Abstracts tagged "Aging"

Abstract Number: 2455 • 2017 ACR/ARHP Annual Meeting
Efficacy of Etanercept in Elderly Patients with Rheumatoid Arthritis
Christopher J. Edwards¹, Katherine Roshak², Jack F Bukowski³, Ronald Pedersen⁴, Mazhar Thakur⁵, Lisa Marshall² and Heather Jones², ¹University Hospital Southampton, Southampton, United Kingdom, ²Inflammation & Immunology Global Medical Affairs, Pfizer, Collegeville, PA, ³Clinical Affairs, Pfizer, Collegeville, PA, ⁴Department of Biostatistics, Pfizer, Collegeville, PA, ⁵Pfizer Ltd, Sandwich, United Kingdom
Background/Purpose: Ageing is associated with declining immune cell function and age-related comorbidities.1,2 In the US, the prevalence of rheumatoid arthritis (RA) is ~2% in individuals…
Abstract Number: 2717 • 2017 ACR/ARHP Annual Meeting
Late Onset of IgA Vasculitis Is Associated with More Severe Renal Involvement
Alexandra Audemard-Verger¹, Aurélie Baldolli², Noemie Le Gouellec³, Loic Raffray⁴, Alban Deroux⁵, Julie Goutte⁶, Bertrand Lioger⁷, Zahir Amoura⁸, Patrice Cacoub⁹, Sébastien Sanges¹⁰, Evangeline Pillebout¹¹, Loïc Guillevin for the French Vasculitis Study Group¹² and Benjamin Terrier¹³, ¹Internal Medicine, Caen, France, ²Internal Medicine, CHU, Caen, France, ³Internal Medicine, Lille, France, ⁴Internal Medicine, CHU de Bordeaux, Bordeaux, France, ⁵Internal Medicine, CHU de Grenoble, Grenoble, France, ⁶Internal Medicine, Saint Etienne, France, ⁷GICC UMR 7292, University François Rabelais, Tours, France, ⁸Department of Internal Medicine 2. Referal center for SLE/APS, Hôpital Pitié-Salpêtrière, AP-HP, UPMC Univ Paris 06 & French National Reference Center For Systemic Lupus and Antiphospholipid Syndrome, Paris, France, ⁹Internal Medicine Department, University Hospital “Pitié-Salpêtrière”, “Pierre et Marie Curie Paris VI” University, Paris, France, ¹⁰Université Lille Nord de France, Faculté de Médecine Henri Warembourg, Lille, Lille, France, ¹¹Nephrology, Saint Louis, Paris, France, ¹²Service de Médecine Interne, Centre de Référence Maladies Auto-Immunes et Auto-Inflammatoires Systémiques Rares, Hôpital Cochin, Paris, France, ¹³Internal Medicine, Cochin University Hospital, Paris, France
Background/Purpose: Immunoglobulin A vasculitis (IgAV), formerly called Henoch–Schönlein purpura, is a small-vessel vasculitis characterized by immune-complex deposits with predominant IgA. Although the disease is often…
Abstract Number: 2945 • 2017 ACR/ARHP Annual Meeting
Incident Hand OA Is Strongly Associated with Reduced Peripheral Blood Leukocyte Telomere Length
Timothy E. McAlindon¹, Mary Roberts², Lena Franziska Schaefer³, Jeffrey B. Driban⁴, Jeffrey Duryea³, Francisco J Blanco⁵, Jose-Luis Fernandez-Garcia⁶ and Charles Eaton⁷, ¹Division of Rheumatology, Tufts Medical Center, Boston, MA, ²Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Pawtucket, RI, ³Radiology, Brigham & Women's Hospital/ Harvard Medical School, Boston, MA, ⁴Rheumatology, Tufts Medical Center, Boston, MA, ⁵Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña. España, A Coruña, Spain, ⁶Genetic Department, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ⁷Family Medicine and Epidemiology, Warren Alpert Medical School, School of Public Health, Brown University, Providence, RI
Background/Purpose: Hand OA (HOA) is a painful, destructive and deforming polyarticular disorder that impairs an individual’s ability to perform manipulative activities of daily life and…
Abstract Number: 406 • 2017 ACR/ARHP Annual Meeting
Mapping Changes in Monocyte and Macrophage Populations in the Synovium: An Aging Study in Arthritic KRN Ag7 Mice
Anna B Montgomery¹, Carla Cuda², Philip J. Homan³, Harris Perlman² and Deborah R. WInter², ¹Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease of the joints associated with accelerated aging and increased mortality. Further, RA is linked with a number…
Abstract Number: 904 • 2017 ACR/ARHP Annual Meeting
Deficient Autophagy Induces Lamin a/C Accumulation in Aging and Osteoarthritis
Paloma Lopez de Figueroa¹, Uxia Nogueira-Recalde², Fernando Osorio³, Martin Lotz⁴, Carlos Lopez-Otin³, Francisco J Blanco² and Beatriz Carames¹, ¹Cartilage Biology Group. Rheumatology Division, INIBIC-CHUAC, A Coruña, Spain, A Coruña, Spain, ²Cartilage Biology Group. Rheumatology Division, INIBIC-CHUAC, A Coruña, A Coruña, Spain, ³Degradome Lab, Universidad de Oviedo, Oviedo, Spain, ⁴Department of Molecular & Experience Medicine, Scripps Research Institute, LaJolla, CA
Background/Purpose: Autophagy, an essential chondrocyte homeostasis mechanism, is defective in Aging and Osteoarthritis (OA). However, the targets regulating this mechanism are still unknown. Here, we…
Abstract Number: 1133 • 2017 ACR/ARHP Annual Meeting
Are We Ready? Changes in the Profile of Gout Patients over the Last 25 Years
Sandra Chinchilla^1,2, Irati Urionagüena^2,3 and Fernando Perez-Ruiz^1,2,3, ¹University of the Basque Country (UPV/EHU), Bilbao, Spain, ²BioCruces Health Research Institute, Barakaldo, Spain, ³Rheumatology Division, Hospital Universitario Cruces, Baracaldo, Spain
Background/Purpose: Gout is a rising cause of hospital admissions and emergency consults. It has even replaced rheumatoid arthritis as the principal rheumatological condition causing hospitalizations. Some…
Abstract Number: 1854 • 2017 ACR/ARHP Annual Meeting
Identifying Vulnerable Patient Populations Based on Age and Physical Function on Clinical Outcomes Following Total Knee Arthroplasty
Jesse Christensen¹, Andrew Kittelson², Brian Loyd³, Jackie Del Giorno⁴, Brian Burnikel⁵ and Jennifer Stevens-Lapsley⁶, ¹University of Utah, SLC, UT, ²Rehabilitation Science PhD Program, University of Colorado Anschutz Medical Campus, Aurora, CO, ³University of Colorado Anschutz Medical Campus, Aurora, CO, ⁴ATI Physical Therapy, Greenville, SC, ⁵Steadman Hawkins Clinic of the Carolinas, Greenville Health Systems, Greenville, SC, ⁶Universtiy of Colorado, Anschutz Medical Campus, Aurora, CO
Background/Purpose: : Total knee arthroplasty (TKA) has historically been viewed as a surgical procedure of last resort for older adults suffering with chronic arthritis. However,…
Abstract Number: 1931 • 2017 ACR/ARHP Annual Meeting
Targeting Cartilage Aging As Osteoarthritis Therapeutics By Drug Repurposing
Beatriz Carames¹, Uxia Nogueira-Recalde², Maria I. Loza³, Francisco J Blanco² and Eduardo Dominguez⁴, ¹Cartilage Biology Group. Rheumatology Division, INIBIC–CHUAC, A Coruña, A Coruña, Spain, ²Cartilage Biology Group. Rheumatology Division, INIBIC-CHUAC, A Coruña, A Coruña, Spain, ³BioFarma Research Group. University of Santiago de Compostela, santiago de Compostela, Spain, ⁴BioFarma Research Group. University of Santiago de Compostela, Santiago de Compostela, Spain
Background/Purpose: Background: Effective treatments for Osteoarthritis (OA) are not available. In aging-related diseases, including OA, failure of cellular homeostasis mechanisms, such as autophagy can cause…
Abstract Number: 2341 • 2017 ACR/ARHP Annual Meeting
The Interaction between Genetic Risk Factors and Age of Disease Onset in Juvenile Dermatomyositis
Claire Deakin¹, John Bowes², Lucy Marshall¹, Cerise Johnson¹, Gulnara Mamyrova³, Rodolfo Curiel⁴, Kelly A. Rouster-Stevens⁵, Heinrike Schmeling⁶, Adam Huber⁷, Brian M. Feldman⁸, Ann M Reed⁹, Lauren M. Pachman¹⁰, Soumya Raychaudhuri¹¹, Stephen Eyre¹² and Lucy R Wedderburn¹, ¹Infection, Immunity and Inflammation Programme, UCL Great Ormond Street Institute of Child Health, University College London, United Kingdom, London, United Kingdom, ²Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom, ³Rheumatology, George Washington University School of Medicine and Health Sciences, Washington, DC, ⁴Department of Rheumatology, George Washington University, Washington, DC, ⁵Pediatric Rheumatology, Emory Children's Center, Atlanta, GA, ⁶Alberta Children’s Hospital/University of Calgary, Calgary, AB, Canada, ⁷IWK Health Centre, Halifax, NS, Canada, ⁸Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁹Rheumatology, Duke University, Durham, NC, ¹⁰Cure JM Program of Excellence in Juvenile Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, ¹¹Division of Medicine and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ¹²Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Juvenile dermatomyositis (JDM) is a rare, severe autoimmune disease characterized by muscle weakness and rash. Clinical features of JDM are heterogeneous, and can include…
Abstract Number: 73 • 2016 ACR/ARHP Annual Meeting
Dysregulation of Hypomethylated Age-Related CpG Sites Characterize T-Cells and Monocytes from Treatment Naive Rheumatoid Arthritis Subjects
Ines Colmegna¹, Marie Forest², Aurelie Labbe³, Sasha Bernatsky⁴, Jose Navarro⁵, Tomi Pastinen⁶, Celia Greenwood⁷ and Marie Hudson⁸, ¹Medicine, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ²Jewish General Hospital, Lady Davis Research Institute, Montreal, QC, Canada, ³Epidemiology, Biostatistics & Occupational Health, McGill University, Montreal, QC, Canada, ⁴Division of Rheumatology, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ⁵Experimental Medicine, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ⁶Human Genetics, McGill University, Montreal, QC, Canada, ⁷Centre for Clinical Epidemiology, Jewish General Hospital, Lady Davis Research Institute, Montreal, QC, Canada, ⁸Medicine/Rheumatology, Jewish General Hospital, Lady Davis Research Institute, Montreal, QC, Canada
Background/Purpose: In the general population, an increase in chronological age is associated with differential DNA methylation of particular CpGs in a highly conserved fashion. Since…
Abstract Number: 574 • 2016 ACR/ARHP Annual Meeting
Anti-CCP3.1 and Anti-CCP3-IgA Antibodies Are Associated with Increasing Age in Subjects without Rheumatoid Arthritis
Heather Berens-Norman^1,2, Sonia Khatter³, Wendy M. Kohrt⁴, Catherine Jankowski⁵, Michael Weisman⁶, Michael Mahler⁷, James R. O'Dell⁸, Ted R Mikuls⁸, Richard M. Keating⁹, Jane H. Buckner¹⁰, Peter K. Gregersen¹¹, Jill M. Norris¹², V. Michael Holers¹³, Kevin D. Deane¹³ and M. Kristen Demoruelle¹³, ¹Division of Rheumatology, University of Colorado Denver, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Denver, CO, ³University of Colorado School of Medicine, Aurora, CO, ⁴Geriatric Medicine Division, University of Colorado Denver, Aurora, CO, ⁵University of Colorado College of Nursing, Aurora, CO, ⁶Cedars-Sinai Medical Center, Los Angeles, CA, ⁷Research and Development, Inova Diagnostics, San Diego, CA, ⁸Veteran Affairs Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ⁹Division of Rheumatology, Scripps Health, La Jolla, CA, ¹⁰Benaroya Research Institute at Virginia Mason, Seattle, WA, ¹¹The Feinstein Institute for Medical Research, Manhasset, NY, ¹²Epidemiology, Colorado School of Public Health, Aurora, CO, ¹³Rheumatology Division, University of Colorado Denver, Aurora, CO
Background/Purpose: Serum anti-CCP antibodies are specific for RA in the setting of inflammatory arthritis (IA) and can be elevated for several years prior to the…
Abstract Number: 1538 • 2016 ACR/ARHP Annual Meeting
Lower Ratings of Pain Intensity in Older Adults Lead to Underestimation of Disease Activity By Disease Activity Score 28-C-Reactive Protein (DAS28-CRP) in Patients with Rheumatoid Arthritis
Yong Gil Hwang¹, Juan (June) Feng², Heather Eng², Jason Lyons², Anthony Fabio² and Larry W. Moreland¹, ¹Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ²Epidemiology, University of Pittsburgh, School of Public Health, Pittsburgh, PA
Background/Purpose: To investigate the influence of age on the components of the 28-joint Disease Activity Score (DAS28)-C-reactive protein (CRP) in patients with rheumatoid arthritis…
Abstract Number: 1698 • 2016 ACR/ARHP Annual Meeting
Late Onset Psoriatic Arthritis in a Longitudinal Cohort: Disease Presentation, Activity over Time and Prognosis
Ari Polachek¹, Roa'a Al Johani², Suzanne Li¹, Vinod Chandran¹ and Dafna D Gladman³, ¹Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Medicine, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³University of Toronto, Toronto, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA) often develops between the 3rd to 5th decades of life. However, little is known about PsA activity and prognosis among patients…
Abstract Number: 2132 • 2016 ACR/ARHP Annual Meeting
Deficient Autophagy Induces Premature Senescence in Aging and Osteoarthritis
Beatriz Carames¹, Paloma Lopez de Figueroa¹, Madalena Ribeiro¹, Valentina Calamia², Fernando Osorio³, Carlos Lopez-Otin³ and Francisco J. Blanco^1,4, ¹Cartilage Biology Group. Rheumatology Division, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ²Osteoarticular and Aging Research Lab. Proteomics Unit - Associated Node to ProteoRed, Rheumatology Division, Proteomics Group-ProteoRed/ISCIII, INIBIC-CHUAC, A Coruña, Spain, ³Degradome Lab, Universidad de Oviedo, Oviedo, Spain, ⁴Rheumatology Division, INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), La Coruña, Spain
Background/Purpose: Previous findings indicated that autophagy is defective in Aging and Osteoarthritis (OA). Autophagy is essential to maintain chondrocyte homeostasis by regulating the intracellular macromolecule…
Abstract Number: 2142 • 2016 ACR/ARHP Annual Meeting
Identification of Novel Molecules Targeting Cartilage Aging As Osteoarthritis Therapeutics
Beatriz Carames¹, Uxia Nogueira-Recalde¹, Eduardo Dominguez², Maria I. Loza³ and Francisco J. Blanco^1,4, ¹Cartilage Biology Group. Rheumatology Division, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ²BioFarma Research Group. University of Santiago de Compostela, Santiago de Compostela, Spain, ³BioFarma Research Group. University of Santiago de Compostela, santiago de Compostela, Spain, ⁴Rheumatology Division, INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), La Coruña, Spain
Background/Purpose: Effective treatments for Osteoarthritis (OA) are not available. In aging-related diseases, including OA, failure of cellular homeostasis mechanisms, such as autophagy can cause extracellular…