Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Reduced kidney function render patients with RA rheumatoid arthritis (RA), have an increased risk of cardtiovascular disease (CVD), particulary ischemic heart disease (IHD). This higher risk is not related primarily to traditional cardiovasculr/atherosclerosis risk factors but to the presence of high inflammation associated with RA. Also, subclinical decreased kidney function has been identified as an independent risk factor for CV events. The potential impact of impaired kidney function on atherosclerosis in RA requires more elucidation. This study assess the role of kidney parameters, alongside inflammation and traditional cardiovascular risk factors in predicting CVD; as manifested by carotid intima media thickness (cIMT) among RA population.
68 patients with RA underwent measurement of cIMT and correlated it with kidney function parameters with adjustment for traditional CV risk factors and RA associated inflammation. Glomerular filtration rate (GFR) was estimated with the abbreviated Modification of Diet in Renal Disease formula. Linear regression determined the association between renal parameters and cIMT.
cIMT was positively associated with 1-demographic characteristics: age of the participants (p<0.001), & age at RA sumptoms onset (p=0.001). 2-traditional cardiovascular risk factors such as systolic blood pressure (p<0.001), diastolic blood pressure (p=0.016), triglycerid level (p=0.016), and low densilty lipoprotein (LDL) (p=0.001), and negatively with high density lipoprotein (HDL)(p=0.037), 3-inflammatory markers such as erythrocytes sedimentation rate (ESR) (p=0.020) and c-reactive protein (CRP)(0.020), and 4-renal function parameters such as uric acid level (p=0.006), urine microalbumin level (p=0.030), and negativlely with24 hours urine creatinine level (p=0.020) and glomerular filtration rate (p=0.008).
Even subclinical kidney function in conjunction with tarditional and non-traditional CVD risk factors work synergistically to accelerate atheroscrlerosis in RA population.
To cite this abstract in AMA style:Hannawi S, Al Salmi I. Rheumatoid Arthritis with Kidney Dysfunction Contributes to Higher Risk of Cardiovascular Disease Development [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/rheumatoid-arthritis-with-kidney-dysfunction-contributes-to-higher-risk-of-cardiovascular-disease-development/. Accessed June 6, 2020.
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