Abstracts tagged "anti-CCP antibodies"

Abstract Number: 2278 • 2013 ACR/ARHP Annual Meeting
Ordering Of Serologic Markers Of Rheumatoid Arthritis Among Primary Care and Subspecialty Providers: Under-Utilization Of Anti-Citrullinated Peptide Antibody Tests By Non-Rheumatologists
Emily H. Glynn¹, Mark H. Wener² and Michael Astion³, ¹Laboratory Medicine, University of Washington, Seattle, WA, ²Rheumatology & Lab Med, University of Washington, Seattle, WA, ³Department of Laboratories, Seattle Children's Hospital, Seattle, WA
Background/Purpose: Anti-citrullinated peptide antibodies (ACPA) are more specific and have a superior positive predictive value for diagnosis of rheumatoid arthritis (RA) compared to RF. The…
Abstract Number: 2197 • 2013 ACR/ARHP Annual Meeting
High Titer IgG Anti-Cyclic Citrullinated Peptide Antibodies Are Associated With Joint Destruction In Juvenile Idiopathic Arthritis Patients
Brooke Gilliam, Lance Feller and Terry L. Moore, Internal Medicine/Rheumatology, Saint Louis University, Saint Louis, MO
Background/Purpose: IgG anti-cyclic citrullinated peptide (anti-CCP) antibodies have been identified as an important indicator of destructive disease in juvenile idiopathic arthritis (JIA), as is the…
Abstract Number: 1586 • 2013 ACR/ARHP Annual Meeting
Defining Hand Arthritis In Systemic Lupus Erythematosus, From An Ultrasound, Magnetic Resonance Imaging and Antibody Status Perspective
Elisabeth M.A Ball¹, Arthur Grey², Ai Lyn Tan³, Eiji Fukuba⁴, Gunter Steiner⁵, Dennis McGonagle⁶, Aubrey Bell⁷ and Madeleine Rooney⁸, ¹Rheumatology, Queens' University/Musgrave Park Hospital, Belfast, United Kingdom, ²Rheumatology, Musgrave Park Hospital, Belfast, United Kingdom, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁴Department of Radiology, Shimane University, Izuma, Japan, ⁵Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁶NIHR Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom, ⁷Rheumatology Unit, Musgrave Park Hospital, Belfast, United Kingdom, ⁸Medicine, Queens University Belfast, Belfast, United Kingdom
Background/Purpose: Musculoskeletal involvement in systemic lupus erythematosus (SLE) is common but poorly characterised with only a few Magnetic Resonance Imaging (MRI) or ultrasound (US) studies…
Abstract Number: 1309 • 2013 ACR/ARHP Annual Meeting
Prognosis Of Seronegative Patients In a Large Prospective Cohort Of Patients With Early Inflammatory Arthritis
Lillian J. Barra¹, Janet E. Pope², Boulos Haraoui³, Carol A. Hitchon⁴, J. Carter Thorne⁵, Edward C. Keystone^6,7, Diane Tin⁸, Gilles Boire⁹ and Vivian P. Bykerk¹⁰, ¹Medicine, Division of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ²Medicine, Divsion of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ³Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada, ⁴Rheumatology, University of Manitoba, Winnipeg, MB, Canada, ⁵Southlake Regional Health Centre, Newmarket, ON, Canada, ⁶Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁷Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, University of Toronto, Toronto, ON, Canada, ⁸The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, ⁹Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ¹⁰Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY
Background/Purpose: Rheumatoid Factor (RF) and anti-Cyclic Citrullinated Peptide (anti-CCP) are believed to be associated with more severe clinical outcomes; however, studies in Early Inflammatory Arthritis…
Abstract Number: 808 • 2013 ACR/ARHP Annual Meeting
A Genome Wide Association Study Of Rheumatoid Arthritis Without Antibodies Against Citrullinated Peptides
Lara Bossini-Castillo¹, Carolien de Kovel², Henrik Kallberg³, Marieke J.H. Coenen⁴, Paul P. Tak⁵, Marcel D. Posthumus⁶, Cisca Wijmenga⁷, Thomas W.J. Huizinga⁸, Annette H.M. van der Helm-van Mil⁹, Luis Rodriguez-Rodriguez¹⁰, Isidoro Gonzalez-Alvaro¹¹, Miguel Angel Gonzalez-Gay¹², Irene E. van der Horst-Bruinsma¹³, B.a.C Dijkmans¹⁴, G. J. Wolbink¹⁵, Roel A. Ophoff², Piet L.C.M. van Riel¹⁶, Lars Klareskog³, J.B.a. Crusius¹⁷, Elisabeth Brouwer¹⁸, Javier Martin¹⁹, Niek de Vries⁵, René E.M. Toes⁹, Leonid Padyukov²⁰ and Bobby P.C. Koeleman²¹, ¹Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain, ²Department of Medical Genetics, UMCU Utrecht, Utrecht, Netherlands, ³Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁴Human Genetics (855), Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁵Division of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ⁶Department of Rheumatology, University of Groningen, University Medical Center, Groningen, Netherlands, ⁷Department of Genetics, University Medical Hospital Groningen, University of Groningen, Groningen, Netherlands, ⁸Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ¹⁰Hospital Clínico San Carlos, Department of Rheumatology, Madrid, Spain, ¹¹Servicio de Reumatología, Hospital Universitario de La Princesa, Madrid, Spain, ¹²Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander, Santander, Spain, ¹³Department of Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ¹⁴Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ¹⁵Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ¹⁶Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ¹⁷Pathology, VU University Medical Center, Amsterdam, Netherlands, ¹⁸Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ¹⁹Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain, ²⁰Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ²¹Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is a common autoimmune disease that is associated with a progressive loss of the joints induced by a chronic inflammation of…
Abstract Number: 410 • 2013 ACR/ARHP Annual Meeting
Correlation of Carotid Intima Media Thickness With Interleukin-6, Tumor Necrosis Factor-α and Anti-Cyclic Citrullinated Peptides In Rheumatoid Arthritis
Lourdes Nuñez Atahualpa¹, Mauricio Figuroa Sanchez¹, Daniel Alberto Rocha Muñoz², Raul Vargas Ramirez³, Beatriz Teresita Martin Marquez⁴, Jorge Ivan Gamez Nava⁵, Laura González López⁶, Erika Martínez García³, Esther Sanchez Corona³, Marcelo Petri⁴, Rosa Navarro Hernandez³, Veronica Gonzalez Diaz⁷, Jorge Aguilar Arreola⁸, Ana Guisllaine Bernard Medina⁹, Alejandra Nuñez Atahualpa¹⁰, Javier Andrade Garduño¹⁰, Eduardo Gomez Bañuelos³ and Monica Vazquez Del Mercado^4,8, ¹Radiology, Hospital Civil Fray Antonio Alcalde, Guadalajara, Mexico, ²Unidad de Investigación en Epidemiología Clínica del Hospital de Especialidades Centro Médico Nacional de Occidente, IMSS, Guadalajara, Jalisco, Mexico, ³CUCS, Universidad de Guadalajara, Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético,, Guadalajara, Mexico, ⁴Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Universidad de Guadalajara, Guadalajara, Mexico, ⁵Unidad de Investigación en Epidemiología Clínica, Hospital de Especialidades Centro Médico Nacional de Occidente., Guadalajara, Jalisco, Mexico, ⁶Medicina Interna-Reumatología, Departamento de Medicina Interna-Reumatología, Hospital General Regional 110, Instituto Mexicano del Seguro Social., Guadalajara, Jalisco, Mexico, ⁷Reumatologia, Antiguo Hospital Civil de Guadalajara - Fray Antonio Alcalde, Guadalajara, Mexico, ⁸Rheumatology, Hospital Civil Dr Juan I Menchaca, Guadalajara, Mexico, ⁹Rheumatology, Hospital Civil Fray Antonio Alcalde, Guadalajara, Mexico, ¹⁰Universidad Autónoma de Guadalajara, Guadalajara, Mexico
Background/Purpose: The main cause of death in rheumatoid arthritis patients are cardiovascular events which cannot be entirely explained by traditional risk factors, suggesting, that systemic…
Abstract Number: 1770 • 2012 ACR/ARHP Annual Meeting
Recognition of Citrullinated and Carbamylated Proteins by Human Antibodies: Specificity, Cross-Reactivity and the “AMC-Senshu” Method
Jing Shi¹, George Janssen², Peter van Veelen², Janwouter Drijfhout², Antony Cerami³, Tom Huizinga⁴, Leendert A. Trouw⁵ and René E.M. Toes⁴, ¹Rheumatology, LUMC, Leiden, Netherlands, ²Immunohematology and Bloodbank, LUMC, Leiden, Netherlands, ³Nephrology, LUMC, Leiden, Netherlands, ⁴Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Rheumatology, Leiden University Medical Centre, Leiden, Netherlands
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) play an important role in the diagnosis and prognosis of Rheumatoid Arthritis (RA). The Anti-Modified Citrulline (AMC) (‘Senshu’) method is…
Abstract Number: 394 • 2012 ACR/ARHP Annual Meeting
Remission After One Year in ACPA Positive and ACPA Negative Patients with Early Arthritis
K.V.C. Wevers-de Boer¹, L. Heimans¹, K. Visser¹, A.A. Schouffoer², T.H.E. Molenaar³, J.B. Harbers⁴, C. Bijkerk⁵, I. Speyer⁶, M. de Buck⁷, P.B. de Sonnaville⁸, B.A. Grillet⁹, Tom Huizinga¹ and C.F. Allaart¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Haga Hospital, The Hague, Netherlands, ³Dept of Rheumatology, Groene Hart Hospital, Gouda, Netherlands, ⁴Franciscus Hospital, Roosendaal, ⁵Rheumatology, Reinier de Graaf Gasthuis, Delft, Netherlands, ⁶Rheumatology, Bronovo Hospital, Den Haag, Netherlands, ⁷MCH, The Hague, ⁸Department of Rheumatology, Admiraal de Ruyter hospital, Goes, Netherlands, ⁹Department of Rheumatology, Zorgsaam Hospital, Terneuzen, Netherlands
Background/Purpose: To evaluate possible differences in clinical response after one year of remission steered treatment in Anti Citrullinated Protein Antibody (ACPA) positive and negative RA…
Abstract Number: 1771 • 2012 ACR/ARHP Annual Meeting
Anti Carbamylated Protein Antibodies (Anti-CarP) Are Present in Arthralgia Patients and Predict the Development of Rheumatoid Arthritis
Jing Shi¹, Lotte van de Stadt², Nivine Levarht³, T.W.J. Huizinga⁴, R. E. M. Toes⁴, Leendert A. Trouw⁵ and Dirkjan van Schaardenburg², ¹Rheumatology, LUMC, Leiden, Netherlands, ²Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ³Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Rheumatology, Leiden University Medical Centre, Leiden, Netherlands
Background/Purpose: Recently, we discovered a new autoantibody system in rheumatoid arthritis (RA): anti carbamylated protein antibodies (anti-CarP). These antibodies have additional prognostic value in predicting…
Abstract Number: 177 • 2012 ACR/ARHP Annual Meeting
Antibodies to Citrullinated Peptides in Tuberculosis
Isabella Lima¹, Rodrigo Oliveira², Ajax Atta², Samyra Marchi³, Lúcio Barbosa³, Eliana Reis³, Mitermayer G. Reis³ and Mittermayer Santiago⁴, ¹Escola Bahiana de Medicina e Saúde Pública, Salvador, Brazil, ²Universidade Federal da Bahia, Salvador, Brazil, ³Fundação Oswaldo Cruz, Salvador, Brazil, ⁴Brazilian Registry of Spondyloarthritis, São Paulo, Brazil
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterized by symmetric polyarthritis, rheumatoid factor positivity (RF) in the majority of patients, and bone erosions shown…
Abstract Number: 1691 • 2012 ACR/ARHP Annual Meeting
Early Signs of Subclinical Inflammation and Local Antibody Production in Early Rheumatoid Lungs
Gudrun Reynisdottir¹, Reza Karimi², Jimmy Ytterberg³, Vijay Joshua¹, Helga Olsen², Aase Haj Hensvold¹, Anders Harju⁴, Johan Grunewald², Sven Nyren⁵, Anders Eklund², Lars Klareskog⁶, Roman Zubarev⁷, Magnus Skold² and Anca Catrina¹, ¹Department of Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ²Department of Medicine, Division of Respiratory Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ³Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁴Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ⁵Radiology, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, Stockholm, Sweden, ⁶Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden, ⁷Karolinska Institutet, Stockholm, Sweden
Background/Purpose: The aims of the current study was to investigate if inflammatory lung changes are present in RA patients early in the disease process and…
Abstract Number: 31 • 2012 ACR/ARHP Annual Meeting
Anti Citrullinated Protein Antibodies From Synovial Fluid of Rheumatoid Arthritis Patients Enhance Osteoclastogenesis
Akilan Krishnamurthy¹, Nancy Vivar Pomiano², Catia Cerqueira³, Elena Ossipova³, Karin Lundberg⁴, Ulrike Harre⁵, Vivianne Malmström⁶, Per Johan Jakobsson⁷, Lars Klareskog⁸, Georg Schett⁹ and Anca Catrina³, ¹Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ³Department of Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ⁴Rheumatology unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁵Institute for Clinical Immunology, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁶Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ⁷Rheumatology unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁸Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden, ⁹Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Presence of anti CCP2 antibodies identifies a subgroup of RA patients that are more prone to develop bone erosions. We hypothesized that anti CCP2…
Abstract Number: 1615 • 2012 ACR/ARHP Annual Meeting
Evidence for Distinct Roles of Environmental and Genetic Factors in the Emergence of Anti Citrullinated-Protein Antibodies Positive Rheumatoid Arthritis-an Epidemiological Investigation in Twins
Aase Haj Hensvold¹, Patrik KE Magnusson², Monika Hansson³, Lena Israelsson⁴, Cecilia Carlens¹, Johan Askling⁵, Vivianne Malmström⁶, Lars Klareskog⁷ and Anca Catrina¹, ¹Department of Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ²Medical Epidemiology and Biostatistics, Swedish Twin Registry Karolinska Institutet, Stockholm, Sweden, ³Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁴Department of Medicine, Karolinska Institute, Stockholm, Sweden, ⁵Rheumatology Unit, Karolinska University Hospital, Stockholm, Sweden, ⁶Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ⁷Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden
Background/Purpose: The aim of the current study was to investigate the influence of genetic and environmental factors in developing anti citrullianted-proteins antibodies (ACPA) and ACPA…
Abstract Number: 1336 • 2012 ACR/ARHP Annual Meeting
Changes in the Levels of Anti-Cyclic Citrullinated Protein Antibody and Immunoglobulins in Rheumatoid Arthritis Patients After Administration of Tocilizumab
Masao Sato¹, Masao Takemura², Ryuki Shinohe³, Tsuneo Watanabe² and Katsuji Shimizu³, ¹Rheumatology, Matsunami General Hospital, Gifu, Japan, ²Informative Clinical Medicine, Gifu University, Gifu, Japan, ³Orthopaedic Surgery, Gifu University, Gifu, Japan
Background/Purpose: The recently established scoring system of American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) early arthritis diagnosis criteria have assigned scores of 0, 1,…
Abstract Number: 1254 • 2012 ACR/ARHP Annual Meeting
In Treatment-Naive Early RA the Left Ventricular Function Is Correlated to CRP, Doctors Global and Anti-CCP Status
BB Løgstrup¹, LD Kristensen¹, A. Hedemann-Andersen² and Torkell Ellingsen³, ¹Department of Internal Medicine, Diagnostic Centre Region Hospital Silkeborg Denmark, Silkeborg, Denmark, ²Department of Radiology, Diagnostic Centre Region Hospital Silkeborg Denmark, Silkeborg, Denmark, ³Department of Internal Medicine, Diagnostic Centre Regional Hospital Silkeborg, 8600 Silkeborg, Denmark
Background/Purpose: The role of inflammation and anti-CCP status in the pathogenesis of cardiovascular disease in RA remains unclear. Previous studies have suggested that both disease…

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