Abstracts tagged "Arthritis"

Abstract Number: 1007 • 2018 ACR/ARHP Annual Meeting
Macrophage Mediators of Autoimmune Valvular Carditis and Fibrosis
Lee Meier¹, Mayra Gonzalez-Torres², Jennifer L. Auger², Aubyn Marath³ and Bryce A. Binstadt², ¹Department of Pediatrics and Center for Immunology, University of Minnesota, Minneapols, MN, ²Department of Pediatrics and Center for Immunology, University of Minnesota, Minneapolis, MN, ³CardioStart International, Tampa, FL
Background/Purpose: K/B.g7 TCR transgenic mice spontaneously develop both autoimmune arthritis and valvular carditis. We utilize this model to define mediators of rheumatic disease-associated cardiovascular inflammation…
Abstract Number: 2048 • 2018 ACR/ARHP Annual Meeting
In Vitro Proof-of-Concept of Pathobiology-Guided Therapy in Immune Mediated Inflammatory Arthritis
Morten Aagaard Nielsen¹, Bent Deleuran^2,3 and Tue Wenzel Kragstrup^2,3,4, ¹Of Biomedicine, Aarhus University, Aarhus, Denmark, ²Department of Biomedicine, Aarhus University, Aarhus, Denmark, ³Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ⁴Randers Regional Hospital, Randers, Denmark
Background/Purpose: Immune mediated inflammatory arthritis are very heterogeneous diseases including rheumatoid arthritis (RA), psoriatic arthritis (PsA) and spondyloarthritis (SpA). The available biological and targeted synthetic…
Abstract Number: 1011 • 2018 ACR/ARHP Annual Meeting
Tissue Resident Macrophages Establish a Niche That Limits Monocyte to Macrophage Differentiation in Synovial Tissue during Homeostasis
Qi Quan Huang¹, Renee E. Doyle², Alexander Misharin³, Shang-Yang Chen⁴, Deborah R. Winter⁵ and Richard M. Pope², ¹Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine/pulmonary, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, chicago, IL, ⁵Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Monocytes and Macrophages play critical roles in immune homeostasis and host defense. Recent studies identified that macrophages are highly heterogeneous in terms of location,…
Abstract Number: 2083 • 2018 ACR/ARHP Annual Meeting
Epistasis between HLA-B27 and ERAP1 Affects Gut Microbial Dysbiosis and Arthritis in Experimental Spondyloarthritis
Tejpal Gill¹, Tri Tran¹, Stephen R. Brooks² and Robert Colbert³, ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Biodata Mining and Discovery Section, Office of Science and Technology, NIAMS/NIH, Bethesda, MD, ³National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: Common variants in endoplasmic reticulum (ER)-associated aminopeptidase-1 (ERAP1) affect susceptibility to spondyloarthritis (SpA) in HLA-B27-positive human subjects, with loss-of-function/expression conferring protection. Using HLA-B27/human b2-microglobulin…
Abstract Number: 31 • 2018 ACR/ARHP Annual Meeting
Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) Regulates Inflammation and Joint Damage in the TNF-Tg Mouse Model
Maria de la Luz Garcia-Hernandez¹, Javier Rangel-Moreno², Ananta Paine², Benjamin D. Korman¹, Nelson Huertas² and Christopher T. Ritchlin¹, ¹Division of Allergy/Immunology and Rheumatology and Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester Medical School, Rochester, New York, USA, Rochester, NY, ²Division of Allergy, Immunology and Rheumatology and Center for Musculoskeletal Research School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA, Rochester, NY
Background/Purpose: Pathologic bone resorption in rheumatoid arthritis (RA) is mediated by multinucleated osteoclasts (OC) at the bone-pannus junction. OC differentiation (OCgenesis) is dependent on a…
Abstract Number: 1051 • 2018 ACR/ARHP Annual Meeting
Hoxd Genes Regulate Arthritis-Relevant Pathways
Kerstin Klein¹, Mojca Frank Bertoncelj¹, Monika Krošel¹, Matija Tomšič², Christoph Kolling³, Oliver Distler⁴ and Caroline Ospelt¹, ¹Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²University Medical Centre Ljubljana, Department of Rheumatology, Ljubljana, Slovenia, ³Upper Extremity Dept., Schulthess Clinic Zurich, Zurich, Switzerland, ⁴Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Gene expression and functions of synovial fibroblasts (SF) differ profoundly between distinct joints. This might lead to site-specific activation of arthritis-relevant pathways with implications…
Abstract Number: 2123 • 2018 ACR/ARHP Annual Meeting
Analysis of Lupus Synovitis Gene Expression Reveals Dysregulation of Pathogenic Pathways Activated within Infiltrating Immune Cells
Erika Hubbard, Michelle Catalina, Sarah Heuer, Prathyusha Bachali, Nick Geraci, Isabella Blanco, Robert Robl, Peter Lipsky and Amrie Grammer, AMPEL BioSolutions and RILITE Research Institute, Charlottesville, VA
Background/Purpose: Arthritis is a common manifestation of SLE but the inflammatory and immune cells that infiltrate synovium and the signaling pathways activated are not well…
Abstract Number: 32 • 2018 ACR/ARHP Annual Meeting
T Cell-Intrinsic Nod2 Protects Against Th17-Mediated Autoimmune Arthritis in SKG Mice
Ruth Napier¹, Ellen Lee¹, Emily Vance¹, Paige Snow², Clare Dawson³, Kimberly Samson⁴, Amy Moran⁵, Michael Davey⁶, Shimon Sakaguchi⁷ and Holly Rosenzweig¹, ¹Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, ²Molecular Microbiology and Immunology, VA Portland Health Care System, Portland, OR, ³Portland VA, PORTLAND, OR, ⁴Oregon Health & Science University, Portland, OR, ⁵Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, OR, ⁶VA Portland Health Care System, Portland, OR, ⁷Osaka University, Osaka, Japan
Background/Purpose: Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) is an innate immune receptor known primarily for its role in host protection against bacterial infections. Intriguingly, Nod2…
Abstract Number: 1151 • 2018 ACR/ARHP Annual Meeting
Comparison of Methodologic Approaches to Maximize the Validity of Fitbit Device Data for Arthritis-Related Research Purposes
Jeffrey R. Curtis¹, Shuo Yang¹, Lang Chen¹, Nada Elmagboul¹, David T. Redden², Amy S. Mudano¹, Phillip J. Foster³, Filby Cooper¹, Ted R. Mikuls⁴, Justin K Owensby¹ and Kenneth Saag⁵, ¹University of Alabama at Birmingham, Birmingham, AL, ²Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, ³Department of Medicine, Division of Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁴Internal Medicine, Division of Rheumatology, VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ⁵UAB, Birmingham, AL
Background/Purpose: Health activity tracker devices (e.g. Fitbit) are increasingly used component of medical evaluation. However, the validity and suitability of the data from such devices…
Abstract Number: 2349 • 2018 ACR/ARHP Annual Meeting
“I Was Prepared for the Other Side Effects; I Wasn’t Prepared for This One.”: A Qualitative Study of the Patients’ Experience of Inflammatory Arthritis Due to Immune Checkpoint Inhibitor Therapy for Cancer
Laura C. Cappelli¹, Suzanne Grieb², Ana-Maria Orbai³, Ami A. Shah¹ and Clifton O. Bingham III⁴, ¹Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Johns Hopkins Bayview Medical Center, Center for Child and Community Health Research, Baltimore, MD, ³Johns Hopkins University School of Medicine, Baltimore, MD, ⁴Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Patients treated for cancer with immune checkpoint inhibitors (ICI) can develop a variety of adverse events. Inflammatory arthritis (IA) is an increasingly recognized event…
Abstract Number: 46 • 2018 ACR/ARHP Annual Meeting
Organic Dust Inhalants Shift Immune Responses and Extracellular Matrix Balance between Synovium and Lung in the Collagen-Induced Arthritis Mouse Model
Michael J. Duryee¹, Jill Poole², Amy Nelson³, Katherine Janike², Lynell W. Klassen⁴, James R. O'Dell⁴, Bryant R. England⁵, Ted R. Mikuls⁶ and Geoffrey M. Thiele⁷, ¹Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ²Medicine, University of Nebraska Medical Center, Omaha, NE, ³Department of Medicine, University of Nebrasa Medical Center, Omaha, NE, ⁴Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁵Rheumatology, VA Nebraska-Western Iowa Health Care System & University of Nebraska Medical Center, Omaha, NE, ⁶Internal Medicine, Division of Rheumatology, VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ⁷University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Emerging evidence suggests that the lungs may be an initiating site of autoimmunity leading to RA with organic inhalant exposures such as those…
Abstract Number: 1152 • 2018 ACR/ARHP Annual Meeting
“Doctor, a Storm Is Coming and My Joints Hurt”: Evaluating Associations between Weather Changes and Arthritis Symptoms
Jeffrey R. Curtis¹, Shuo Yang¹, Cassie Clinton¹, Lang Chen¹, W. Benjamin Nowell², Huifeng Yun¹ and David Curtis³, ¹University of Alabama at Birmingham, Birmingham, AL, ²Global Healthy Living Foundation, Upper Nyack, NY, ³Global Healthy Living Foundation, New York, NY
Background/Purpose: Arthritis symptoms reported by patients have been anecdotally associated with weather changes, but large-scale, systemic evaluations are few in number. A variety of parameters…
Abstract Number: 2429 • 2018 ACR/ARHP Annual Meeting
Long-Term Outcome of Children Born to Mothers with Chronic Arthritis and Exposed to TNF-Inhibitors during Pregnancy: A Case-Control Study
Laura Andreoli¹, Maria Chiara Gerardi², Chiara Bazzani³, Matteo Filippini³, Micaela Fredi², Roberto Gorla³, Maria Grazia Lazzaroni², Cecilia Nalli², Marco Taglietti³, Andrea Lojacono⁴, Sonia Zatti⁴, Mario Motta⁵ and Angela Tincani², ¹Department of Clinical and Experimental Sciences, Spedali Civili and University of Brescia, Brescia, Italy, Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy, ²Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy, ³Rheumatology and Clinical Immunology, Spedali Civili of Brescia, Brescia, Italy, ⁴Obstetrics and Gynaecology, Spedali Civili and University of Brescia, Brescia, Italy, ⁵Neonatology and NICU, Spedali Civili of Brescia, Brescia, Italy
Background/Purpose: Treatment with tumor necrosis factors inhibitors (TNFi) during pregnancy may be required to control maternal disease which can be a threat for maternal-fetal well-being.…
Abstract Number: 62 • 2018 ACR/ARHP Annual Meeting
CCR6+CD4+ T Cells Drive IL-23R Signaling-Dependent Progression of Antigen-Induced Arthritis
W Razawy¹, N Salioska², P Asmawidjaja³, A Otten-Mus⁴, N Kops⁵, M Oukka⁶, V Kuchroo⁷ and Erik Lubberts³, ¹Rheumatology and Immunology, Erasmus MC, Rotterdam, Netherlands, ²Rheumatology, Erasmus MC, Rotterdam, Netherlands, ³Rheumatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁴Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁵Orthopedics, Erasmus MC, Rotterdam, Netherlands, ⁶Pediatrics, Seattle Children's Research Institute, Seattle, WA, ⁷Center for Neurologic Diseases, Harvard Institute of Medicine, Boston, MA
Background/Purpose: The IL-23/IL-17A immune pathway is important for the progression of T cell-mediated arthritis. However, it is not known where IL-23R+ T cells locate during…
Abstract Number: 1212 • 2018 ACR/ARHP Annual Meeting
Superiority of Musculoskeletal Ultrasound (MSUS) over Clinical Examination Regarding Detection of Arthritis in Patients with Systemic Sclerosis
Daria Feldmann¹, Reinhard Voll², Florian Kollert³ and Stephanie Finzel¹, ¹Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, ²Clinic for Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, ³Department of Rheumatology, Immunology, and Allergology, Inselspital, University Hospital Bern, Bern, Switzerland
Background/Purpose: Arthralgia is frequent in patients with systemic sclerosis (SSc). However, correct clinical assessment of arthritis remains a challenge especially in patients with severe soft…

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