Session Information
Date: Monday, October 22, 2018
Session Title: Metabolic and Crystal Arthropathies – Basic and Clinical Science Poster I
Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: Obesity is a moderate low-grade chronic inflammatory condition. Also, it has been reported to be a risk factor for inflammatory rheumatic diseases, seronegative inflammatory polyarthritis, and psoriatic arthritis. The cause of low-grade inflammation in obese patients who have non-specific musculoskeletal symptoms may be the subject of debate in clinical practice. Our aim is to determine whether inflammation is associated with obesity or rheumatic disease, and the association between leptin, chemerin, visfatin and inflammatory markers in obese patients with/without musculoskeletal symptoms.
Methods: In the period between March 2017 and January 2018, seventy-four obese patients (4 male, 70 female, with the mean age of 47.09±10.7 years) who admitted to our clinic with non-specific musculoskeletal symptoms were enrolled. The control group consisted of 40 obese patients (5 male, 35 female, with the mean age of 44.9±10 years) who have no rheumatic symptoms. Body mass index (BMI) is calculated in kg/m2 with body weight ratio to height squared, and defined obesity BMI 30 or above. Age, gender, sedimentation, CRP, TNF-α, IL-6, IL-1, leptin, chemerin, and visfatin were evaluated. The relationship between all parameters was assessed by Spearman correlation, Wilcoxon Signed-rank, and paired t-tests.
Results: There were no significant differences for sex, gender, and BMI between obese patients with non-specific musculoskeletal symptoms and control group. The mean TNF-α, IL-1β, IL-6 concentrations were 60.8, 39.9, and 26.2 in obese patients with non-specific musculoskeletal symptoms respectively and significantly higher than the control group. Sedimentation and CRP levels were higher in those patients compared to control group without statistical difference. There were significant differences for chemerin, visfatin, but not for leptin between both group (Table 1). Also, the significant correlation was found between proinflammatory cytokines and visfatin, chemerin.
Conclusion: Visfatin and chemerin correlated with inflammation may be a useful indicator of undifferentiated inflammatory arthritis in obese patients who have non-specific musculoskeletal symptoms with low-grade inflammation.
Table 1. Demographic characteristics and laboratory values of obese patients with clinically suspect arthralgia and without any rheumatic symptoms
|
|
with clinically suspect artralgia |
without any rheumatic symptoms |
p-value |
|
Obese patients (n) |
74 |
40 |
– |
|
Age (years) |
47.09±10,7 |
44.9±10 |
NS |
|
Gender (female/male) |
70/4 |
35/5 |
NS |
|
Body Mass Index (kg/m2) |
37.6±7.2 |
36.9±4.8 |
NS |
|
Sedimentation (mm/h) |
32.9±15.1 |
27.5±16.1 |
NS |
|
CRP (mg/dL) |
8.4 [0.1-35.3] |
7.9 [1-54.7] |
NS |
|
IL-1β (pg/ml) |
39.9 [4-347.5] |
20.4 [0.7-266.1] |
0,04* |
|
IL-6 |
26.2 [3.8-350.9] |
13.2 [3-63] |
0,001* |
|
TNF-α (pg/ml) |
60.8 [11.3-301.6] |
36.2 [5.6-243.3] |
<0,001* |
|
Visfastin (ng/ml) |
4.8 [0.2-48.9] |
1.5 [0.1-19.5] |
<0,001* |
|
Chemerin (ng/ml) |
4.2 [0.1-39.5] |
1.3 [0.1-20.4] |
<0,001* |
|
Leptin (pg/ml) |
3460.8±510.9 |
3285.2±696.6 |
0,16 |
NS: not significant, [minimum-maximum], * significant difference
To cite this abstract in AMA style:
Senturk T, Kose R, Sargin G, Cildag S, Unubol M, Abas Bİ, Yenisey C. The Association between Clinically Suspect Arthralgia and Adipokines in Obese Patients [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/the-association-between-clinically-suspect-arthralgia-and-adipokines-in-obese-patients/. Accessed March 21, 2023.« Back to 2018 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/the-association-between-clinically-suspect-arthralgia-and-adipokines-in-obese-patients/