ACR Meeting Abstracts

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Abstracts tagged "Antibodies"

  • Abstract Number: 1748 • 2012 ACR/ARHP Annual Meeting

    Antibody Secreting Cells Arising After Vaccination of Lupus Patients May Produce High Affinity Autoantibodies

    Kenneth Smith1, Jennifer Muther1, Angie Duke1, Emily McKee1, Alina Lorant1, Patrick C. Wilson2 and Judith A. James3, 1Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Rheumatology and Knapp center for Lupus and Immunology Research, University of Chicago, Chicago, IL, 3Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Vaccinating SLE patients with influenza and pneumococcal vaccines is generally considered safe and effective.  However, conflicting reports regarding the impact of vaccination on autoantibody…
  • Abstract Number: 1936 • 2012 ACR/ARHP Annual Meeting

    The Human Leukocyte Antigen DRB1*13:02-DQB1*06:04-DPB1*04:01 Haplotype Is Closely Associated with Dermatomyositis Patients with Anti-CADM-140 (Melanoma Differentiation-Associated Protein 5: MDA5) Antibody

    Yuji Hosono1, Chikashi Terao2, Ran Nakashima1, Yoshitaka Imura3, Naoichiro Yukawa4, Hajime Yoshifuji1, Motomu Hashimoto5, Koichiro Ohmura6, Takao Fujii7 and Tsuneyo Mimori1, 1Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 2Center for Genomic Medicine, Kyoto University, Kyoto, Japan, 3Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 4Dept of Rheum & Clinical Immun, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 5The Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 6Rheumatology & Clin Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 7Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan

    Background/Purpose: Recent studies have revealed that anti-CADM-140 (MDA5/IFIH1)-antibody positive dermatomyositis (DM) patients frequently develop acute or subacute progressive interstitial pneumonia (A/SIP) with poor prognosis. However,…
  • Abstract Number: 1941 • 2012 ACR/ARHP Annual Meeting

    Clinical Evaluation of Anti-Aminoacyl tRNA Synthetase Antibodies in Japanese Patients with Connective Tissue Diseases

    Masakazu Matsushita, Toshio Kawamoto, Ken Yamaji, Naoto Tamura and Yoshinari Takasaki, Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

    Background/Purpose: Anti-Jo-1 antibody is an autoantibody specifically detected in sera of patients with polymyositis/dermatomyositis (PM/DM). The antigen corresponding to this autoantibody is histidyl-tRNA synthase, being…
  • Abstract Number: 2598 • 2012 ACR/ARHP Annual Meeting

    Anti-Drug Antibodies Are Associated with Diminished Drug Levels and Treatment Failure

    Miha Kosmac1, Natasa Toplak2, Gabriele Simonini3, Ilaria Pagnini4, Rolando Cimaz5, Vladka Curin Serbec1 and Tadej Avcin5, 1Research and Development Unit, Blood Transfusion Centre of Slovenia, Ljubljana, Slovenia, 2Department of Allergology, Rheumatology and Clinical Immunology, University Children's Hospital Ljubljana Slovenia, Ljubljana, Slovenia, 3Rheumatology Unit-Department of Paediatrics, A. Meyer Children's Hospital, Florence, Italy, 4Rheumatoloy Unit, Anna Meyer Children's Hospital, Department of Pediatrics, University of Florence, Florence, Italy, 5Paediatric Rheumatology International Trials Organization (PRINTO), Istituto Giannina Gaslini, Genova, Italy

    Background/Purpose: Due to their proteinaceus character biologics can often induce an unwanted immune response that results in the formation of anti-drug antibodies in patients receiving…
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