Abstracts tagged "Atherosclerosis"

Abstract Number: 1913 • 2014 ACR/ARHP Annual Meeting
Rosuvastatin Induced Carotid Plaque Regression in Patients with Inflammatory Joint Diseases
Silvia Rollefstad¹, Eirik Ikdahl¹, Jonny Hisdal², Inge C. Olsen³, Ingar Holme⁴, Hilde Berner Hammer⁵, Knut T. Smerud⁶, G Kitas⁷, Terje R. Pedersen⁸, Tore K. Kvien⁹ and Anne Grete Semb¹, ¹Preventive Cardio-Rheuma clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Section of Vascular Investigations, Uslo University Hospital-Aker, Oslo, Norway, ³Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁴Department of biostatistics, epidemiology and health economics, Oslo University Hospital, Oslo, Norway, ⁵Postboks 23 Vinderen, Diakonhjemmet Hospital, Oslo, Norway, ⁶Smerud Medical Research International AS, Oslo, Norway, ⁷The Dudley Group of Hospitals NHS Foundation Trust, Dudley, United Kingdom, ⁸Faculty of Medicine, University of Oslo, Oslo, Norway, ⁹PsAID taskforce, EULAR, Zurich, Switzerland
Background/Purpose Patients with rheumatoid arthritis (RA) and carotid artery plaques (CP) have increased risk of acute coronary syndromes. Statin treatment with low density lipoprotein cholesterol…
Abstract Number: 438 • 2014 ACR/ARHP Annual Meeting
Distinct Profiles of Proinflammatory Macrophages in Rheumatoid Arthritis and Coronary Artery Disease
Tsuyoshi Shirai¹, Eric L. Matteson², David G. Harrison³, Barbara B. Wallis⁴, Themistocles L. Assimes⁵, Jorg J. Goronzy⁶ and Cornelia M. Weyand¹, ¹Medicine, Stanford University School of Medicine, Stanford, CA, ²Rheumatology, Mayo Clinic, Rochester, MN, ³Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, ⁴Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, ⁵Stanford University School of Medicine, Stanford, CA, ⁶Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Patients with RA have an increased risk of developing coronary artery disease (CAD) compared to the general population. The underlying pathological process of CAD…
Abstract Number: 1633 • 2014 ACR/ARHP Annual Meeting
Galectin-3-Binding Protein Is Associated with Disease Activity, but Not with Atherosclerosis in SLE Patients
Susan Kay¹, Niels Heegaard² and Anne Voss³, ¹Rheumatolog, Rheumatology, Odense, Denmark, ²Cinical Biochemistry and Pharmacology, Cinical Biochemistry and Pharmacology, Odense, Denmark, ³Reumatology, Reumatology, Odense, Denmark
Background/Purpose . Patients with systemic lupus erythematosus (SLE) have an increased risk of cardiovascular disease (CVD), which may be due to an increased prevalence of atherosclerosis.…
Abstract Number: 398 • 2014 ACR/ARHP Annual Meeting
Anti-Rheumatic Therapy Decreases Syndecan-1 Shedding in Rheumatoid Arthritis (RA)
Ivana Hollan¹, Gunnbjørg Hjeltnes², Torstein Lyberg³, Stefan Agewall³, Allan Wiik⁴, Knut Mikkelsen⁵, Øystein T. Førre⁶, Tram T. Vuong³ and Svein O. Kolset³, ¹Rheumatology, Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, ²Medicine, Innlandet Hospital Trust, Lillehammer, Norway, ³University of Oslo, Oslo, Norway, ⁴Clinical Biochem/Immunology, Statens Serum Institute, Copenhagen S, Denmark, ⁵Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, ⁶Oslo University Hospital, Oslo, Norway
Background/Purpose Intact glycocalyx is of importance for healthy endothelial function. Changes in the endothelial glycocalyx, characterized by increased levels of circulating syndecan-1, might be related…
Abstract Number: 1591 • 2014 ACR/ARHP Annual Meeting
Exploring the Association of Serum Paraoxonase and Arylesterase Activities with Cardiovascular Risk in Psoriasis and Psoriatic Arthritis
M. Elaine Husni¹, Danielle Brennan², WH Wilson Tang³ and Stanley Hazen³, ¹Rheumatology Dept A50, Cleveland Clinic Foundation, Cleveland, OH, ²Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH, ³Cardiology, CCF, Cleveland, OH
Background/Purpose Psoriatic diseases are systemic inflammatory joint and skin disorders associated with increased cardiovascular (CV) morbidity. Paraoxonase (PON) and Arylesterase (ARYL) are antioxidant enzymatic proteins…
Abstract Number: 374 • 2014 ACR/ARHP Annual Meeting
IL-33 and Soluble ST2 Levels As Novel Predictors for Remission and Progression of Carotid Plaque in Early Rheumatoid Arthritis: A Prospective Study
Jiayun Shen¹, Qing Shang¹, Ying Ying Leung², Shui Lian Yu¹, Chun-Kwok Wong³, Edmund Li¹, Tracy Y. Zhu¹ and Lai-Shan Tam¹, ¹Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ²Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore, ³Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong, Hong Kong
Background/Purpose Clinical remission is achievable for patients with early rheumatoid arthritis (ERA). Identification of predictors for response of treatment may provide risk estimation and help…
Abstract Number: 1443 • 2014 ACR/ARHP Annual Meeting
Increased Occurence of Carotid and Femoral Plaques, but Not Increased Arterial Stiffness of Hypertrophy, in Classical Risk Factor-Free Patients with Rheumatoid Arthritis
Aikaterini I. Arida¹, Evaggelia Zampeli¹, George Konstantonis¹, Kalliopi Fragkiadaki¹, George D. Kitas², Athanasios D. Protogerou¹ and Petros P. Sfikakis¹, ¹First Department of Propedeutic Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece, ²The Dudley Group of Hospitals NHS Foundation Trust, Dudley, and Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom
Background/Purpose Several lines of evidence indicate that classical cardiovascular disease (CVD) risk factors, such as arterial hypertension, diabetes mellitus, smoking and dyslipidemia, are significantly increased…
Abstract Number: 373 • 2014 ACR/ARHP Annual Meeting
Biomarkers of Cardiac Dysfunction and Inflammation in Plasma Predict Occult Coronary Plaque Burden and Composition in Rheumatoid Arthritis
George A. Karpouzas¹, Joel Estis², John Todd² and Matthew Budoff³, ¹Rheumatology, Harbor-UCLA Medical Center, Torrance, CA, ²Singulex, Alameda, California, Alameda, CA, ³Cardiology, Harbor-UCLA Medical Center, Torrance, CA
Background/Purpose Rheumatoid arthritis (RA) is associated with accelerated coronary atherogenesis, myocardial infarction, and mortality. We previously reported a higher prevalence, severity, and different composition of…
Abstract Number: 1440 • 2014 ACR/ARHP Annual Meeting
Asymptomatic Carotid Plaques in RA Patients Are Associated with Increased HDL Function
Silvia Rollefstad¹, Bente Halvorsen², Tonje Skarpengland², Sella Provan³, Tore K. Kvien⁴ and Anne Grete Semb¹, ¹Preventive Cardio-Rheuma clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway, ³Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁴PsAID taskforce, EULAR, Zurich, Switzerland
Background/Purpose Reverse cholesterol transport (RCT) is a major anti atherogenic function of high density lipoprotein cholesterol (HDL) and has been shown to be related to…
Abstract Number: 334 • 2014 ACR/ARHP Annual Meeting
Inflammatory Arthritis in K/BxN Mice Is Associated with Abnormal HDL Function
C. Charles-Schoeman¹, Ani Shahbazian¹, Yuen Yin Lee¹ and Srinivasa T. Reddy², ¹Medicine-Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ²Medicine-Cardiology, UCLA David Geffen School of Medicine, Los Angeles, CA
Background/Purpose Patients with rheumatoid arthritis (RA) have significantly increased cardiovascular (CV) morbidity and mortality. Abnormal function of high density lipoprotein (HDL) has been implicated as…
Abstract Number: 1437 • 2014 ACR/ARHP Annual Meeting
Cholesterol Efflux Capacity of HDL and Coronary Atherosclerosis in Rheumatoid Arthritis
Michelle J. Ormseth¹, Patricia Yancey², Suguru Yamamoto², Annette M. Oeser¹, Tebeb Gebretsadik³, Ayumi Shintani¹, MacRae F. Linton¹, Sergio Fazio¹, Sean Davies¹, L Jackson Roberts II¹, Kasey C. Vickers¹, Paolo Raggi⁴, Valentina Kon¹ and C Michael Stein¹, ¹Vanderbilt University, Nashville, TN, ²Medicine, Vanderbilt University, Nashville, TN, ³Biostatistics, Vanderbilt University, Nashville, TN, ⁴Emory University, Atlanta, GA
Background/Purpose: Cardiovascular (CV) risk is increased in patients with rheumatoid arthritis (RA), but not fully explained by traditional risk factors such as LDL and HDL…
Abstract Number: 79 • 2014 ACR/ARHP Annual Meeting
PECAM-1 GENE Polymorphisms and Soluble PECAM-1 LEVEL in Rheumatoid Arthritis and Systemic LUPUS Erythematosus Patients Is There a Link with Clinical Atherosclerotic Events?
Omer Nuri Pamuk¹, Hilmi Tozkir², Mehmet Sevki Uyanik³, Hakan Gurkan⁴, Julide Duymaz⁴, Salim Donmez⁵, Metin Yazar² and Gulsum Pamuk³, ¹Rheumatology, Trakya University Medical Faculty, Edirne, Turkey, ²Genetics, Trakya University Medical Faculty, EDIRNE, Turkey, ³Hematology, Trakya University Medical Faculty, Edirne, Turkey, ⁴Trakya University Medical Faculty, EDIRNE, Turkey, ⁵Department of Rheumatology, Trakya University School of Medicine, Edirne, Turkey
Background/Purpose: Platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31) which plays a role in the transmigration of leucocytes into tissues is a member of the immunoglobulin (Ig) superfamily.…
Abstract Number: 1218 • 2014 ACR/ARHP Annual Meeting
The Reduction of Serum Uric Acid Level Might Prevent Atherosclerosis in Mice
Yoshitaka Kimura^1,2, Tamiko Yanagida³, Akiko Onda⁴, Hajime Kono², Maki Takayama², Kurumi Asako², Akiko Okamoto², Hirotoshi Kikuchi² and Toshihiro Nanki⁵, ¹Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ²Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ³Depart ment of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ⁴Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ⁵Department of Clinical Research Medicine, Teikyo University, Tokyo, Japan
Background/Purpose: Excess amount of uric acid in human body causes acute inflammation, gout. In addition, uric acid is identified as a danger signal and is…
Abstract Number: 1182 • 2014 ACR/ARHP Annual Meeting
Do Patients with Active RA Also Have Inflamed Atherosclerotic Plaques on PET-MRI?
Sarah Skeoch¹, Heather Williams², Penny Cristanacce³, Jacqueline James⁴, Paul Hockings⁵, Yvonne Alexander⁶, John Waterton^7,8 and Ian N. Bruce⁹, ¹University of Manchester, Manchester, United Kingdom, ²Centre for Imaging Sciences Biomedical Imaging Institute, University of Manchester, Manchester, United Kingdom, ³Biomedical Imaging Institute, University of Manchester, Manchester, United Kingdom, ⁴Department of Nuclear Medicine, Central Manchester University Hospitals Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁵MedTech West, Chalmers University of Technology, Gottenburg, Sweden, ⁶Healthcare Science Research Institute, Manchester Metropolitan University, Manchester, United Kingdom, ⁷R&D Personalised Healthcare & Biomarkers, Astra Zeneca, MACCLESFIELD, United Kingdom, ⁸Bioimaging Institute, University of Manchester, Manchester, United Kingdom, ⁹Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Inflammation plays a key role in the progression and destabilisation of atherosclerotic plaque in the general population. In RA, inflammation is thought to accelerate…
Abstract Number: 1941 • 2013 ACR/ARHP Annual Meeting
Imaging Atherosclerotic Plaque Inflammation In RA: Methodology and Initial Findings In a Single Centre Cohort
Sarah Skeoch¹, Penny Hubbard², Heather Williams^3,4, Dongxiang Xu⁵, Sun Jie⁵, Niranjan Balu⁵, Wei Zhang⁵, Jacqueline James³, Thomas Hatsukami⁵, Chun Yuan⁵, M. Yvonne Alexander⁶, Paul Hockings⁷, John Waterton^4,8 and Ian N. Bruce⁹, ¹Arthritis Research UK Centre for Epidemiology and NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ²Centre for Imaging Sciences Biomedical Imaging Institute Oxford Road Manchester, M13 9PT United Kingdom, University of Manchester, Manchester, United Kingdom, ³Department of Nuclear Medicine, Central Manchester University Hospitals Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁴Centre for Imaging Sciences Biomedical Imaging Institute, University of Manchester, Manchester, United Kingdom, ⁵Vascular Imaging Laboratory, Department of Radiology, University of Washington, Seattle, WA, ⁶Healthcare Science Research Institute, Faculty of Science and Engineering, Healthcare Science Research Institute, Manchester Metropolitan University, Manchester, United Kingdom, ⁷Drug Safety and Metabolism, Astra Zeneca, Mölndal, Sweden, ⁸R&D Personalised Healthcare & Biomarkers, Astra Zeneca, MACCLESFIELD, United Kingdom, ⁹Kellgren Centre for Rheumatology, Central Manchester University Hospitals Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom
Background/Purpose: Chronic inflammation in RA may contribute to an unstable atherosclerotic plaque phenotype. Dynamic contrast enhanced MRI (DCE MRI) can be used to image carotid…

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