, Memphis, TN

    Background/Purpose: Myositis specific and associated autoantibodies are now being used more frequently in the diagnosis of idiopathic inflammatory myositis. However there is a no study…
  • Abstract Number: 1456 • ACR Convergence 2020

    Exploring the RA Bone Marrow Niche by Single-cell Technology to Identify Long Lived ACPA+ Plasma Cells

    Khaled Amara1, Aase Hensvold2, Radha Thyagarajan1, Lena Israelsson1, Johanna Steen1, Heidi Wähämaa1, Monika Hansson1, Marianne Engström1, Annika van Vollenhoven1, Anca Catrina2, Vivianne Malmström3 and Caroline Grönwall1, 1Karolinska Institutet, Stockholm, Sweden, 2Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm, Stockholms Lan, Sweden, 3Karolinska Institutet, Stockholm, Stockholms Lan, Sweden

    Background/Purpose: Autoantibodies is a hallmark of rheumatoid arthritis, placing the adaptive immune system and B-cells centrally in the pathogenesis. The anti-citrullinated autoantibodies (ACPA) detected in…
  • Abstract Number: 1910 • ACR Convergence 2020

    Integrated Molecular Analysis of Systemic Sclerosis Skin and Blood Highlights Significant Differences Between Major Autoantibody Subgroups

    Kristina Clark1, Corrado Campochiaro2, Eszter Csomor3, Adam Taylor3, Katherine Nevin3, Nicholas Galwey3, Mary Morse3, Voon Ong4, Emma Derrett-Smith5, Shaun Flint3 and Christopher Denton1, 1University College London, London, United Kingdom, 2Royal Free Hospital NHS trust, London, United Kingdom, 3GlaxoSmithKline, Stevenage, United Kingdom, 4UCL, London, United Kingdom, 5University College London Division of Medicine, London, United Kingdom

    Background/Purpose: The major antinuclear autoantibodies of systemic sclerosis (SSc) associate with different skin score trajectories and risk of internal organ manifestations.  To elucidate molecular differences…
  • Abstract Number: 0195 • ACR Convergence 2020

    Epidemiology and Characteristics of Incident Rheumatoid Arthritis in Persons with and Without HIV

    Jennifer Hanberg1, Kathleen Akgun2, Liana Fraenkel3, Evelyn Hsieh2 and Amy Justice4, 1Yale University School of Medicine; West Haven VA, Boston, MA, 2Yale University School of Medicine; West Haven VA, New Haven, CT, 3Yale School of Medicine; West Haven VA; Berkshire Medical Center, Lenox, MA, 4Yale University School of Medicine; Yale School of Public Health; West Haven VA, West Haven, CT

    Background/Purpose: Rheumatoid arthritis (RA) is the most common chronic inflammatory arthritis, affecting 1-2% of the population. Estimates of the incidence of RA in patients with…
  • Abstract Number: 0773 • ACR Convergence 2020

    The Anti-carbamylated Fibrinogen Response in Rheumatoid Arthritis Targets a Specific Epitope on the γ-chain and Is Associated with a More Active Disease

    Pauline Brevet1, Manuel Freret1, Pascal Rottenberg2, Clément Guillou3, Thierry Lequerre4, Pascal Cosette5, Olivier Boyer2 and Olivier Vittecoq6, 1Inserm U1234 and Rouen University , IRIB, Rouen, France ; Rouen University Hospital, Rheumatology Department, Rouen, France, Rouen, Haute-Normandie, France, 2Inserm U1234 and Rouen University , IRIB, Rouen, France ; Rouen University Hospital, Rheumatology Department, Rouen, France, Rouen, France, 3CNRS 6270, PISSARO, IRIB, Rouen, France ; Centre hospitalo-universitaire de Rouen, Immunology Laboratory, Rouen, France, Rouen, Haute-Normandie, France, 4Rheumatology, University Teaching Hospital, Rouen, France, 5CNRS 6270, PISSARO, IRIB, Rouen, France ; Centre hospitalo-universitaire de Rouen, Immunology Laboratory, Rouen, France, Rouen, France, 6University Hospital of Rouen, Rouen, France

    Background/Purpose: Anti-carbamylated protein autoantibodies (anti-CarP Abs) of IgG and/or IgA isotype have potential diagnostic and prognostic value Carbamylated Fetal Calf Serum (FCS) is the substrate…
  • Abstract Number: 1078 • ACR Convergence 2020

    Highly Reactive anti-Jo1 Autoantibodies to Distinct HisRS Variants and Domains Associate with Lung and Joint Involvement in Patients with Myositis

    Antonella Notarnicola1, Charlotta Preger2, Susanna L. Lundström2, Nuria Renard2, Edvard Wigren2, Eveline Van Gompel2, Angeles S. Galindo-Feria2, Helena Persson3, Maryam Fathi4, Johan Grunewald2, Per-Johan Jakobsson2, Susanne Gräslund2, Ingrid Lundberg5 and Cátia Fernandes-Cerqueira2, 1Karolinska Institutet, Stockholm, Stockholms Lan, Sweden, 2Karolinska Institutet, stockholm, Sweden, 3Science for Life Laboratories, KTH, Stockholm, Sweden, 4Karolinska University Hospital, stockholm, Sweden, 5Division of Rheumatology, Department of Medicine, Karolinska Institutet,, Stockholm, Sweden

    Background/Purpose: To address the reactivity and affinity against histidyl-transfer RNA synthetase (HisRS) autoantigen of anti-Jo1 autoantibodies from serum and bronchoalveolar lavage fluid (BALF) and associations…
  • Abstract Number: 1500 • ACR Convergence 2020

    Electrocardiographic QT Intervals in Infants Exposed to Hydroxychloroquine Throughout Gestation

    Deborah Friedman1, Mimi Kim2, Nathalie Costedoat-Chalumeau3, Robert Clancy4, Joshua Copel5, Colin Phoon6, Bettina Cuneo7, Rebecca Cohen6, Mala Masson6, Benjamin Wainwright6, Noel Zahr8, Amit Saxena4, Peter Izmirly9 and Jill Buyon10, 1New York Medical College, Valhalla, 2Albert Einstein College of Medicine, Bronx, 3APHP, Université de Paris, Paris, France, 4NYU School of Medicine, New York, 5Yale School of Medicine, New Haven, 6New York University School of Medicine, New York, 7University of Colorado School of Medicine, Aurora, 8Pitié-Salpêtrière University Hospital, Paris, France, 9Department of Medicine, New York University School of Medicine, New York, NY, 10Department of Medicine, NYU School of Medicine, New York, NY

    Background/Purpose: Based on inhibition of viral replication and limited reports on clinical efficacy, hydroxychloroquine (HCQ) was initially considered as a prophylaxis and treatment of COVID-19. …
  • Abstract Number: 1917 • ACR Convergence 2020

    In Myositis Patients, Sjögren’s Syndrome Is Associated with Inclusion Body Myositis and with anti-cN1A Antibody Independently of the Myositis Subgroups

    Dan Lévy1, Benoit Nespola2, Margherita Giannini3, Renaud Felten4, Francois Severac3, Coralie Varoquier3, Marina Rinagel3, Anne-Sophie Korganow5, Vincent Poindron5, Thierry Martin5, Julien Campagne6, Hassam Chereih7, Bastien Bouldoires8, Baptiste Hervier9, Cédric Lenormand3, Emmanuel Chatelus3, Laurent Arnaud10, Bernard Gény3, Jean Sibilia4, Jacques-Eric Gottenberg11 and Alain Meyer12, 1CHU Strasbourg, CH, 2Department of Immunobiology, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 3CHU Strasbourg, Strasbourg, 4Department of rheumatology, University Hospitals of Strasbourg and French National Reference Center for Rare Auto-immune diseases, Strasbourg, France, 5Department of Clinical Immunology and Internal Medicine, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 6Department of Internal Medicine, Hôpitaux Privés de Metz, Metz, France, 7CH Pontarlier, Pontarlier, 8HP Colmar, Colmar, 9APHP Paris, Paris, 10Department of rheumatology, University Hospitals of Strasbourg and French National Reference Center for Rare Auto-immune diseases, Strasbourg, Alsace, France, 11Strasbourg University Hospital, Strasbourg, France, 12Service de rhumatologie et Centre de références des maladies autoimmunes rares, Hôpitaux universitaires de Strasbourg, Strasbourg, Alsace, France

    Background/Purpose: Myositis are characterized by weakness and muscle inflammation. They encompass heterogeneous conditions, which include dermatomyositis (DM), inclusion body myositis (IBM) and polymyositis (PM) according…
  • Abstract Number: 0242 • ACR Convergence 2020

    Autoantibody Profile and Ethnicity: Risk Factors for Accelerated Development of Lupus Nephritis

    Majed Albirdisi1, David d'Cruz2, Shirish Sangle2 and Natasha Jordan3, 1King Fahad Medical City, riyadh, Saudi Arabia, 2guys and st thomas hospital, london, United Kingdom, 3addebrooke's hospital, cambridge, United Kingdom

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is a multisystem autoimmune disease. African ancestry is associated with an increased risk of Lupus Nephritis (LN). Anti-DNA autoantibodies play…
  • Abstract Number: 0775 • ACR Convergence 2020

    T and B Cell Responses to Common Tenascin-C Peptides in RA

    JING Song1, Anja Schwenzer2, Sara Turcinov3, Alicia Wong2, Cliff Rims1, Lorena Rodriguez Martinez2, David Arribas-Layton4, Christina Gerstner5, Virginia Muir6, Jeffrey Carlin7, Kim Midwood2, Vivianne Malmström8, Eddie James1 and Jane Buckner1, 1Center for Translational Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, 2Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, 3Division of Rheumatology, Department of Medicine,Center for Molecular Medicine, Institutet, Stockholm, Sweden, 4Center for Translational Immunology, Benaroya Research Institute at Virginia Mason, Seattle, 5Division of Rheumatology, Department of Medicine,Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden, 6Center for Systems Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, 7Department of Rheumatology, Virginia Mason Medical Center, Seattle, WA, 8Karolinska Institutet, Stockholm, Stockholms Lan, Sweden

    Background/Purpose: Although autoreactive CD4+ T cell and antibody responses against citrullinated antigens are known to contribute to loss of immune tolerance in rheumatoid arthritis (RA),…
  • Abstract Number: 1082 • ACR Convergence 2020

    The Presence of Anti-Jo1, anti-PL7, And/or anti-MDA5 Antibodies in Idiopathic Inflammatory Myopathy Confers an Increased Risk of a Significant Restrictive Pulmonary Defect

    Dmitriy Cherny1 and Carrie Richardson1, 1Rush University Medical Center, Chicago, IL

    Background/Purpose: A subset of patients with idiopathic inflammatory myopathy develop significant restrictive lung disease, although risk factors for this are poorly defined. Autoantibodies may be…
  • Abstract Number: 1501 • ACR Convergence 2020

    Obstetrical Outcome and Thromboses in a Multicentric Cohort of Antiphospholipid Syndrome (APS) Patients with Severe Preeclampsia: An Analysis of APS Classification Criteria

    Maddalena Larosa1, Nathalie Morel2, Meriem Belhocine3, Amelia Ruffatti4, Nicolas Martin Silva5, Romain Paule6, Luc Mouthon7, Michel Dreyfus8, Jean-Charles Piette9, Odile Souchaud-Debouverie10, Catherine Deneux-Tharaux11, Vassilis Tsatsaris12, Emmanuelle Pannier Metzger13, Gaëlle Guettrot-Imbert14, Veronique Le Guern15, Andrea Doria16 and Nathalie Costedoat-Chalumeau17, 1Rheumatology Unit-Department of Medicine-University of Padova, Italy, Padova, Veneto, Italy, 2AP-HP, université René-Descartes Paris V, hôpital Cochin, centre de référence maladies auto-immunes et systémiques rares, pôle médecine, service de médecine interne, Paris, France., Paris, Ile-de-France, France, 3Hôpital Sacré-Coeur de Montréal , Montréal, Montreal, QC, Canada, 4Department of Medicine, University of Padova, Padova, Veneto, Italy, 5Centre Hospitalier et Universitaire de Caen, Caen, France, 6Foch Hospital, Paris, France, 7Hopital Cochin - Paris University, Paris, France, 8CHU de Caen, Caen, France, 9Department of Internal Medicine, Hôpital Pitié-Salpêtrière, Paris, France, Paris, France, 10CENTRE HOSPITALIER UNIVERSITAIRE LA MILETRIE, poitiers, France, 11INSERM U1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team, Center for Epidemiology and Statistics Sorbonne Paris Cité , Paris Descartes University , Paris , France, Paris, France, 12Maternité Port-Royal,Hôpital Cochin, Paris, France, Paris, France, 13Maternité Port-Royal,Hôpital Cochin, Paris, France, 14Médecine Interne,Hôpital Cochin, paris, France, 15Médecine Interne,Hôpital Cochin, Paris, France, Paris, France, 16University of Padua, Padua, Italy, 17APHP, Université de Paris, Paris, France

    Background/Purpose: According to APS classification criteria1, clinical manifestations of antiphospholipid syndrome (APS) consist in thrombotic and obstetric events, including severe preeclampsia (PE). Because little is…
  • Abstract Number: 2039 • ACR Convergence 2020

    Short Telomeres and Autoantibodies Targeting Telomere-Associated Proteins in Scleroderma

    Britany Adler1, Ami Shah2, Francesco Boin3, Paul Wolters3, Livia Casciola-Rosen4 and Antony Rosen1, 1Johns Hopkins University, baltimore, MD, 2Johns Hopkins University School of Medicine, Ellicott City, MD, 3University of California, San Francisco, San Francisco, CA, 4Johns Hopkins University, Johns Hopkins University, MD

    Background/Purpose: Scleroderma is a systemic fibrosing disease of unknown etiology that often manifests with interstitial lung disease (ILD). Prior studies have found an association between…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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