Abstracts tagged "Animal models"

Abstract Number: 2323 • 2012 ACR/ARHP Annual Meeting
A Genetic Polymorphism on New Zealand Black Chromosome 1 Is Associated with Abnormal Dendritic Cell Function Leading to Expansion of T_H1, T_H17 and T Follicular Helper (T_FH) Cells
Nafiseh Talaei¹, Carolina Landolt-Marticorena², Babak Noamani¹, Evelyn Pau³, Nan-Hua Chang⁴ and Joan E. Wither⁵, ¹Genetics and developmental biology, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada, ²Rheumatology, University Health Network, Toronto, ON, Canada, ³Toronto Western Research Institute, University Health Network, Toronto, ON, Canada, ⁴Genetics and Development, Toronto Western Research Institute, Toronto Western Hospital, Toronto, ON, Canada, ⁵1E420/Div of Rheumatology, Toronto Western Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: We have previously shown that B6 mice with an introgressed homozygous New Zealand Black chromosome (c) 1 interval (70 to 100 cM) develop high titres…
Abstract Number: 1639 • 2012 ACR/ARHP Annual Meeting
FLIP in Macrophages Promotes the Progression of Serum Transfer-Induced Arthritis
Qi Quan Huang¹, Robert Birkett², Renee E. Koessler¹, G. Kenneth Haines III³, Harris R. Perlman⁴ and Richard M. Pope⁵, ¹Medicine/Rheumatology, Northwestern University, Chicago, IL, ²Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Pathology, Yale University, New Haven, CT, ⁴Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁵Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose: Flip is well known as an anti-apoptotic protein induced by chronic inflammation that protects against death receptor-mediated apoptosis. Employing a FLIP myeloid lineage knock-out…
Abstract Number: 785 • 2012 ACR/ARHP Annual Meeting
Resident Lung Fibroblast Gene Expression Signatures Predict Susceptibility or Resistance to Experimental Lung Fibrosis
Emma Derrett-Smith¹, Rachel Hoyles¹, Korsa Khan², David J. Abraham³ and Christopher P. Denton², ¹Centre for Rheumatology and Connective Tissue Diseases,, UCL Medical School, London, United Kingdom, ²Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ³UCL Medical School, London, United Kingdom
Background/Purpose: In scleroderma (SSc), lung fibrosis is linked to epithelial damage and dysregulated repair mechanisms. Resident lung fibroblasts may affect multiple cell types including…
Abstract Number: 326 • 2012 ACR/ARHP Annual Meeting
Silencing Intraarticular Snail Expression Ameliorates Rat Collagen-Induced Arthritis Through Induction of Mesenchymal-Epithelial Transition in Synovial Fibroblasts
Chrong-Reen Wang¹, Shih-Yao Chen², Ai-Li Shiau³, Yuan-Tsung Li⁴, Ming-Fei Liu⁵ and Chao-Liang Wu², ¹Section of Rheumatology and Immunology, Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ²Biochemistry and Molecular Biology, National Cheng Kung University Medical College, Tainan, Taiwan, ³Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan, ⁴Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ⁵Internal Medicine, National Cheng Kung University Medical College, Tainan, Taiwan
Background/Purpose: Morphological characteristics of rheumatoid arthritis (RA) synovial fibroblasts (SF) are similar to transformed cells. We hypothesized that epithelial-mesenchymal transition (EMT) of SF regulated by…
Abstract Number: 2290 • 2012 ACR/ARHP Annual Meeting
Type I Interferon Associated Gene IRF7 in the Pathogenesis of Fibrosis in Systemic Sclerosis (SSc)
Minghua Wu¹, Michael R. Blackburn², Shervin Assassi¹, Xiaochun Liu¹, John D. Reveille¹, Filemon K. Tan¹, Sandeep K. Agarwal³ and Maureen D. Mayes¹, ¹Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²Biochemistry and Molecular Biology, The University of Texas Medical School at Houston, Houston, TX, ³Medicine, Section of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX
Background/Purpose: Fibrosis in Systemic Sclerosis is characterized by excessive collagen production and accumulation in the skin and lungs. It has been increasingly appreciated that a…
Abstract Number: 1634 • 2012 ACR/ARHP Annual Meeting
Delivering Mesenchymal Stem Cells to Arthritic Joints with Nano-Fiber Scaffold Resulted in Inhibition of Arthritis and Joint Damage in Arthritis Models
Xiangmei Zhang¹, Kunihiro Yamaoka¹, Koshiro Sonomoto¹, Masahiro Kondo¹, Shunsuke Fukuyo¹, Makoto Satake², Hiroaki Kaneko², Kazuhisa Nakano¹, Shingo Nakayamada³, Yosuke Okada¹ and Yoshiya Tanaka¹, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²The Third Laboratory, Integrative Technology Research Institute, Teijin Limited, Tokyo, Japan, ³First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
Background/Purpose: Even though treatment of rheumatoid arthritis (RA) has emerged, aiming bone repair is still a challenge. Mesenchymal stem cells (MSCs) possess immunoregulatory function with…
Abstract Number: 787 • 2012 ACR/ARHP Annual Meeting
Aberrant Adipogenesis in the Pathogenesis of Scleroderma
Roberta Goncalves Marangoni¹, Jun Wei², Monique E. Hinchcliff¹, Feng Fang³, Warren Tourtellotte⁴ and John Varga⁵, ¹Division of Rheumatology, Northwestern University Medical School, Chicago, IL, ²Rheumatology Division, Northwestern University, Chicago, IL, ³Rheumatology Division, Northwestern University Medical School, Chicago, IL, ⁴Pathology, Northwestern University Medical School, Chicago, IL, ⁵Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Skin fibrosis in systemic sclerosis (SSc) is associated with loss of subcutaneous adipose tissue (SCAT) and reduction in adiponectin. The mechanism underlying SCAT atrophy…
Abstract Number: 329 • 2012 ACR/ARHP Annual Meeting
The SYK Inhibitor, Fostamatinib, Administered Alone or in Combination with Methotrexate in Rat Collagen-Induced Arthritis, Reduces Bone Erosions, Biomarkers of Cartilage/Bone Destruction, and Synovial Osteoclastogenic Cytokines
Polly Pine¹, Ayodele Apatira¹, Betty Y. Chang¹, Nathan Schoettler², Elliott B. Grossbard³ and Ernest Brahn², ¹Pharmacology, Rigel Pharmaceuticals, So San Francisco, CA, ²Rheumatology, UCLA School of Medicine, Los Angeles, CA, ³Rigel Pharmaceuticals, So San Francisco, CA
Background/Purpose: Spleen tyrosine kinase (SYK) is expressed in hematopoietic cells and is a major downstream regulator of signaling through Fcγ and immunoglobulin receptors as well…
Abstract Number: 2300 • 2012 ACR/ARHP Annual Meeting
The Effects of Salvianolic Acid B in Fibrotic Models in Vivo and in Vitro
Qingmei Liu¹, Wenyu Wu², Wenzheng Tu³, Haiyan Chu¹, Yanyun Ma¹, Hejian Zou⁴, Xiaodong Zhou⁵ and Jiu-Cun Wang¹, ¹Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China, ²Huashan Hospital, Shanghai, China, ³Shanghai Traditional Chinese Medicine-Integrated Hospital, Shanghai, China, ⁴Rheumatology, Huashan Hospital, Shanghai, China, ⁵Rheumatology, University of Texas Health Science Center at Houston, Houston, TX
Background/Purpose: , Methods: , Results: and Conclusion: Background: Scleroderma or systemic sclerosis (SSc) is characterized by the fibrosis of skin and visceral organs. Salvianolic acid…
Abstract Number: 1603 • 2012 ACR/ARHP Annual Meeting
Inhibitor of DNA Binding 1 As a Secreted Angiogenic Transcription Factor in Rheumatoid Arthritis
Takeo Isozaki¹, M. Asif Amin², Alisa E. Koch³, Ali Arbab⁴, Stephanie A. Shuman¹, Christine M. Ha¹, G. Kenneth Haines III⁵ and Jeffrey H. Ruth⁶, ¹Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, ²Department of Medicine, University of Michigan, Ann Arbor, MI, ³Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI, ⁴Diagnostic Radiology, Henry Ford Hospital and Medical Centers, Detroit, MI, ⁵Department of Pathology, Yale University, New Haven, CT, ⁶Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Rheumatoid arthritis (RA) is characterized by enhanced blood vessel development in joint synovium. This involves the recruitment of endothelial progenitor cells (EPCs), allowing for…
Abstract Number: 757 • 2012 ACR/ARHP Annual Meeting
Beneficial Role of Rapamycin in Experimental Autoimmune Myositis
Nicolas Prevel¹, Yves Allenbach², David Klatzman¹, Benoit Salomon¹ and Olivier Benveniste³, ¹UPMC Université Paris 06, UMR 7211, Paris, France, ²Internal Medicine Dpt 1, Pitié-Salpêtrière Hospital, APHP, Paris, France, ³Internal Medecine Dpt 1, Pitié-Salpêtrière Hospital, APHP, Paris, France
Background/Purpose: Idiopathic inflammatory myopathies are a heterogeneous group of different diseases, classified into four main categories: dermatomyositis, polymyositis, immune-mediated necrotizing myopathy, and sporadic inclusion body…
Abstract Number: 32 • 2012 ACR/ARHP Annual Meeting
Development of a Quantitative Model of Endotoxin-Induced Calvarial Bone Erosion Utilizing Micro-Computed Tomography and Pax-It Imaging Analysis Software
Diane Thome, Donald Souza, Aruna Behera, Jie Zheng, Jennifer Swantek and Gerald H. Nabozny, Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT
Background/Purpose: To facilitate an understanding of the biological factors involved in inflammation- mediated bone loss, in vitro systems and murine models of bone loss, such…
Abstract Number: 2082 • 2012 ACR/ARHP Annual Meeting
Peripheral and Local Effects of Anti-C5aR Treatment in the Collagen Induced Arthritis Model
Christina Andersson¹, Carola Wenander¹, Pernille Usher², Josephine Hebsgaard² and Lars Hornum³, ¹AID Models, Immunopharmacology, Biopharmaceutical Research Unit, Novo Nordisk A/S, Måløv, Denmark, ²Histology, Biopharmaceutical Research Unit, Novo Nordisk A/S, Måløv, Denmark, ³Immunopharmacology, Biopharmaceutical Research Unit, Novo Nordisk A/S, Måløv, Denmark
Background/Purpose: The activated C5a-fragment of complement factor C5 is a potent pro-inflammatory effector molecule that chemo-attracts and activates myeloid cells such as neutrophils, monocytes, and…
Abstract Number: 1518 • 2012 ACR/ARHP Annual Meeting
Damage-Associated Endogenous TLR4 Ligand Fibronectin-EDA Is Overexpressed in Scleroderma and Drives Persistent Fibrosis Via TLR4 and Inhibition of TLR4 Prevents and Reverses Experimental Dermal Fibrosis: Novel Target for Scleroderma Therapy
Swati Bhattacharyya¹, Zenshiro Tamaki², Wenxia Wang³, Paul Hoover⁴, Adam Booth⁵, Alyssa Dreffs⁶, Monique E. Hinchcliff⁷, Feng Fang⁸, Spiro Getsios⁴, Hang Yin⁹, Eric S. White⁶ and John Varga¹⁰, ¹Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ²Medicine, Rheumatology, Northwestern Univ Med School, Chicago, IL, Chicago, IL, ³Medicine/Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁴Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁵Ann Arbor, MI, ⁶Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁷Division of Rheumatology, Northwestern Univ Med School, Chicago, IL, ⁸Rheumatology Division, Northwestern University, Chicago, IL, ⁹University of Colorado at Boulder, Boulder, CO, ¹⁰Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Recent studies implicate innate immune signaling and Toll like receptor-4 (TLR4) in fibrogenesis. We hypothesized that injury in scleroderma leads to tissue accumulation of…
Abstract Number: 734 • 2012 ACR/ARHP Annual Meeting
Chemokine (C-C Motif) Receptor 2 Signaling Mediates Persistent Pain in Experimental Osteoarthritis
Rachel E. Miller¹, Phuong Tran², Rosalina Das², Nayereh Ghoreishi-Haack², Richard J. Miller³ and Anne-Marie Malfait⁴, ¹Rheumatology/Biochemistry, Rush University Medical Center, Chicago, IL, ²Rheumatology, Rush University Medical Center, Chicago, IL, ³Molecular Biochemistry and Pharmacology, Northwestern University, Chicago, IL, ⁴Internal Medicine/Biochemistry, Rush University Medical Center, Chicago, IL
Background/Purpose: To investigate the role of MCP-1/CCR2 in the development of pain in osteoarthritis (OA) using a mouse model, destabilization of the medial meniscus (DMM).…

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