ACR Meeting Abstracts

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Abstracts tagged "Antiphospholipid antibodies"

  • Abstract Number: 166 • 2018 ACR/ARHP Annual Meeting

    Superior Sensitivity for Detection of Primary Antiphospholipid Syndrome By a 9-Test Panel in Patients with Deep Venous Thrombosis, Pulmonary Embolism, and Stroke or Transient Ischemic Attack

    Konrad Dziamski1, Katalin Banki2 and Andras Perl3, 1Rheumatology, SUNY Upstate Medical University, Syracuse, NY, 2Clinical Pathology, SUNY Upstate Medical University, Syracuse, NY, 3Medicine, SUNY Upstate Medical University, Syracuse, NY

    Background/Purpose: Antiphospholipid Syndrome (APS) is characterized by thrombotic events mediated by antiphospholipid antibodies (aPL). Most patients have primary APS (PAPS), while a significant minority has…
  • Abstract Number: 167 • 2018 ACR/ARHP Annual Meeting

    Recurrent Thrombosis in Patients with Antiphospholipid Antibodies Following an Initial Venous or Arterial Thromboembolic Event

    Tom Ortel1, Sreelatha Meleth2, Diane Catellier2, Mark Crowther3, Doruk Erkan4, Paul R. Fortin5, David Garcia6, Nana Haywood2, Steven R. Levine7, Michael J. Phillips2 and Nedra Whitehead2, 1Duke University, Durham, NC, 2RTI International, Research, Triangle Park, NC, 3McMaster University, Hamilton, ON, Canada, 4Rheumatology, Hospital for Special Surgery- Weill Cornell Medicine, New York, NY, 5Medicine, CHU de Québec - University of Laval, Quebec, QC, Canada, 6Hematology, University of Washington Medical Center, Seattle, WA, 7Neurology, State University of New York Downstate Medical Center, Brooklyn, NY

    Background/Purpose: After an initial thromboembolic event (TE), several studies reported that patients with antiphospholipid syndrome (APS) manifest a high-risk for recurrent TE. A systematic review…
  • Abstract Number: 168 • 2018 ACR/ARHP Annual Meeting

    IgG Anti-High-Density Lipoproteins Antibodies Discriminate between Arterial and Venous Events in Thrombotic Antiphospholipid Syndrome Patients

    Irene Cecchi1, Massimo Radin2, Elena Rubini3, Ana Suárez4, Dario Roccatello5, Savino Sciascia6 and Javier Rodríguez-Carrio7, 1Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 2Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 3Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin and S. Giovanni Bosco Hospital, Turin, Italy., Turin, Italy, 4Area of Immunology, Department of Functional Biology, University of Oviedo, Oviedo, Spain, 5Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin and S. Giovanni Bo, Turin, Italy, 6Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy, 7Bone and Mineral Research Unit, Instituto Reina Sofía de Investigación Nefrológica, REDinREN del ISCIII, Hospital Universitario Central de Asturias, Oviedo, Spain

    Background/Purpose: Reliable biomarkers for risk stratification in Antiphospholipid Syndrome (APS) are still lacking. Anti-high-density lipoproteins antibodies (anti-HDL) showed promising results in predicting the development of…
  • Abstract Number: 170 • 2018 ACR/ARHP Annual Meeting

    Predictive Value of Antiphospholipid Antibodies in the Acute Phase of Deep Vein Thrombosis

    Katja Perdan Pirkmajer1, Anja Boc2, Saša Čučnik3, Alenka Mavri4, Polona Žigon3, Eva Podovsovnik5, Monika Štalc6, Nina Vene7 and Ales Ambrozic8, 1Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, 2Faculty of Medicine, Institute of Anatomy, University of Ljubljana, Ljubljana, Slovenia, 3University Medical Centre Ljubljana, Department of Rheumatology, Ljubljana, Slovenia, 4University Medical Centre Ljubljana, Ljubljana, Slovenia, 5Faculty for Tourism Studies, University of Primorska, Portoroz, Slovenia, 6Department of Nuclear Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia, 7Department of Vascular Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia, 8Department of Rheumatology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia

    Background/Purpose: Deep vein thrombosis (DVT) is frequent and potentially life threatening disease with tendency to reoccur. Anticoagulant treatment of the first episode of DVT usually…
  • Abstract Number: 173 • 2018 ACR/ARHP Annual Meeting

    The Efficacy of Treatment with Low Dose Aspirin and Low Molecular Weight Heparin in Pregnant Women with Criteria Anti-Phospholipid Antibodies

    Cecilia B. Chighizola1, Francesca Pregnolato2, Maria Gabriella Raimondo3, Chiara Comerio4, Laura Trespidi5, Maria Orietta Borghi6, Maria Gerosa7, Barbara Acaia8, Wally Ossola5, Enrico Ferrazzi8, Alessandro Bulfoni9 and Pier Luigi Meroni10, 1Rheumatology, Istituto Auxologico Italiano, University of Milan, Milan, Italy, 2Istituto Auxologico Italiano, Cusano Milanino, Italy, 3University of Milan, Istituto Ortopedico Gaetano Pini, Milan, Italy, 4University of Milan, Milan, Italy, 5Department of Obstetrics and Gynaecology, Fondazione Policlinico, Mangiagalli e Regina Elena, Milan, Italy, 6University of Milan, IRCCS Istituto Auxologico Italiano, Milan, Italy, 7Istituto Ortopedico Gaetano Pini, University of Milan, Milano, Italy, 8Department of Obstetrics and Gynaecology, Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy, 9Division of Obstetrics and Gynaecology, Humanitas S. Pio X, Milan, Italy, 10Laboratory of Immuno-rheumatology, Laboratory of Immuno-rheumatology, IRCCS Istituto Auxologico Italiano, Cusano Milanino, Italy

    Background/Purpose: Anti-phospholipid antibodies (aPL) are the biomarkers of anti-phospholipid syndrome (APS), a systemic autoimmune condition characterized by thrombosis and/or pregnancy morbidity (PM). The aim of…
  • Abstract Number: 852 • 2018 ACR/ARHP Annual Meeting

    Antigenic Property of Prothrombin/HLA-DR Complex on Procoagulant Cells in Patients with Antiphospholipid Syndrome

    Naoki Ohnishi1, Yuichiro Fujieda1, Ryo Hisada1, Hiroyuki Nakamura1, Masaru Kato1, Kenji Oku1, Toshiyuki Bohgaki1, Olga Amengual1, Shinsuke Yasuda1, Hisashi Arase2 and Tatsuya Atsumi1, 1Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, 2Department of Immunochemistry, Research Institute for Microbial Disease, Osaka University, Suita, Japan

    Background/Purpose: Antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity and the presence of antiphospholipid antibodies (aPL). Phosphatidylserine-dependent antiprothrombin antibodies (aPS/PT) recognize the phosphatidylserine/prothrombin…
  • Abstract Number: 853 • 2018 ACR/ARHP Annual Meeting

    Enhanced Type I Interferon Gene Signature in Primary Antiphospholipid Syndrome: Association with Earlier Disease Onset and Preeclampsia

    Michelle Lopes1, Giovana Torrezan2, Ana Paula Gandara1, Eloisa Olivieri3, Iana Nascimento1, Erica Okazaki4, Eloisa Bonfa5, Dirce Carraro6 and Danieli Andrade1, 1Rheumatology, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, 2Genomics and Molecular Biology  Laboratory, AC Camargo Cancer Center, São Paulo, Brazil, 3Macromolecules Laboratory, AC Camargo Cancer Center, São Paulo, Brazil, 4Hemathology, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, 5Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, 6Division of Genomic Diagnostics, AC Camargo Cancer Center, São Paulo, Brazil

    Background/Purpose: Primary antiphospholipid syndrome (PAPS) is an autoimmune vasculopathy mediated by autoantibodies with thrombosis as its main clinical manifestation. The presence of antiphospholipid antibodies, while…
  • Abstract Number: 1857 • 2018 ACR/ARHP Annual Meeting

    Low Molecular Weight Heparin and Aspirin Combination Therapy Modulates Th1/Th2 Cell Imbalance in Pregnant Patients with Antiphospholipid Antibody-Associated Recurrent Pregnancy Loss

    Meiying Wang1,2, Peng Zhang3, gengmin zhou1, jiyang lv1, chengshan guo4 and Qingwen Wang1, 1Rheumatology and Immunology, Peking University Shenzhen Hospital, shenzhen, China, 2Rheumtology, David Geffen school of Medicine at UCLA, Los Angeles, CA, 3SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES, shenzhen, China, 4Rheumatology and Immunology, The people's Hospital of Bao’an District Shenzhen City., shenzhen, China

    Background/Purpose: Type 1/type 2 T helper (Th1/Th2) cells and their cytokines are implicated in the pathogenesis of autoimmune diseases[1]; however, their roles in antiphospholipid antibody-associated…
  • Abstract Number: 2414 • 2018 ACR/ARHP Annual Meeting

    The Global Antiphospholipid Syndrome Score in Women with Systemic Lupus Erythematosus and Adverse Pregnancy Outcomes

    Karen Schreiber1, Massimo Radin2, Irene Cecchi3, Elena Rubini4, Dario Roccatello5, Søren Jacobsen6, Maria Jose Cuadrado7 and Savino Sciascia8, 1Department of Thrombosis and Haemophilia, Guy's and St Thomas' Hospital, London, United Kingdom., London, United Kingdom, 2Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 3Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 4Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin and S. Giovanni Bosco Hospital, Turin, Italy., Turin, Italy, 5Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin and S. Giovanni Bo, Turin, Italy, 6University of Copenhagen, Copenhagen, Denmark, 7Clinica Universidad de Navarra, Madrid, Spain, 8Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy

    Background/Purpose: Systemic lupus erythematosus (SLE) and antiphospholipid antibodies (aPL) are associated with pregnancy complications. Methods: 143 women ever pregnant with SLE who presented in our…
  • Abstract Number: 2428 • 2018 ACR/ARHP Annual Meeting

    Correlation between Antibodies to the Phosphotidylserine/Prothrombin Complex (aPS/PT) and Anti-β2glycoprotein-1-Domain 1 (anti-β2GP1-D1) and Vascular Thrombosis (VT) and/or Pregnancy Morbidity (PM)

    Eric Campbell1, Tania Pannu1, Marvin J. Fritzler2, Michelle Jung3, Claire Barber4, Yvan St. Pierre5 and Ann E. Clarke2, 1Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 2Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 3Division of Rheumatology, University of Calgary, Calgary, AB, Canada, 4Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 5Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada

    Background/Purpose: aPS/PT is considered to be a risk factor for vascular thrombosis (VT) and/or pregnancy morbidity (PM). Anti-β2GP1-D1 is potentially superior to anti-β2GP1 in predicting…
  • Abstract Number: 2635 • 2018 ACR/ARHP Annual Meeting

    Combined Panel of Nine Tests Has the Greatest Sensitivity but the Lowest Specificity to Detect Antiphospholipid Antibody Syndrome in Patients with Systemic Lupus Erythematosus

    Saika Sharmeen1, Katalin Banki2 and Andras Perl3, 1Medicine, State University of New York Upstate Medical University, Syracuse, NY, 2Clinical Pathology, SUNY Upstate Medical University, Syracuse, NY, 3Medicine, SUNY Upstate Medical University, Syracuse, NY

    Background/Purpose: Antiphospholipid antibody syndrome (APS) is an autoimmune hypercoagulable state caused by antiphospholipid antibodies (aPL) which represent a diagnostic criterion and underlie significant comorbidities in…
  • Abstract Number: 156 • 2018 ACR/ARHP Annual Meeting

    Assessing the Role of Ascvd Score in Primary Thrombosis Prophylaxis Strategy Among Asymptomatic Antiphospholipid Antibody Carriers

    Yu Zuo1, Akrithi Udupa2, Jennifer Fan1, Una E. Makris1, David Karp1,3 and Yu-min Shen1, 1University of Texas Southwestern Medical Center, Dallas, TX, 2Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 3Internal Medicine/Division of Rheumatic Diseases, University of Texas Southwestern Medical Center, Dallas, TX

    Background/Purpose: Primary thrombosis prophylaxis among asymptomatic antiphospholipid antibody (aPL) carriers is challenging. The presence of aPL does not always lead to thromboembolic events. Additional factors…
  • Abstract Number: 2641 • 2018 ACR/ARHP Annual Meeting

    Hydroxychloroquine Could Modulate S100 Proteins Expression, Which Reflect the Activity of Lupus Nephritis or Skin Lesion, in Systemic Lupus Erythematosus Patients with Low Disease Activity

    Risa Wakiya, Tomohiro Kameda, Shusaku Nakashima, Hiromi Shimada, Mikiya Kato, Taichi Miyagi, Kiyo Ueeda and Hiroaki Dobashi, Internal Medicine Division of Hematology, Rheumatology, and Respiratory Medicine, Kagawa University, Kagawa, Japan

    Background/Purpose: To find the effect of HCQ treatment on expression of S100 proteins which were reported to reflect the activity of SLE including lupus nephritis…
  • Abstract Number: 7 • 2017 ACR/ARHP Annual Meeting

    Predictive Value for Thrombosis of Double or Triple Positivity in Secondary APS Depends on the Component Assays and the Type of Thrombosis

    Michelle Petri1, Daniel Goldman2 and Laurence S Magder3, 1Medicine (Rheumatology), Division of Rheumatology, Johns Hopkins University School of Medicine, MD, USA, Baltimore, MD, 2Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 3Epidemiology and Public health, University of Maryland School of Medicine, Baltimore, MD

    Background/Purpose: The lupus anticoagulant (LAC) is individually the antiphospholipid antibody (aPL) most associated with thrombotic risk in both primary and secondary APS. Anticardiolipin (aCL) and…
  • Abstract Number: 9 • 2017 ACR/ARHP Annual Meeting

    Renal Protective Effect of Antiplatelet Therapy in Antiphospholipid Antibody-Positive Lupus Nephritis Patients without the Antiphospholipid Syndrome

    Hironari Hanaoka1, Tomofumi Kiyokawa1, Harunobu Iida1, Yukiko Takakuwa1, Takahiro Okazaki2, Hidehiro Yamada3, Shoichi Ozaki4 and Kimito Kawahata1, 1Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, 2Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, 3Rheumatology, Seirei Yokohama Hospital, Yokohama, Japan, 4Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan

    Background/Purpose: Lupus nephritis (LN) class III or IV is associated with a poor prognosis for both patient and renal survival. Since antiphospholipid syndrome (APS) is…
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