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Abstract Number: 1267

The Association between Clinically Suspect Arthralgia and Adipokines in Obese Patients

Taskin Senturk1, Reyhan Kose1, Gokhan Sargin1, Songul Cildag2, Mustafa Unubol3, Burçin İrem Abas4 and Cigdem Yenisey4, 1Rheumatology, Adnan Menderes University Medical School, Aydin, Turkey, 2Allergy and Immunology, Adnan Menderes University Medical School, Aydin, Turkey, 3Endocrinology and Metabolism, Adnan Menderes University Medical School, Aydin, Turkey, 4Biochemistry, Adnan Menderes University Medical School, Aydin, Turkey

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: Adipokines, Arthritis, Obesity and rheumatic disease

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Session Information

Date: Monday, October 22, 2018

Session Title: Metabolic and Crystal Arthropathies – Basic and Clinical Science Poster I

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose: Obesity is a moderate low-grade chronic inflammatory condition. Also, it has been reported to be a risk factor for inflammatory rheumatic diseases, seronegative inflammatory polyarthritis, and psoriatic arthritis. The cause of low-grade inflammation in obese patients who have non-specific musculoskeletal symptoms may be the subject of debate in clinical practice. Our aim is to determine whether inflammation is associated with obesity or rheumatic disease, and the association between leptin, chemerin, visfatin and inflammatory markers in obese patients with/without musculoskeletal symptoms.

Methods: In the period between March 2017 and January 2018, seventy-four obese patients (4 male, 70 female, with the mean age of 47.09±10.7 years) who admitted to our clinic with non-specific musculoskeletal symptoms were enrolled. The control group consisted of 40 obese patients (5 male, 35 female, with the mean age of 44.9±10 years) who have no rheumatic symptoms. Body mass index (BMI) is calculated in kg/m2 with body weight ratio to height squared, and defined obesity BMI 30 or above. Age, gender, sedimentation, CRP, TNF-α, IL-6, IL-1, leptin, chemerin, and visfatin were evaluated. The relationship between all parameters was assessed by Spearman correlation, Wilcoxon Signed-rank, and paired t-tests.

Results: There were no significant differences for sex, gender, and BMI between obese patients with non-specific musculoskeletal symptoms and control group. The mean TNF-α, IL-1β, IL-6 concentrations were 60.8, 39.9, and 26.2 in obese patients with non-specific musculoskeletal symptoms respectively and significantly higher than the control group. Sedimentation and CRP levels were higher in those patients compared to control group without statistical difference. There were significant differences for chemerin, visfatin, but not for leptin between both group (Table 1). Also, the significant correlation was found between proinflammatory cytokines and visfatin, chemerin.

Conclusion: Visfatin and chemerin correlated with inflammation may be a useful indicator of undifferentiated inflammatory arthritis in obese patients who have non-specific musculoskeletal symptoms with low-grade inflammation.

Table 1. Demographic characteristics and laboratory values of obese patients with clinically suspect arthralgia and without any rheumatic symptoms

with clinically suspect artralgia

without any

rheumatic symptoms

p-value

Obese patients (n)

74

40

–

Age (years)

47.09±10,7

44.9±10

NS

Gender (female/male)

70/4

35/5

NS

Body Mass Index (kg/m2)

37.6±7.2

36.9±4.8

NS

Sedimentation (mm/h)

32.9±15.1

27.5±16.1

NS

CRP (mg/dL)

8.4 [0.1-35.3]

7.9 [1-54.7]

NS

IL-1β (pg/ml)

39.9 [4-347.5]

20.4 [0.7-266.1]

0,04*

IL-6

26.2 [3.8-350.9]

13.2 [3-63]

0,001*

TNF-α (pg/ml)

60.8 [11.3-301.6]

36.2 [5.6-243.3]

<0,001*

Visfastin (ng/ml)

4.8 [0.2-48.9]

1.5 [0.1-19.5]

<0,001*

Chemerin (ng/ml)

4.2 [0.1-39.5]

1.3 [0.1-20.4]

<0,001*

Leptin (pg/ml)

3460.8±510.9

3285.2±696.6

0,16

NS: not significant, [minimum-maximum], * significant difference


Disclosure: T. Senturk, None; R. Kose, None; G. Sargin, None; S. Cildag, None; M. Unubol, None; B. İ. Abas, None; C. Yenisey, None.

To cite this abstract in AMA style:

Senturk T, Kose R, Sargin G, Cildag S, Unubol M, Abas Bİ, Yenisey C. The Association between Clinically Suspect Arthralgia and Adipokines in Obese Patients [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/the-association-between-clinically-suspect-arthralgia-and-adipokines-in-obese-patients/. Accessed March 21, 2023.
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