Abstracts tagged "Arthritis"

Abstract Number: 979 • 2019 ACR/ARP Annual Meeting
Platelet Derived Growth Factor Receptor Alpha (PDGFRα) Blockade Inhibits Arthritis in Mice
Bhanupriya Madarampalli¹, Paul Panipinto ¹, Erica Chow ¹, Kendahl Sugai ¹, Fanqi Shi ¹ and Erika Noss ¹, ¹University of Washington, Seattle, WA
Background/Purpose: The interplay between infiltrating immune cells and activated joint stromal cells drives inflammation, cartilage destruction, and bone erosion in rheumatoid arthritis (RA). Among joint…
Abstract Number: 2722 • 2019 ACR/ARP Annual Meeting
The down Syndrome Arthropathy Cohort in the New Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry: Clinical Characteristics, Treatment and Outcomes
Jordan Jones¹, Daniel J. Lovell ², Chelsey Smith ³ and Mara Becker ⁴, ¹Children's Mercy Kansas City, Kansas City, MO, ²Pediatric Rheumatology Collaborative Study Group (PRCSG), Cincinnati Children’s Hospital Medical Center, Cincinnati, ³Children's Mercy Kansas City, Kansas, MO, ⁴Duke Children's Hospital, Durham, NC
Background/Purpose: Down syndrome arthropathy (DA) is under-recognized with a 19-month average delay in diagnosis (1). The majority present with polyarticular, rheumatoid factor (RF) and anti-nuclear…
Abstract Number: 984 • 2019 ACR/ARP Annual Meeting
Important Role of CD11c+ Cells in Inflammatory Arthritis
Antonia Puchner¹, Elisabeth Simader ¹, Victoria Saferding ², Gerhard Kroenke ³, Rene Pfeifle ⁴, Daniel Aletaha ¹, Josef Smolen ¹ and Stephan Blueml ¹, ¹Medical University of Vienna, Vienna, Austria, ²Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, ³Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Austria, ⁴University Hospital Erlangen, Erlangen, Germany
Background/Purpose: Dendritic cells (DCs) are important antigen presenting cells (APCs) and therefore they play an important role in bridging the innate and the adaptive immune…
Abstract Number: 990 • 2019 ACR/ARP Annual Meeting
Development of a Novel Anti TNF-Steroid Antibody Drug Conjugate That Shows Promising Efficacy at Doses That Avoid Steroid Side Effects in a Mouse Model of Rheumatoid Arthritis
Wendy Waegell¹, Christian Goess ², Robert Stoffel ¹, Michael McPherson ¹, Adrian Hobson ¹, Suzanne Mathieu ², Lucy Phillips ¹ and Shaughn Bryant ¹, ¹AbbVie, Worcester, ²Abbvie bioresearch Center, Worcester, MA
Background/Purpose: TNF-inhibitors are a well established therapy for autoimmune diseases including rheumatoid arthritis, Crohn’s disease, psoriasis and ankylosing spondylitis but they have limited efficacy in…
Abstract Number: 998 • 2019 ACR/ARP Annual Meeting
Stimulation of Splenic Neurovascular Bundle Protect Mice from Developing Collagen-induced Arthritis
Thomas Simon¹, Clara Panzolini ², Julien Lavergne ², Arun Srihar ³, Margriet Vervoordeldonk ³, nicolas Glaichenhaus ² and Philippe Blancou ², ¹CNRS/IPMC, Valbonne, France, ²IPMC/CNRS, VALBONNE, France, ³Galvani Bioelectronics, Stevenage, United Kingdom
Background/Purpose: Vagus nerve (VN) stimulation has shown the potential to improve the disease development in animal models of arthritis and in patients with RA. However,…
Abstract Number: 1001 • 2019 ACR/ARP Annual Meeting
Oral Collagen Type V Supplementation Inhibits Cartilage Degeneration in Experimental Arthritis
Lizandre Keren Silveira ¹, José Eduardo Rodrigues ¹, Silvana Atayde ¹, Sergio Catanozi ¹, Antonio dos Santos Filho ², Vera Luiza Capelozzi ¹, Ricardo Fuller ², Ana Paula Velosa ² and Walcy Teodoro¹, ¹Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Sao Paulo, Sao Paulo, Brazil, ²Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Sao Paulo, Sao Paulo, Brazil
Background/Purpose: It is known that collagen V (col V) can generate autoimmunity when exposed. In contrast, induction of tolerance with col V supplementation is able…
Abstract Number: 1185 • 2019 ACR/ARP Annual Meeting
New Imaging Modality to Evaluate Arthritis in Lupus Based on Frequency-domain Optical Transmission
Anca Askanase¹, Fiamma Van Biema ², Alessandro Marone ², Youngwan Kim ², Tommy Chen ², Teja Kapoor ², Laura Geraldino ², Yevgeniya Gartshteyn ³ and Andreas Hielscher ², ¹Columbia University Medical Center, New York, NY, ²Columbia University School of Medicine, New York, NY, ³Columbia University School of Medicine, Glen Rock, NJ
Background/Purpose: 95% of the people with SLE experience joint pain, stiffness and swelling at some time during their illness. It is currently difficult to both…
Abstract Number: 1186 • 2019 ACR/ARP Annual Meeting
How Accurate Is Physical Joint Inflammation of the MTP-joints and What Can We Learn from Additional MRI on Forefoot Involvement in Early Arthritis?
Yousra Dakkak¹, Aleid Boer ¹, Debbie Boeters ¹, Annette van der Helm-van Mil ² and Monique Reijnierse ¹, ¹Leiden University Medical Center, Leiden, Netherlands, ²LUMC, Leiden, Zuid-Holland, Netherlands
Background/Purpose: Magnetic resonance imaging (MRI) is more sensitive than physical examination in detecting inflammation. This has predominantly been studied in metacarpophalangeal-(MCP) and wrist-joints. Data on…
Abstract Number: 1263 • 2019 ACR/ARP Annual Meeting
The Prevalence and Patterns of Celiac Disease Associated Arthropathy and Coexistence of Celiac Disease with Rheumatic Disorders in a Single Tertiary Medical Center
Anita Moudgal¹, Pooja Bhadbhade ¹, Ammar Haikal ¹ and Mehrdad Maz ¹, ¹The University of Kansas Medical Center, Kansas City, KS
Background/Purpose: Celiac disease (CD) is a gluten-sensitive enteropathy that develops in genetically predisposed individuals. Arthropathy has been reported as an extra-intestinal manifestation of CD. The…
Abstract Number: 32 • 2018 ACR/ARHP Annual Meeting
T Cell-Intrinsic Nod2 Protects Against Th17-Mediated Autoimmune Arthritis in SKG Mice
Ruth Napier¹, Ellen Lee¹, Emily Vance¹, Paige Snow², Clare Dawson³, Kimberly Samson⁴, Amy Moran⁵, Michael Davey⁶, Shimon Sakaguchi⁷ and Holly Rosenzweig¹, ¹Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, ²Molecular Microbiology and Immunology, VA Portland Health Care System, Portland, OR, ³Portland VA, PORTLAND, OR, ⁴Oregon Health & Science University, Portland, OR, ⁵Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, OR, ⁶VA Portland Health Care System, Portland, OR, ⁷Osaka University, Osaka, Japan
Background/Purpose: Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) is an innate immune receptor known primarily for its role in host protection against bacterial infections. Intriguingly, Nod2…
Abstract Number: 1151 • 2018 ACR/ARHP Annual Meeting
Comparison of Methodologic Approaches to Maximize the Validity of Fitbit Device Data for Arthritis-Related Research Purposes
Jeffrey R. Curtis¹, Shuo Yang¹, Lang Chen¹, Nada Elmagboul¹, David T. Redden², Amy S. Mudano¹, Phillip J. Foster³, Filby Cooper¹, Ted R. Mikuls⁴, Justin K Owensby¹ and Kenneth Saag⁵, ¹University of Alabama at Birmingham, Birmingham, AL, ²Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, ³Department of Medicine, Division of Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁴Internal Medicine, Division of Rheumatology, VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ⁵UAB, Birmingham, AL
Background/Purpose: Health activity tracker devices (e.g. Fitbit) are increasingly used component of medical evaluation. However, the validity and suitability of the data from such devices…
Abstract Number: 2349 • 2018 ACR/ARHP Annual Meeting
“I Was Prepared for the Other Side Effects; I Wasn’t Prepared for This One.”: A Qualitative Study of the Patients’ Experience of Inflammatory Arthritis Due to Immune Checkpoint Inhibitor Therapy for Cancer
Laura C. Cappelli¹, Suzanne Grieb², Ana-Maria Orbai³, Ami A. Shah¹ and Clifton O. Bingham III⁴, ¹Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Johns Hopkins Bayview Medical Center, Center for Child and Community Health Research, Baltimore, MD, ³Johns Hopkins University School of Medicine, Baltimore, MD, ⁴Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Patients treated for cancer with immune checkpoint inhibitors (ICI) can develop a variety of adverse events. Inflammatory arthritis (IA) is an increasingly recognized event…
Abstract Number: 46 • 2018 ACR/ARHP Annual Meeting
Organic Dust Inhalants Shift Immune Responses and Extracellular Matrix Balance between Synovium and Lung in the Collagen-Induced Arthritis Mouse Model
Michael J. Duryee¹, Jill Poole², Amy Nelson³, Katherine Janike², Lynell W. Klassen⁴, James R. O'Dell⁴, Bryant R. England⁵, Ted R. Mikuls⁶ and Geoffrey M. Thiele⁷, ¹Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ²Medicine, University of Nebraska Medical Center, Omaha, NE, ³Department of Medicine, University of Nebrasa Medical Center, Omaha, NE, ⁴Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁵Rheumatology, VA Nebraska-Western Iowa Health Care System & University of Nebraska Medical Center, Omaha, NE, ⁶Internal Medicine, Division of Rheumatology, VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ⁷University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Emerging evidence suggests that the lungs may be an initiating site of autoimmunity leading to RA with organic inhalant exposures such as those…
Abstract Number: 1152 • 2018 ACR/ARHP Annual Meeting
“Doctor, a Storm Is Coming and My Joints Hurt”: Evaluating Associations between Weather Changes and Arthritis Symptoms
Jeffrey R. Curtis¹, Shuo Yang¹, Cassie Clinton¹, Lang Chen¹, W. Benjamin Nowell², Huifeng Yun¹ and David Curtis³, ¹University of Alabama at Birmingham, Birmingham, AL, ²Global Healthy Living Foundation, Upper Nyack, NY, ³Global Healthy Living Foundation, New York, NY
Background/Purpose: Arthritis symptoms reported by patients have been anecdotally associated with weather changes, but large-scale, systemic evaluations are few in number. A variety of parameters…
Abstract Number: 2429 • 2018 ACR/ARHP Annual Meeting
Long-Term Outcome of Children Born to Mothers with Chronic Arthritis and Exposed to TNF-Inhibitors during Pregnancy: A Case-Control Study
Laura Andreoli¹, Maria Chiara Gerardi², Chiara Bazzani³, Matteo Filippini³, Micaela Fredi², Roberto Gorla³, Maria Grazia Lazzaroni², Cecilia Nalli², Marco Taglietti³, Andrea Lojacono⁴, Sonia Zatti⁴, Mario Motta⁵ and Angela Tincani², ¹Department of Clinical and Experimental Sciences, Spedali Civili and University of Brescia, Brescia, Italy, Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy, ²Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy, ³Rheumatology and Clinical Immunology, Spedali Civili of Brescia, Brescia, Italy, ⁴Obstetrics and Gynaecology, Spedali Civili and University of Brescia, Brescia, Italy, ⁵Neonatology and NICU, Spedali Civili of Brescia, Brescia, Italy
Background/Purpose: Treatment with tumor necrosis factors inhibitors (TNFi) during pregnancy may be required to control maternal disease which can be a threat for maternal-fetal well-being.…