ACR Meeting Abstracts

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Abstracts tagged "anti-CCP antibodies"

  • Abstract Number: 447 • 2015 ACR/ARHP Annual Meeting

    Components of Treatment Delay in Rheumatoid Arthritis Differ According to Autoantibody Status

    Arthur G Pratt1, Ben Hargreaves2, Dennis W Lendrem2, Osman Aslam2 and John D Isaacs2, 1Institute of Cellular Medicine (Musculoskeletal Research Group), National Institute for Health Research Newcastle Biomedical Research Centre based at Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom, 2Institute of Cellular Medicine (Musculoskeletal Research Group), NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom

    Background/Purpose: Despite a proliferation of early arthritis (EA) clinics intended to expedite the diagnosis of rheumatoid arthritis (RA), patients continue to experience substantial and multifactorial…
  • Abstract Number: 2213 • 2015 ACR/ARHP Annual Meeting

    RA-Associated Autoantibodies Promote Synovial Fibroblasts Migration and Adhesion through a Peptidylarginine Deiminases (PAD) Dependent Pathway

    Meng Sun1, Vijay Joshua2, Aase Haj Hensvold1,3, Khaled Amara4, Vivianne Malmström1, Heidi Wähämaa1 and Anca I Catrina1, 1Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, 2Unit of Rheumatology, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 3Rheumatology Unit, Department of Medicine, Solna, Karolinska Institute, Stockholm, Sweden, Stockholm, Sweden, 4Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: The presence of anti-citrullinated proteins antibodies (ACPAs) in RA is associated with a more aggressive disease phenotype and bone destruction. Synovial fibroblasts (SFs) are…
  • Abstract Number: 479 • 2015 ACR/ARHP Annual Meeting

    How to Recruit Anti-CCP Positive Patients from Primary Care

    Jackie L. Nam1, Laura Hunt1, Elizabeth M.A. Hensor1 and Paul Emery1,2, 1NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds Institute of Molecular Medicine and LMBRU, Leeds, United Kingdom

    Background/Purpose: Around 1% of the population test positive for anti-cyclic citrullinated peptide (anti-CCP) antibodies. This biomarker predicts progression to rheumatoid arthritis (RA) but over a…
  • Abstract Number: 2372 • 2015 ACR/ARHP Annual Meeting

    Timing of Onset and Cluster with Other Manifestations Influence the Spectrum of Arthritis in Anti Jo-1 Positive Antisynthetase Syndrome: Results from a Multicenter, International, Retrospective Study

    Alberto Sifuentes Giraldo1, Carlo Alberto Scirè2, Santos Castañeda3, Laura Nuño4, Francisco Javier Lopez Longo5, Julia Martínez-Barrio5, Franco Franceschini6, Ilaria Cavazzana6, Paolo Airò7, Elena Bartoloni Bocci8, Javier Bachiller Corral9, Rossella Neri10, Simone Barsotti11, Roberto Caporali12, Carlomaurizio Montecucco13, Marcello Govoni14, Renato La Corte14, Federica Furini14, Florenzo Iannone15, Margherita Giannini16, Enrico Fusaro17, Simone Parisi18, Giuseppe Paolazzi19, Giovanni Barausse19, Raffaele Pellerito20, Alessandra Russo20, Lesley Ann Saketkoo21, Norberto Ortego-Centeno22, Luca Quartuccio23, Christof Specker24, Andreas Schwarting25, Kostantinos Triantafyllias26, Carlo Selmi27, Fausto Salaffi28, Marco Amedeo Cimmino29, Annamaria Iuliano30, Fabrizio Conti31, Gianluigi Baiocchi32, Elena Bravi33, Veronica Codullo12, Anna Ghirardello34, Trinitario Pina35, Miguel Angel Gonzalez-Gay35, Lorenzo Cavagna13 and AENEAS (American and European NEtwork of Antisynthetase Syndrome) collaborative group, 1Department of Rheumatology, University Hospital Ramón y Cajal, Madrid, Spain, 2Epidemiology Unit – Italian Society for Rheumatology (SIR), Milano, Italy, 3Rheumatology, H.U. La Princesa, Madrid, Spain, 4Servicio de Reumatologia, Hospital Universitario La Paz, Madrid, Spain, 5Servicio de Reumatologia, Hospital General Universitario Gregorio Marañón, Madrid, Spain, 6Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy, 7Rheumatology Unit, Spedali Civili of Brescia, Brescia, Italy, 8Rheumatology Unit, Department of Clinical & Experimental Medicine, University of Perugia, Perugia, Italy, 9Rheumatology, University Hospital Ramón y Cajal, Madrid, Spain, 10Rheumatology Unit, University of Pisa, Italy, Pisa, Italy, 11Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, 12Division of Rheumatology, University of Pavia, IRCCS Foundation Policlinico S. Matteo, Pavia, Italy, 13Division of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy, 14UOC Reumatologia, Azienda Ospedaliera Universitaria S. Anna, Ferrara, Italy, 15Interdisciplinary Department of Medicine (DIM), Rheumatology Unit, University of Bari, Bari, Italy, 16DIM, Rheumatology Unit, Bari, Italy, 17Department of Rheumatology, Città della Salute e della Scienza, Torino, Italy, 18Department of Rheumatology, Città Della Salute e della Scienza, Torino, Italy, 19Rheumatology Unit, Santa Chiara Hospital, Trento, Italy, 20Division of Rheumatology, Mauriziano Hospital, Turin, Italy, 21Tulane University Lung Center, New Orleans Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, LA, 22Systemic Autoimmune Diseases Unit, Hospital Universitario San Cecilio, Granada, Spain, 23Clinic of Rheumatology, Department of Medical and Biological Sciences (DSMB), Santa Maria della Misericordia Hospital, University of Udine, Udine, Italy, 24Department for Rheumatology and Clinical Immunology, St. Josef Krankenhaus, University Clinic, Essen, Germany, 25Department of Internal Medicine, Rheumatology and Clinical Immunology, University Hospital Johannes-Gutenberg, Mainz, Germany, 26ACURA Rheumatology Center, Bad Kreuznach, Germany, 27Internal Medicine- Unit of Rheumatology and Clinical Immunology, Humanitas Clinical and Research Center, Rozzano, Italy, 28Rheumatology Department, Polytechnic University of Marche, C. Urbani Hospital, Jesi,, Ancona, Italy, 29Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Genoa, Italy, 30Osp. San Camillo, Roma, Italy, 31Rheumatology Unit, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy, 32Rheumatology Unit, Department of Internal Medicine, S.Maria Hospital –IRCCS, Reggio Emilia, Italy, 33Internal Medicine, Rheumatology Unit, Ospedale Guglielmo da Saliceto, Piacenza, Italy, 34Department of Medicine-DIMED, University of Padova, Padova, Italy, 35Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain

    Background/Purpose: arthritis, myositis and interstitial lung disease (ILD) are reported in up to 90% of patients affected by antisynthetase syndrome (ASSD) and thus represent the…
  • Abstract Number: 518 • 2015 ACR/ARHP Annual Meeting

    Antibody Responses to Citrullinated Porphyromonas Gingivalis Peptidylarginine Deiminase: Associations with Disease Risk Factors and Severity in Rheumatoid Arthritis

    Priyanka Vashisht1, Jeffrey Payne2, Geoffrey M. Thiele3, Harlan Sayles4, Fang Yu5, Michael J. Duryee6, Carlos D. Hunter6, Benjamin Wiese1, Anne-Marie Quirke7, Patrick Venables7 and Ted R. Mikuls8, 1Internal Medicine - Rheumatology, University of Nebraska Medical Center, Omaha, NE, 2College of Dentistry, University of Nebraska Medical Center, Lincoln, NE, 3Research Services 151, Omaha VA Medical Center, Omaha, NE, 4University of Nebraska Medical Center, Omaha, NE, 5Public Health, University of Nebraska Medical Center, Omaha, NE, 6Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 7Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, 8Medicine, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by autoimmunity to citrullinated proteins. Porphyromonas gingivalis (Pg) has been proposed as an epidemiologic link between RA and periodontitis…
  • Abstract Number: 2464 • 2015 ACR/ARHP Annual Meeting

    Characterization of the Serum Anti-Citrullinated Protein Antibody Profile in Juvenile Idiopathic Arthritis: Association with Oral Health

    Sampath Prahalad1, Lauren J. Lahey2, Geoffrey M. Thiele3, Lori Ponder1, Sheila T. Angeles-Han1, Lauren Lange4, Aimee O. Hersh5, Mina Rohani-Pichavant1, Se Ryeong Jang1, Larry B. Vogler1, Patricia Vega-Fernandez1, Kelly A. Rouster-Stevens1, John F. Bohnsack6, Ted R. Mikuls7 and Jeremy Sokolove8, 1Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, 2Medicine, VA Palo Alto HealthCare System and Stanford University, Palo Alto, CA, 3Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 4Pediatrics, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 5Pediatrics/Rheumatology, University of Utah, Salt Lake City, UT, 6Pediatrics, University of Utah Health Sciences Center, Salt Lake City, UT, 7Veteran Affairs Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, 8Stanford University, Palo Alto, CA

    Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common chronic childhood arthropathy. Most children with JIA phenotypically differ from adults with rheumatoid arthritis (RA) although…
  • Abstract Number: 529 • 2015 ACR/ARHP Annual Meeting

    Immunoglobulin-a and Immunoglobulin-G Isotypes of Anti-CCP Antibodies Are Present in the Sputum of Subjects at Risk for Future Development of RA

    Kristen Demoruelle1, Linh Ho2, Michael H. Weisman3, Ryan W. Gan4, Mark C. Parish1, Marie L. Feser1, Chelsie Fleischer1, Michael Mahler5, Andrea Seaman5, Jill M. Norris4, V. Michael Holers1 and Kevin D. Deane1, 1Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 2University of Colorado School of Medicine, Aurora, CO, 3Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 4Epidemiology, Colorado School of Public Health, Aurora, CO, 5Inova Diagnostics, San Diego, CA

    Background/Purpose: Serum elevations of anti-CCP prior to inflammatory arthritis (IA) in RA suggest that anti-CCP is generated at a site outside of the joints. Data…
  • Abstract Number: 2616 • 2015 ACR/ARHP Annual Meeting

    Study of Anti-Carbamylated Protein Antibody in the Rheumatoid Patients Who Were Clinically Active and Under Treatment with Biological Dmards

    Kazuko Shiozawa1 and Shunichi Shiozawa2, 1Rheumatic Diseases Center, Konan Kakogawa Hospital, Kakogawa, Japan, 2Department of Medicine, Rheumatic Diseases Unit, Kyushu University Beppu Hospital, Beppu, Japan

    Background/Purpose: A newly discovered anti-carbamylated protein antibody (anti-CarP) is found prior to disease-onset, associates with the conversion towards arthralgia and with a more severe disease…
  • Abstract Number: 530 • 2015 ACR/ARHP Annual Meeting

    Immunomodulation of Naïve RA Patients PBMCs with a Multi-Epitope Peptide Derived from Citrullinated Autoantigens

    Smadar Gertel1, Yehuda Shoenfeld2 and Howard Amital3, 1Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel, 2Head Dept of Medicine B, Sheba Medical Center, Ramat-Gan, Israel, 3Sheba Medical Center, Tel-Hashomer, Israel

    Background/Purpose: Citrullinated peptides are major targets of disease-specific autoantibodies in rheumatoid arthritis (RA). We generated a multi-epitope citrullinated peptide (Cit-ME), derived from major prevalent citrullinated…
  • Abstract Number: 2660 • 2015 ACR/ARHP Annual Meeting

    Elevated 14-3-3η Serum Protein Levels Increase RA Confirmation Rates in Recent-Onset Polyarthritis Patients

    Nathalie Carrier1, Anthony Marotta2, Artur de Brum-Fernandes3,4, Patrick Liang3,4, Ariel Masetto5,6, Yuan Gui2, Jane Savill2, Sara Michienzi2, Henri Ménard7, Walter Maksymowych8 and Gilles Boire4, 1Division of Rheumatology, Université de Sherbrooke, Sherbrooke, QC, Canada, 2Augurex Life Sciences Corp., Vancouver, BC, Canada, 3Department of Medicine/Division of Rheumatology, Université de Sherbrooke, Sherbrooke, QC, Canada, 4Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada, 5Department of Medicine/Division of Rheumatology, Université de Sherbrooke, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada, 6Department of Medicine/Division of Rheumatology, University of Sherbrooke, Sherbrooke, QC, Canada, 7MSK Research Axis, McGill University Health Center Research Institute, Montreal, QC, Canada, 8Department of Medicine, University of Alberta, Edmonton, AB, Canada

    Background/Purpose: The 14-3-3 family of conserved regulatory proteins consists of seven isoforms: α/β, γ, δ/ζ, ε, η, θ/τ and σ. These proteins exist as intracellular…
  • Abstract Number: 1100 • 2015 ACR/ARHP Annual Meeting

    Citrullinated Antigen-Specific B Cells in Peripheral Blood and Synovial Fluid of Patients with Rheumatoid Arthritis: Identification and Phenotypic Characterization

    Priscilla Kerkman1, Ellen I.H. van der Voort1, Arnaud Zaldumbide2, Emeline Fabre1, Yoann Rombouts1, Theo Rispens3, Gertjan Wolbink4, Rob Hoeben2, Hergen Spits5, Dominique Baeten6, T. W. J. Huizinga1, René E. M. Toes1 and Hans Ulrich Scherer1, 1Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, Netherlands, 3Sanquin Research, Amsterdam, Netherlands, 4Immunopathology, Sanquin Research, Amsterdam, Netherlands, 5Department of Cell Biology and Histology, Amsterdam Rheumatology and Immunology Center, Amsterdam, Netherlands, 6Amsterdam Rheumatology and Immunology Center, Amsterdam, Netherlands

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by the presence of anti-citrullinated protein antibodies (ACPA) in the majority of patients. ACPA represent highly disease-specific biomarkers that…
  • Abstract Number: 1208 • 2015 ACR/ARHP Annual Meeting

    How Well Do Acpas Discriminate and Predict RA in the General Population – a Study Based on 12,590 Population-Representative Swedish Twins

    Aase Haj Hensvold1, Thomas Frisell2, Johan Askling2 and Anca I Catrina1, 1Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, 2Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Anti citrullinated protein antibodies (ACPA) are highly specific for rheumatoid arthritis (RA), but the distribution and diagnostic accuracy of ACPA in general population has…
  • Abstract Number: 1250 • 2015 ACR/ARHP Annual Meeting

    DNA Methylation and Its Relation to Immunological Phenotypes in Peripheral Blood: A Study of Anti-CCP Antibody Positivity from a Population-Based Pool

    Sasha Bernatsky1, Xiaojian Shao2, Marie-Michelle Simon2, Marvin J. Fritzler3, Philip Awadalla4,5, Marie Hudson6, Ines Colmegna7, Tony Kwan2 and Tomi Pastinen2, 1Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, 2Department of Human Genetics, McGill University and Génome Québec Innovation Centre, Montreal, QC, Canada, 3Medicine, University of Calgary, Calgary, AB, Canada, 4Medicine, Université de Montreal, Montreal, QC, Canada, 5Ontario Institute for Cancer Research, Toronto, ON, Canada, 6McGill University, Jewish General Hospital, Montreal, QC, Canada, 7Rheumatology, McGill University Health Centre, Montreal, QC, Canada

    Background/Purpose: DNA methylation represents an important potential mediator of environmental influences on autoimmunity, including rheumatoid arthritis (RA).  Genome-wide methylation in the context of clinical phenotypes…
  • Abstract Number: 1559 • 2015 ACR/ARHP Annual Meeting

    Clinical Characteristics and Medication Use Among Arab Patients with Rheumatoid Arthritis in Some Arab States

    Karim Bayoumy1, Soha Roger Dargham1, Wessam Elhaq1, Samar Al Emadi2, Mohammed Hammoudeh2, Basel Masri3, Hussein Halabi4, Humeira Badsha5, Imad Uthman6, Salah Mahdy2, Robert Plenge7, Richa Saxena7, Marianthi Kapiri1 and Thurayya Arayssi8, 1Weill Cornell Medical College in Qatar, Doha, Qatar, 2Medicine, Hamad Medical Corporation, Doha, Qatar, 3Jordan Hospital, Amman, Jordan, 4Medicine, King Faisal Specialist Hospital and research center, Jeddah, Saudi Arabia, 5Al Biraa Arthritis and Bone Clinic, Dubai, United Arab Emirates, 6Internal Medicine, American University of Beirut, Beirut, Lebanon, 7The Broad Institute of MIT and Harvard, Program of Medical and Population Genetics, Cambridge, MA, 8Internal Medicine, Weill Cornell Medical College in Qatar, Doha, Qatar

    Background/Purpose: Data on the clinical and genetic characteristics of Arab patients with Rheumatoid Arthritis (RA) is limited. Our aim is to report on the clinical…
  • Abstract Number: 1578 • 2015 ACR/ARHP Annual Meeting

    Serum Rheumatoid Factor and Anti-Cyclic Citrullinated Peptide Antibody Are Associated with Subclinical Interstitial Lung Disease in the Multi-Ethnic Study of Atherosclerosis: A Population-Based Study

    Elana J. Bernstein1, R. Graham Barr2, John H.M. Austin3, Steven M. Kawut4, Ganesh Raghu5, Jessica L. Sell6, Eric A. Hoffman7, John D. Newell Jr.8, Jubal R. Watts Jr.9, P. Hrudaya Nath10, Sushil K. Sonavane9, Joan M. Bathon1, Darcy S. Majka11 and David J. Lederer2, 1Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, 2Medicine, Columbia University College of Physicians & Surgeons, New York, NY, 3Radiology, Columbia University College of Physicians & Surgeons, New York, NY, 4Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, PA, 5University of Washington, Seattle, WA, 6Columbia University College of Physicians & Surgeons, New York, NY, 7University of Iowa, Iowa City, IA, 8Radiology, University of Iowa, Iowa City, IA, 9Radiology, University of Alabama at Birmingham, Birmingham, AL, 10University of Alabama at Birmingham, Birmingham, AL, 11Division of Rheumatology, Northwestern University, Chicago, IL

    Background/Purpose: Approximately 30% of adults diagnosed with interstitial lung disease (ILD) have an underlying established autoimmune disease. Based on the strong links between autoimmunity and…
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