Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Background/Purpose: Pathogen-associated transient antiphospholipid antibodies suggest a microbial trigger for antiphospholipid syndrome (APS). We hypothesized that the gut microbiota could represent a chronic stimulus in APS patients and defined the fecal microbiome and IgA-coated microbiota in APS patients over time and correlated them with autoantigen-related responses.
Conclusion: High-throughput sequencing of APS gut microbiomes revealed a persistent enrichment of the genus Slackia over time, particularly among the anti-DI IgG+ APS patients. Slackia is capable of producing phospholipids including cardiolipin. We speculate that gut commensal-derived cardiolipin contributes to a conformational change of
To cite this abstract in AMA style:Aguiar CL, Ruff W, Goodman A, Erkan D, Kriegel M. Cardiolipin-Producing Candidate Commensals in the Gut Microbiome of Antiphospholipid Syndrome Patients [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/cardiolipin-producing-candidate-commensals-in-the-gut-microbiome-of-antiphospholipid-syndrome-patients/. Accessed October 20, 2020.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/cardiolipin-producing-candidate-commensals-in-the-gut-microbiome-of-antiphospholipid-syndrome-patients/