Abstracts tagged "Arthritis"

Abstract Number: 56 • 2019 ACR/ARP Annual Meeting
Choline Metabolite Is Associated with Inflammation in Arthritis in the Elderly
francesca cedola¹, Roxana Coras ², Elsa Sanchez-Lopez ³, Lourdes Mateo ⁴, Anders Pedersen ⁵, Anahy Brandy-Garcia ⁴, Águeda Prior-Español ⁴, Brin S rosenthal ⁶, Melania Martínez-Morillo ⁴ and Monica Guma ⁷, ¹University of California San Diego, Rome, Italy, ². Department of Medicine, School of Medicine. University of California, San Diego, ³Department of Pharmacology, University of California San Diego, La Jolla, San Diego, ⁴Hospital Universitari Germans Trias i Pujol, Badalona, Spain, ⁵University of Gothenburg, Gothenburg, Sweden, ⁶University of California San Diego, san diego, ⁷Department of Medicine, School of Medicine. University of California San Diego, La Jolla, United States
Background/Purpose: Elderly-onset RA (EORA) and polymyalgia rheumatica (PMR) are common rheumatic disease in the elderly and their pathogenesis are still not completely understood. Perturbations caused…
Abstract Number: 2139 • 2019 ACR/ARP Annual Meeting
Rheumatic Immune-Related Adverse Events Associated with Treatment with Immune Checkpoint Inhibitors: A Multicenter Study of 38 Cases
Sebastian Rodriguez-Garcia¹, David Lobo ², Fabiola Ojeda ³, Raul Castellanos-Moreira ⁴, Ana Laiz ², Roberto Gumucio ⁴, Cesar Diaz-Torné ², Virginia Ruiz-Esquide ⁵, Milena Millan ², Ivan Castellvi ⁶, Patricia Moya Alvarado ⁷, Berta Magallares ², Carolina Perez ³, Hector Corominas ⁸ and Jose Gomez-Puerta ⁹, ¹Rheumatology Department. Hospital Clínic Barcelona, Barcelona, Spain, ²Rheumatology Department. Hospital Sant Pau, Barcelona, Catalonia, Spain, ³Rheumatology Department. Hospital del Mar, Barcelona, Catalonia, Spain, ⁴Rheumatology Department. Hospital Clínic Barcelona, Barcelona, Catalonia, Spain, ⁵Department of Rheumatology, Hospital Clínic, Barcelona, Barcelona, Catalonia, Spain, ⁶Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, ⁷Hospital de la Santa Creu i Sant Pau, Barcelona, Catalonia, Spain, ⁸Rheumatology Department, Hospital Sant Pau, Barcelona, Catalonia, Spain, ⁹Department of Rheumatology, Hospital Clínic, Barcelona, Barcelona, Spain
Background/Purpose: Immune checkpoint inhibitors (ICI) against CTLA-4 or PD- 1/PD-L1 and more recently TIM3, have demonstrated efficacy in improving the survival of patients with diverse…
Abstract Number: 99 • 2019 ACR/ARP Annual Meeting
Mass Cytometry Immunophenotyping of Synovial Fluid from Checkpoint Inhibitor Related Arthritis
Runci Wang¹, Karmela Kim Chan ², Amy Cunningham-Bussel ³, Laura Donlin ⁴, Gregory Vitone ², Aidan Tirpack ², Caroline Benson ², Gregory Keras ³, Anna Helena Jonsson ⁵, Michael Brenner ⁶, Anne Bass ⁷ and Deepak Rao ¹, ¹Brigham and women's hospital, Boston, MA, ²Hospital For Special Surgery, New York, ³Brigham and women's hospital, Boston, ⁴Hospital For Special Surgery, New York, NY, ⁵Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁶Brigham and Women’s Hospital:, Boston, ⁷Hospital for Special Surgery/Weill Cornell Medicine, New York, NY
Background/Purpose: Anti-PD-1/PD-L1 checkpoint inhibitor therapies have produced remarkable results in stimulating immune responses against tumors. Checkpoint inhibitor therapy can also trigger a variety of autoimmune…
Abstract Number: 2157 • 2019 ACR/ARP Annual Meeting
Checkpoint Inhibitor-Associated Arthritis: Phenotype, Steroid Dose, Serology and Survival
Karmela Kim Chan ¹, Aidan Tirpack ¹, Caroline Benson ¹, Gregory Vitone ¹, Jackie Finik ², Vivian Bykerk ³, Susan Goodman ⁴, Laura Donlin ⁵, Deepak Rao ⁶ and Anne Bass⁴, ¹Hospital For Special Surgery, New York, ²Hospital for Special Surgery, New York, NY, New York, NY, ³Hospital for Special Surgery, New York City, NY, ⁴Hospital For Special Surgery/Weill Cornell Medicine, New York, NY, ⁵Hospital For Special Surgery, New York, NY, ⁶Brigham and Women's Hospital, Boston, MA
Background/Purpose: Previous studies suggest that steroid dose1and rheumatoid factor positivity2 impact cancer survival in checkpoint inhibitor (CI)-treated patients (with CI-associated hypophysitis, and in all-comers with non-small…
Abstract Number: 114 • 2019 ACR/ARP Annual Meeting
Persistent Synovial Resident Memory T Cells Mediate Arthritis Flares
Margaret Chang¹, Anaïs Levescot ², Rachel Blaustein ², Nathan Nelson-Maney ², Allyn Morris ², Robert Fuhlbrigge ³ and Peter Nigrovic ⁴, ¹Division of Immunology, Boston Children's Hospital, Boston, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, MA, ³Department of Rheumatology, Children’s Hospital Colorado, Denver, CO, ⁴Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA ; Department of Medicine, Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA., Boston
Background/Purpose: Resident memory T cells (TRM) are site-specific memory T cells that take up long-term residence in peripheral tissues and aid in pathogen defense. However,…
Abstract Number: 2324 • 2019 ACR/ARP Annual Meeting
Metabolic Syndrome and Early Arthritis: Frequency, Association with Antibodies Profile and Disease Activity
Francisco Guiñazú¹, Carla Gobbi ², Paula Alba ¹, Carla Maldini ³, Carla Alonso ¹, Alejandro Albiero ¹, Eduardo Albiero ¹, Viviana Neme ⁴, Marcela Demarchi ⁴ and Marcelo Yorio ³, ¹UNIDAD DE REUMATOLOGÍA, CÁTEDRA DE SEMIOLOGÍA, HOSPITAL CÓRDOBA, FACULTAD DE CIENCIAS MÉDICAS, UNIVERSIDAD NACIONAL DE CÓRDOBA, ARGENTINA, Cordoba, Cordoba, Argentina, ²CÁTEDRA DE CLÍNICA MÉDICA I, HOSPITAL CÓRDOBA, FACULTAD DE CIENCIAS MÉDICAS, UNIVERSIDAD NACIONAL DE CÓRDOBA, ARGENTINA, Cordoba, Cordoba, Argentina, ³CÁTEDRA DE SEMIOLOGÍA, HOSPITAL CÓRDOBA, FACULTAD DE CIENCIAS MÉDICAS, UNIVERSIDAD NACIONAL DE CÓRDOBA, ARGENTINA, Cordoba, Cordoba, Argentina, ⁴SERVICIO DE BIOQUÍMICA. HOSPITAL CÓRDOBA, ARGENTINA, Cordoba, Cordoba, Argentina
Background/Purpose: The Metabolic Syndrome (MetS) is an independent factor of cardiovascular morbidity and mortality and most studies show that its prevalence is higher in established…
Abstract Number: 979 • 2019 ACR/ARP Annual Meeting
Platelet Derived Growth Factor Receptor Alpha (PDGFRα) Blockade Inhibits Arthritis in Mice
Bhanupriya Madarampalli¹, Paul Panipinto ¹, Erica Chow ¹, Kendahl Sugai ¹, Fanqi Shi ¹ and Erika Noss ¹, ¹University of Washington, Seattle, WA
Background/Purpose: The interplay between infiltrating immune cells and activated joint stromal cells drives inflammation, cartilage destruction, and bone erosion in rheumatoid arthritis (RA). Among joint…
Abstract Number: 2722 • 2019 ACR/ARP Annual Meeting
The down Syndrome Arthropathy Cohort in the New Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry: Clinical Characteristics, Treatment and Outcomes
Jordan Jones¹, Daniel J. Lovell ², Chelsey Smith ³ and Mara Becker ⁴, ¹Children's Mercy Kansas City, Kansas City, MO, ²Pediatric Rheumatology Collaborative Study Group (PRCSG), Cincinnati Children’s Hospital Medical Center, Cincinnati, ³Children's Mercy Kansas City, Kansas, MO, ⁴Duke Children's Hospital, Durham, NC
Background/Purpose: Down syndrome arthropathy (DA) is under-recognized with a 19-month average delay in diagnosis (1). The majority present with polyarticular, rheumatoid factor (RF) and anti-nuclear…
Abstract Number: 984 • 2019 ACR/ARP Annual Meeting
Important Role of CD11c+ Cells in Inflammatory Arthritis
Antonia Puchner¹, Elisabeth Simader ¹, Victoria Saferding ², Gerhard Kroenke ³, Rene Pfeifle ⁴, Daniel Aletaha ¹, Josef Smolen ¹ and Stephan Blueml ¹, ¹Medical University of Vienna, Vienna, Austria, ²Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, ³Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Austria, ⁴University Hospital Erlangen, Erlangen, Germany
Background/Purpose: Dendritic cells (DCs) are important antigen presenting cells (APCs) and therefore they play an important role in bridging the innate and the adaptive immune…
Abstract Number: 990 • 2019 ACR/ARP Annual Meeting
Development of a Novel Anti TNF-Steroid Antibody Drug Conjugate That Shows Promising Efficacy at Doses That Avoid Steroid Side Effects in a Mouse Model of Rheumatoid Arthritis
Wendy Waegell¹, Christian Goess ², Robert Stoffel ¹, Michael McPherson ¹, Adrian Hobson ¹, Suzanne Mathieu ², Lucy Phillips ¹ and Shaughn Bryant ¹, ¹AbbVie, Worcester, ²Abbvie bioresearch Center, Worcester, MA
Background/Purpose: TNF-inhibitors are a well established therapy for autoimmune diseases including rheumatoid arthritis, Crohn’s disease, psoriasis and ankylosing spondylitis but they have limited efficacy in…
Abstract Number: 998 • 2019 ACR/ARP Annual Meeting
Stimulation of Splenic Neurovascular Bundle Protect Mice from Developing Collagen-induced Arthritis
Thomas Simon¹, Clara Panzolini ², Julien Lavergne ², Arun Srihar ³, Margriet Vervoordeldonk ³, nicolas Glaichenhaus ² and Philippe Blancou ², ¹CNRS/IPMC, Valbonne, France, ²IPMC/CNRS, VALBONNE, France, ³Galvani Bioelectronics, Stevenage, United Kingdom
Background/Purpose: Vagus nerve (VN) stimulation has shown the potential to improve the disease development in animal models of arthritis and in patients with RA. However,…
Abstract Number: 983 • 2018 ACR/ARHP Annual Meeting
A MAPK Activated Kinase 2 Inhibitor Attenuates Inflammatory and Destructive Arthritis in Human Ex Vivo Models
Tue Wenzel Kragstrup^1,2, Anders Mellemkjær³, Morten Aagaard Nielsen⁴, Line Dam Heftdal², Marie Iversen³, Peter Schafer⁵ and Bent Deleuran², ¹Randers Regional Hospital, Randers, Denmark, ²Department of Biomedicine, Aarhus University, Aarhus, Denmark, ³Aarhus University, Aarhus, Denmark, ⁴Of Biomedicine, Aarhus University, Aarhus, Denmark, ⁵Celgene Corporation, Summit, NJ
Background/Purpose: Targeting intracellular pathways with oral small molecules is an attractive therapeutic approach for treating immune mediated inflammatory diseases. The mitogen-activated protein kinase (MAPK) pathway…
Abstract Number: 2027 • 2018 ACR/ARHP Annual Meeting
Whole Exome Trio Sequencing Implicates DOCK2 in Juvenile Idiopathic Arthritis
Laura A McIntosh^1,2, Yoshinori Fukui³, Thomas A. Griffin⁴, Kenneth Kaufman^1,2,5, Jarek Meller^6,7, Sherry Thornton⁸, Halima Moncrieffe^1,2 and Susan D Thompson^1,2, ¹Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Department of Pediatrics, University of Cincinnati, Cincinnati, OH, ³Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan, ⁴Levine Children’s Hospital at Carolinas Medical Center, Charlotte, NC, ⁵US Department of Veterans Affairs Medical Center, Cincinnati, OH, ⁶Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ⁷Department of Environmental Health, University of Cincinnati, Cincinnati, OH, ⁸Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease of childhood and has a strong genetic component to disease risk. Genome-wide association studies…
Abstract Number: 1007 • 2018 ACR/ARHP Annual Meeting
Macrophage Mediators of Autoimmune Valvular Carditis and Fibrosis
Lee Meier¹, Mayra Gonzalez-Torres², Jennifer L. Auger², Aubyn Marath³ and Bryce A. Binstadt², ¹Department of Pediatrics and Center for Immunology, University of Minnesota, Minneapols, MN, ²Department of Pediatrics and Center for Immunology, University of Minnesota, Minneapolis, MN, ³CardioStart International, Tampa, FL
Background/Purpose: K/B.g7 TCR transgenic mice spontaneously develop both autoimmune arthritis and valvular carditis. We utilize this model to define mediators of rheumatic disease-associated cardiovascular inflammation…
Abstract Number: 2048 • 2018 ACR/ARHP Annual Meeting
In Vitro Proof-of-Concept of Pathobiology-Guided Therapy in Immune Mediated Inflammatory Arthritis
Morten Aagaard Nielsen¹, Bent Deleuran^2,3 and Tue Wenzel Kragstrup^2,3,4, ¹Of Biomedicine, Aarhus University, Aarhus, Denmark, ²Department of Biomedicine, Aarhus University, Aarhus, Denmark, ³Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ⁴Randers Regional Hospital, Randers, Denmark
Background/Purpose: Immune mediated inflammatory arthritis are very heterogeneous diseases including rheumatoid arthritis (RA), psoriatic arthritis (PsA) and spondyloarthritis (SpA). The available biological and targeted synthetic…

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