ACR Meeting Abstracts

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Abstracts tagged "Aging"

  • Abstract Number: 009 • 2023 Pediatric Rheumatology Symposium

    The Bridge to Adult Care from Childhood for Young Adults with Rheumatic Disease (BACC YARD) Program, a Pediatric-to-Adult Rheumatology Transition Program

    John Bridges1, Livie Huie2, Amanda Alexander2, Randy Cron2, Maria I. ("Maio") Danila3, Victoria Gennaro4, Laura Hughes2, Bailey Lipham5, Linda McAllister4, Matthew Mullen2, Annelle Reed6, Daniel Reiff2, Carolyn Smith6, Emily Smitherman2, Matthew Stoll2, Peter Weiser2 and Melissa Mannion2, 1University of Alabama at Birmingham/Children's of Alabama, Birmingham, AL, 2University of Alabama at Birmingham, Birmingham, AL, 3University of Alabama at Birmingham (UAB), Birmingham VA Medical Center, Birmingham, AL, 4Children's of Alabama, Birmingham, AL, 5University of Alabama Medical School, Birmingham, AL, 6Children's of Alabama, Birmingham, AL

    Background/Purpose: Children with chronic rheumatic conditions age and require transfer to adult rheumatologists for continued care. The transition period from pediatric to adult-oriented care is…
  • Abstract Number: 0734 • ACR Convergence 2022

    Comfort Levels and Practice Patterns for Osteoporosis-Related Care Among Persons Living with HIV in Peru: A National Physician Survey

    Rebecca Slotkin1, Camila Lucero Granda Calderón2, Diego Cabrera3, Carlos Manuel Benites Villafane4, Patricia Jannet Garcia5 and Evelyn Hsieh3, 1Yale University School of Public Health, New Haven, CT, 2Facultad de Medicina Alberto Hurtado de la Universidad Peruana Cayetano Heredia, Lima, Peru, 3Section of Rheumatology, Allergy and Immunology, Yale School of Medicine, New Haven, CT, 4Ministerio de Salud, Lima, Peru, 5Epidemiology, STD, and HIV Unit, School of Public Health, Universidad Peruana Cayetano Heredia, Lima, Peru

    Background/Purpose: As they age, persons living with HIV (PLWH) are at increased risk for osteoporosis due to chronic infection and antiretroviral therapies (ART). In Peru,…
  • Abstract Number: 0837 • ACR Convergence 2022

    Providers’ Adoption of 2017 Guidelines on DMARD Use Perioperatively for Elective Total Hip and Knee Arthroplasty at a Single Academic Center

    Chris Ching1, Erica Mulcaire-Jones2, Andrew Shaffer1, Jeremy Gililland1, Michael Battistone3 and Dorota Lebiedz-Odrobina1, 1University of Utah, Salt Lake City, UT, 2Intermountain Healthcare, Salt Lake City, UT, 3Salt Lake City VA, Salt Lake City, UT

    Background/Purpose: Rate of prosthetic joint infection (PJI) after total joint arthroplasty (TJA) is higher in patients with rheumatic conditions than in patients with OA. Our…
  • Abstract Number: 1196 • ACR Convergence 2022

    Interaction of Cumulative Inflammation with Smoking and Lipids in Risk Modification of Dementia Among Patients with Rheumatoid Arthritis: A Population-based Cohort Study

    Chanakya Kodishala1, Stephanie Duong2, Cassondra Hulshizer2, Ryan Lennon2, Rabia Javed2, Maria Vassilaki2, Michelle Mielke3, John Davis2, Cynthia Crowson4 and Elena Myasoedova2, 1Mayo Clinic Rochester Minnesota, Rochester, MN, 2Mayo Clinic, Rochester, MN, 3Wake Forest University School of Medicine, Winston-Salem, NC, 4Mayo Clinic, Eyota, MN

    Background/Purpose: Patients with rheumatoid arthritis (RA) have increased risk of developing dementia. Systemic inflammation is implicated in the pathogenesis of cognitive decline. However, the association…
  • Abstract Number: 1327 • ACR Convergence 2022

    Immune Cell Subsets and Risk of Incident Hip Fracture in Older Adults: The Cardiovascular Health Study

    Rachel Elam1, Petra Buzkova2, Joseph Delaney3, Howard Fink4, Joshua Barzilay5, Laura Carbone1, Rick Saha1, John Robbins6, Kenneth Mukamal7, Rodrigo Valderrabano8, Bruce Psaty2, Russell Tracy9, Nels Olson9, Sally Huber10, Margaret Doyle9, Alan Landay11 and Jane Cauley12, 1Augusta University, Augusta, GA, 2University of Washington, Seattle, WA, 3University of Manitoba, Winnipeg, MB, Canada, 4University of Minnesota, Minneapolis, MN, 5Kaiser Permanente, Atlanta, GA, 6UC Davis, Davis, CA, 7Beth Israel Deaconess Medical Center, Boston, MA, 8Brigham and Women's Hospital, Boston, MA, 9University of Vermont, Burlington, VT, 10University of Vermont, Burlingon, VT, 11Rush University Medical Center, Chicago, IL, 12University of Pittsburgh, PIttsburgh, PA

    Background/Purpose: Cell-mediated immunity may play a role in osteoporosis development. Fracture is the major consequence of osteoporosis. Thus, cell-mediated immunity may impact fracture risk. We…
  • Abstract Number: 1396 • ACR Convergence 2022

    Risk of Hospitalized Infections in Older Elderly Rheumatoid Arthritis Patients Treated with Biological/Targeted Synthetic DMARDs: Evaluation Using Data from a Japanese Claims Database

    Masayoshi Harigai1, Takao Fujii2, Ryoko Sakai3, Ataru Igarashi4, Ayako Shoji5, Hiroko Yamaguchi6, Katsuhiko Iwasaki6, Misako Makishima7, Amika Yoshida7, Norihiro Okada7, Katsuhisa Yamashita7 and Yutaka Kawahito8, 1Division of Rheumatology, Department of Internal Medicine, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan, 2Department of Rheumatology and Clinical Immunology, Wakayama Medical University, Wakayama, Japan, 3Department of Public Health and Epidemiology, Meiji Pharmaceutical University, Tokyo, Japan, 4Department of Health Economics & Outcomes Research, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan; Unit of Public Health and Preventive Medicine, Yokohama City University of Medicine, Kanagawa, Japan, 5Medilead Inc., Tokyo, Japan; Department of Health Economics and Outcomes Research, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan; Healthcare Consulting Inc., Tokyo, Japan, Shinjuku-ku, Japan, 6Medilead Inc., Tokyo, Japan, Shinjuku-ku, Japan, 7Chugai Pharmaceutical Co., Ltd., Chuo-ku, Tokyo, Japan, 8Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan, Kyoto, Kyoto, Japan

    Background/Purpose: Safety evidence of biological or targeted synthetic DMARDs (b/tsDMARDs) is still insufficient in older elderly ( >=75 years old (y/o)) patients with rheumatoid arthritis…
  • Abstract Number: 1460 • ACR Convergence 2022

    Neuropsychiatric Lupus in Late and Early Onset Systemic Lupus Erythematosus Patients: A Systemic Review and Meta-analysis

    Omer Pamuk1, Saja Ali2 and Sarfaraz Hasni2, 1NIH/NIAMS, Bethesda, MD, 2NIAMS/NIH, Bethesda, MD

    Background/Purpose: The diagnosis of neuropsychiatric lupus (NPSLE) is challenging due to its variegated presentation, absence of diagnostic biomarkers and radiological imaging. The NPSLE is further…
  • Abstract Number: 1481 • ACR Convergence 2022

    Dementia in Adults with Systemic Lupus Erythematosus 65 Years of Age and Above: A National Administrative Claims Data Analysis

    Sarah Lieber1, Musarrat Nahid2, Iris Navarro-Millan2, Mangala Rajan2, Sebastian Sattui3, Robyn Lipschultz1, M. Carrington Reid2 and Lisa Mandl1, 1Hospital for Special Surgery, New York, NY, 2Weill Cornell Medicine, New York, NY, 3University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Systemic lupus erythematosus (SLE) has been associated with increased risk of dementia relative to age-matched comparators without systemic rheumatic disease (SRD) in non-US-based samples…
  • Abstract Number: 0008 • ACR Convergence 2022

    CD11c+ T-Bet+ B Cells Traffic to Human Bone Marrow

    Jennifer Barnas1, Diana Alzamareh2, Nida Meednu2 and Jennifer Anolik2, 1University of Rochester, Rochester, NY, 2University of Rochester Medical Center, Rochester, NY

    Background/Purpose: CD11c+ age/autoimmunity-associated B cells (ABC) are associated with autoantibody producing cells and disease flare in systemic lupus erythematosus. ABC were initially identified in aged…
  • Abstract Number: 1539 • ACR Convergence 2022

    Gene Expression Meta-Analysis Reveals Aging and Cellular Senescence Signatures in Scleroderma-associated Interstitial Lung Disease

    Monica Yang1, Seoyeon Lee2, Jessica Neely3, Marina Sirota2 and Paul Wolters2, 1UCSF, SF, CA, 2UCSF, SF, 3UCSF Benioff Children's Hospital, San Francisco, CA

    Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune disease characterized by diffuse fibrosis and vasculopathy that has potential to affect nearly every organ system. Interstitial lung…
  • Abstract Number: 0032 • ACR Convergence 2022

    Defective Chaperone-mediated Autophagy Is a Hallmark of Joint Disease in Patients with Knee Osteoarthritis

    Irene Lorenzo-Gomez1, uxia Nogueira-recalde1, Christian garcía-Domínguez1, Natividad Oreiro2, Martin Lotz3, JA Pinto-Tasende2, FJ Blanco2 and beatriz caranes1, 1Instituto de Investigación Biomédica de A Coruña (INIBIC), Unidad de Biología del Cartílago, A Coruña, Spain, 2Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, 3Scripps Research, La Jolla

    Background/Purpose: Defects in autophagy contribute to joint aging and Osteoarthritis (OA). Identifying specific autophagy types could be useful for developing novel treatments for OA.Methods: A…
  • Abstract Number: 1961 • ACR Convergence 2022

    COVID-19 mRNA Vaccine Induced Antibody Titers and IFN-g Responses Are Decreased in Persons with Rheumatoid Arthritis and Older Age

    Holly Dudley1, megan O'Mara2, Ann Auma1, Jenny Gong3, Yael Ross4, Natalie Gurevich2, Larraine Gordesky5, Nora Singer6, Lenche Kostadinova7, Brigid Wilson7, David Zidar7, Christopher King1, David Canaday1, Carey Shive1, Maya Mattar8 and Donald Anthony9, 1Case Western Reserve University, Cleveland, OH, 2Cleveland Veteran Affairs Medical Center, Cleveland, OH, 3Case Western School of Medicine, Cleveland, OH, 4Case Western Reserve University at MetroHealth Medical Center, Atlanta, GA, 5MetroHealth Medical Center, Cleveland, OH, 6The MetroHealth System at Case Western Reserve University School of Medicine, Cleveland, OH, 7VA Medical Center, Cleveland, OH, 8Louis Stokes VA Medical Center, Mayfield Heights, OH, 9Case, VA, Metro, Chardon, OH

    Background/Purpose: People with autoimmune diseases have worse outcomes if infected by SARS-CoV2. In particular, persons with rheumatoid arthritis (RA), have lower antibody responses to COVID-19…
  • Abstract Number: 0033 • ACR Convergence 2022

    Adenosine A2A Receptor Signaling Enhances Expression of an Endogenous p53 Mouse Variant in Bone Marrow Mesenchymal Stem Cells

    Benjamin Friedman1 and Bruce Cronstein2, 1NYU Langone, New York, NY, 2NYU School of Medicine, New York, NY

    Background/Purpose: Our lab has demonstrated the ability of an intra-articular liposomal formulation of an adenosine A2A receptor (A2AR), CGS21680, to regenerate cartilage in multiple rodent…
  • Abstract Number: 2009 • ACR Convergence 2022

    Long-term Outcome of a Treat-to-target Strategy in Elderly-onset Rheumatoid Arthritis with Chronic Lung Diseases

    Manami Nomura1, Takahiko Sugihara2, Hiroyuki Baba1, Tatsuro Ishizaki3, Tadashi Hosoya1, Mari Kamiya1, Takumi Matsumoto2, Kanae Kubo4, Fumio Hirano5, Masayo Kojima6, Nobuyuki Miyasaka5, Shinsuke Yasuda5 and Masayoshi Harigai7, 1Tokyo Medical and Dental University (TMDU), Tokyo, Japan, 2Department of Medicine and Rheumatology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan, 3Human Care Research Team, Tokyo Metropolitan Institute of Gerontology., Tokyo, Japan, 4Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan, 5Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, 6Department of Frailty Research, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Nagoya, Japan, 7Division of Rheumatology, Department of Internal Medicine, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan

    Background/Purpose: Elderly patients with rheumatoid arthritis (RA) tend to have a higher risk for drug-related adverse events (AEs) than younger patients, and the effectiveness and…
  • Abstract Number: 0070 • ACR Convergence 2022

    Post-operative Delirium and Cognitive Impairment: An Analysis of Predictors and 120-day Outcomes in England Using the National Hip Fracture Database (NHFD)

    Samuel Hawley1, Dominic Inman2, Celia Gregson1, Michael Whitehouse1, Antony Johansen3 and Andrew Judge1, 1University of Bristol, Bristol, United Kingdom, 2Northumbria Healthcare NHS Foundation Trust, Northumbria, United Kingdom, 3Cardiff University, Cardiff, Wales, United Kingdom

    Background/Purpose: Post-operative delirium and cognitive impairment are common after hip fracture. We set out to identify risk factors and examine the association with returning home…
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