ACR Meeting Abstracts

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Abstracts tagged "anti-CCP antibodies"

  • Abstract Number: 2197 • 2013 ACR/ARHP Annual Meeting

    High Titer IgG Anti-Cyclic Citrullinated Peptide Antibodies Are Associated With Joint Destruction In Juvenile Idiopathic Arthritis Patients

    Brooke Gilliam, Lance Feller and Terry L. Moore, Internal Medicine/Rheumatology, Saint Louis University, Saint Louis, MO

    Background/Purpose: IgG anti-cyclic citrullinated peptide (anti-CCP) antibodies have been identified as an important indicator of destructive disease in juvenile idiopathic arthritis (JIA), as is the…
  • Abstract Number: 1586 • 2013 ACR/ARHP Annual Meeting

    Defining Hand Arthritis In Systemic Lupus Erythematosus, From An Ultrasound, Magnetic Resonance Imaging and Antibody Status Perspective

    Elisabeth M.A Ball1, Arthur Grey2, Ai Lyn Tan3, Eiji Fukuba4, Gunter Steiner5, Dennis McGonagle6, Aubrey Bell7 and Madeleine Rooney8, 1Rheumatology, Queens' University/Musgrave Park Hospital, Belfast, United Kingdom, 2Rheumatology, Musgrave Park Hospital, Belfast, United Kingdom, 3Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 4Department of Radiology, Shimane University, Izuma, Japan, 5Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 6NIHR Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom, 7Rheumatology Unit, Musgrave Park Hospital, Belfast, United Kingdom, 8Medicine, Queens University Belfast, Belfast, United Kingdom

    Background/Purpose: Musculoskeletal involvement in systemic lupus erythematosus (SLE) is common but poorly characterised with only a few Magnetic Resonance Imaging (MRI) or ultrasound (US) studies…
  • Abstract Number: 1309 • 2013 ACR/ARHP Annual Meeting

    Prognosis Of Seronegative Patients In a Large Prospective Cohort Of Patients With Early Inflammatory Arthritis

    Lillian J. Barra1, Janet E. Pope2, Boulos Haraoui3, Carol A. Hitchon4, J. Carter Thorne5, Edward C. Keystone6,7, Diane Tin8, Gilles Boire9 and Vivian P. Bykerk10, 1Medicine, Division of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, 2Medicine, Divsion of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, 3Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada, 4Rheumatology, University of Manitoba, Winnipeg, MB, Canada, 5Southlake Regional Health Centre, Newmarket, ON, Canada, 6Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 7Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, University of Toronto, Toronto, ON, Canada, 8The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, 9Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, 10Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY

    Background/Purpose: Rheumatoid Factor (RF) and anti-Cyclic Citrullinated Peptide (anti-CCP) are believed to be associated with more severe clinical outcomes; however, studies in Early Inflammatory Arthritis…
  • Abstract Number: 808 • 2013 ACR/ARHP Annual Meeting

    A Genome Wide Association Study Of Rheumatoid Arthritis Without Antibodies Against Citrullinated Peptides

    Lara Bossini-Castillo1, Carolien de Kovel2, Henrik Kallberg3, Marieke J.H. Coenen4, Paul P. Tak5, Marcel D. Posthumus6, Cisca Wijmenga7, Thomas W.J. Huizinga8, Annette H.M. van der Helm-van Mil9, Luis Rodriguez-Rodriguez10, Isidoro Gonzalez-Alvaro11, Miguel Angel Gonzalez-Gay12, Irene E. van der Horst-Bruinsma13, B.a.C Dijkmans14, G. J. Wolbink15, Roel A. Ophoff2, Piet L.C.M. van Riel16, Lars Klareskog3, J.B.a. Crusius17, Elisabeth Brouwer18, Javier Martin19, Niek de Vries5, René E.M. Toes9, Leonid Padyukov20 and Bobby P.C. Koeleman21, 1Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain, 2Department of Medical Genetics, UMCU Utrecht, Utrecht, Netherlands, 3Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 4Human Genetics (855), Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 5Division of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, 6Department of Rheumatology, University of Groningen, University Medical Center, Groningen, Netherlands, 7Department of Genetics, University Medical Hospital Groningen, University of Groningen, Groningen, Netherlands, 8Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 9Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 10Hospital Clínico San Carlos, Department of Rheumatology, Madrid, Spain, 11Servicio de Reumatología, Hospital Universitario de La Princesa, Madrid, Spain, 12Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander, Santander, Spain, 13Department of Rheumatology, VU University Medical Center, Amsterdam, Netherlands, 14Rheumatology, VU University Medical Center, Amsterdam, Netherlands, 15Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, 16Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 17Pathology, VU University Medical Center, Amsterdam, Netherlands, 18Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 19Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain, 20Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, 21Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: Rheumatoid arthritis (RA) is a common autoimmune disease that is associated with a progressive loss of the joints induced by a chronic inflammation of…
  • Abstract Number: 410 • 2013 ACR/ARHP Annual Meeting

    Correlation of  Carotid Intima Media Thickness With Interleukin-6, Tumor Necrosis Factor-α and Anti-Cyclic Citrullinated Peptides In Rheumatoid Arthritis

    Lourdes Nuñez Atahualpa1, Mauricio Figuroa Sanchez1, Daniel Alberto Rocha Muñoz2, Raul Vargas Ramirez3, Beatriz Teresita Martin Marquez4, Jorge Ivan Gamez Nava5, Laura González López6, Erika Martínez García3, Esther Sanchez Corona3, Marcelo Petri4, Rosa Navarro Hernandez3, Veronica Gonzalez Diaz7, Jorge Aguilar Arreola8, Ana Guisllaine Bernard Medina9, Alejandra Nuñez Atahualpa10, Javier Andrade Garduño10, Eduardo Gomez Bañuelos3 and Monica Vazquez Del Mercado4,8, 1Radiology, Hospital Civil Fray Antonio Alcalde, Guadalajara, Mexico, 2Unidad de Investigación en Epidemiología Clínica del Hospital de Especialidades Centro Médico Nacional de Occidente, IMSS, Guadalajara, Jalisco, Mexico, 3CUCS, Universidad de Guadalajara, Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético,, Guadalajara, Mexico, 4Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Universidad de Guadalajara, Guadalajara, Mexico, 5Unidad de Investigación en Epidemiología Clínica, Hospital de Especialidades Centro Médico Nacional de Occidente., Guadalajara, Jalisco, Mexico, 6Medicina Interna-Reumatología, Departamento de Medicina Interna-Reumatología, Hospital General Regional 110, Instituto Mexicano del Seguro Social., Guadalajara, Jalisco, Mexico, 7Reumatologia, Antiguo Hospital Civil de Guadalajara - Fray Antonio Alcalde, Guadalajara, Mexico, 8Rheumatology, Hospital Civil Dr Juan I Menchaca, Guadalajara, Mexico, 9Rheumatology, Hospital Civil Fray Antonio Alcalde, Guadalajara, Mexico, 10Universidad Autónoma de Guadalajara, Guadalajara, Mexico

    Background/Purpose: The main cause of death in rheumatoid arthritis patients are cardiovascular events which cannot be entirely explained by traditional risk factors, suggesting, that systemic…
  • Abstract Number: 2660 • 2013 ACR/ARHP Annual Meeting

    Omega-3 Supplement Use Is Associated With a Reduced Risk Of Anti-Cyclic Citrullinated Protein Positivity In a Population Without Rheumatoid Arthritis, But At Risk For Future Disease

    Ryan W. Gan1, Kendra A. Young1, Gary O. Zerbe2, M. Kristen Demoruelle3, Michael H. Weisman4, Jane H. Buckner5, Peter K. Gregersen6, Ted R. Mikuls7, James R. O'Dell8, Richard M. Keating9, Michael J. Clare-Salzler10, Kevin D. Deane3, V. Michael Holers11 and Jill M. Norris1, 1Epidemiology, Colorado School of Public Health, Aurora, CO, 2Biostatistics and Informatics, Colorado School of Public Health / University of Colorado Anschutz Medical Campus, Aurora, CO, 3Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 4Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 5Benaroya Research Institute at Virginia Mason, Seattle, WA, 6Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, 7Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 8Dept of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 9Rheumatology Section, The University of Chicago, Chicago, IL, 10Experimental Pathology, University of Florida, College of Medicine, Gainesville, FL, 11Rheumatology Division, University of Colorado School of Medicine, Aurora, CO

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by systemic inflammation and circulating autoantibodies, which can be present in serum years prior to RA diagnosis and can…
  • Abstract Number: 1336 • 2012 ACR/ARHP Annual Meeting

    Changes in the Levels of Anti-Cyclic Citrullinated Protein Antibody and Immunoglobulins in Rheumatoid Arthritis Patients After Administration of Tocilizumab

    Masao Sato1, Masao Takemura2, Ryuki Shinohe3, Tsuneo Watanabe2 and Katsuji Shimizu3, 1Rheumatology, Matsunami General Hospital, Gifu, Japan, 2Informative Clinical Medicine, Gifu University, Gifu, Japan, 3Orthopaedic Surgery, Gifu University, Gifu, Japan

    Background/Purpose: The recently established scoring system of American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) early arthritis diagnosis criteria have assigned scores of 0, 1,…
  • Abstract Number: 1254 • 2012 ACR/ARHP Annual Meeting

    In Treatment-Naive Early RA the Left Ventricular Function Is Correlated to CRP, Doctors Global and Anti-CCP Status

    BB Løgstrup1, LD Kristensen1, A. Hedemann-Andersen2 and Torkell Ellingsen3, 1Department of Internal Medicine, Diagnostic Centre Region Hospital Silkeborg Denmark, Silkeborg, Denmark, 2Department of Radiology, Diagnostic Centre Region Hospital Silkeborg Denmark, Silkeborg, Denmark, 3Department of Internal Medicine, Diagnostic Centre Regional Hospital Silkeborg, 8600 Silkeborg, Denmark

    Background/Purpose: The role of inflammation and anti-CCP status in the pathogenesis of cardiovascular disease in RA remains unclear. Previous studies have suggested that both disease…
  • Abstract Number: 1200 • 2012 ACR/ARHP Annual Meeting

    Anti-Cyclic Citrullinated Peptide Antibodies in Idiopathic Pulmonary Fibrosis Are Not Citrulline-Specific: Implications for the Pathogenesis of Rheumatoid Arthritis

    Elena B. Lugli1, Muslima Chowdhury1, Peter J. Charles2, Michael G. Crooks3, Simon P. Hart3, Patrick Venables1 and Benjamin A. Fisher4, 1Kennedy Institute of Rheumatology, Oxford University, London, United Kingdom, 2Oxford University, Kennedy Institute of Rheumatology, Oxford, United Kingdom, 3Castle Hill Hospital, Hull York Medical School, Cottingham, United Kingdom, 4Rheumatology Research Group, University of Birmingham, Birmingham, United Kingdom

    Background/Purpose: The association of rheumatoid arthritis (RA) with smoking and silica exposure has led to the hypothesis that the lung is the site where RA autoimmunity…
  • Abstract Number: 1208 • 2012 ACR/ARHP Annual Meeting

    Stable Synovial Fluid Phenotype for Anti Citrullinated-Protein Antibodies in Established Rheumatoid Arthritis

    Vijay Joshua1, Lena Israelsson2, Lars Klareskog3, Anca Catrina1 and Vivianne Malmström4, 1Department of Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, 2Department of Medicine, Karolinska Institute, Stockholm, Sweden, 3Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden, 4Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Presence of anti citrullinated-protein antibodies (ACPA) in the peripheral blood of patients with rheumatoid arthritis is a validated disease biomarker. We have previously shown…
  • Abstract Number: 2615 • 2012 ACR/ARHP Annual Meeting

    Circulating Levels of Citrullinated Vimentin Fragments Are Diagnostic and Prognostic in Ankylosing Spondylitis; Evidence for Disease-Related Citrullination

    Anne C. Bay-Jensen1, Morten Asser Karsdal2, Efstathios Vassiliadis3, Stephanie Wichuk4, Zheng Zhao5, Robert GW Lambert6, Rik Lories7, Claus Christiansen8 and Walter P. Maksymowych9, 1Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, 2Nordic Bioscience A/S, Herlev, Denmark, 3Nordic Bioscience, Herlev, Denmark, 4Medicine, University of Alberta, Edmonton, AB, Canada, 5Department of Rheumatology, University of Alberta and PLA General Hospital, Beijing, PR China, Beijing, AB, China, 6Radiology, University of Alberta, Edmonton, AB, Canada, 7Laboratory of Tissue Homeostasis and Disease - SBE Research Center, KU Leuven, Leuven, Belgium, 8CCBR, Ballerup, Denmark, 9Department of Medicine, University of Alberta, Edmonton, AB, Canada

    Background/Purpose: Rheumatoid arthritis (RA) is considered an anti-CCP positive disease whereas ankylosing spondylitis (AS) is considered an anti-CCP negative disease. Anti-CCP has prognostic capacity in…
  • Abstract Number: 1211 • 2012 ACR/ARHP Annual Meeting

    ANTI-Cyclic Citrullinated Protein Antibodies Induce Inflammation and Oxidative Stress in WHITE Blood CELLS of Rheumatoid Arthritis Patients

    Chary Lopez-Pedrera1, Carlos Perez-Sanchez1, Patricia Ruiz-Limon1, Mª Angeles Aguirre2, Rosario M. Carretero-Prieto1, Antonio Rodriguez-Ariza3, Nuria Barbarroja1, Pilar Font1, Francisco Martinez2, Inmaculada Gomez-Gracia2, Mª Jose Cuadrado4 and Eduardo Collantes-Estevez2, 1Rheumatology Unit, IMIBIC-Reina Sofia University Hospital, Cordoba, Spain, 2Rheumatology, IMIBIC-Reina Sofia Hospital, Cordoba, Spain, 3Oncology Service and Research Unit, IMIBIC-Reina Sofia Hospital, Cordoba, Spain, 4Lupus Research Unit, The Rayne Institute, London, United Kingdom

    Background/Purpose: Anti-cyclic citrulinated protein antibodies (anti-CCP) are the most specific autoantibody markers in rheumatoid arthritis (RA) patients. However no previous studies have evaluated their role…
  • Abstract Number: 2581 • 2012 ACR/ARHP Annual Meeting

    Anti- Citrullinated Protein Antibodies but Not Rheumatoid Factor Are Associated with Larger Bone Erosions in rheumatoid arthritis patients- a Cross-Sectional Micro Computed Tomography Study

    Carolin Hecht1, Stephanie Finzel1, Matthias Englbrecht1, Sarah Schmidt1, Juergen Rech2, Elizabeth Araujo1 and Georg Schett1, 1Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 2Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany

    Background/Purpose: Anti- citrullinated protein antibodies (ACPA) are known to be associated with joint destruction and a more severe disease course in rheumatoid arthritis (RA) patients.…
  • Abstract Number: 1193 • 2012 ACR/ARHP Annual Meeting

    Podoplanin Expression in Rheumatoid Stroma Correlates with Lymphoid Neogenesis and Is Downregulated by Anti-TNF-α Therapy

    Regina Faré1, Elena Izquierdo1, Manuel J. Del Rey1, Raquel Celis2, Alicia Usategui1, Juan D. Cañete3 and Jose L. Pablos1, 1Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, 2Arthritis Unit, Rheumatology Department, Arthritis Unit, Rheumatology Dpt, Hospital Clinic of Barcelona and IDIBAPS, Barcelona, Spain, 3Rheumatology, Hospital Clínic of Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain

    Background/Purpose:  In rheumatoid arthritis (RA), synovial fibroblasts (SF) expand and undergo phenotypic changes that contribute to chronic inflammation and joint destruction. Podoplanin (Pdp) is a…
  • Abstract Number: 2156 • 2012 ACR/ARHP Annual Meeting

    Anti-Cyclic Citrullinated Protein Antibodies As a Predictor of Response to Tocilizumab in Patients with Rheumatoid arthritis   A Prospective Study

    Kensuke Kume1, Kanzo Amano1, Susumu Yamada1, Kuniki Amano2, Kazuhiko Hatta3, Hiroyuki Ohta4 and Noriko Kuwaba5, 1Rheumatology, Hiroshima Clinic, Hiroshima, Japan, 2Rheumatology, Sky Clinic, Hiroshima, Japan, 3Rheumatology, Hatta Clinic, Kure, Japan, 4Medical Research, hiroshima clinic, Hiroshima, Japan, 5Medical Research, Sanki Clinical Link, Hiroshima, Japan

    Background/Purpose:  Tocilizumab, interleukin-6 receptor antibody is very effective in patients with rheumatoid arthritis (RA). Anti-cyclic citrullinated protein antibodies (ACPA) are highly specific and sensitive for…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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