Abstracts tagged "Apoptosis"

Abstract Number: 2559 • 2015 ACR/ARHP Annual Meeting
PRO-Resolving Mediators Issued from Apoptotic CELL Efferocytosis (SUPERMAPO) Modulate Antigen Presenting CELL Properties Toward a Tolerogenic Profile: Efficacy in the Treatment of Collagen- Induced Arthritis
Francis Bonnefoy¹, Romain Vallion², Mélanie Couturier³, Anna Daoui³, Eric Toussirot⁴ and Sylvain Perruche¹, ¹UMR1098 INSERM, EFS Bourgogne Franche Comté, Besançon, France, ²INSERM UMR 1098, EFS Bourgogne Franche Comté, Besançon, France, ³INSERM UMR1098, EFS Bourgogne Franche Comté, Besançon, France, ⁴Service de Rhumatologie, CHU J Minjoz, Besancon, France
Background/Purpose: Pro-resolving mediators produced by macrophages eliminating apoptotic effector cells during the resolution of inflammation have been shown to stop inflammation, favor tissue repair and…
Abstract Number: 2705 • 2015 ACR/ARHP Annual Meeting
AAA-Atpase p97-HDAC6 Controlled Poly-Ubiquitin Turnover Regulates Apoptotic and Autophagy-Associated Cell Death in Arthritis
Masaru Kato¹, Kerstin Klein², Caroline Ospelt², Christoph Kolling³, Michihito Kono¹, Shinsuke Yasuda¹, Renate E. Gay⁴, Steffen Gay⁵ and Tatsuya Atsumi¹, ¹Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, ²Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³Schulthess Clinic, Zurich, Switzerland, ⁴Center of Experimental Rheumatology, University Hospital Zurich, Switzerland, Zurich, Switzerland, ⁵Center of Experimental Rheumatology, University Hospital Zurich, University Zurich, Zurich, Switzerland
Background/Purpose: The AAA-ATPase valosin containing protein (p97) and histone deacetylase 6 (HDAC6) interact with each other and are implicated in the degradation of ubiquitin-labelled proteins.…
Abstract Number: 3003 • 2015 ACR/ARHP Annual Meeting
Increased Heparanase Expression in Keratinocytes Promotes Dermal Fibrosis in Scleroderma
In-Woon Baek¹, Wan-Uk Kim², Chul-Soo Cho¹ and Ki-Jo Kim³, ¹Internal Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea, ²Internal Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea, ³Internal Medicine, St. Vincent’s Hospital, The Catholic University of Korea, Suwon, South Korea
Background/Purpose: Interactions between keratinocyte and dermal fibroblast via paracrine loop play an important role in wound repair and keloid formation. In this study, we investigated…
Abstract Number: 2872 • 2014 ACR/ARHP Annual Meeting
B-Cell Autoepitope and Tetramer Analysis Reveals Expansion of Apoptotic Autoantigen La and snRNP Reactive B Cells in BXD2 Mice
Jennie Hamilton¹, Jun Li², Qi Wu³, PingAr Yang³, Bao Luo³, Hao Li⁴, Troy Randall⁵, John Edwin Bradley⁵, Justin J. Taylor⁶, John D. Mountz^7,8 and Hui-Chen Hsu^3,4, ¹University of Alabama at Birmingham, Birmingham, AL, ²Med - Immunology/Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁴Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁵Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁶Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, ⁷Dept of Med/Rheumatology Div, University of Alabama at Birmingham, Birmingham, AL, ⁸Birmingham VA Medical Center, Birmingham, AL
Background/Purpose Systemic lupus erythematous (SLE) is characterized by production of highly pathogenic IgG autoantibodies (autoAbs). While serum autoAb profiling is standard, it remains challenging to…
Abstract Number: 2839 • 2014 ACR/ARHP Annual Meeting
BCL-2 As a Potential Therapeutic Target in Human Lupus Tubulointerstitial Inflammation
Kichul Ko¹, Denisse Yanez¹, Natalya Kaverina¹, Vladimir M. Liarski¹, Yahui Peng², Li Lan³, Stuart Perper⁴, Annette Schwartz⁵, Liz O'connor⁶, Andrew Souers⁷, Steven Elmore⁷, Lisa Olson⁵, Maryellen L. Giger³, Li Chun Wang⁴ and Marcus R. Clark¹, ¹Rheumatology and Knapp Center for Lupus Research, University of Chicago, Chicago, IL, ²School of Electronic and Information Engineering, Beijing Jiaotong University, Beijing, China, ³Radiology, University of Chicago, Chicago, IL, ⁴Immunology, AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA, ⁵AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA, ⁶Toxicology, AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA, ⁷AbbVie Inc, North Chicago, IL
Background/Purpose Lupus nephritis (LuN) is the most common, severe manifestation of systemic lupus erythematosus (SLE). We have previously shown that glomerulonephritis appears to be a…
Abstract Number: 2734 • 2014 ACR/ARHP Annual Meeting
B55β Regulates T Cell Survival through the Modulation of AKT during Cytokine Deprivation
José C. Crispin¹, Sokratis A. Apostolidis², Noe Rodriguez Rodriguez¹, Tran Nguyen² and George C. Tsokos³, ¹Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
Background/Purpose . The abundance of cytokines controls the length of immune responses through poorly defined mechanisms. B55β is a molecule that triggers apoptosis in activated…
Abstract Number: 2166 • 2014 ACR/ARHP Annual Meeting
Bim Suppresses the Development of Glomerulonephritis By Inhibiting M2 Polarization
Fu-Nien Tsai, Northwestern University, Chicago, IL
Background/Purpose Only recently have monocytes and macrophages been accepted as critical players in the pathogenesis of SLE. However, very little is known regarding the molecular…
Abstract Number: 1031 • 2014 ACR/ARHP Annual Meeting
Induction of Pro-Apoptotic Noxa Expression By Ursolic Acid Sensitizes Rheumatoid Arthritis Synovial Fibroblasts to Apoptosis: A Role of Mir-181a
Salahuddin Ahmed¹, Laura Walsh², Anil Singh¹, Maria Beamer³, Kuladeep Sudini⁴ and Douglas Leaman⁴, ¹Department of Pharmaceutical Sciences, Washington State University, Spokane, WA, ²Department of Pharmacology, University of Toledo, Toledo, OH, ³Department of Pharmacology, Department of Pharmacology, University of Toledo, Toledo, OH, ⁴Department of Biological Sciences, University of Toledo, Toledo, OH
Background/Purpose: In rheumatoid arthritis (RA), the paucity of pro-apoptotic protein expression may significantly contribute to the resistance of synovial fibroblasts (FLS) to apoptosis. In the…
Abstract Number: 757 • 2014 ACR/ARHP Annual Meeting
Distinctive Patterns of Telomere Shortening and Apoptosis in Limited and Diffuse cutaneous Systemic Sclerosis
Jasper Broen¹, Liane McGlynn², Dagmara McGuinness², Rina Wichers³, Jacqueline Thomson², Rajan Madhok⁴, Robert Lafyatis⁵, Carol A. Feghali-Bostwick⁶, Paul Shiels² and T.R.D.J. Radstake¹, ¹Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²University of Glasgow, Glasgow, United Kingdom, ³UMC Utrecht, Utrecht, Netherlands, ⁴Glasgow Royal Infirmary, Glasgow, United Kingdom, ⁵Arthritis Center, Boston University, Boston, MA, ⁶Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: Aberrant telomere shortening and DNA damage-responses have been previously described in SSc, here we aim to validate these observations and incorporate them in a…
Abstract Number: 343 • 2014 ACR/ARHP Annual Meeting
The Caspase 8/RIPK3 Signaling Axis Has Opposing Roles in Myeloid and Dendritic Cells during Progression of a Murine Model of Acute Inflammatory Arthritis
Carla M. Cuda¹, Alexander Misharin², George Kenneth Haines III³ and Harris R. Perlman⁴, ¹Medicine / Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Northwestern University, Chicago, IL, ³Pathology, The Mount Sinai Hospital, New York, NY, ⁴Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose Rheumatoid arthritis (RA) manifests in persistent synovial inflammation, cellular infiltration and pro-inflammatory cytokine production, and results in progressive joint destruction. Both myeloid cells and…
Abstract Number: 551 • 2013 ACR/ARHP Annual Meeting
Different Cell Death Programs Contribute To Severity Of Lupus Glomerulonephritis In Males and Females
Neelakshi Jog¹ and Roberto Caricchio², ¹Rheumatology, Temple University, Philadelphia, PA, ²Medicine/Rheumatology, Temple University, Philadelphia, PA
Background/Purpose: Lupus glomerulonephritis (GN) is a leading cause of long-term disability in SLE. Although lupus is more common in females, GN occurs earlier and in…
Abstract Number: 555 • 2013 ACR/ARHP Annual Meeting
Therapeutic Inhibition Of Anti-Apoptotic BCL-2 Family Proteins In a Murine Model Of Lupus Nephritis
Li Chun Wang¹, Stuart Perper², Danise Perron³, Edit Tarcsa⁴, Philip Bardwell³, Neelufar Mozaffarian⁵, Andrew Souers⁵, Steven Elmore⁶, Tariq Ghayur⁷ and Lisa Olson³, ¹Immunology, AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA, ²Pharmacology, AbbVie Bioresearch Center, Inc, Worcester, MA, ³Immunology, AbbVie Bioresearch Center, Inc, Worcester, MA, ⁴Immunology, AbbVie Bioresearch Center, Worcester, MA, ⁵AbbVie, North Chicago, IL, ⁶AbbVie Inc, North Chicago, IL, ⁷AbbVie Bioresearch Center, Inc, Worcester, MA
Background/Purpose: Apoptosis is both a conserved and highly regulated process that is essential for normal development and tissue homeostasis. This process, also known as programmed…
Abstract Number: 560 • 2013 ACR/ARHP Annual Meeting
Purified IgG From Patients With Systemic Lupus Erythematosus Enhances Apoptosis In Neonatal Rat Cardiomyocytes Exposed To Simulated Myocardial Ischaemic/Reperfusion Injury
Lauren Bourke¹, James McCormick², Vera Ripoll³, Charis Pericleous⁴, Anna Radziszewska⁵, Anastasis Stephanou⁶ and Yiannis Ioannou⁷, ¹Centre for Rheumatology Research, University College London, London, United Kingdom, ²Clinical & Molecular Genetics Unit, University College London, London, United Kingdom, ³Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom, ⁴Centre for Rheumatology, Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, ⁵The Rayne Institute, Arthritis Research UK Centre for Adolescent Rheumatology at University College London, Great Ormond Street Hospital and UCLH, University College London, London, United Kingdom, ⁶Medical and Molecular Biology Unit (MMBU), University College London, London, United Kingdom, ⁷Arthritis Research UK Centre for Adolescent Rheumatology at University College London, Great Ormond Street Hospital and UCLH, University College London, London, United Kingdom
Background/Purpose: A significant amount of myocardial damage during a myocardial infarction (MI) occurs during the reperfusion stage which is known as ischaemic reperfusion (I/R) injury…
Abstract Number: 2819 • 2013 ACR/ARHP Annual Meeting
Administration Of a Multi-Epitope Citrullinated Peptide Attuneuates adjuvant Induced Arthritis In Rats Via Induction Of Immune Tolerance
Howard Amital¹, Smadar Gertel² and Yehuda Shoenfeld³, ¹The Zabludowicz Center For Autoimmune Diseases, and Department of Medicine 'B',, Sheba Medical Center,Tel-Hashomer, Tel-Aviv University, Tel-hashomer, Israel, ²The Zabludowicz Center For Autoimmune Diseases, and Department of Medicine 'B', Sheba Medical Center, Tel-Hashomer, Israel, ³Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Affiliated to Sackler Faculty of Medicine, Tel-Aviv University,Tel-Aviv, Tel-Aviv, Israel
Background/Purpose: Antigen-induced peripheral tolerance is a potentially efficient and specific therapeutic approach to attenuate autoimmunity. Citrullinated peptides are major targets of disease-specific autoantibodies in Rheumatoid…
Abstract Number: 2822 • 2013 ACR/ARHP Annual Meeting
IKKε Deficiency Prolongs Neutrophil Survival Paradoxically Prolonging Inflammation In The Absence Of a Type I Interferon Response
Maripat Corr¹, Christopher Chung², Seong-Kyu Kim³, D. L Boyle⁴ and G. S. Firestein⁵, ¹Medicine, Univ of California-San Diego, La Jolla, CA, ²Medicine, UCSD School of Medicine, La Jolla, CA, ³Catholic University of Daegu School of Medicine, Daegu, South Korea, ⁴Div of Rheum, UCSD School of Medicine, La Jolla, CA, ⁵Div of Rheumatology, UCSD School of Medicine, La Jolla, CA
Background/Purpose: Deficiency of the IKK-related kinases IKKε synergizes with the anti-inflammatory effects of IFNß in a murine model of arthritis., and this effect is mediated…

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