Abstracts tagged "Aging"

Abstract Number: 1417 • ACR Convergence 2020
Risk of Relapse of ANCA-associated Vasculitis in Patients of 75 Years and Older: A Retrospective Study
Sara Thietart¹, Guillaume Beinse², Perrine Smets³, Alexandre Karras⁴, Carole Philipponnet⁵, Jean-François Augusto⁶, Khalil El Karoui⁷, Rafik Mesbah⁸, Dimitri Titeca Beauport⁹, Mohamed Hamidou¹⁰, Pierre-Louis Carron¹¹, Julien Campagne¹², Karim Sacre¹³, Pascal Cohen¹, Eric Liozon¹⁴, Claire Blanchard-Delaunay¹⁵, Alex Kostianovsky¹⁶, Christian Pagnoux¹⁷, Luc Mouthon¹, Loïc Guillevin¹⁸, Benjamin Terrier¹ and Xavier Puéchal for the French Vasculitis Study Group¹, ¹National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris-Descartes University, Paris, France, ²Inserm UMR 1138, Centre de Recherche des Cordeliers, Paris, France, ³Department of Internal Medicine, Centre Hospitalier Universitaire Clermont-Ferrand Hôpital Gabriel-Montpied, Clermont Ferrand, France, ⁴Department of Nephrology, Hôpital Européen Georges Pompidou, Paris, France, ⁵Department of Nephrology, CHU Clermont-Ferrand, Clermont-Ferrand, Clermont Ferrand, France, ⁶Department of Nephrology-Dialysis-Transplantation, CHU Angers, Angers, France, ⁷Department of Nephrology and Transplantation, Hôpital Universitaire Henri-Mondor, Creteil, France, ⁸Department of Nephrology, CH Boulogne-sur-Mer, Boulogne-Sur-Mer, France, ⁹Department of Nephrology, Amiens University Medical Center, Amiens, France, ¹⁰Department of Internal Medicine, Hôtel-Dieu, CHU Nantes, Nantes, France, ¹¹Department of Nephrology-Dialysis-Transplantation, CHU Grenoble-Alpes, Grenobles, France, ¹²Department of Internal Medicine, Hôpitaux Privés de Metz, Metz, France, ¹³Département de Médecine Interne, Hôpital Bichat, APHP, Paris, France, ¹⁴Department of Internal Medicine and Clinical Immunology, Limoges University Hospital, Limoges, France, ¹⁵Department of Internal Medicine, CH, Niort, France, ¹⁶Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno", Buenos Aeres, Argentina, ¹⁷Vasculitis Clinic, Canadian Network for Research on Vasculitides (CanVasc), Department of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ¹⁸Department of Internal Medecine, National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris-Descartes University, Paris, France
Background/Purpose: ANCA-associated vasculitis (AAV) frequently occurs among older patients, with different clinical presentations than the younger. Little is known on the outcome of older patients…
Abstract Number: 1483 • ACR Convergence 2020
A Randomised Controlled Trial Evaluating the Efficacy of Internet-based Exercises Aimed at Treating Knee Osteoarthritis (iBEAT-OA)
Sameer Gohir¹, Abhishek Abhishek², Anthony Kelly² and Ana M Valdes³, ¹NIHR Nottingham Biomedical Research Centre, GRAYS ESSEX, England, United Kingdom, ²University of Nottingham, Nottingham, United Kingdom, ³NIHR Nottingham Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, England, United Kingdom
Background/Purpose: Osteoarthritis (OA) is the commonest cause of pain and disability in the general population and is usually managed by family doctors and physiotherapists. This…
Abstract Number: 1509 • ACR Convergence 2020
Leukocyte Telomere Length and Childhood Onset of Systemic Lupus Erythematosus in the Black Women’s Experiences Living with Lupus (BeWELL) Study
John Bridges¹, Kara Chung², Connor Martz², Emily Smitherman¹, Cristina Drenkard³, S. Sam Lim⁴ and David Chae², ¹University of Alabama at Birmingham, Birmingham, AL, ²Auburn University, Auburn, AL, ³Division of Rheumatology, Department of Medicine, Emory School of Medicine, Atlanta, GA, ⁴Emory University, Atlanta, GA
Background/Purpose: Childhood-onset SLE is generally more aggressive than adult-onset SLE. Leukocyte telomere length (LTL) has been posited to reflect immune system aging. Short LTL in…
Abstract Number: 1974 • ACR Convergence 2020
Validation of a Deep Learning Based Algorithm to Diagnose Vertebral Compression Fractures
John Page¹, Franklin Moser², Marcel Maya³, Ravi Prasad³ and Barry Pressman², ¹Amgen, Inc, Thousand Oaks, CA, ²Cedars-Sinai Medical Center, Los Angeles, CA, ³Cedars-Sinai Medical Center, Los Angeles
Background/Purpose: Vertebral Compression Fractures are common in patients above age 50, but are often undiagnosed. Patients with one VCF are at higher risk of other…
Abstract Number: 2039 • ACR Convergence 2020
Short Telomeres and Autoantibodies Targeting Telomere-Associated Proteins in Scleroderma
Britany Adler¹, Ami Shah², Francesco Boin³, Paul Wolters³, Livia Casciola-Rosen⁴ and Antony Rosen¹, ¹Johns Hopkins University, baltimore, MD, ²Johns Hopkins University School of Medicine, Ellicott City, MD, ³University of California, San Francisco, San Francisco, CA, ⁴Johns Hopkins University, Johns Hopkins University, MD
Background/Purpose: Scleroderma is a systemic fibrosing disease of unknown etiology that often manifests with interstitial lung disease (ILD). Prior studies have found an association between…
Abstract Number: 0351 • ACR Convergence 2020
Ustekinumab-Treated Patients with Psoriatic Arthritis in a Real-world Study: Similar Clinical Responses and Treatment Persistence over One Year in Elderly and Younger Patients
Laure Gossec¹, Elke Theander², Soumya Chakravarty³, Paul Bergmans⁴, Iris Lin⁵, Wim Noël⁶, Stefan Siebert⁷ and Josef Smolen⁸, ¹Sorbonne Université and Hôpital Universitaire Pitié Salpêtrière, Paris, France, ²Janssen Cilag, Lund, Sweden, ³Janssen Scientific Affairs, LLC, Horsham, PA, USA and Drexel University College of Medicine, Horsham, PA, ⁴Janssen Biostatistics and Medical Affairs, Tilburg, Netherlands, ⁵Janssen Immunology Global Commercial Strategy Organization, Horsham, ⁶Janssen Medical Affairs, LLC, Beerse, Belgium, ⁷University of Glasgow, Glasgow, United Kingdom, ⁸Division of Rheumatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria
Background/Purpose: In the PsABio study (NCT02627768), real-world data from patients with PsA showed comparable clinical results after treatment with ustekinumab (UST, an anti-p40 IL-12/23 inhibitor)…
Abstract Number: 0422 • ACR Convergence 2020
Frailty and Health-Related Quality of Life in Patients with Polymyalgia Rheumatica
Sebastian Sattui¹, Deanna Jannat-Khah², Lindsay Lally¹, Sarah Lieber¹, Lisa Mandl¹ and Robert Spiera³, ¹Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, New York City, NY, ³Division of Rheumatology, Hospital for Special Surgery, New York, New York, USA, New York, NY
Background/Purpose: Frailty is a syndrome characterized by an increased vulnerability to stressors. Frailty and pre-frailty have been reported in 10% and 44%of community dwelling elderly,…
Abstract Number: 0612 • ACR Convergence 2020
Differences in 30-Day Rehospitalization Risk and Predictors by Age Group Among Patients with Lupus in Medicare
Maria Schletzbaum¹, Yi Chen², Ann Sheehy³, Farah Kaiksow³, Ryan Powell⁴, Andrea Gilmore-Bykovskyi⁵, Amy Kind⁶ and Christie Bartels⁷, ¹University of Wisconsin-Madison School of Medicine and Public Health, Department of Population Health Sciences, Madison, WI, ²University of Wisconsin School of Medicine and Public Health, Department of Biostatistics and Medical Informatics, Madison, WI, ³University of Wisconsin School of Medicine and Public Health, Department of Medicine, Hospital Medicine Division, Madison, WI, ⁴University of Wisconsin School of Medicine and Public Health, Department of Medicine, Geriatrics Division, Madison, WI, ⁵University of Wisconsin - Madison, School of Nursing, Madison, WI, ⁶University of Wisconsin-Madison School of Medicine and Public Health, Department of Medicine, Health Services and Care Research Program, Geriatrics Division, Madison, WI, ⁷University of Wisconsin School of Medicine and Public Health, Department of Medicine, Division of Rheumatology, Madison, WI
Background/Purpose: Although our recent research demonstrates that young adult Medicare beneficiaries (age 18-35) with lupus (SLE) have higher risk of 30-day rehospitalization, predictors specific to…
Abstract Number: 0624 • ACR Convergence 2020
Association of Regional Body Composition and Physical Function Using the Short Physical Performance Battery Among Peruvian Women with HIV
Diego Cabrera¹, Mijahil Pavel Cornejo Ortega², Yvett Pinedo³, Patricia Garcia⁴ and Evelyn Hsieh⁵, ¹Yale University, Universidad Peruana Cayetano Heredia, Lima, Peru, ²Hospital Nacional Arzobispo Loayza, Lima, Peru, ³Hospital Nacional Arzobispo Loayza, Lima, ⁴Universidad Peruana Cayetano Heredia, Lima, Peru, ⁵Yale University School of Medicine; West Haven VA, New Haven, CT
Background/Purpose: The musculoskeletal (MSK) system is significantly affected by HIV and its treatment. Changes in body composition can reflect important changes in bone and MSK…
Abstract Number: 0693 • ACR Convergence 2020
Effect of Physical Activity on Cartilage Degradation and Inflammation in Individuals with Lumbar Spinal Stenosis
Gustavo Almeida¹, Samannaaz Khoja², Lauren Terhorst³, Gwendolyn Sowa⁴, Sara Piva² and Michael Schneider², ¹Department of Physical Therapy, UT HEALTH SAN ANTONIO, San Antonio, TX, ²Department of Physical Therapy, University of Pittsburgh, Pittsburgh, PA, ³Department of Occupational Therapy, University of Pittsburgh, Pittsburgh, PA, ⁴Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Guidelines recommend 150 minutes a week in moderate-intensity physical activity (MPA) to improve health in individuals with chronic disease such as those with lumbar…
Abstract Number: 0694 • ACR Convergence 2020
Relationships Among Adherence and Patient Outcomes in a Cognitive Behavioral Plus Physical Activity Intervention for Older Adults with Osteoarthritis and Hypertension
Xiaojun Shi¹, Elizabeth Schlenk² and Susan Sereika¹, ¹University of Pittsburgh School of Nursing, Pittsburgh, ²University of Pittsburgh School of Nursing, Pittsburgh, PA
Background/Purpose: Osteoarthritis of the knee (OAK) affects nearly 14 million older adults and more than half are diagnosed with hypertension (HTN). Cognitive behavior therapy (CBT)…
Abstract Number: 0709 • ACR Convergence 2020
Anatomical Distribution of Mrgprd-expressing Nonpeptidergic C-fibers in the Mouse Knee
Alia Obeidat¹, Rachel Miller¹ and Anne-Marie Malfait¹, ¹Rush University, CHICAGO, IL
Background/Purpose: The voltage-gated sodium channel, NaV1.8, marks the majority of C-fiber nociceptors. We have used NaV1.8 tdTomato reporter mice to describe the nociceptive innervation of…
Abstract Number: 0807 • ACR Convergence 2020
Safety of Biologic & Targeted Therapies Among Elderly Patients with Rheumatoid Arthritis: A Systematic Review and Meta-analysis
Akhil Sood¹, Soham Al Snih¹, Vijaya Murthy², Emilio Gonzalez¹ and Mukaila Raji¹, ¹University of Texas Medical Branch, Galveston, TX, ²University of Texas Medical Branch, League City, TX
Background/Purpose: Recent developments in biologic and targeted therapy have led to better control of disease activity and improved quality of life in patients with rheumatoid…
Abstract Number: 1298 • ACR Convergence 2020
Lupus Damage Free-Survival by Age at Diagnosis: A Retrospective Incident Lupus Cohort
Maria Schletzbaum¹, Nnenna Ezeh², Trevor McKown³, Shivani Garg⁴ and Christie Bartels⁵, ¹University of Wisconsin-Madison School of Medicine and Public Health, Department of Population Health Sciences, Madison, WI, ²University of Wisconsin School of Medicine and Public Health, Milwaukee, WI, ³William S. Middleton Memorial Veterans Hospital, Madison, WI, ⁴UW Madison, Madison, WI, ⁵University of Wisconsin School of Medicine and Public Health, Department of Medicine, Division of Rheumatology, Madison, WI
Background/Purpose: While medical comorbidities increase with age, younger age at onset of Systemic Lupus Erythematosus (SLE) has been associated with greater risk of some types…
Abstract Number: 1325 • ACR Convergence 2020
Monoclonal Gammopathy in Psoriatic Arthritis
Vanessa Ocampo¹ and Dafna Gladman², ¹University of Toronto, University Health Network, Psoriatic Arthritis Research Program, Toronto, Canada, ²Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic premalignant clonal plasma disorder, defined by the presence of a serum monoclonal protein (M-protein) at…

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