Abstracts tagged "Arthritis"

Abstract Number: 0532 • ACR Convergence 2020
State-Specific Percentage of Adults with Arthritis Who Report Both Severe Joint Pain and Physical Inactivity and Their Characteristics, United States, Behavioral Risk Factor Surveillance System, 2017
Dana Guglielmo¹, Louise Murphy¹, Jennifer Hootman¹, Michael Boring¹, Kristina Theis¹, Charles Helmick¹, Susan Carlson¹, Yong Liu¹, Hua Lu¹ and Janet Croft¹, ¹Centers for Disease Control and Prevention, Atlanta, GA
Background/Purpose: About one in four (27%) US adults with arthritis have severe joint pain, and only 36% meet the Physical Activity Guidelines for Americans. While…
Abstract Number: 046 • 2020 Pediatric Rheumatology Symposium
Near Infrared Indocyanine Green Imaging Reveals Altered Anatomy and Diminished Function in Lymphatic Vessels in the Hands of Rheumatoid Arthritis Patients During Flare
Richard Bell ¹, Homaira Rahimi², H. Mark Kenney ², Ronald Wood ², Alicia Lieberman ³, Edward Schwarz ⁴ and Christopher Ritchlin ⁵, ¹University of Rochester Medical Center, Rochester, ²University of Rochester, Rochester, ³Batavia, ⁴University of Rochester, Rochester, NY, USA, Rochester, ⁵University of Rochester Medical Center, Canandaigua
Background/Purpose: Near infrared (NIR) imaging studies of subdermal indocyanine green (ICG) in murine models of inflammatory arthritis have established abnormal lymphatic vessel (LV) function during…
Abstract Number: 067 • 2020 Pediatric Rheumatology Symposium
Response to Treatment with Intra-articular Triamcinolone Hexacetonide and Triamcinolone Acetonide in Oligo-articular Juvenile Idiopathic Arthritis
Rana Masoud¹, Wajiha Jeelani ², Barbine Agbor Agbor ³, Teresa Hennon ², Brian Wrotniak ⁴ and Rabheh Abdul Aziz ², ¹Department of Pediatrics, University at Buffalo, Oishei Children's Hospital, Buffalo, New York, ²Department of Pediatric Rheumatology, University at Buffalo, Oishei Children's Hospital, Buffalo, ³Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, Buffalo, ⁴Department of Pediatrics, University at Buffalo, Oishei Children's Hospital, Buffalo, NY, USA, Buffalo
Background/Purpose: Oligo-articular juvenile idiopathic arthritis (Oligo JIA) is the most common subtype of juvenile idiopathic arthritis. Intra-articular corticosteroid (IAC) injection is a mainstay treatment of…
Abstract Number: 089 • 2020 Pediatric Rheumatology Symposium
Associations Among Pain, Mood, and Sleep in Children with Rheumatic Conditions
Arionna Rudolph¹, Kathryn Thompson ¹, Aaron Fobian ¹, Matthew Stoll ¹, Peter Weiser ² and Burel Goodin ¹, ¹University of Alabama at Birmingham, Birmingham, ²Birmingham
Background/Purpose: Chronic pain in school-aged children and adolescents is highly prevalent and can be debilitating. Literature suggests that children with musculoskeletal pain are at risk…
Abstract Number: 114 • 2020 Pediatric Rheumatology Symposium
Musculoskeletal Ultrasound Study in Childhood Arthritis: A Limited Examination
Patricia Vega-Fernandez¹, Tracy Ting ¹, Edward Oberle ², Janet Figueroa ³, Courtney McCracken ⁴ and Johannes Roth ⁵, ¹Cincinnati Children's Hospital Medical Center, Cincinnati, ²Division of Rheumatology, Nationwide Children's Hospital, Columbus, ³Emory University, Atlanta, ⁴Emory University School of Medicine, Atlanta, ⁵Division of Pediatric Rheumatology, Children Hospital of Eastern Ontario, Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada
Background/Purpose: A challenge in the management of Juvenile Idiopathic Arthritis (JIA) is most of the core set of assessment measurements are subjective by nature. A…
Abstract Number: 1771 • 2019 ACR/ARP Annual Meeting
MyD88 S209R Enhances Inflammation in Mouse Models of Arthritis
Sufia Bakshi¹, Anders Lindstedt ², Malika Waschmann ³, Wanxia Tsai ¹, Robert Colbert ⁴ and Keith Sikora ¹, ¹National Institutes of Health, Bethesda, MD, ²NIH, Bethesda, MD, ³Oregon Health and Science University, Portland, OR, ⁴Pediatric Clinical Trials Unit, Pediatric Translational Research Branch, NIAMS, NIH, Bethesda, MD
Background/Purpose: MyD88 is a critical adaptor protein that connects Toll-like and IL-1 receptor signaling to activation of NF-kB. We previously reported a heterozygous de novo gain-of-function mutation in MYD88 (S222R)…
Abstract Number: 2062 • 2019 ACR/ARP Annual Meeting
Arthritis, Physical Function, and Disability Among Older Mexican Americans over 20-Years of Follow-up
Martin A Rodriguez¹, Lin-Na Chou ¹, Jaspreet K Sodhi ¹, Kyriakos S Markides ¹, Kenneth J Ottenbacher ¹ and Soham Al Snih ¹, ¹The University of Texas Medical Branch, Galveston
Background/Purpose: Hispanics are the fastest growing group of older adults in the US, with older Mexican Americans the largest segment of US Hispanics (65%), a…
Abstract Number: 2063 • 2019 ACR/ARP Annual Meeting
Arthritis, Upper-Lower Extremity Functional Limitations, and Disability in American Older Adults: Findings from the National Health and Aging Trends Study (NHATS)
Martin A Rodriguez¹, Jaspreet K Sodhi ¹ and Soham Al Snih ¹, ¹The University of Texas Medical Branch, Galveston
Background/Purpose: To examine the effect of arthritis on upper-lower extremity (UE-LE) functional limitations and disability over 6-years of follow-up among American older adults.Methods: Data are…
Abstract Number: 2119 • 2019 ACR/ARP Annual Meeting
Impact of Day of Admission and Time to Diagnostic Arthrocentesis on Mortality and Other Outcomes in Septic Arthritis: A Nationwide Analysis
Gustavo Contreras¹, Ana B Arevalo ¹, Shane Murray ¹, Faris Haddadin ¹ and Yiming Luo ¹, ¹Mount Sinai St. Luke's - West/ Icahn School of Medicine, New York, NY
Background/Purpose: Multiple studies have been done assessing the “weekend effect” and outcomes for hospitalized patients 1,2,3,4, however, there is no data evaluating the outcome of…
Abstract Number: 2130 • 2019 ACR/ARP Annual Meeting
Enrichment of IL-17-producing CD4+ T Cells in Synovial Fluid from Patients with Arthritis After anti-CTLA-4 and anti-PD-1 Combination Therapy
Sang Kim¹, Jean Tayar ¹, Maria E. Suárez-Almazor ², Huifang Lu ¹, Yang-Zhi Zhao ¹, Zhongshan Liu ³, Emma Rodriguez ¹, Sattva Neelapu ¹, Jennifer Wang ¹, Amishi Shah ¹, Nizar Tannir ³, Don Gibbons ³, Guillermo Garcia-Manero ³, Hussein Tawbi ³, Patrick Hwu ¹, Andrew Futreal ³, Adi Diab ³ and Roza Nurieva ³, ¹MD Anderson Cancer Center, Houston, TX, ²Department of Rheumatology/Clinical Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX , USA., Houston, TX, ³MD Anderson Cancer Center, Houston
Background/Purpose: Immune checkpoint inhibitors (ICIs) are associated with immune-related adverse events (irAEs), including arthritis (arthritis-irAE). Understanding the pathophysiology of arthritis-irAE is critical to treating it…
Abstract Number: 56 • 2019 ACR/ARP Annual Meeting
Choline Metabolite Is Associated with Inflammation in Arthritis in the Elderly
francesca cedola¹, Roxana Coras ², Elsa Sanchez-Lopez ³, Lourdes Mateo ⁴, Anders Pedersen ⁵, Anahy Brandy-Garcia ⁴, Águeda Prior-Español ⁴, Brin S rosenthal ⁶, Melania Martínez-Morillo ⁴ and Monica Guma ⁷, ¹University of California San Diego, Rome, Italy, ². Department of Medicine, School of Medicine. University of California, San Diego, ³Department of Pharmacology, University of California San Diego, La Jolla, San Diego, ⁴Hospital Universitari Germans Trias i Pujol, Badalona, Spain, ⁵University of Gothenburg, Gothenburg, Sweden, ⁶University of California San Diego, san diego, ⁷Department of Medicine, School of Medicine. University of California San Diego, La Jolla, United States
Background/Purpose: Elderly-onset RA (EORA) and polymyalgia rheumatica (PMR) are common rheumatic disease in the elderly and their pathogenesis are still not completely understood. Perturbations caused…
Abstract Number: 2139 • 2019 ACR/ARP Annual Meeting
Rheumatic Immune-Related Adverse Events Associated with Treatment with Immune Checkpoint Inhibitors: A Multicenter Study of 38 Cases
Sebastian Rodriguez-Garcia¹, David Lobo ², Fabiola Ojeda ³, Raul Castellanos-Moreira ⁴, Ana Laiz ², Roberto Gumucio ⁴, Cesar Diaz-Torné ², Virginia Ruiz-Esquide ⁵, Milena Millan ², Ivan Castellvi ⁶, Patricia Moya Alvarado ⁷, Berta Magallares ², Carolina Perez ³, Hector Corominas ⁸ and Jose Gomez-Puerta ⁹, ¹Rheumatology Department. Hospital Clínic Barcelona, Barcelona, Spain, ²Rheumatology Department. Hospital Sant Pau, Barcelona, Catalonia, Spain, ³Rheumatology Department. Hospital del Mar, Barcelona, Catalonia, Spain, ⁴Rheumatology Department. Hospital Clínic Barcelona, Barcelona, Catalonia, Spain, ⁵Department of Rheumatology, Hospital Clínic, Barcelona, Barcelona, Catalonia, Spain, ⁶Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, ⁷Hospital de la Santa Creu i Sant Pau, Barcelona, Catalonia, Spain, ⁸Rheumatology Department, Hospital Sant Pau, Barcelona, Catalonia, Spain, ⁹Department of Rheumatology, Hospital Clínic, Barcelona, Barcelona, Spain
Background/Purpose: Immune checkpoint inhibitors (ICI) against CTLA-4 or PD- 1/PD-L1 and more recently TIM3, have demonstrated efficacy in improving the survival of patients with diverse…
Abstract Number: 99 • 2019 ACR/ARP Annual Meeting
Mass Cytometry Immunophenotyping of Synovial Fluid from Checkpoint Inhibitor Related Arthritis
Runci Wang¹, Karmela Kim Chan ², Amy Cunningham-Bussel ³, Laura Donlin ⁴, Gregory Vitone ², Aidan Tirpack ², Caroline Benson ², Gregory Keras ³, Anna Helena Jonsson ⁵, Michael Brenner ⁶, Anne Bass ⁷ and Deepak Rao ¹, ¹Brigham and women's hospital, Boston, MA, ²Hospital For Special Surgery, New York, ³Brigham and women's hospital, Boston, ⁴Hospital For Special Surgery, New York, NY, ⁵Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁶Brigham and Women’s Hospital:, Boston, ⁷Hospital for Special Surgery/Weill Cornell Medicine, New York, NY
Background/Purpose: Anti-PD-1/PD-L1 checkpoint inhibitor therapies have produced remarkable results in stimulating immune responses against tumors. Checkpoint inhibitor therapy can also trigger a variety of autoimmune…
Abstract Number: 2157 • 2019 ACR/ARP Annual Meeting
Checkpoint Inhibitor-Associated Arthritis: Phenotype, Steroid Dose, Serology and Survival
Karmela Kim Chan ¹, Aidan Tirpack ¹, Caroline Benson ¹, Gregory Vitone ¹, Jackie Finik ², Vivian Bykerk ³, Susan Goodman ⁴, Laura Donlin ⁵, Deepak Rao ⁶ and Anne Bass⁴, ¹Hospital For Special Surgery, New York, ²Hospital for Special Surgery, New York, NY, New York, NY, ³Hospital for Special Surgery, New York City, NY, ⁴Hospital For Special Surgery/Weill Cornell Medicine, New York, NY, ⁵Hospital For Special Surgery, New York, NY, ⁶Brigham and Women's Hospital, Boston, MA
Background/Purpose: Previous studies suggest that steroid dose1and rheumatoid factor positivity2 impact cancer survival in checkpoint inhibitor (CI)-treated patients (with CI-associated hypophysitis, and in all-comers with non-small…
Abstract Number: 114 • 2019 ACR/ARP Annual Meeting
Persistent Synovial Resident Memory T Cells Mediate Arthritis Flares
Margaret Chang¹, Anaïs Levescot ², Rachel Blaustein ², Nathan Nelson-Maney ², Allyn Morris ², Robert Fuhlbrigge ³ and Peter Nigrovic ⁴, ¹Division of Immunology, Boston Children's Hospital, Boston, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, MA, ³Department of Rheumatology, Children’s Hospital Colorado, Denver, CO, ⁴Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA ; Department of Medicine, Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA., Boston
Background/Purpose: Resident memory T cells (TRM) are site-specific memory T cells that take up long-term residence in peripheral tissues and aid in pathogen defense. However,…

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