Abstracts tagged "Antiphospholipid antibodies"

Abstract Number: 2759 • 2017 ACR/ARHP Annual Meeting
The Risk of Ischaemic Stroke in Primary APS Patients: A Prospective Study
Massimo Radin¹, Karen Schreiber², Irene Cecchi³, Dario Roccatello⁴, Maria Jose Cuadrado⁵ and Savino Sciascia⁶, ¹Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ²Department of Thrombosis and Haemophilia, Guy's and St Thomas' Hospital, London, United Kingdom., London, United Kingdom, ³Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ⁴Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin and S. Giovanni Bo, Turin, Italy, ⁵St Thomas Hospital, Lupus Research Unit, London, United Kingdom, ⁶Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy
Background/Purpose: The antiphospholipid syndrome(APS)is an autoimmune condition characterized by thrombosis and/or pregnancy morbidity andpersistent positivityfor antiphospholipid antibodies(aPL). The most common neurological manifestation of APS is…
Abstract Number: 2760 • 2017 ACR/ARHP Annual Meeting
Antiphospholipid Syndrome Alliance for Clinical Trials & International Networking (APS ACTION) Clinical Database and Repository (“Registry”) Analysis: First and Recurrent Thrombosis Risk after 1201 Patient-Years of Follow-up
Ozan Unlu¹, Danieli Andrade², Alessandra Banzato³, D. Ware Branch⁴, Paul R. Fortin⁵, Maria Gerosa⁶, Roger A. Levy⁷, Michelle Lopes⁸, Michelle Petri⁹, Ignasi Rodriguez¹⁰, Maria Tektonidou¹¹, Amaia Ugarte¹², Rohan Willis¹³, Doruk Erkan¹⁴ and , on Behalf of APS ACTION .¹⁵, ¹Barbara Volcker Center for Women and Rheumatic Diseases, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ²Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR., Sao Paulo, Brazil, ³Department of Cardiac Thoracic and Vascular Sciences, Clinical Cardiology, Thrombosis Centre, University of Padova, Padova, Italy, ⁴Obstetrics and Gynecology, University of Utah and Intermountain Healthcare, Salt Lake City, UT, ⁵Medicine, CHU de Quebec - Universite de Laval, Quebec, QC, Canada, ⁶Istituto Ortopedico Gaetano Pini, University of Milan, Milano, Italy, ⁷Rheumatology, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, ⁸Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁹Medicine (Rheumatology), Division of Rheumatology, Johns Hopkins University School of Medicine, MD, USA, Baltimore, MD, ¹⁰Rheumatology, Hospital Clinica, Barcelona, Spain, ¹¹First Department of Internal Medicine, School of Medicine, National University of Athens, Athens, Greece, ¹²Autoimmune Diseases Research Unit, Department of Internal Medicine, BioCruces Health Research Institute, Hospital Universitario Cruces, University of the Basque Country, Biscay, Spain, ¹³Rheumatology/Dept Int Med, University of Texas Medical Branch, Galveston, TX, ¹⁴Rheumatology, Hospital for Special Surgery- Weill Cornell Medicine, New York, NY, ¹⁵., New York, NY
Background/Purpose: APS ACTION Registry was created to study the natural course of disease over 10 years in persistently antiphospholipid antibody (aPL)-positive patients with/without other systemic…
Abstract Number: 115 • 2017 Pediatric Rheumatology Symposium
Anti-Phospholipid Antibodies in Children with Down Syndrome
Buthaina Al-Adba¹, Haitham El Bashir², Khalid ZahrAldin³, Ronald Thomas^4,5, Mohammad Al-Khalifa⁶, Asmaa Al-Marwani⁶, Dekra Al-Faridi⁶, Muhamad Al Dabbagh⁷ and Basil Fathalla³, ¹Pediatrics - Rheumatology, Hamad Medical Corporation, Doha, Qatar, ²Developmental Pediatrics & Children’s Rehabilitation - Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar, ³Pediatrics, Hamad Medical Corporation, Doha, Qatar, ⁴Department of Research and Biostatistics, Children's Hospital of Michigan, Detroit, MI, ⁵Children's Research Center, Wayne State University, Detroit, MI, ⁶Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar, ⁷Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar
Background/Purpose: The prevalence of anti-phospholipid antibodies (APL) in children with Down syndrome (DS) is unknown. Furthermore, it is unknown if an intermittent or persistent presence…
Abstract Number: 1067 • 2016 ACR/ARHP Annual Meeting
History of Thrombocytopenia Is Associated with Lower Prevalence of Thrombotic Events in Systemic Lupus Erythematosus Patients with Antiphospholipid Antibodies
Vinicius Domingues¹, Janet Nwaukoni², Jill P. Buyon³ and H. Michael Belmont⁴, ¹Rheumatology, NYU Langone Medical Center, New York, NY, ²Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ³Medicine, New York University School of Medicine, New York, NY, ⁴New York University School of Medicine, New York, NY
Background/Purpose: Thrombocytopenia is a common feature of both systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) and in the former most frequently results from antiplatelet…
Abstract Number: 1382 • 2016 ACR/ARHP Annual Meeting
Effect of Lupus Anticoagulant on Rotational Thromboelastometry in Juvenile Systemic Lupus Erythematosus: Preliminary Data on a Single Center Cohort
Maria Pereira¹, Eyal Muscal², Lisa Hensch³, Vadim Kostousov³, Karen Bruzdoski³, Shiu-Ki Hui³, Jun Teruya³ and Marietta DeGuzman¹, ¹Allergy, Immunology and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, ²Immunology, allergy and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, ³Pathology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX
Background/Purpose: Interpretation of coagulation tests remain a challenge in jSLE with positive aPL. Lupus anticoagulant (LA) can mimic bleeding diathesis and its effect on prolonged…
Abstract Number: 1799 • 2016 ACR/ARHP Annual Meeting
Smoking, Antiphospholipid Antibodies and Thrombosis in SLE
Michelle Petri¹, George Stojan² and Wei Fu³, ¹Rheumatology Division, Johns Hopkins University School of Medicine, Baltimore, MD, ²Rheumatology, Johns Hopkins University, Baltimore, MD, ³Division of Rheumatology, School of Medicine, Johns Hopkins University, Baltimore, MD
Background/Purpose: Anticardiolipin Ever smoking 411 (48.1%) Past smoking 246 (49.8%) Current smoking 165 (46.6%) Never smoking 721 (48.9%) P Value (Ever vs. Never) 0.6943…
Abstract Number: 1962 • 2016 ACR/ARHP Annual Meeting
Antiphospholipid Syndrome Neutrophils Are Characterized By Overexpression of P-Selectin Glycoprotein Ligand 1, a Potential Therapeutic Target
Jason S Knight¹, Patrick S. Coit¹, He Meng¹, Srilakshmi Yalavarthi¹, Paul Renauer¹, Robert C Grenn¹, Levi F Mazza¹, Hui Wang², Daniel T Eitzman² and Amr H Sawalha¹, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI
Background/Purpose: Treatment of the thrombotic manifestations of antiphospholipid syndrome (APS) primarily focuses on inhibiting clotting pathways. In an effort to identify upstream inflammatory targets that…
Abstract Number: 1965 • 2016 ACR/ARHP Annual Meeting
Antiphospholipid Syndrome Alliance for Clinical Trials & International Networking Registry Analysis: First and Recurrent Thrombosis Risk after 720 Patient-Years of Follow-up
Ozan Unlu¹, W. David Branch², Paul R. Fortin³, Maria Gerosa⁴, Guillermo J. Pons-Estel⁵, Maria Tektonidou⁶, Amaia Ugarte⁷, Doruk Erkan⁸ and On Behalf of APS ACTION .⁹, ¹Barbara Volcker Center for Women and Rheumatic Diseases, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ²Obstetrics and Gynecology, University of Utah and Intermountain Healthcare, Salt Lake City, UT, ³Medicine, CHU de Québec - Université Laval, Québec, QC, Canada, ⁴University of Milan, Istituto Ortopedico Gaetano Pini, Milano, Italy, ⁵Department of Autoimmune Diseases, Institut Clínic de Medicina i Dermatologia, Hospital Clínic de Barcelona, Barcelona, Spain, ⁶First Department of Internal Medicine, School of Medicine, National University of Athens, Athens, Greece, ⁷Hospital Universitario Cruces, Biscay, Spain, ⁸Rheumatology, Hospital for Special Surgery- Weill Cornell Medicine, New York, NY, ⁹., New York, NY
Background/Purpose: APS ACTION Registry was created to study the natural course of disease over 10 years in persistently antiphospholipid antibody (aPL)-positive patients. Previously, based on…
Abstract Number: 2086 • 2016 ACR/ARHP Annual Meeting
Hexagonal Phase Phospholipid Neutralization Assay Is the Most Sensitive but Least Specific Among Nine Tests for Detecting APS in SLE or Non-SLE Patients
Katalin Banki¹, Phillip Aleksiejuk², Jessica Patel² and Andras Perl³, ¹Clinical Pathology, SUNY Upstate Medical University, Syracuse, NY, ²Internal Medicine, SUNY Upstate Medical University, Syracuse, NY, ³Department of Medicine, Upstate Medical University, Syracuse, NY
Background/Purpose: Antiphospholipid antibody syndrome (APS) is an autoimmune, hypercoagulable state which may elicit thrombosis and pregnancy loss. Although several tests exist to guide diagnosis of…
Abstract Number: 2093 • 2016 ACR/ARHP Annual Meeting
Association of Conventional Risk Factors and Antiphospholipid Antibodies to Thrombosis in Patients with Autoimmune Diseases: Lessons Learned from a Year-Long Systematic Assessment
Polona Žigon¹, Anuška Podovšovnik², Ales Ambrozic³, Matija Tomsic¹, Alojzija Hocevar¹, Natasa Gaspersic³, Ziga Rotar¹, Sonja Praprotnik⁴, Snezna Sodin Semrl^1,5 and Saša Čučnik^1,6, ¹Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ²Divison of Internal Medicine, General Hospital Izola, Izola, Slovenia, ³Department of Rheumatology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia, ⁴Department of Rheumatology, University Medical Centre Ljubljana, Slovenia, Ljubljana, Slovenia, ⁵Faculty of Mathematics, Natural Science and Information Technology, University of Primorska, Koper, Slovenia, ⁶Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
Background/Purpose: Patients with autoimmune disorders are at risk for thrombotic events and antiphospholipid antibodies (aPL) are one of known markers of increased thrombotic risk. The…
Abstract Number: 2094 • 2016 ACR/ARHP Annual Meeting
Complement Activation in Antiphospholipid Syndrome Due to the Multi-Activated Pathways of the Complement System
Hiroyuki Nakamura¹, Kenji Oku², Ryo Hisada², Kazumasa Ohmura², Masaru Kato², Toshiyuki Bohgaki², Olga Amengual², Tetsuya Horita², Shinsuke Yasuda² and Tatsuya Atsumi², ¹Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan, ²Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Background/Purpose: Complement activation is proposed as one of the major thrombophilic mechanisms in antiphospholipid syndrome (APS). Among three complement pathways (classical, alternative and lectin), activation…
Abstract Number: 2097 • 2016 ACR/ARHP Annual Meeting
Cardiolipin-Producing Candidate Commensals in the Gut Microbiome of Antiphospholipid Syndrome Patients
Cassyanne L. Aguiar^1,2, William Ruff³, Andrew Goodman⁴, Doruk Erkan⁵ and Martin Kriegel^3,6, ¹Hospital for Special Surgery- NewYork-Presbyterian / Weill Cornell Medicine, New York, NY, ²Pediatric Rheumatology, Cohen Children's Medical Center / Hofstra Northwell School of Medicine, Lake Success, NY, ³Immunobiology, Yale School of Medicine, New Haven, CT, ⁴Microbial Pathogenesis, Yale School of Medicine, New Haven, CT, ⁵Rheumatology, Hospital for Special Surgery- Weill Cornell Medicine, New York, NY, ⁶Medicine, Section of Rheumatology, Yale School of Medicine, New Haven, CT
Background/Purpose: Pathogen-associated transient antiphospholipid antibodies suggest a microbial trigger for antiphospholipid syndrome (APS). We hypothesized that the gut microbiota could represent a chronic stimulus in…
Abstract Number: 2099 • 2016 ACR/ARHP Annual Meeting
Micrornas As Potential Modulators of Atherothrombosis in Antiphospholipid Syndrome
Patricia Ruiz-Limon¹, Maria Ángeles Aguirre Zamorano², Nuria Barbarroja², Yolanda Jiménez-Gómez², IVÁN ARIAS DE LA ROSA², Eduardo Collantes-Estévez², Pedro Segui², Francisco Velasco³, Rocio Gonzalez-Conejero⁴, Raul Teruel⁴, Constantino Martinez⁴, Maria Jose Cuadrado⁵, Carlos Perez-Sanchez² and Chary Lopez-Pedrera², ¹Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³Hematology, IMIBIC-Reina Sofia Hospital, Hematology Unit, Cordoba, Spain, ⁴Regional Centre for Blood Donation, University of Murcia, Murcia, Spain, ⁵St Thomas Hospital, Lupus Research Unit, London, United Kingdom
Background/Purpose: 1) To identify and characterize microRNAs linked to thrombosis and atherosclerosis development in APS; 2) To assess the effects of antiphospholipid antibodies in that…
Abstract Number: 2456 • 2016 ACR/ARHP Annual Meeting
Risk Factors for Adverse Pregnancy Outcome in Antiphospholipid Antibodies Carriers: Results from a Multicenter Italian Cohort over 20 Years of Experience
Maria Grazia Lazzaroni¹, Laura Andreoli¹, Cecilia B. Chighizola², Teresa Del Ross³, Maria Gerosa⁴, Anna Kuzenko³, Maria Gabriella Raimondo⁴, Andrea Lojacono⁵, Sonia Zatti⁵, Francesca Ramazzotto⁵, Laura Trespidi⁶, Pier Luigi Meroni⁷, Vittorio Pengo³, Amelia Ruffatti³ and Angela Tincani¹, ¹Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy, ²Department of Clinical Sciences and Community Health, University of Milan, IRCCS Istituto Auxologico Italiano, Milano, Italy, ³Azienda Ospedaliera of Padova, University of Padova, Padova, Italy, ⁴University of Milan, Istituto Ortopedico Gaetano Pini, Milano, Italy, ⁵Obstetrics and Gynecology, Spedali Civili and University of Brescia, Brescia, Italy, ⁶L.Mangiagalli Obstetric Clinic, IRCSS Cà Granda, Ospedale Maggiore of Milano, Milano, Italy, ⁷Hospital G.Pini, University of Milano, IRCSS Instute Auxologico Italiano, Milano, Italy
Risk Factors for Adverse Pregnancy Outcome in Antiphospholipid Antibodies Carriers: Results From a Multicenter Italian Cohort Over 20 Years Of Experience Background/Purpose: Antiphospholipid antibodies (aPL)…
Abstract Number: 2457 • 2016 ACR/ARHP Annual Meeting
Role of Hydroxychloroquine in Improving Pregnancy Outcomes in Women with Antiphospholipid Antibodies without Other Underlying Connective Tissue Disease
Savino Sciascia¹, Simone Baldovino², Dario Roccatello² and Maria Jose Cuadrado³, ¹Department of Rare, Immunologic, Hematologic and Immunohematologic Diseases, Centro di Immunopatologia e Documentazione su Malattie rare, Torino, Italy, ²Department of Medicine and Experimental Oncology, CMID - Center of Research of Immunopathology and Rare Diseases, Turin, Italy, ³St Thomas Hospital, Lupus Research Unit, London, United Kingdom
Background/Purpose: Heparins and/or low-dose aspirin represent the treatment of choice for the management of pregnant women with antiphospholipid antibodies (aPL). However, despite these treatments, maternal, fetal, and…

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