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Abstracts tagged "Antibodies"

  • Abstract Number: L02 • 2019 ACR/ARP Annual Meeting

    Multiple Industrial Air Pollutants and Anti-Citrullinated Protein Antibody Positivity

    Naizhuo Zhao 1, Audrey Smargiassi 2, Marianne Hatzopoulou 3, Ines Colmegna 4, Marie Hudson 5, Marvin Fritzler 6, Philip Awadalla 7 and Sasha Bernatsky8, 1Research Institute of the McGill University Health Centre, Montreal, Canada, 2University of Montreal, Montreal, Canada, 3University of Toronto, Toronto, Canada, 4McGill University Health Center, Montreal, QC, Canada, 5Jewish General Hospital, Lady Davis Institute for Medical Research, and Department of Medicine, McGill University, Montreal, Canada, 6Cumming School of Medicine, University of Calgary, Calgary, Canada, 7Ontario Institute for Cancer Research, Toronto, Canada, 8Research Institute of the McGill University Health Centre, Montreal, QC, Canada

    Background/Purpose: Studies of associations between industrial air emissions and rheumatic disease, or diseases-related serological biomarkers, are few. Moreover, previous evaluations typically studied individual (not mixed)…
  • Abstract Number: 109 • 2019 ACR/ARP Annual Meeting

    Targeting CD6 Expression Attenuates T Cell Activity in Murine Collagen Induced Arthritis

    Yan Li 1, Jeffrey H. Ruth 2, Stephanie Rasmussen 3, Kalana S. Athukorala 2, Daniel P. Weber 2, M. Asif Amin 2, Phillip Campbell 3, Nora Singer 4, David Fox5 and Feng Lin 1, 1Cleveland Clinic, Cleveland, OH, 2University of Michigan, Ann Arbor, MI, 3Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 4The MetroHealth System -Case Western Reserve University School of Medicine, Cleveland, OH, 5Division of Rheumatology, Department of Internal Medicine, Autoimmunity Center of Excellence,University of Michigan, Ann Arbor, MI

    Background/Purpose: CD6, an important regulator of T cell function, interacts with the ligands CD166 and CD318. We previously examined CD318 expression on synovial tissues (STs)…
  • Abstract Number: 964 • 2019 ACR/ARP Annual Meeting

    Identifying Jo-1-Specific B Cells in the Primary Immune Repertoire in Idiopathic Inflammatory Myopathies

    Jennifer Young-Glazer1, Erin Wilfong 2, Peggy Kendall 1, Rachel Bonami 1 and Leslie Crofford 2, 1Vanderbilt University Medical Center, Nashville, TN, 2Vanderbilt University, Nashville

    Background/Purpose: Idiopathic inflammatory myopathies (IIM) are systemic autoimmune diseases traditionally classified as dermatomyositis or polymyositis, but these disorders are increasingly defined by the presence of…
  • Abstract Number: 1274 • 2019 ACR/ARP Annual Meeting

    New Aspects of Clinical and Immunological Characteristics in Patients with Anti-KS Antibody

    Sho Sasaki1, Akira Ishii 2, Mai Sugiyama 2, Yuto Izumi 2, Yoko Nakagome 2, Kazuki Hirano 3, Takayoshi Kurabayashi 1, Shinichi Nogi 4, Noriko Sasaki 2, Chiho Yamada 2 and Shinji Sato 5, 1Tokai Universitiy School of Medicine, Isehara, Japan, 2Tokai University School of Medicine, Isehara, Japan, 3Tokai University School of Medicine, Isehara, 4National Hospital Organization Sagamihara Hospital, Sagamihara, Japan, 5Division of Rheumatology, Department of Internal Medicine, Tokai University School of Medicine, Yokohama, Japan

    Background/Purpose: Anti-KS antibody, an anti-aminoacyl tRNA synthetase (ARS) antibody, is found mainly in patients with interstitial lung disease (ILD) accompanied by polymyositis/dermatomyositis (PM/DM). Although anti-KS…
  • Abstract Number: 1288 • 2019 ACR/ARP Annual Meeting

    Line Blot Immunoassay in Inflammatory Myopathies: Diagnostic Accuracy and Factors Predicting Positive Results in Routine Clinical Practice

    Fergus To1, Clara Ventín Rodríguez 2, Shuayb Elkhalifa 3, James Lilleker 4 and Hector Chinoy 4, 1University of British Columbia, Vancouver, Canada, 2Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain, 3(3) Department of Immunology, Salford Royal NHS Foundation, Salford, United Kingdom, 4University of Manchester, Manchester, United Kingdom

    Background/Purpose: To evaluate the real-world accuracy of a line blot immunoassay (LIA) for myositis-specific (MSA) and myositis-associated (MSA) autoantibody testing in patients at a tertiary…
  • Abstract Number: 1742 • 2018 ACR/ARHP Annual Meeting

    Disease-Specific Autoantibodies Associate with Remarkably Different Risk of Development of Significant Lung Fibrosis in Systemic Sclerosis

    Svetlana I. Nihtyanova1, Alper Sari2, Anna Leslie3, Voon H. Ong4 and Christopher P. Denton5, 1Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, 2Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, 3Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, 4Division of Medicine, University College London, London, United Kingdom, 5University College London, London, United Kingdom

    Background/Purpose: Pulmonary fibrosis (PF) is a leading cause of disease-related death in SSc patients. Some studies suggest that the timing of PF development differs between…
  • Abstract Number: 1898 • 2018 ACR/ARHP Annual Meeting

    Type I Interferon-Induced Proteins May Facilitate the Occurrence of Long QT Syndrome (LQTS) in Parallel with Anti-Ro/SSA and Anti-Ro52/TRIM21 Antibody Levels in Patients with Systemic Lupus Erythematous (SLE): A Bench to Bedside Approach

    Luis F. Perez-Garcia1,2, Irving O. Estevez-Garcia3, Ricardo Marquez-Velasco3, Pedro Iturralde4, Luis H. Silveira5 and Luis M. Amezcua-Guerra2,6,7, 1Rheumatology, Erasmus MC, Rotterdam, Netherlands, 2Rheumatology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico, 3Immunology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico, 4Cardiology - Electrophysiology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico, 5Rheumatology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City DF, Mexico, 6Cardiovascular Research Laboratory, Unidad de Investigacion Traslacional, Universidad Nacional Autonoma de Mexico/Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico, 7Department of Health Care, Universidad Autonoma Metropolitana, Xochimilco, Mexico City, Mexico

    Background/Purpose: Long QT syndrome (LQTS) is an abnormal QT corrected (QTc) interval prolongation, strongly associated with increased risk of sudden death. Studies have associated LQTS…
  • Abstract Number: 2118 • 2018 ACR/ARHP Annual Meeting

    Prevalence of Acquired Activated Protein C Resistance and Anti-Protein C Antibodies in Systemic Lupus Erythematosus

    Giuseppe Alvise Ramirez1,2,3,4, Hannah Cohen5,6, David A. Isenberg4,7 and Maria Efthymiou5, 1Università Vita-Salute San Raffaele, Milan, Italy, 2Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom, 3Unit of Immunology, Rheumatology, Allergy and Rare Diseases, San Raffaele Scientific Institute, Milan, Italy, 4Department of Rheumatology, University College London Hospitals NHS Foundation Trust, London, United Kingdom, 5Haemostasis Research Unit, Department of Haematology, University College London, London, United Kingdom, 6Department of Haematology, University College London Hospitals NHS Foundation Trust, London, United Kingdom, 7University College London, London, United Kingdom

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease characterised by increased cardiovascular risk, with a 5-20 fold increased risk for venous thromboembolism (VTE)…
  • Abstract Number: 2576 • 2018 ACR/ARHP Annual Meeting

    Anti-Drug Antibodies, Efficacy, and Impact of Concomitant Methotrexate in Ixekizumab-Treated Patients with Psoriatic Arthritis

    Christopher T. Ritchlin1, Joseph F. Merola2, Amanda M. Gellett3, Chen-Yen Lin3 and Talia Muram3, 1University of Rochester Medical Center, Rochester, NY, 2Clinical Unit for Research Innovation & Trials, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 3Eli Lilly and Company, Indianapolis, IN

    Background/Purpose: Anti-drug antibody (ADA) development can potentially affect the efficacy of biologics; concomitant MTX decreases the development of ADA for some biologics.1 Ixekizumab (IXE), a…
  • Abstract Number: 168 • 2018 ACR/ARHP Annual Meeting

    IgG Anti-High-Density Lipoproteins Antibodies Discriminate between Arterial and Venous Events in Thrombotic Antiphospholipid Syndrome Patients

    Irene Cecchi1, Massimo Radin2, Elena Rubini3, Ana Suárez4, Dario Roccatello5, Savino Sciascia6 and Javier Rodríguez-Carrio7, 1Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 2Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 3Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin and S. Giovanni Bosco Hospital, Turin, Italy., Turin, Italy, 4Area of Immunology, Department of Functional Biology, University of Oviedo, Oviedo, Spain, 5Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin and S. Giovanni Bo, Turin, Italy, 6Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy, 7Bone and Mineral Research Unit, Instituto Reina Sofía de Investigación Nefrológica, REDinREN del ISCIII, Hospital Universitario Central de Asturias, Oviedo, Spain

    Background/Purpose: Reliable biomarkers for risk stratification in Antiphospholipid Syndrome (APS) are still lacking. Anti-high-density lipoproteins antibodies (anti-HDL) showed promising results in predicting the development of…
  • Abstract Number: 2682 • 2018 ACR/ARHP Annual Meeting

    Novel Antibody Against Commensal Bacterial Antigen in Prediction of the Response of Rituximab in Systemic Lupus Erythematosus

    Yu-Min Kuo1,2, Jenhao Chen3, Jean-san Chia4, Chiau-jing Jung5 and Song-Chou Hsieh6, 1Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan, Taipei, Taiwan, 2Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, 3Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, National Taiwan University Hospital,Yunlin branch, Yunlin County, Taiwan, 4Graduate Institute of Immunology, National Taiwan University College of Medicine, Taipei, Taiwan, 5Department of Microbiology and Immunology, School of Medicine,, College of Medicine, Taipei Medical University, Taipei, Taiwan, 6National Taiwan University Hospital, Taipei, Taiwan

    Background/Purpose: Streptoccocal infections can cause rheumatic fever sharing clinical presentations similar to SLE. Whether oral commensal streptococci could induce cross-reactive and pathogenic antibodies remained unknown.…
  • Abstract Number: 390 • 2018 ACR/ARHP Annual Meeting

    Severe Axial and Pelvifemoral Muscle Damage in Immune-Mediated Necrotizing Myopathy Evaluated By Whole-Body MRI

    Océane Landon-Cardinal1, Cedi Koumako2, Giulia Hardouin3, Benjamin Granger3, Harmen Reyngoudt2, Jean-Marc Boisserie2, Aude Rigolet1, Baptiste Hervier1, Nicolas Champtiaux1, Perrine Guillaume1, Mathieu Vautier1, Pierre Carlier2, Olivier Benveniste1 and Yves Allenbach1, 1Department of Internal Medicine and Clinical Immunology and Inflammation-Immunopathology-Biotherapy Department (I2B), Pitié-Salpêtrière University Hospital, Assistance Publique-Hôpitaux de Paris, East Paris Neuromuscular Diseases Reference Center, Paris, France, 2Laboratoire de RMN AIM & CEA, Centre d'Explorations Fonctionnelles, Institut de Myologie, Paris, France, 3Département de Biostatistiques, Santé Publique et Information Médicale, Groupe hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France

    Background/Purpose: Immune-mediated necrotizing myopathies (IMNM) are a severe condition with early muscle damage attested by MRI of thigh muscles. Presence of damage in the other…
  • Abstract Number: 2801 • 2018 ACR/ARHP Annual Meeting

    A Novel B-Cell-Helper IL-21-Producing CD8+ T Cell Subset Involved in the Pathogenesis of Rheumatoid Arthritis

    Kazuhiko Higashioka1, Masahiro Ayano1, Yasutaka Kimoto2, Hiroki Mitoma1, Mitsuteru Akahoshi1, Yojiro Arinobu1, Koichi Akashi1, Takahiko Horiuchi3 and Hiroaki Niro4, 1Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 2Department of Internal Medicine, Kyushu University Beppu Hospital, Oita, Japan, 3Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, 4Department of Medical Education, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan

    Background/Purpose: A plethora of evidence from genome-wide association studies and relevant animal models implicates a pivotal role of T cells in the pathogenesis of rheumatoid…
  • Abstract Number: 397 • 2018 ACR/ARHP Annual Meeting

    Myositis-Specific Autoantibodies and Their Clinical Associations

    Victor Tak Lung Wong1, Ho So1, Ricky Wai Ki Ip2, Virginia W Lao3, Steve H Pang3, Lai-Shan Tam4, Priscilla Wong5, Lydia Ho Pui Tam6, Tsz On Lam7, Mei Yan Law8, Isaac CW Yim9, Tin Lok LAI10, Patrick Man Leung Lee11 and Ronald Man Lung Yip12, 1Kwong Wah Hospital, Kowloon, Hong Kong, 2Queen Mary Hospital, Hong Kong, Hong Kong, 3Department of Medicine, Kwong Wah Hospital, Hong Kong, Hong Kong, 4Department of Medicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China, Hong Kong, Hong Kong, 5Department of Medicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China, Hong Kong, China, 6Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, 7Prince of Wales Hospital, New Territories, Hong Kong, 8Alice Ho Miu Ling Nethersole Hospital, New Territories, Hong Kong, 9Department of Medicine, Tseung Kwan O Hospital, Hong Kong, Hong Kong, 10Medicine, Tseung Kwan O Hospital, Tseung Kwan O, Hong Kong, 11Yan Chai Hospital, Kowloon, Hong Kong, 12Tung Wah Group of Hospitals, Hong Kong, Hong Kong, Hong Kong

    Background/Purpose: Myositis-specific autoantibodies (MSAs) have been shown to predict clinical features and have prognostic implications in patients with idiopathic inflammatory myopathies (IIMs), with anti-melanoma differentiation-associated…
  • Abstract Number: 2935 • 2018 ACR/ARHP Annual Meeting

    A Practical Classification of Systemic Sclerosis Using Subset and Autoantibodies for the Purpose of Early Risk Stratification

    Svetlana I. Nihtyanova1, Emma C. Derrett-Smith2, Carmen Maria Fonseca3, Voon H. Ong2 and Christopher P. Denton4, 1Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, 2Division of Medicine, University College London, London, United Kingdom, 3Department of Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, 4University College London, London, United Kingdom

    Background/Purpose: The Le Roy et al. classification of SSc into limited and diffuse cutaneous subtype remains the most commonly used. Nevertheless, autoantibodies are much better…
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