ACR Meeting Abstracts

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Abstracts tagged "Aging"

  • Abstract Number: 1592 • ACR Convergence 2023

    Memantine Attenuates the Development of Osteoarthritis by Blocking NMDA Receptor Mediated Calcium Overload and Chondrocyte Senescence

    Ning Wang1, Qingmei Cheng1, Xiaoxiao Li2, ke he1, Junyu Zhu1, Hui Li3 and Jie Wei4, 1中南大学湘雅医院, Changsha, China, 2Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China, 3Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China, 4Health Management Center, Xiangya Hospital Central South University, Changsha, China

    Background/Purpose: Memantine is an FDA proved drug utilized for the treatment of dementia and exerts its function by blocking the NMDA (N-methyl-D-aspartate) receptor, a calcium…
  • Abstract Number: 1628 • ACR Convergence 2023

    The Impact of Cardiovascular and Cerebrovascular Disease on the Risk of Dementia in Rheumatoid Arthritis. a Mediation Analysis

    Edward Lovering1, Chanakya Kodishala2, Rakesh Kumar1, Cynthia Crowson1, Ryan Lennon1, John Davis1 and Elena Myasoedova1, 1Mayo Clinic, Rochester, MN, 2Mayo Clinic Rochester Minnesota, Rochester, MN

    Background/Purpose: Alzheimer's disease and related dementias have an immense disease burden, with predicted continuous increase in incidence and prevalence. Systemic inflammation plays a major role…
  • Abstract Number: 009 • 2023 Pediatric Rheumatology Symposium

    The Bridge to Adult Care from Childhood for Young Adults with Rheumatic Disease (BACC YARD) Program, a Pediatric-to-Adult Rheumatology Transition Program

    John Bridges1, Livie Huie2, Amanda Alexander2, Randy Cron2, Maria I. ("Maio") Danila3, Victoria Gennaro4, Laura Hughes2, Bailey Lipham5, Linda McAllister4, Matthew Mullen2, Annelle Reed6, Daniel Reiff2, Carolyn Smith6, Emily Smitherman2, Matthew Stoll2, Peter Weiser2 and Melissa Mannion2, 1University of Alabama at Birmingham/Children's of Alabama, Birmingham, AL, 2University of Alabama at Birmingham, Birmingham, AL, 3University of Alabama at Birmingham (UAB), Birmingham VA Medical Center, Birmingham, AL, 4Children's of Alabama, Birmingham, AL, 5University of Alabama Medical School, Birmingham, AL, 6Children's of Alabama, Birmingham, AL

    Background/Purpose: Children with chronic rheumatic conditions age and require transfer to adult rheumatologists for continued care. The transition period from pediatric to adult-oriented care is…
  • Abstract Number: 0268 • ACR Convergence 2022

    Risks of Mortality in Elderly-onset Rheumatoid Arthritis: Analysis from the TRA Clinical Electronic Registry

    Ching-Tsai Lin1, Wen-Nan Huang1, Yi-Hsin Chen2 and Yi-Ming Chen3, 1Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, 2Taichung Veterans General Hospital, Taichung, Taiwan, 3Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan

    Background/Purpose: Patients with rheumatoid arthritis (RA) were associated with increased mortality rate. Our study aimed to investigate the risk factors associated with all causes of…
  • Abstract Number: 0281 • ACR Convergence 2022

    Clinical Outcomes of Filgotinib in Patients with RA Aged ≥65 Years: A Post Hoc Subgroup Analysis of Phase 2 and 3 Clinical Trials and Ongoing Long-Term Extensions

    Maya Buch1, BERNARD COMBE2, Jose A Gomez-Puerta3, Roberto Felice Caporali4, jacques-eric gottenberg5, Paul Van Hoek6, Vijay Rajendran7, Pieter-Jan Stiers6, Katrien Van Beneden6, Daniel Aletaha8, Gerd Burmester9, Rene Westhovens10 and Yoshiya Tanaka11, 1University of Manchester and NIHR Manchester Biomedical Research Centre, Manchester, United Kingdom, 2Montpellier University, Montpellier, France, 3Hospital Clínic de Barcelona, Barcelona, Spain, 4University of Milan, Milano, Italy, 5Strasbourg University Hospital, Strasbourg, France, 6Galapagos NV, Mechelen, Belgium, 7Galapagos NV, Gent, Belgium, 8Medical University Vienna, Wien, Austria, 9Charité University Medicine Berlin, Berlin, Germany, 10University Hospitals Leuven, Leuven, Belgium, 11University of Occupational and Environmental Health, Kitakyusyu Fukuoka, Japan

    Background/Purpose: Filgotinib (FIL) is a Janus kinase 1 preferential inhibitor approved for the treatment of moderate to severe active RA.1 It was previously reported that…
  • Abstract Number: 0529 • ACR Convergence 2022

    Complex Relationships Between Inflammation and Clonal Hematopoiesis in Systemic Vasculitis

    Adrianna Jones1, Kristina Wells1, Fernanda Gutierrez-Rodrigues2, Cameron Rankin3, Wanxia Tsai3, Bhavisha Patel4, Kaitlin Quinn1, Dalton Hironaka2, Massimo Gadina5, Keith Sikora1, Neal Young2 and Peter Grayson6, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 2National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, 3NIAMS/NIH, Bethesda, MD, 4National Institutes of Health, Beltsville, MD, 5Translational Immunology Section, NIAMS, NIH, Bethesda, MD, 6National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD

    Background/Purpose: Clonal hematopoiesis of indeterminate potential (CHIP) is defined by somatic mutations in a set of genes commonly associated with myeloid neoplasms in an otherwise…
  • Abstract Number: 0574 • ACR Convergence 2022

    Osteoporosis in Elderly Men; An Underestimated and Underdiagnosed Morbid Entity

    Arash Mollaeian1 and Stanley Ballou2, 1Metro Health Medical Center/Case Western Reserve University, Rocky River, OH, 2Case Western Reserve University - Metro Health, Cleveland, OH

    Background/Purpose: 20-25% of osteoporosis-related fractures occur in men and the mortality of osteoporotic fractures is higher in men [1]. Nevertheless, no uniform consensus exists for…
  • Abstract Number: 0734 • ACR Convergence 2022

    Comfort Levels and Practice Patterns for Osteoporosis-Related Care Among Persons Living with HIV in Peru: A National Physician Survey

    Rebecca Slotkin1, Camila Lucero Granda Calderón2, Diego Cabrera3, Carlos Manuel Benites Villafane4, Patricia Jannet Garcia5 and Evelyn Hsieh3, 1Yale University School of Public Health, New Haven, CT, 2Facultad de Medicina Alberto Hurtado de la Universidad Peruana Cayetano Heredia, Lima, Peru, 3Section of Rheumatology, Allergy and Immunology, Yale School of Medicine, New Haven, CT, 4Ministerio de Salud, Lima, Peru, 5Epidemiology, STD, and HIV Unit, School of Public Health, Universidad Peruana Cayetano Heredia, Lima, Peru

    Background/Purpose: As they age, persons living with HIV (PLWH) are at increased risk for osteoporosis due to chronic infection and antiretroviral therapies (ART). In Peru,…
  • Abstract Number: 0837 • ACR Convergence 2022

    Providers’ Adoption of 2017 Guidelines on DMARD Use Perioperatively for Elective Total Hip and Knee Arthroplasty at a Single Academic Center

    Chris Ching1, Erica Mulcaire-Jones2, Andrew Shaffer1, Jeremy Gililland1, Michael Battistone3 and Dorota Lebiedz-Odrobina1, 1University of Utah, Salt Lake City, UT, 2Intermountain Healthcare, Salt Lake City, UT, 3Salt Lake City VA, Salt Lake City, UT

    Background/Purpose: Rate of prosthetic joint infection (PJI) after total joint arthroplasty (TJA) is higher in patients with rheumatic conditions than in patients with OA. Our…
  • Abstract Number: 1196 • ACR Convergence 2022

    Interaction of Cumulative Inflammation with Smoking and Lipids in Risk Modification of Dementia Among Patients with Rheumatoid Arthritis: A Population-based Cohort Study

    Chanakya Kodishala1, Stephanie Duong2, Cassondra Hulshizer2, Ryan Lennon2, Rabia Javed2, Maria Vassilaki2, Michelle Mielke3, John Davis2, Cynthia Crowson4 and Elena Myasoedova2, 1Mayo Clinic Rochester Minnesota, Rochester, MN, 2Mayo Clinic, Rochester, MN, 3Wake Forest University School of Medicine, Winston-Salem, NC, 4Mayo Clinic, Eyota, MN

    Background/Purpose: Patients with rheumatoid arthritis (RA) have increased risk of developing dementia. Systemic inflammation is implicated in the pathogenesis of cognitive decline. However, the association…
  • Abstract Number: 1327 • ACR Convergence 2022

    Immune Cell Subsets and Risk of Incident Hip Fracture in Older Adults: The Cardiovascular Health Study

    Rachel Elam1, Petra Buzkova2, Joseph Delaney3, Howard Fink4, Joshua Barzilay5, Laura Carbone1, Rick Saha1, John Robbins6, Kenneth Mukamal7, Rodrigo Valderrabano8, Bruce Psaty2, Russell Tracy9, Nels Olson9, Sally Huber10, Margaret Doyle9, Alan Landay11 and Jane Cauley12, 1Augusta University, Augusta, GA, 2University of Washington, Seattle, WA, 3University of Manitoba, Winnipeg, MB, Canada, 4University of Minnesota, Minneapolis, MN, 5Kaiser Permanente, Atlanta, GA, 6UC Davis, Davis, CA, 7Beth Israel Deaconess Medical Center, Boston, MA, 8Brigham and Women's Hospital, Boston, MA, 9University of Vermont, Burlington, VT, 10University of Vermont, Burlingon, VT, 11Rush University Medical Center, Chicago, IL, 12University of Pittsburgh, PIttsburgh, PA

    Background/Purpose: Cell-mediated immunity may play a role in osteoporosis development. Fracture is the major consequence of osteoporosis. Thus, cell-mediated immunity may impact fracture risk. We…
  • Abstract Number: 1396 • ACR Convergence 2022

    Risk of Hospitalized Infections in Older Elderly Rheumatoid Arthritis Patients Treated with Biological/Targeted Synthetic DMARDs: Evaluation Using Data from a Japanese Claims Database

    Masayoshi Harigai1, Takao Fujii2, Ryoko Sakai3, Ataru Igarashi4, Ayako Shoji5, Hiroko Yamaguchi6, Katsuhiko Iwasaki6, Misako Makishima7, Amika Yoshida7, Norihiro Okada7, Katsuhisa Yamashita7 and Yutaka Kawahito8, 1Division of Rheumatology, Department of Internal Medicine, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan, 2Department of Rheumatology and Clinical Immunology, Wakayama Medical University, Wakayama, Japan, 3Department of Public Health and Epidemiology, Meiji Pharmaceutical University, Tokyo, Japan, 4Department of Health Economics & Outcomes Research, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan; Unit of Public Health and Preventive Medicine, Yokohama City University of Medicine, Kanagawa, Japan, 5Medilead Inc., Tokyo, Japan; Department of Health Economics and Outcomes Research, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan; Healthcare Consulting Inc., Tokyo, Japan, Shinjuku-ku, Japan, 6Medilead Inc., Tokyo, Japan, Shinjuku-ku, Japan, 7Chugai Pharmaceutical Co., Ltd., Chuo-ku, Tokyo, Japan, 8Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan, Kyoto, Kyoto, Japan

    Background/Purpose: Safety evidence of biological or targeted synthetic DMARDs (b/tsDMARDs) is still insufficient in older elderly ( >=75 years old (y/o)) patients with rheumatoid arthritis…
  • Abstract Number: 1460 • ACR Convergence 2022

    Neuropsychiatric Lupus in Late and Early Onset Systemic Lupus Erythematosus Patients: A Systemic Review and Meta-analysis

    Omer Pamuk1, Saja Ali2 and Sarfaraz Hasni2, 1NIH/NIAMS, Bethesda, MD, 2NIAMS/NIH, Bethesda, MD

    Background/Purpose: The diagnosis of neuropsychiatric lupus (NPSLE) is challenging due to its variegated presentation, absence of diagnostic biomarkers and radiological imaging. The NPSLE is further…
  • Abstract Number: 1481 • ACR Convergence 2022

    Dementia in Adults with Systemic Lupus Erythematosus 65 Years of Age and Above: A National Administrative Claims Data Analysis

    Sarah Lieber1, Musarrat Nahid2, Iris Navarro-Millan2, Mangala Rajan2, Sebastian Sattui3, Robyn Lipschultz1, M. Carrington Reid2 and Lisa Mandl1, 1Hospital for Special Surgery, New York, NY, 2Weill Cornell Medicine, New York, NY, 3University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Systemic lupus erythematosus (SLE) has been associated with increased risk of dementia relative to age-matched comparators without systemic rheumatic disease (SRD) in non-US-based samples…
  • Abstract Number: 0008 • ACR Convergence 2022

    CD11c+ T-Bet+ B Cells Traffic to Human Bone Marrow

    Jennifer Barnas1, Diana Alzamareh2, Nida Meednu2 and Jennifer Anolik2, 1University of Rochester, Rochester, NY, 2University of Rochester Medical Center, Rochester, NY

    Background/Purpose: CD11c+ age/autoimmunity-associated B cells (ABC) are associated with autoantibody producing cells and disease flare in systemic lupus erythematosus. ABC were initially identified in aged…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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