ACR Meeting Abstracts

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Abstracts tagged "anti-CCP antibodies"

  • Abstract Number: 2278 • 2013 ACR/ARHP Annual Meeting

    Ordering Of Serologic Markers Of Rheumatoid Arthritis Among Primary Care and Subspecialty Providers:  Under-Utilization Of Anti-Citrullinated Peptide Antibody Tests By Non-Rheumatologists

    Emily H. Glynn1, Mark H. Wener2 and Michael Astion3, 1Laboratory Medicine, University of Washington, Seattle, WA, 2Rheumatology & Lab Med, University of Washington, Seattle, WA, 3Department of Laboratories, Seattle Children's Hospital, Seattle, WA

    Background/Purpose: Anti-citrullinated peptide antibodies (ACPA) are more specific and have a superior positive predictive value for diagnosis of rheumatoid arthritis (RA) compared to RF. The…
  • Abstract Number: 2197 • 2013 ACR/ARHP Annual Meeting

    High Titer IgG Anti-Cyclic Citrullinated Peptide Antibodies Are Associated With Joint Destruction In Juvenile Idiopathic Arthritis Patients

    Brooke Gilliam, Lance Feller and Terry L. Moore, Internal Medicine/Rheumatology, Saint Louis University, Saint Louis, MO

    Background/Purpose: IgG anti-cyclic citrullinated peptide (anti-CCP) antibodies have been identified as an important indicator of destructive disease in juvenile idiopathic arthritis (JIA), as is the…
  • Abstract Number: 1586 • 2013 ACR/ARHP Annual Meeting

    Defining Hand Arthritis In Systemic Lupus Erythematosus, From An Ultrasound, Magnetic Resonance Imaging and Antibody Status Perspective

    Elisabeth M.A Ball1, Arthur Grey2, Ai Lyn Tan3, Eiji Fukuba4, Gunter Steiner5, Dennis McGonagle6, Aubrey Bell7 and Madeleine Rooney8, 1Rheumatology, Queens' University/Musgrave Park Hospital, Belfast, United Kingdom, 2Rheumatology, Musgrave Park Hospital, Belfast, United Kingdom, 3Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 4Department of Radiology, Shimane University, Izuma, Japan, 5Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 6NIHR Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom, 7Rheumatology Unit, Musgrave Park Hospital, Belfast, United Kingdom, 8Medicine, Queens University Belfast, Belfast, United Kingdom

    Background/Purpose: Musculoskeletal involvement in systemic lupus erythematosus (SLE) is common but poorly characterised with only a few Magnetic Resonance Imaging (MRI) or ultrasound (US) studies…
  • Abstract Number: 1309 • 2013 ACR/ARHP Annual Meeting

    Prognosis Of Seronegative Patients In a Large Prospective Cohort Of Patients With Early Inflammatory Arthritis

    Lillian J. Barra1, Janet E. Pope2, Boulos Haraoui3, Carol A. Hitchon4, J. Carter Thorne5, Edward C. Keystone6,7, Diane Tin8, Gilles Boire9 and Vivian P. Bykerk10, 1Medicine, Division of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, 2Medicine, Divsion of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, 3Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada, 4Rheumatology, University of Manitoba, Winnipeg, MB, Canada, 5Southlake Regional Health Centre, Newmarket, ON, Canada, 6Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 7Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, University of Toronto, Toronto, ON, Canada, 8The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, 9Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, 10Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY

    Background/Purpose: Rheumatoid Factor (RF) and anti-Cyclic Citrullinated Peptide (anti-CCP) are believed to be associated with more severe clinical outcomes; however, studies in Early Inflammatory Arthritis…
  • Abstract Number: 808 • 2013 ACR/ARHP Annual Meeting

    A Genome Wide Association Study Of Rheumatoid Arthritis Without Antibodies Against Citrullinated Peptides

    Lara Bossini-Castillo1, Carolien de Kovel2, Henrik Kallberg3, Marieke J.H. Coenen4, Paul P. Tak5, Marcel D. Posthumus6, Cisca Wijmenga7, Thomas W.J. Huizinga8, Annette H.M. van der Helm-van Mil9, Luis Rodriguez-Rodriguez10, Isidoro Gonzalez-Alvaro11, Miguel Angel Gonzalez-Gay12, Irene E. van der Horst-Bruinsma13, B.a.C Dijkmans14, G. J. Wolbink15, Roel A. Ophoff2, Piet L.C.M. van Riel16, Lars Klareskog3, J.B.a. Crusius17, Elisabeth Brouwer18, Javier Martin19, Niek de Vries5, René E.M. Toes9, Leonid Padyukov20 and Bobby P.C. Koeleman21, 1Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain, 2Department of Medical Genetics, UMCU Utrecht, Utrecht, Netherlands, 3Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 4Human Genetics (855), Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 5Division of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, 6Department of Rheumatology, University of Groningen, University Medical Center, Groningen, Netherlands, 7Department of Genetics, University Medical Hospital Groningen, University of Groningen, Groningen, Netherlands, 8Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 9Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 10Hospital Clínico San Carlos, Department of Rheumatology, Madrid, Spain, 11Servicio de Reumatología, Hospital Universitario de La Princesa, Madrid, Spain, 12Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander, Santander, Spain, 13Department of Rheumatology, VU University Medical Center, Amsterdam, Netherlands, 14Rheumatology, VU University Medical Center, Amsterdam, Netherlands, 15Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, 16Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 17Pathology, VU University Medical Center, Amsterdam, Netherlands, 18Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 19Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain, 20Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, 21Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: Rheumatoid arthritis (RA) is a common autoimmune disease that is associated with a progressive loss of the joints induced by a chronic inflammation of…
  • Abstract Number: 410 • 2013 ACR/ARHP Annual Meeting

    Correlation of  Carotid Intima Media Thickness With Interleukin-6, Tumor Necrosis Factor-α and Anti-Cyclic Citrullinated Peptides In Rheumatoid Arthritis

    Lourdes Nuñez Atahualpa1, Mauricio Figuroa Sanchez1, Daniel Alberto Rocha Muñoz2, Raul Vargas Ramirez3, Beatriz Teresita Martin Marquez4, Jorge Ivan Gamez Nava5, Laura González López6, Erika Martínez García3, Esther Sanchez Corona3, Marcelo Petri4, Rosa Navarro Hernandez3, Veronica Gonzalez Diaz7, Jorge Aguilar Arreola8, Ana Guisllaine Bernard Medina9, Alejandra Nuñez Atahualpa10, Javier Andrade Garduño10, Eduardo Gomez Bañuelos3 and Monica Vazquez Del Mercado4,8, 1Radiology, Hospital Civil Fray Antonio Alcalde, Guadalajara, Mexico, 2Unidad de Investigación en Epidemiología Clínica del Hospital de Especialidades Centro Médico Nacional de Occidente, IMSS, Guadalajara, Jalisco, Mexico, 3CUCS, Universidad de Guadalajara, Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético,, Guadalajara, Mexico, 4Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Universidad de Guadalajara, Guadalajara, Mexico, 5Unidad de Investigación en Epidemiología Clínica, Hospital de Especialidades Centro Médico Nacional de Occidente., Guadalajara, Jalisco, Mexico, 6Medicina Interna-Reumatología, Departamento de Medicina Interna-Reumatología, Hospital General Regional 110, Instituto Mexicano del Seguro Social., Guadalajara, Jalisco, Mexico, 7Reumatologia, Antiguo Hospital Civil de Guadalajara - Fray Antonio Alcalde, Guadalajara, Mexico, 8Rheumatology, Hospital Civil Dr Juan I Menchaca, Guadalajara, Mexico, 9Rheumatology, Hospital Civil Fray Antonio Alcalde, Guadalajara, Mexico, 10Universidad Autónoma de Guadalajara, Guadalajara, Mexico

    Background/Purpose: The main cause of death in rheumatoid arthritis patients are cardiovascular events which cannot be entirely explained by traditional risk factors, suggesting, that systemic…
  • Abstract Number: 2114 • 2012 ACR/ARHP Annual Meeting

    Joint Damage Progression in Rheumatoid Arthritis: Role of the HLA-DRB1 Shared Epitope and Anti-CCP

    Jose Felix Restrepo1, Inmaculada del Rincon1, Roy W. Haas2, Daniel F. Battafarano3 and Agustin Escalante2, 1Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX, 2Dept. of Medicine-Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX, 3Medicine / MCHE-MDR, Brooke Army Medical Ctr, San Antonio, TX

    Background/Purpose: The HLA-DRB1 shared epitope (SE) and antibodies to cyclic citrullinated peptides (anti-CCP) are important to the susceptibility to rheumatoid arthritis (RA), and are thought…
  • Abstract Number: 973 • 2012 ACR/ARHP Annual Meeting

    New Genetic Risk Loci for the Radiographic Severity of Rheumatoid Arthritis

    Diederik P.C. de Rooy1, Sacha Zhernakova1, Roula Tsonaka2, Fina Kurreeman3, René E.M. Toes1, Tom W. J. Huizinga4, Jeanine Houwing-Duistermaat5, Peter K. Gregersen6 and Annette H.M. van der Helm-van Mil1, 1Rheumatology, Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Medical Statistics, Leiden University Medical Center, Leiden, Netherlands, 3Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 4Department of Rheumatology, Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 5Statistics, Statistics, Leiden University Medical Center, Leiden, Netherlands, 6Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY

    Background/Purpose: The severity of joint destruction is highly variable between Rheumatoid Arthritis (RA) patients; approximately 54% of this variance is explained by genetic factors. Many…
  • Abstract Number: 2116 • 2012 ACR/ARHP Annual Meeting

    The Associations of HLA-DR Shared Epitope Alleles and Serum Cytokines Among Postmenopausal Women with Rheumatoid Factor and Anti-Citrullinated Protein Antibody-Positive Rheumatoid Arthritis

    Mehret Birru Talabi1, Rachel Mackey2, Larry W. Moreland3, Jan Dorman4, Kevin D. Deane5, Jeremy Sokolove6, V. Michael Holers7, William H. Robinson8, Brian Wallitt9 and Lewis Kuller10, 1Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, 2Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, 3Division of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 4School of Nursing, University of Pittsburgh School of Nursing, Pittsburgh, PA, 5Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 6Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, 7Rheumatology Division, University of Colorado School of Medicine, Aurora, CO, 8Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, 9Washington Hospital Center, Baltimore, MD, 10Epidemiology, University of Pittsburgh, Pittsburgh, PA

    Title: The Associations of HLA-DRβ1 Shared Epitope Alleles and Serum Cytokines Among Postmenopausal Women with Rheumatoid Factor and Anti-Citrullinated Protein Antibody-Positive Rheumatoid ArthritisBackground/Purpose: This study…
  • Abstract Number: 436 • 2012 ACR/ARHP Annual Meeting

    Synthetic Anti-CCP Antibody Aggravated Severity of Animal Arthritis and Captured Citrullinated Antigen in the Serum of Patients with Rheumatoid Arthritis

    Youngkyun Kim1, Su-Jin Moon2, Hyoju Yi2 and Ji Hyeon Ju3, 11Convergent Research Consortium for Immunologic Disease, The Catholic University of Korea, Seoul, South Korea, 2Rheumatology, College of Medicine, The Catholic University of Korea, Seoul, South Korea, 3Rheumatology, College of Medicine, The Catholic University of Korea & Stanford University, Seoul & Palo Alto, CA

    Background/Purpose: Auto-antibodies against citrullinated protein antigens (ACPA) have shown their relevance for the prognosis and diagnosis of rheumatoid arthritis (RA), and have been implicated in…
  • Abstract Number: 2120 • 2012 ACR/ARHP Annual Meeting

    Predictive Value of Anti-CCP Positivity On Disease Course and Response to Therapy in Early Rheumatoid Arthritis. Results From the Swedish EIRA Study

    Saedis Saevarsdottir1, Marie Holmqvist2, Johan Askling3, Lars Alfredsson4 and Lars Klareskog5, 1Rheumatology Unit, Dept. of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, 2Karolinska Institutet, Stockholm, Sweden, 3Department of Medicine, Rheumatology Unit & Clinical Epidemiology Unit, Karolinska Institute, Stockholm, Sweden, 4Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 5Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden

    Background/Purpose: Does anti-CCP-positivity predict disease course and response to therapy in early rheumatoid arthritis (RA)? Methods: We retrieved clinical follow-up data for patients entering the…
  • Abstract Number: 439 • 2012 ACR/ARHP Annual Meeting

    Interaction of Antibodies Against Citrullinated Peptides with HLA Shared Epitope, PTPN22 1858T Variant, and Smoking in Individuals Prior to and After the Development of Rheumatoid Arthritis

    Heidi Kokkonen1, Mikael Brink2, Monika Hansson3, Linda Mathsson4, Ewa Lassen5, Per Johan Jakobsson6, Rikard Holmdahl7, Johan Rönnelid4, Lars Klareskog8 and Solbritt M. Rantapaa-Dahlqvist9, 1Rheumatology, Umeå University, Umea, Sweden, 2Umea University, Umea, Sweden, 3Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 4Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden, 5Transfusional Medicin, Umeå University, Umeå, Sweden, 6Rheumatology unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 7Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden, 8Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden, 9Rheumatology, Institution of Public health and clinical medicine/ Rheumatology, University of Umeå, Umeå, Sweden, Umea, Sweden

    Background/Purpose: The presence of antibodies against cyclic citrullinated peptides (ACPA) has been demonstrated to precede the development of rheumatoid arthritis (RA) by several years. The…
  • Abstract Number: 1769 • 2012 ACR/ARHP Annual Meeting

    Affinity Purification and Characterisation of Anti-CCP Antibodies From Plasma and Synovial Fluids of Patients with Rheumatoid Arthritis

    Elena Ossipova1, Catia Cerqueira2, Evan Reed2, Nastya Kharlamova2, Lena Israelsson2, Rikard Holmdahl3, Anca Catrina2, Vivianne Malmström2, Yngve Sommarin4, Lars Klareskog2, Per Johan Jakobsson2 and Karin Lundberg2, 1Rheumatology unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 2Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 3Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden, 4Euro-Diagnostica AB, Malmö, Sweden

    Background/Purpose: Autoimmunity in rheumatoid arthritis (RA) is characterized by autoantibodies to citrullinated proteins/peptides (ACPA). These antibodies (present in 60-70% of patients) antedate clinical onset and…
  • Abstract Number: 412 • 2012 ACR/ARHP Annual Meeting

    Single Nucleotide Polymorphisms within the HLA-DRB1 Gene in Relation to Antibodies Against Citrullinated Peptides in Individuals Prior to the Development of Rheumatoid Arthritis

    Lisbeth Arlestig1, Mikael Brink2, Monika Hansson3, Per Johan Jakobsson4, Rikard Holmdahl5, Linda Mathsson6, Johan Ronnelid6, Lars Klareskog7 and Solbritt M. Rantapaa-Dahlqvist8, 1Rheumatology, Umeå University, Umea, Sweden, 2Umea University, Umea, Sweden, 3Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 4Rheumatology unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 5Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden, 6Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden, 7Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden, 8Rheumatology, Institution of Public health and clinical medicine/ Rheumatology, University of Umeå, Umeå, Sweden, Umea, Sweden

    Background/Purpose: Multiplex analysis has demonstrated the presence of several antibodies against cyclic citrullinated peptides (ACPA) preceding the development of rheumatoid arthritis (RA) by several years.…
  • Abstract Number: 1770 • 2012 ACR/ARHP Annual Meeting

    Recognition of Citrullinated and Carbamylated Proteins by Human Antibodies: Specificity, Cross-Reactivity and the “AMC-Senshu” Method

    Jing Shi1, George Janssen2, Peter van Veelen2, Janwouter Drijfhout2, Antony Cerami3, Tom Huizinga4, Leendert A. Trouw5 and René E.M. Toes4, 1Rheumatology, LUMC, Leiden, Netherlands, 2Immunohematology and Bloodbank, LUMC, Leiden, Netherlands, 3Nephrology, LUMC, Leiden, Netherlands, 4Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 5Rheumatology, Leiden University Medical Centre, Leiden, Netherlands

    Background/Purpose: Anti-citrullinated protein antibodies (ACPA) play an important role in the diagnosis and prognosis of Rheumatoid Arthritis (RA). The Anti-Modified Citrulline (AMC) (‘Senshu’) method is…
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