Abstracts tagged "Aging"

Abstract Number: 1343 • 2013 ACR/ARHP Annual Meeting
Are There Differences Between Young and Older Onset Early Rheumatoid Arthritis and Does This Impact Outcomes? An Analysis From The Canadian Early Arthritis Cohort
Michael Arnold¹, Vivian P. Bykerk², Gilles Boire³, Boulos Haraoui⁴, Carol A. Hitchon⁵, J. Carter Thorne⁶, Edward Keystone⁷ and Janet E. Pope⁸, ¹Medicine/Rheumatology, University College Dublin, Ireland, Dublin, Ireland, ²Divison of Rheumatology, Hospital for Special Surgery, New York, NY, ³Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁴Rheumatology, Institut de Rhumatologie de Montréal, Montreal, QC, Canada, ⁵Rheumatology, University of Manitoba, Winnipeg, MB, Canada, ⁶Southlake Regional Health Centre, Newmarket, ON, Canada, ⁷Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, University of Toronto, Toronto, ON, Canada, ⁸Medicine, Divsion of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada
Background/Purpose: To determine the impact of age on disease and remission in early rheumatoid arthritis (ERA). Methods: Data from the Canadian Early Arthritis Cohort (CATCH)…
Abstract Number: 132 • 2013 ACR/ARHP Annual Meeting
Relation Of Age With Symptom Severity and Quality Of Life In Patients With Fibromyalgia
Juan Jiao^1,2, Ann Vincent³, Connie A. Luedtke⁴, Stephen Cha⁵ and Terry H. Oh⁶, ¹Rheumatology, Guang'anmen Hospital , China Academy of Chinese Medical Sciences, Beijing, China, ²Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, ³General Internal Medicine, Mayo Clinic, Rochester, MN, ⁴Department of Nursing, Mayo Clinic, Rochester, MN, ⁵Health Sciences Research, Mayo Clinic, Rochester, MN, ⁶Physical Medicine & Rehabilitation, Mayo Clinic, Rochester, MN
Background/Purpose: The relationship of age and fibromyalgia symptom severity and quality of life (QOL) is still debated. Reports range from no differences between patients younger…
Abstract Number: 64 • 2013 ACR/ARHP Annual Meeting
Fibulin-3 In Joint Aging and Osteoarthritis Pathogenesis
Akihiko Hasegawa^1,2, Tomo Yonezawa¹, Noboru Taniguchi¹, Koji Otabe¹, Yukio Akasaki¹, Tetsuya Matsukawa¹, Masahiko Saito³, Masashi Neo⁴, Lihua Y. Marmorstein⁵ and Martin K. Lotz¹, ¹Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ²Orthopaedic Surgery, Osaka Medical College, Takatsuki, Osaka, Japan, ³Orthopaedic Surgery, Toho University Sakura Medical Center, Sakura, Japan, ⁴Department of Orthopedic Surgery, Osaka Medical College, Osaka, Japan, ⁵Department of Ophthalmology and Vision Science, University of Arizona, Tucson, AZ
Background/Purpose: Osteoarthritis (OA) is the most common joint disease. Among the earliest lesions during OA development is disruption of the superficial zone (SZ) of articular…
Abstract Number: 68 • 2013 ACR/ARHP Annual Meeting
Autophagy Activation Protects From Mitochondrial Dysfunction In Human Chondrocytes
Beatriz Caramés¹, Paloma López de Figueroa², Martin Lotz³ and Francisco J. Blanco⁴, ¹Osteoarticular and Aging Research Lab, INIBIC–Complejo Hospitalario Universitario A Coruña, SPAIN, A Coruña, Spain, ²Cartilage Biology group. Rheumatology Division, INIBIC-A Coruña, Spain, A Coruña, Spain, ³The Scripps Research Institute, La Jolla, USA, La Jolla, CA, ⁴Osteoarticular and Aging Res. Lab. CIBER-BBN. INIBIC- University of A Coruña, A Coruña, Spain
Background/Purpose: A common feature of aging-related diseases, such as osteoarthritis (OA), is the progressive accumulation of damaged macromolecules leading to cell dysfunction and death. Autophagy,…
Abstract Number: 72 • 2013 ACR/ARHP Annual Meeting
Autophagy Changes During Aging: A Study In GFP-LC3 Mice
Beatriz Carames¹, William B. Kiosses², Merissa Olmer³ and Martin Lotz⁴, ¹Cartilage Biology Group. Rheumatology Division, INIBIC–A Coruña, SPAIN, A Coruña, Spain, ²The Scripps Research Institute, La Jolla, CA, ³The Sripps Research Institute, La Jolla, CA, ⁴The Scripps Research Institute, La Jolla, USA, La Jolla, CA
Background/Purpose: Aging is a main risk factor for osteoarthritis (OA), the most prevalent musculoskeletal disorder. Aging-associated changes in autophagy, an essential cellular homeostasis mechanism, have…
Abstract Number: 59 • 2013 ACR/ARHP Annual Meeting
Downregulated Forkhead-Box Class O Transcription Factors Attenuate Oxidative Stress Resistance In Human Chondrocytes
Yukio Akasaki and Martin K. Lotz, Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA
Background/Purpose: Aging-associated changes in articular chondrocytes represent a major risk factor for osteoarthritis (OA). The major signaling pathway that regulates cellular aging is the Insulin/IGF-1/Pl3k/Akt/forkhead-box…
Abstract Number: 43 • 2013 ACR/ARHP Annual Meeting
Overexpression Of Lamin A In Mesenchymal STEM CELLS Compromises Chondrogenesis and Enhances Adipogenesis
Jesús Mateos^1,2, Arancha Landeira^1,2, Alexandre De la Fuente^1,2, Iván Lesende-Rodríguez^1,3, Pablo Fernández-Pernas^1,3, Maria Carmen Arufe^2,3 and Francisco J. Blanco^1,2,4, ¹Rhematology Division, ProteoRed/ISCIII. INIBIC-Hospital A Coruña, 15006, A Coruña, Spain, ²CIBER-BBN, Zaragoza, Spain, ³Department of Medicine, Area of Anatomy and Human Embryology, University of A Coruña-INIBIC, A Coruña, Spain, ⁴Department of Medicine. University of Santiago de Compostela, Santiago de Compostela, Spain
Background/Purpose: Previous work by our group and others indicated that an accumulation of lamin A (LMNA) is associated with the osteoarthritis (OA) chondrocyte phenotype. Mutations…
Abstract Number: 56 • 2013 ACR/ARHP Annual Meeting
Age-Related Loss Of The Transforming Growth Factor Beta Receptor ALK5 Precedes Osteoarthritis Development In Cartilage
Arjan van Caam¹, Esmeralda N. Blaney Davidson², Eva Thijssen¹, Wim B. van den Berg¹ and Peter M. van der Kraan¹, ¹Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Osteoarthritis (OA) is the most common joint disease and (old) age is its main risk factor. One of OA's main hallmarks is degradation of…
Abstract Number: 28 • 2013 ACR/ARHP Annual Meeting
Differentiation, Activation, and Autoreactivity Of CD11c+ B Cells (ABCs)
Alice E. Wiedeman¹, Natalia V. Giltiay², Lena Tanaka³ and Keith B. Elkon³, ¹Immunology, University of Washington, Seattle, WA, ²Department of Immunology, Division of Rheumatology, University of Washington, Seattle, WA, ³Rheumatology, University of Washington, Seattle, WA
Background/Purpose: Recently, a population of CD11c+ age-associated B cells (ABCs) was identified in normal aged female mice. These cells could be expanded following activation by…