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Abstracts tagged "Autoantibody(ies)"

  • Abstract Number: 067 • 2023 Pediatric Rheumatology Symposium

    Clinical and Demographic Characteristics of Children with Anti-NMDAR Encephalitis

    Yike Jiang, Alexander Sandweiss, Timothy Erickson, Eyal Muscal and Kristy Murray, Baylor College of Medicine, Houston, TX

    Background/Purpose: The discovery of anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis heralded a new class of neuropsychiatric illnesses mediated by autoantibodies, known collectively as autoimmune encephalitis. The clinical…
  • Abstract Number: 114 • 2023 Pediatric Rheumatology Symposium

    Clinical Significance of SSA and SSB Antibodies in Pediatric SLE Patients: A Single Center Cohort

    Yiressy Pina1, Dawn Janysek1, Danielle Guffey2, Maria Pereira Palacios3 and Marietta De Guzman1, 1Baylor College of Medicine, Texas Children's Hospital, Houston, TX, 2Baylor College of Medicine, Houston, TX, 3Baylor College of Medicine, Texas Children's Hospital, Houston, TX

    Background/Purpose: Anti-nuclear antibodies (ANA) are important in the diagnosis of Systemic Lupus Erythematosus (SLE). Of the disease specific ANAs, anti-dsDNA and anti- Smith antibodies carry…
  • Abstract Number: 116 • 2023 Pediatric Rheumatology Symposium

    Clinical Significance of Anti-Scl-70 Antibodies in Pediatric Lupus Patients: A Single Center Cohort

    Dawn Janysek1, Yiressy Pina2, Danielle Guffey3 and Marietta De Guzman1, 1Baylor College of Medicine, Texas Children's Hospital, Houston, TX, 2Baylor College of Medicine, Texas Children's Hospital, Houston, TX, 3Baylor College of Medicine, Houston, TX

    Background/Purpose: Production of autoantibodies is a hallmark of SLE, with ANAs as a required diagnostic feature and anti-dsDNA and anti-Smith antibodies being disease-specific. Anti-Scl-70 antibodies…
  • Abstract Number: L13 • ACR Convergence 2022

    Fetal Cardiac Targets Identify the Autoantibodies Associated with Congenital Heart Block

    Stephanie Benjamin1, Lisa Vi2, Diptendu Chatterjee1, Edgar Jaeggi1, Marie Wahren-Herlenius3, Amelia Ruffatti4, Linda Hiraki5, Michelle Lohbihler2, Lusia Sepiashvili1, Carl Laskin6, Meena Fatah1, Daniela Dominguez5, Lawrence Ng5, Anthony Gramolini2, Vincent Christoffels7, Stephanie Protze2 and Robert Hamilton8, 1Hospital for Sick Children, Toronto, ON, Canada, 2University of Toronto, Toronto, ON, Canada, 3Karolinska Institutet, Stockholm, Stockholms Lan, Sweden, 4Universitå di Padova, Padova, Italy, 5The Hospital for Sick Children, Toronto, ON, Canada, 6Mt. Sinai Hospital/University of Toronto, Toronto, ON, Canada, 7Amsterdam UMC, Amsterdam, Zuid-Holland, Netherlands, 8Hospital for Sick Children, Markham, ON, Canada

    Background/Purpose: Autoimmune congenital heart block (CHB+) affects the fetus of mothers with anti-Ro antibodies. Anti-Ro (Ro+) antibodies (Abs) are usually present in maternal sera when…
  • Abstract Number: 0166 • ACR Convergence 2022

    Detection of the Novel Autoantibodies Against Transcription Factor Sp4 Is Related with Low Risk of Cancer in Idiopathic Inflammatory Myopathy Patients

    Yuji Hosono1, Azusa Kojima1, Akira Ishii1, Mai Sugiyama1, Yuto Izumi1, Noriko Sasaki2, Chiho Yamada1 and Shinji Sato1, 1Tokai University School of Medicine, Isehara Kanagawa, Japan, 2Tokai University School of Medicine, sagamihara-city, Japan

    Background/Purpose: In idiopathic inflammatory myopathy (IIM), many kinds of autoantibodies are often detected and associated with each clinical phenotype. Recently, autoantibody against transcription factor Sp4…
  • Abstract Number: 0683 • ACR Convergence 2022

    ANA-positive versus ANA-negative Antiphospholipid Antibody-positive Patients Without Other Systemic Autoimmune Diseases: Clinical and Serological Characteristics, Results from the APS ACTION Clinical Database and Repository

    Irene Cecchi1, Massimo Radin2, Silvia Grazietta Foddai2, Maria Laura Bertolaccini3, Danieli De Andrade4, Maria Tektonidou5, Vittorio Pengo6, Guillermo Ruiz-Irastorza7, H. Michael Belmont8, Maria Gerosa9, Paul Fortin10, Chary Lopez-Pedrera11, Zhouli Zhang12, Tatsuya Atsumi13, Guilherme de Jesus14, Hannah Cohen15, Nina Kello16, Ware Branch17, Denis Wahl18, Laura Andreoli19, Esther Rodriguez20, Michelle Petri21, Megan R.W. Barber22, Ricard Cervera23, Jason Knight24, Bahar Artim-Esen25, Rohan Willis26, Guillermo Pons-Estel27, Doruk Erkan28 and Savino Sciascia1, 1University of Turin, Torino, Italy, 2University of Turin, Turin, Italy, 3King's College London, London, United Kingdom, 4University of São Paulo, São Paulo, Brazil, 5University of Athens, Athens, Greece, 6University of Padova, Padova, Italy, 7University of the Basque Country, Barakaldo, Spain, 8New York University School of Medicine, New York, NY, 9University of Milan, Milano, Italy, 10CHU de Québec Université Laval, Québec, QC, Canada, 11Hospital Universitario Reina Sofía, Cordoba, Spain, 12Beijing Medical University, Beijing, China, 13Hokkaido University, Sapporo, Japan, 14Universidade do Estado do Rio de Janeiro, Rio De Janeiro, Brazil, 15University College London, London, United Kingdom, 16Northwell Health, New York, NY, 17University of Utah Health, Salt Lake City, 18Nancy University Hospital, Nancy, France, 19University of Brescia, Brescia, Italy, 20Hospital Universitario 12 de Octubre, Madrid, Spain, 21Johns Hopkins University School of Medicine, Baltimore, MD, 22University of Calgary, Calgary, AB, Canada, 23University of Barcelona, Barcelona, Spain, 24University of Michigan, Ann Arbor, MI, 25Istanbul University, Istanbul, Turkey, 26University of Texas, Galveston, TX, 27Centro Regional de Enfermedades Autoinmunes y Reumáticas, Rosario, Argentina, 28Barbara Volcker Center for Women and Rheumatic Diseases, New York, NY

    Background/Purpose: APS ACTION is an international Clinical Database and Repository of persistently antiphospholipid antibody (aPL)-positive subjects, collecting demographic, medical history, and aPL data.This study focused…
  • Abstract Number: 1048 • ACR Convergence 2022

    Nailfold Capillaroscopy and Candidate Biomarker Levels in Systemic Sclerosis-associated Pulmonary Hypertension, Profiling of Non-invasive Markers: A Cross Sectional Study

    Jacqueline Lemmers1, Arjan van Caam2, Brigit Kersten2, Els Ende, van den2, Hanneke KNAAPEN2, Arie Dijk, van2, Wanda Hagmolen of ten Have2, Frank van den Hoogen2, Hans Koenen2, Sander van Leuven3, wynand Alkema4, Ruben Smeets2 and Madelon Vonk5, 1Radboud University Medical Centre Nijmegen, Nijmegen, Netherlands, 2Radboudumc, Nijmegen, Netherlands, 3Radboud University, Nijmegen, Netherlands, 4Hanze University, Groningen the Netherlands, Dept. Data Science for Life Sciences & Health, Groningen, Netherlands, 5Department of Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands

    Background/Purpose: Pulmonary hypertension (PH) is one of the leading causes of death in Systemic Sclerosis (SSc). Early detection and treatment of PH in SSc is…
  • Abstract Number: 1476 • ACR Convergence 2022

    Anti-Neutrophil Extracellular Traps (NET) Antibodies and Their Association with Disease Activity and Clinical Phenotypes in Systemic Lupus Erythematosus

    Rosa Arvizu-Rivera1, jiram torres-Ruiz2, Alfredo Pérez-Fragoso2, Beatriz Alcalá-Carmona3, Miroslava Nuñez-Aguirre4, Ana Sofía Vargas-Castro4, Abdiel Absalón-Aguilar3, Jaquelin Lira-Luna4 and Diana Gómez-Martín2, 1Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de México, Mexico, 2INCMNSZ, Ciudad de México, Mexico, 3Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, Mexico, 4Instituto Nacional de Ciencias Medicas y Nutricion "Salvador Zubiran", Ciudad de México, Mexico

    Background/Purpose: Enhanced netosis has been acknowledged as pathogenic in Systemic Lupus Erythematosus (SLE). The presence of antibodies against neutrophil extracellular traps (anti-NETs) in patients with…
  • Abstract Number: 1965 • ACR Convergence 2022

    Autoantibodies Against a Specific 25-mer Peptide from P. Gingivalis Are Present in Sera of Patients with Rheumatoid Arthritis and Early Arthritis

    Hsin-Yi Peng1, Ting-Yin Xue1, Fei-Hung Hsieh1, Yi-Ko Chen1, Mei-Chin Yin2, Che-Yi Chao2, Shu-Yao Tsai2, Chung-Ping Lin3, Po-Hao Huang3, Chien-Chung Huang3, Jiunn-Horng Chen3, Chung-Ming Huang3, Der-Yuan Chen4, Joung-Liang Lan5 and Gregory Tsay3, 1China Medical University, Taichung, Taiwan, 2Asia University, Taichung, Taiwan, 3China Medical University Hospital, Taichung, Taiwan, 4China Medical University Hospital Rheumatology and Immunology Center, Taichung, Taiwan, 5China Medoical University Hospital, Taichung, Taiwan

    Background/Purpose: The presence of rheumatoid factor (RF) or anti-cyclic citrullinated protein/peptide antibodies (ACPA) are included in the 2010 the ACR/EULAR classification criteria of rheumatoid arthritis…
  • Abstract Number: 0167 • ACR Convergence 2022

    Accuracy of Multi-Centric Local Determination of Anti-Synthetase Autoantibodies in Patients with Anti-Synthetase Syndrome and Other Autoimmune Diseases

    Giovanni Zanframundo1, Angela Ceribelli2, Sara Faghihi Kashani3, Monica Morosini4, Sara Bozzini5, Natasa Isailovic6, Carlo Selmi7, Lorenzo Cavagna8 and Rohit Aggarwal9, 1Università di Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, Milano, Italy, 2Humanitas Research Hospital, Humanitas University, Rozzano (MI) Italy, Borgo San Giacomo, Italy, 3Stanford University, Stanford, CA, 4Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, Pavia, Italy, 5Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, Pavia, 6IRCCS Humanitas Research Hospital, Rozzano (MI), Italy, Rozzano, Italy, 7IRCCS Humanitas Research Hospital, Humanitas University, Rozzano (MI), Italy, Rozzano, Italy, 8Università di Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, Pavia, Italy, 9Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: RNA-immunoprecipitation (RNA-IP) is considered the gold standard method for anti-tRNA synthetase antibodies (ARS-Ab) detection. This technique, however, is not widely available, unlike commercial kits,…
  • Abstract Number: 0684 • ACR Convergence 2022

    Single Antiphospholipid Antibody Positive Thrombotic APS Patients’ Clinical Characteristics: Retrospective Results from the APS ACTION Clinical Database and Repository (Registry)

    Silvia Grazietta Foddai1, Irene Cecchi2, Massimo Radin1, Danieli De Andrade3, Maria Tektonidou4, Vittorio Pengo5, Guillermo Ruiz-Irastorza6, H. Michael Belmont7, Maria Gerosa8, Paul Fortin9, Rosario Lopez-Pedrera10, Zhouli Zhang11, Tatsuya Atsumi12, Guilherme de Jesus13, Hannah Cohen14, Nina Kello15, Ware Branch16, Denis Wahl17, Laura Andreoli18, Esther Rodriguez19, Michelle Petri20, Ann E. Clarke21, Ricard Cervera22, Jason Knight23, Bahar Artim-Esen24, Rohan Willis25, Guillermo Pons-Estel26, Doruk Erkan27, Dario Roccatello1 and Savino Sciascia2, 1University of Turin, Turin, Italy, 2University of Turin, Torino, Italy, 3University of São Paulo, São Paulo, Brazil, 4University of Athens, Athens, Greece, 5University of Padova, Padova, Italy, 6University of the Basque Country, Barakaldo, Spain, 7New York University School of Medicine, New York, NY, 8University of Milan, Milano, Italy, 9CHU de Québec Université Laval, Québec, QC, Canada, 10University of Cordoba, Cordoba, Spain, 11Beijing Medical University, Beijing, China, 12Hokkaido University, Sapporo, Japan, 13Universidade do Estado do Rio de Janeiro, Rio De Janeiro, Brazil, 14University College London, London, United Kingdom, 15Northwell Health, New York, NY, 16University of Utah Health, Salt Lake City, 17Nancy University Hospital, Nancy, France, 18University of Brescia, Brescia, Italy, 19Hospital Universitario 12 de Octubre, Madrid, Spain, 20Johns Hopkins University School of Medicine, Baltimore, MD, 21University of Calgary, Calgary, AB, Canada, 22University of Barcelona, Barcelona, Spain, 23University of Michigan, Ann Arbor, MI, 24Istanbul University, Istanbul, Turkey, 25University of Texas, Galveston, TX, 26Centro Regional de Enfermedades Autoinmunes y Reumáticas, Rosario, Argentina, 27Barbara Volcker Center for Women and Rheumatic Diseases, New York, NY

    Background/Purpose: The APS ACTION is a network collecting and analyzing data ofaPL positive patients recruited by international centers. Based on the assumption that triple aPL-positive…
  • Abstract Number: 1068 • ACR Convergence 2022

    Anti-vinculin Antibodies in Systemic Sclerosis: Associations with Slow Gastric Transit and Extra-Intestinal Clinical Phenotype

    Maria Herran1, Brit Adler2, Jamie Perin3, Walter Morales4, Mark Pimentel5 and Zsuzsanna McMahan6, 1School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia, 2Johns Hopkins University, Division of Rheumatology, Baltimore, MD, 3John Hopkins University, Baltimore, MD, 4Medically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, 5Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai, Los Angeles, CA, 6Johns Hopkins Rheumatology, Baltimore, MD

    Background/Purpose: The gastrointestinal tract is commonly affected in systemic sclerosis (SSc). Prior studies have reported an association between higher levels of anti-vinculin antibodies and gastrointestinal…
  • Abstract Number: 1523 • ACR Convergence 2022

    Anti-RNPC3 Autoantibodies in Mixed Connective Tissue Disease Are Associated with Systemic Sclerosis Skin Involvement

    Darya S. Jalaledin1, Hajar El Kamouni2, Alexandra Albert3, Sabrina Hoa4, Josiane Bourre-Tessier5, Eric Rich5, Jean-Richard Goulet6, Martial Koenig7, Minoru Satoh8, Marvin Fritzler9, May Choi10, Yves Troyanov11, Jean-Luc Senécal, MD12 and Océane Landon-Cardinal5, 1Division of Internal Medicine, Centre Hospitalier de l'Université de Sherbrooke, Saint-Lambert, Canada, 2Division of Rheumatology, Centre Hospitalier de l'Université de Montréal, Laval, Canada, 3Division of Rheumatology, Centre Hospitalier de l'Université Laval, Québec, QC, Canada, 4University of Montreal, Montréal, QC, Canada, 5Division of Rheumatology, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada, 6Division of Rheumatology, Centre Hospitalier de l'Université de Montréal, Saint-Lambert, Canada, 7Division of Internal Medicine, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada, 8Department of Human, Information and Science, University of Occupational Environmental Health, Kitakyusyu Fukuoka, Japan, 9University of Calgary, Calgary, AB, Canada, 10Brigham and Women's Hospital | University of Calgary, Calgary, AB, Canada, 11Division of Rheumatology, Hôpital du Sacré-Coeur de Montréal, Montréal, QC, Canada, 12Division of Rheumatology, Centre Hospitalier de l'Université de Montréal, Montréal, Canada

    Background/Purpose: RNA-binding region containing 3 (RNPC3) protein acts as a molecular bridge, promoting U11/U12 RNP complex formation. In previous studies, systemic sclerosis (SSc) patients who…
  • Abstract Number: 2021 • ACR Convergence 2022

    Early Histopathological Changes of the Salivary Glands Associated with the Development of Primary Sjögren’s Syndrome

    Xiaomei Shan1, Clara Reichardt1, Jeeshan Singh1, Anne Zeitler2, Christine Schauer1, Jasmin Knopf1, Martin Herrmann1, Gerhard Grossmayer1, Georg Schett1 and Luis Munoz1, 1Universitätsklinikum Erlangen, Erlangen, Germany, 2Friedrich-Alexander University Erlangen Nürnberg, Erlangen, Germany

    Background/Purpose: Primary Sjögren's syndrome (PSS) is a chronic inflammatory disease affecting exocrine glands including salivary and lacrimal glands that leads to dry eyes and mouth…
  • Abstract Number: 0228 • ACR Convergence 2022

    Are We Choosing Wisely? Results of a Survey of Internal Medicine Residents in a Single Center

    Joel Wright and Dipal Patel, Englewood Health, Englewood, NJ

    Background/Purpose: High value care must be prioritized given the rising costs associated with health care in the United States. The unwarranted testing of ANAs often…
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