ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: L02

Multiple Industrial Air Pollutants and Anti-Citrullinated Protein Antibody Positivity

Naizhuo Zhao 1, Audrey Smargiassi 2, Marianne Hatzopoulou 3, Ines Colmegna 4, Marie Hudson 5, Marvin Fritzler 6, Philip Awadalla 7 and Sasha Bernatsky8, 1Research Institute of the McGill University Health Centre, Montreal, Canada, 2University of Montreal, Montreal, Canada, 3University of Toronto, Toronto, Canada, 4McGill University Health Center, Montreal, QC, Canada, 5Jewish General Hospital, Lady Davis Institute for Medical Research, and Department of Medicine, McGill University, Montreal, Canada, 6Cumming School of Medicine, University of Calgary, Calgary, Canada, 7Ontario Institute for Cancer Research, Toronto, Canada, 8Research Institute of the McGill University Health Centre, Montreal, QC, Canada

Meeting: 2019 ACR/ARP Annual Meeting

Date of first publication: October 23, 2019

Keywords: , , , ,

Session Information

Date: Tuesday, November 12, 2019

Session Title: Late-Breaking Abstracts ePoster

Session Type: Late-Breaking Abstract Poster Session

Session Time: 9:00AM-11:00AM

Background/Purpose: Studies of associations between industrial air emissions and rheumatic disease, or diseases-related serological biomarkers, are few. Moreover, previous evaluations typically studied individual (not mixed) emissions. We investigated associations between individual and combined exposures to industrial sulfur dioxide (SO2), nitrogen dioxide (NO2), and fine particles matter (PM2.5) on anti-citrullinated protein antibodies (ACPA), a characteristic biomarker for rheumatoid arthritis (RA).

Methods: Serum ACPA was determined for 7600 randomly selected CARTaGENE general population subjects in Quebec, Canada. Industrial SO2, NO2, and PM2.5 concentrations, estimated by the California Puff (CALPUFF) atmospheric dispersion model, were assigned based on residential postal codes at the time of sera collection. Single-exposure logistic regressions were performed for ACPA positivity defined by 20 U/ml, 40 U/ml, and 60U/ml thresholds, adjusting for age, sex, French Canadian origin, smoking, and family income. Associations between regional overall PM2.5 exposure and ACPA positivity were also investigated. The associations between the combined three industrial exposures and the ACPA positivity were assessed by weighted quantile sum (WQS) regressions.

Results: Significant associations between individual and combined industrial exposures and ACPA positivity (defined by the 20 U/ml and 40 U/ml thresholds) were seen with both single-exposure logistic and multi-exposure WQS regression models, for industrial emissions of PM2.5 and SO2, without clear associations for NO2.  The WQS model suggested that industrial PM2.5 may have a stronger effect than the other exposures.

Conclusion: We noted positive associations between ACPA and industrial emissions of PM2.5 and SO2. Industrial PM2.5 exposure may play a particularly important role in this regard.

Odds ratios – ORs (95% confidence intervals – CIs) from the single-pollutant logistic and the weighted quantile sum (WQS) regression models, adjusting by age, sex, ancestry, smoking, and family income.

Disclosure: N. Zhao, None; A. Smargiassi, None; M. Hatzopoulou, None; I. Colmegna, None; M. Hudson, None; M. Fritzler, Alexion Canada, 7, BioRad, 5, Dr. Fooke Laboratorien GmbH, 5, Euroimmun GmbH, 5, 7, ImmunoConcepts, 7, Inova Diagnostics, 5, 7, 8, Inova Diagnostics Inc. San diego, CA, 5, Inova Dx, Mikrogen GmbH, 5, Werfen International, 5; P. Awadalla, None; S. Bernatsky, None.

To cite this abstract in AMA style:

Zhao N, Smargiassi A, Hatzopoulou M, Colmegna I, Hudson M, Fritzler M, Awadalla P, Bernatsky S. Multiple Industrial Air Pollutants and Anti-Citrullinated Protein Antibody Positivity [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/multiple-industrial-air-pollutants-and-anti-citrullinated-protein-antibody-positivity/. Accessed January 22, 2020.

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