ACR Meeting Abstracts

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Abstracts tagged "anti-CCP antibodies"

  • Abstract Number: 2212 • 2015 ACR/ARHP Annual Meeting

    Identification of a Novel Chemokine-Dependent Molecular Mechanism Underlying Rheumatoid Arthritis-Associated Autoantibody-Mediated Bone Destruction

    Akilan Krishnamurthy1, Vijay Joshua2, Aase Haj Hensvold3, Tao Jin4, Meng Sun3, Marianne Engström3, Khaled Amara1, Malin MAgnusson4, Camilla Svensson5, Vivianne Malmström3, L. Klareskog1, Heidi Wähämaa3 and Anca I Catrina3, 1Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 2Unit of Rheumatology, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 3Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, 4Department of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden, Gothenberg, Sweden, 5Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Rheumatoid arthritis (RA)-specific anti-citrullinated protein/peptide antibodies (ACPAs) appear before disease onset and are associated with bone destruction. We aimed to dissect the role of…
  • Abstract Number: 447 • 2015 ACR/ARHP Annual Meeting

    Components of Treatment Delay in Rheumatoid Arthritis Differ According to Autoantibody Status

    Arthur G Pratt1, Ben Hargreaves2, Dennis W Lendrem2, Osman Aslam2 and John D Isaacs2, 1Institute of Cellular Medicine (Musculoskeletal Research Group), National Institute for Health Research Newcastle Biomedical Research Centre based at Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom, 2Institute of Cellular Medicine (Musculoskeletal Research Group), NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom

    Background/Purpose: Despite a proliferation of early arthritis (EA) clinics intended to expedite the diagnosis of rheumatoid arthritis (RA), patients continue to experience substantial and multifactorial…
  • Abstract Number: 2213 • 2015 ACR/ARHP Annual Meeting

    RA-Associated Autoantibodies Promote Synovial Fibroblasts Migration and Adhesion through a Peptidylarginine Deiminases (PAD) Dependent Pathway

    Meng Sun1, Vijay Joshua2, Aase Haj Hensvold1,3, Khaled Amara4, Vivianne Malmström1, Heidi Wähämaa1 and Anca I Catrina1, 1Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, 2Unit of Rheumatology, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 3Rheumatology Unit, Department of Medicine, Solna, Karolinska Institute, Stockholm, Sweden, Stockholm, Sweden, 4Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: The presence of anti-citrullinated proteins antibodies (ACPAs) in RA is associated with a more aggressive disease phenotype and bone destruction. Synovial fibroblasts (SFs) are…
  • Abstract Number: 479 • 2015 ACR/ARHP Annual Meeting

    How to Recruit Anti-CCP Positive Patients from Primary Care

    Jackie L. Nam1, Laura Hunt1, Elizabeth M.A. Hensor1 and Paul Emery1,2, 1NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds Institute of Molecular Medicine and LMBRU, Leeds, United Kingdom

    Background/Purpose: Around 1% of the population test positive for anti-cyclic citrullinated peptide (anti-CCP) antibodies. This biomarker predicts progression to rheumatoid arthritis (RA) but over a…
  • Abstract Number: 2372 • 2015 ACR/ARHP Annual Meeting

    Timing of Onset and Cluster with Other Manifestations Influence the Spectrum of Arthritis in Anti Jo-1 Positive Antisynthetase Syndrome: Results from a Multicenter, International, Retrospective Study

    Alberto Sifuentes Giraldo1, Carlo Alberto Scirè2, Santos Castañeda3, Laura Nuño4, Francisco Javier Lopez Longo5, Julia Martínez-Barrio5, Franco Franceschini6, Ilaria Cavazzana6, Paolo Airò7, Elena Bartoloni Bocci8, Javier Bachiller Corral9, Rossella Neri10, Simone Barsotti11, Roberto Caporali12, Carlomaurizio Montecucco13, Marcello Govoni14, Renato La Corte14, Federica Furini14, Florenzo Iannone15, Margherita Giannini16, Enrico Fusaro17, Simone Parisi18, Giuseppe Paolazzi19, Giovanni Barausse19, Raffaele Pellerito20, Alessandra Russo20, Lesley Ann Saketkoo21, Norberto Ortego-Centeno22, Luca Quartuccio23, Christof Specker24, Andreas Schwarting25, Kostantinos Triantafyllias26, Carlo Selmi27, Fausto Salaffi28, Marco Amedeo Cimmino29, Annamaria Iuliano30, Fabrizio Conti31, Gianluigi Baiocchi32, Elena Bravi33, Veronica Codullo12, Anna Ghirardello34, Trinitario Pina35, Miguel Angel Gonzalez-Gay35, Lorenzo Cavagna13 and AENEAS (American and European NEtwork of Antisynthetase Syndrome) collaborative group, 1Department of Rheumatology, University Hospital Ramón y Cajal, Madrid, Spain, 2Epidemiology Unit – Italian Society for Rheumatology (SIR), Milano, Italy, 3Rheumatology, H.U. La Princesa, Madrid, Spain, 4Servicio de Reumatologia, Hospital Universitario La Paz, Madrid, Spain, 5Servicio de Reumatologia, Hospital General Universitario Gregorio Marañón, Madrid, Spain, 6Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy, 7Rheumatology Unit, Spedali Civili of Brescia, Brescia, Italy, 8Rheumatology Unit, Department of Clinical & Experimental Medicine, University of Perugia, Perugia, Italy, 9Rheumatology, University Hospital Ramón y Cajal, Madrid, Spain, 10Rheumatology Unit, University of Pisa, Italy, Pisa, Italy, 11Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, 12Division of Rheumatology, University of Pavia, IRCCS Foundation Policlinico S. Matteo, Pavia, Italy, 13Division of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy, 14UOC Reumatologia, Azienda Ospedaliera Universitaria S. Anna, Ferrara, Italy, 15Interdisciplinary Department of Medicine (DIM), Rheumatology Unit, University of Bari, Bari, Italy, 16DIM, Rheumatology Unit, Bari, Italy, 17Department of Rheumatology, Città della Salute e della Scienza, Torino, Italy, 18Department of Rheumatology, Città Della Salute e della Scienza, Torino, Italy, 19Rheumatology Unit, Santa Chiara Hospital, Trento, Italy, 20Division of Rheumatology, Mauriziano Hospital, Turin, Italy, 21Tulane University Lung Center, New Orleans Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, LA, 22Systemic Autoimmune Diseases Unit, Hospital Universitario San Cecilio, Granada, Spain, 23Clinic of Rheumatology, Department of Medical and Biological Sciences (DSMB), Santa Maria della Misericordia Hospital, University of Udine, Udine, Italy, 24Department for Rheumatology and Clinical Immunology, St. Josef Krankenhaus, University Clinic, Essen, Germany, 25Department of Internal Medicine, Rheumatology and Clinical Immunology, University Hospital Johannes-Gutenberg, Mainz, Germany, 26ACURA Rheumatology Center, Bad Kreuznach, Germany, 27Internal Medicine- Unit of Rheumatology and Clinical Immunology, Humanitas Clinical and Research Center, Rozzano, Italy, 28Rheumatology Department, Polytechnic University of Marche, C. Urbani Hospital, Jesi,, Ancona, Italy, 29Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Genoa, Italy, 30Osp. San Camillo, Roma, Italy, 31Rheumatology Unit, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy, 32Rheumatology Unit, Department of Internal Medicine, S.Maria Hospital –IRCCS, Reggio Emilia, Italy, 33Internal Medicine, Rheumatology Unit, Ospedale Guglielmo da Saliceto, Piacenza, Italy, 34Department of Medicine-DIMED, University of Padova, Padova, Italy, 35Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain

    Background/Purpose: arthritis, myositis and interstitial lung disease (ILD) are reported in up to 90% of patients affected by antisynthetase syndrome (ASSD) and thus represent the…
  • Abstract Number: 2921 • 2014 ACR/ARHP Annual Meeting

    Contraceptive Factors Are Associated with Serum Antibodies to Citrullinated Protein Antigens in Women at Elevated Risk for Future Rheumatoid Arthritis

    Sonia Khatter1, Mark C. Parish2, Marie L. Feser2, Jason R. Kolfenbach2, Ryan W. Gan3, Michael H. Weisman4, James R. O'Dell5, Ted R. Mikuls6, Richard M. Keating7, Peter K. Gregersen8, Jane H. Buckner9, V. Michael Holers10, Kevin D. Deane2, Jill M. Norris3 and M. Kristen Demoruelle2, 1University of Colorado School of Medicine, Aurora, CO, 2Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 3Epidemiology, Colorado School of Public Health, Aurora, CO, 4Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 5Veteran Affairs Nebraska Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, 6Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 7Division of Rheumatology, Scripps Clinic, La Jolla, CA, 8Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, 9Benaroya Research Institute at Virginia Mason, Seattle, WA, 10Rheumatology Division, University of Colorado School of Medicine, Aurora, CO

    Background/Purpose: The preclinical period of rheumatoid arthritis (RA) development is characterized by elevations of serum RA-related autoantibodies (Abs) including Abs to citrullinated protein antigens (ACPA)…
  • Abstract Number: 1404 • 2014 ACR/ARHP Annual Meeting

    Presence and Significance of Anti-CCP Antibody in Patients with Interstitial Lung Disease with and without Clinically Apparent Rheumatoid Arthritis

    Muhammad Imran1, Shanley O'brien2, Mark Hamblin3 and Mehrdad Maz4, 1Rheumatology, University of Kansas Medical Center, Kansas City, KS, 2Internal Medicine, Kansas University Medical Center, Kansas city, MO, 3Pulmonary and Critical Care Medicine, ILD Clinic, Kansas University Medical Center, Kansas city, MO, 4Division of Rheumatology, University of Kansas Medical Center, Kansas City, KS

    Background/Purpose:   Interstitial lung disease (ILD) can be idiopathic or associated with underlying etiologies including rheumatoid arthritis (RA). The purpose of this study is to determine…
  • Abstract Number: 1377 • 2014 ACR/ARHP Annual Meeting

    Anti-Citrullinated Peptide Antibody Titers and the Prevalence of Interstitial Lung Disease in Patients with and without Rheumatoid Arthritis

    Chase Correia1, Melissa R. Bussey2, Brittany Panico1, Rong Guo3 and Rochella A. Ostrowski4, 1Internal Medicine, Loyola University Medical Center, Chicago, IL, 2Rheumatology, Division of Rheumatology, Loyola University Medical Center, Maywood, IL, 3Loyola University Medical Center, Chicago, IL, 4Rheumatology, Loyola University Medical Center, Maywood, IL

    Background/Purpose:   Rheumatoid arthritis (RA) is a multisystem inflammatory disease characterized by a symmetric, destructive polyarthritis.  Interstitial lung disease (ILD) is an extra-articular manifestation that…
  • Abstract Number: 1039 • 2014 ACR/ARHP Annual Meeting

    Interleukin-20 Is Triggered By TLR Ligands and Associates with Rheumatoid Arthritis Disease Activity

    Ladislav Senolt1, Klara Prajzlerova1, Hana Hulejova2, David Veigl3, Karel Pavelka1 and Jiri Vencovsky1, 1Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, 2Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, 31st Orthopaedic Clinic, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and subsequent joint damage with systemic manifestations. Interleukin-20 (IL-20) has been…
  • Abstract Number: 388 • 2014 ACR/ARHP Annual Meeting

    Soluble TREM-1 Is a Biomarker of Anti-CCP-Positive, DMARD-Naive Early Rheumatoid Arthritis

    Shachaf Ofer-Shiber1, Elisheva Pokroy-Shapira2, Yair Molad3,4, Shirly Oren2, Hagit Shay-Aharoni2 and Ilan Babai5, 1Department of Internal Medicine H, Rabin Medical Center, Beilinson Hospital and Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel, 2Rheumatology Unit, Rabin Medical Center, Beilinson Hospital and Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel, 3Rheumatology Unit, Rabin Medical Center, Beilinson Hospital and Sackler Faculty of Medicine, Tel Aviv University, Petah Teqva, Israel, 4Laboratory of Inflammation Research, Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel, 5Laboratory of Clinical Immunology, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel

    Background/Purpose : Triggering receptor expressed on myeloid cells-1 (TREM-1) is a cell-surface receptor, expressed mainly on monocytes and neutrophils and involved in amplification of the inflammatory…
  • Abstract Number: 380 • 2014 ACR/ARHP Annual Meeting

    In Palindromic Rheumatism, Older Age, Shorter Interval Between Attacks and Positive Anti-CCP Antibodies May Predict Progression to RA

    Masatoshi Hayashi1,2, Jackie L. Nam3, Laura Hunt3, Elizabeth Hensor3, Toshihisa Kanamono4, Toshihisa Kojima5, Naoki Ishiguro5 and Paul Emery6, 1NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds., Leeds, United Kingdom, 25-22-1 Wakasato, Nagano Red Cross Hospital, Nagano, Japan, 3NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 4Departments of Orthopedic surgery and Rheumatology, Nagano Red Cross Hospital, Nagano, Japan, 5Orthopaedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 6NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds., United Kingdom, Leeds, United Kingdom

    Background/Purpose Palindromic rheumatism (PR) is a clinical syndrome characterised by episodes of joint swelling that settle spontaneously.  A proportion of patients with PR progress and…
  • Abstract Number: 371 • 2014 ACR/ARHP Annual Meeting

    The Impact of Missing Anti-Citrullinated Protein Antibody (ACPA) on Outcomes in Early Rheumatoid Arthritis: From the Canadian Early Arthritis Cohort

    Jenny Shu1, Vivian P. Bykerk2, Gilles Boire3, Carol A. Hitchon4, J. Carter Thorne5, Diane Tin6, Edward C. Keystone7, Boulos Haraoui8 and Janet E. Pope9, 1Medicine/Rheumatology, University of Western Ontario, London, ON, Canada, 2Rheumatology, Hospital for Special Surgery, New York, NY, 3Rheumatology Division, CHUS - Sherbrooke University, Sherbrooke, QC, Canada, 4Rheumatology, University of Manitoba, Winnipeg, MB, Canada, 5Southlake Regional Health Centre, Newmarket, ON, Canada, 6The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, 7Medicine, University of Toronto, Toronto, ON, Canada, 8Rheumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada, 9St Joseph Health Care, London, ON, Canada

    Background/Purpose: The impact of missing ACPA in early inflammatory arthritis patients was studied to determine if failure to perform ACPA testing could cause a care…
  • Abstract Number: 124 • 2014 ACR/ARHP Annual Meeting

    Ultrasound Power Doppler Findings in the Wrists and Hands Joints of Anti-CCP Antibody Positive Individuals with Non-Specific Musculoskeletal Symptoms and the Development of Inflammatory Arthritis

    Jackie L. Nam, Laura Hunt, Elizabeth M.A. Hensor, Philip G. Conaghan, Richard J. Wakefield and Paul Emery, NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom

    Background/Purpose The use of musculoskeletal ultrasound is increasing in rheumatology practice. Recently we have shown that use of power Doppler signal (PD) on ultrasound in…
  • Abstract Number: 1309 • 2013 ACR/ARHP Annual Meeting

    Prognosis Of Seronegative Patients In a Large Prospective Cohort Of Patients With Early Inflammatory Arthritis

    Lillian J. Barra1, Janet E. Pope2, Boulos Haraoui3, Carol A. Hitchon4, J. Carter Thorne5, Edward C. Keystone6,7, Diane Tin8, Gilles Boire9 and Vivian P. Bykerk10, 1Medicine, Division of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, 2Medicine, Divsion of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, 3Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada, 4Rheumatology, University of Manitoba, Winnipeg, MB, Canada, 5Southlake Regional Health Centre, Newmarket, ON, Canada, 6Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 7Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, University of Toronto, Toronto, ON, Canada, 8The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, 9Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, 10Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY

    Background/Purpose: Rheumatoid Factor (RF) and anti-Cyclic Citrullinated Peptide (anti-CCP) are believed to be associated with more severe clinical outcomes; however, studies in Early Inflammatory Arthritis…
  • Abstract Number: 808 • 2013 ACR/ARHP Annual Meeting

    A Genome Wide Association Study Of Rheumatoid Arthritis Without Antibodies Against Citrullinated Peptides

    Lara Bossini-Castillo1, Carolien de Kovel2, Henrik Kallberg3, Marieke J.H. Coenen4, Paul P. Tak5, Marcel D. Posthumus6, Cisca Wijmenga7, Thomas W.J. Huizinga8, Annette H.M. van der Helm-van Mil9, Luis Rodriguez-Rodriguez10, Isidoro Gonzalez-Alvaro11, Miguel Angel Gonzalez-Gay12, Irene E. van der Horst-Bruinsma13, B.a.C Dijkmans14, G. J. Wolbink15, Roel A. Ophoff2, Piet L.C.M. van Riel16, Lars Klareskog3, J.B.a. Crusius17, Elisabeth Brouwer18, Javier Martin19, Niek de Vries5, René E.M. Toes9, Leonid Padyukov20 and Bobby P.C. Koeleman21, 1Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain, 2Department of Medical Genetics, UMCU Utrecht, Utrecht, Netherlands, 3Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 4Human Genetics (855), Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 5Division of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, 6Department of Rheumatology, University of Groningen, University Medical Center, Groningen, Netherlands, 7Department of Genetics, University Medical Hospital Groningen, University of Groningen, Groningen, Netherlands, 8Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 9Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 10Hospital Clínico San Carlos, Department of Rheumatology, Madrid, Spain, 11Servicio de Reumatología, Hospital Universitario de La Princesa, Madrid, Spain, 12Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander, Santander, Spain, 13Department of Rheumatology, VU University Medical Center, Amsterdam, Netherlands, 14Rheumatology, VU University Medical Center, Amsterdam, Netherlands, 15Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, 16Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 17Pathology, VU University Medical Center, Amsterdam, Netherlands, 18Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 19Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain, 20Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, 21Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: Rheumatoid arthritis (RA) is a common autoimmune disease that is associated with a progressive loss of the joints induced by a chronic inflammation of…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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