Abstracts tagged "Arthritis"

Abstract Number: 664 • 2018 ACR/ARHP Annual Meeting
Prevalence and Factors Associated with Peripheral Manifestations in Spondyloarthritis. an Ancillary Analysis of the ASAS-Comospa Study
Clementina López-Medina¹, Anna Molto² and Maxime Dougados³, ¹Rheumatology Department, Cochin Hospital, Paris, France, ²Hôpital Cochin, Department of Rheumatology, Paris Descartes University, Paris, France, ³Department of Rheumatology, Paris Descartes University and Cochin Hospital, Paris, France
Background/Purpose: Peripheral manifestations (arthritis, enthesitis and dactylitis) can be observed in patients with Spondyloarthritis (SpA), but the factors associated with their presence are not well…
Abstract Number: 1475 • 2018 ACR/ARHP Annual Meeting
Eicosanoid Mediators of Systemic Inflammation and Arthritis in the Elderly
Roxana Coras^1,2, Rekha Narasimhan¹, Arthur Kavanaugh³, Lourdes Mateo⁴, Oswald Quehenberger⁵, Melania Martinez-Morillo⁶ and Monica Guma^1,2, ¹Medicine, University of California San Diego, La Jolla, CA, ²Medicine, Autonomous University of Barcelona, Bellatera, Spain, ³University of California, San Diego, School of Medicine, La Jolla, CA, ⁴Rheumatology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain, ⁵Pharmacology, Medicine, University of California San Diego, La Jolla, CA, ⁶Rheumatology, Germans Trias i Pujol University Hospital, Barcelona, Spain
Background/Purpose: Elderly-onset RA, EORA, which is defined as rheumatoid arthritis (RA) starting at >60 years of age, has received less attention than young-onset RA. Polymyalgia rheumatica (PMR) is…
Abstract Number: 679 • 2018 ACR/ARHP Annual Meeting
Ultrasonographic Research of the Relationship between Nail Disorders and Peripheral Arthritis or Enthesitis in Patients with Psoriasis and Psoriatic Arthritis
Tadashi Okano¹, Kentaro Inui², Koji Mandai³, Yutaro Yamada⁴, Tatsuya Koike⁵ and Hiroaki Nakamura², ¹Orthopedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan, ²Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan, ³Orthopaedic surgery, Osaka City University Graduate School of Medicine, Osaka, Japan, ⁴Orthopedic surgery, Yodogawa Christian Hospital, Osaka, Japan, ⁵Center for Senile Degenerative Disorders, Osaka City University Graduate School of Medicine, Osaka, Japan
Background/Purpose: Although skin lesion is the most typical findings in patients with psoriasis (PsO), nail psoriasis is also one of the important clinical manifestation. Moreover,…
Abstract Number: 1493 • 2018 ACR/ARHP Annual Meeting
Clinical Predictor Factors Associated with Sustained Disease Activity Among Patients with Early Rheumatoid Arthritis
Gabriela Gonzalez and Juan Molina, Rheumatology, La Paz University Hospital, Madrid, Spain
Background/Purpose: in rheumatoid arthritis (RA) patients the disease outcome has an unpredictable course and may differ even with an early diagnosis and treatment. Low disease…
Abstract Number: 760 • 2018 ACR/ARHP Annual Meeting
Diagnosing SLE Arthritis with Dynamic Diffuse Optical Spectroscopy
George Danias¹, Youngwan Kim², Alessandro Marone³, Kayla Neville¹, Andrea Frantz¹, Teja Kapoor⁴, Laura Geraldino-Pardilla¹, Ioannis Kymissis², Andreas Hielscher^2,3,5 and Anca Askanase¹, ¹Rheumatology, Columbia University Medical Center, New York, NY, ²Electrical Engineering, Columbia University, New York, NY, ³Biomedical Engineering, Columbia University, New York, NY, ⁴Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ⁵Radiology, Columbia University Medical Center, New York, NY
Background/Purpose: SLE arthritis is difficult to evaluate because of the sometimes-evanescent nature of the symptoms and limitations of physical exams and imaging studies. Dynamic diffuse…
Abstract Number: 1660 • 2018 ACR/ARHP Annual Meeting
Depression Has a Greater Impact on Psoriatic Arthritis Than Rheumatoid Arthritis
Surjeet Dheer¹, Vivekanand Tiwari², Ammarah Hussain¹, Kakageldi Hommadov¹, Ana Maheshwari¹ and Martin J. Bergman³, ¹Mercy Catholic Medical Center, Philadelphia, PA, ²St John's Hospital, Springfield, IL, ³Drexel University College of Medicine, Philadelphia, PA
Background/Purpose: Depression has been shown to be more common in patients with psoriatic arthritis (PsA) and rheumatoid arthritis (RA), than in the general population. The…
Abstract Number: 914 • 2018 ACR/ARHP Annual Meeting
Increased Adverse Childhood Experiences in Children with Arthritis: An Analysis of the National Survey of Children’s Health
Tamar Rubinstein¹, Danielle R. Bullock², Kaveh Ardalan³, Wenzhu B. Mowrey⁴, Nicole Brown⁵ and Ruth E K Stein⁶, ¹Pediatric Rheumatology, Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, NY, ²Pediatrics, University of Minnesota, Minneapolis, MN, ³Division of Rheumatology, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, ⁴Albert Einstein College of Medicine, Bronx, NY, ⁵Albert Einstein College of Medicine/ Children's Hospital at Montefiore, Bronx, NY, ⁶Pediatrics, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Adverse Childhood Experiences (ACEs) are associated with increased risk of chronic disease and poorer health in children and adults. Emerging data suggest an association…
Abstract Number: 1950 • 2018 ACR/ARHP Annual Meeting
Self-Reported Depression and Anxiety Among US Adults Aged 18-44 Years with Arthritis, National Health Interview Survey 2014-2016
Dana Guglielmo¹, Jennifer M. Hootman², Louise Murphy², Michael Boring³, Kristina Theis², Charles G. Helmick², Kamil E. Barbour² and Patricia Katz⁴, ¹Oak Ridge Institute for Science and Education, Oak Ridge, TN, ²Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA, ³Cutting Edge Technology and Solutions, Mesa, AZ, ⁴University of California San Francisco, San Francisco, CA
Background/Purpose: Depression and anxiety are frequent comorbid conditions among adults with arthritis, and are associated with poorer quality of life, reduced adherence and efficacy of…
Abstract Number: 951 • 2018 ACR/ARHP Annual Meeting
IFN-Gamma Production in Lyme Arthritis Synovial Tissue Promotes Differentiation of Fibroblast-like Synoviocytes into Inflammatory Effector Cells
Robert Lochhead¹, David Ordonez-Del Valle¹, Sheila Arvikar², Allen C. Steere² and Klemen Strle³, ¹Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, BOSTON, MA, ²Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Department of Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, BOSTON, MA
Background/Purpose: Lyme arthritis (LA), a late-disease manifestation of Borrelia burgdorferi infection, usually responds to antibiotic therapy. However, some patients may develop a proliferative synovitis lasting…
Abstract Number: 1974 • 2018 ACR/ARHP Annual Meeting
Dynamics of Transcriptional Signatures from Synovial Macrophage Subsets during Acute and Chronic Murine Models of Inflammatory Arthritis
Philip J. Homan¹, Anna B Montgomery², Salina Dominguez³, Carla M. Cuda³, Harris Perlman³ and Deborah R. Winter³, ¹Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Macrophages play an integral role in the progression and persistence of rheumatoid arthritis (RA) through production of degradative enzymes, cytokines, and chemokines and recruitment…
Abstract Number: 983 • 2018 ACR/ARHP Annual Meeting
A MAPK Activated Kinase 2 Inhibitor Attenuates Inflammatory and Destructive Arthritis in Human Ex Vivo Models
Tue Wenzel Kragstrup^1,2, Anders Mellemkjær³, Morten Aagaard Nielsen⁴, Line Dam Heftdal², Marie Iversen³, Peter Schafer⁵ and Bent Deleuran², ¹Randers Regional Hospital, Randers, Denmark, ²Department of Biomedicine, Aarhus University, Aarhus, Denmark, ³Aarhus University, Aarhus, Denmark, ⁴Of Biomedicine, Aarhus University, Aarhus, Denmark, ⁵Celgene Corporation, Summit, NJ
Background/Purpose: Targeting intracellular pathways with oral small molecules is an attractive therapeutic approach for treating immune mediated inflammatory diseases. The mitogen-activated protein kinase (MAPK) pathway…
Abstract Number: 2027 • 2018 ACR/ARHP Annual Meeting
Whole Exome Trio Sequencing Implicates DOCK2 in Juvenile Idiopathic Arthritis
Laura A McIntosh^1,2, Yoshinori Fukui³, Thomas A. Griffin⁴, Kenneth Kaufman^1,2,5, Jarek Meller^6,7, Sherry Thornton⁸, Halima Moncrieffe^1,2 and Susan D Thompson^1,2, ¹Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Department of Pediatrics, University of Cincinnati, Cincinnati, OH, ³Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan, ⁴Levine Children’s Hospital at Carolinas Medical Center, Charlotte, NC, ⁵US Department of Veterans Affairs Medical Center, Cincinnati, OH, ⁶Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ⁷Department of Environmental Health, University of Cincinnati, Cincinnati, OH, ⁸Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease of childhood and has a strong genetic component to disease risk. Genome-wide association studies…
Abstract Number: 1007 • 2018 ACR/ARHP Annual Meeting
Macrophage Mediators of Autoimmune Valvular Carditis and Fibrosis
Lee Meier¹, Mayra Gonzalez-Torres², Jennifer L. Auger², Aubyn Marath³ and Bryce A. Binstadt², ¹Department of Pediatrics and Center for Immunology, University of Minnesota, Minneapols, MN, ²Department of Pediatrics and Center for Immunology, University of Minnesota, Minneapolis, MN, ³CardioStart International, Tampa, FL
Background/Purpose: K/B.g7 TCR transgenic mice spontaneously develop both autoimmune arthritis and valvular carditis. We utilize this model to define mediators of rheumatic disease-associated cardiovascular inflammation…
Abstract Number: 2048 • 2018 ACR/ARHP Annual Meeting
In Vitro Proof-of-Concept of Pathobiology-Guided Therapy in Immune Mediated Inflammatory Arthritis
Morten Aagaard Nielsen¹, Bent Deleuran^2,3 and Tue Wenzel Kragstrup^2,3,4, ¹Of Biomedicine, Aarhus University, Aarhus, Denmark, ²Department of Biomedicine, Aarhus University, Aarhus, Denmark, ³Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ⁴Randers Regional Hospital, Randers, Denmark
Background/Purpose: Immune mediated inflammatory arthritis are very heterogeneous diseases including rheumatoid arthritis (RA), psoriatic arthritis (PsA) and spondyloarthritis (SpA). The available biological and targeted synthetic…
Abstract Number: 1011 • 2018 ACR/ARHP Annual Meeting
Tissue Resident Macrophages Establish a Niche That Limits Monocyte to Macrophage Differentiation in Synovial Tissue during Homeostasis
Qi Quan Huang¹, Renee E. Doyle², Alexander Misharin³, Shang-Yang Chen⁴, Deborah R. Winter⁵ and Richard M. Pope², ¹Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine/pulmonary, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, chicago, IL, ⁵Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Monocytes and Macrophages play critical roles in immune homeostasis and host defense. Recent studies identified that macrophages are highly heterogeneous in terms of location,…

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