Abstract Number: 1737 • 2014 ACR/ARHP Annual Meeting
Altered Phenotype and Function of Senescent Regulatory T Cells in Rheumatoid Arthritis
Background/Purpose Immunosenescence accompanied by accumulation of senescent T cells is a hallmark feature in the pathogenesis of rheumatoid arthritis (RA). Here we characterize a novel senescent…Abstract Number: 1379 • 2014 ACR/ARHP Annual Meeting
Studies on Ageing and the Severity of Radiographic Joint Damage in Rheumatoid Arthritis
Background/Purpose: The Western population is getting older; consequently the proportion of elderly persons presenting with Rheumatoid Arthritis (RA) is increasing. We studied whether age is…Abstract Number: 1220 • 2014 ACR/ARHP Annual Meeting
Higher Inflammatory Response in Elderly Patients during Gout Attack
Higher inflammatory response in elderly patients during gout attack Background/Purpose Clinical experiences suggest that gout attacks in elderly patients are accompanied by stronger systemic inflammatory…Abstract Number: 757 • 2014 ACR/ARHP Annual Meeting
Distinctive Patterns of Telomere Shortening and Apoptosis in Limited and Diffuse cutaneous Systemic Sclerosis
Background/Purpose: Aberrant telomere shortening and DNA damage-responses have been previously described in SSc, here we aim to validate these observations and incorporate them in a…Abstract Number: 221 • 2014 ACR/ARHP Annual Meeting
An Analysis of Age-Related Loss of Skeletal Muscle Mass and Its Significance on Osteoarthritis in a Korean Population
Background/Purpose This study was conducted in order to analyze the effects of sarcopenia and sarcopenic obesity on age-related OA of the knee in a Korean…Abstract Number: 191 • 2014 ACR/ARHP Annual Meeting
Utilization and Outcomes Following Total Shoulder Arthroplasty in Elderly and Non-Elderly Patients
Background/Purpose: To assess the age-related differences in total shoulder arthroplasty (TSA) outcomes and utilization and associated time-trends.Methods: Nationwide Inpatient Sample (NIS) from 1998-2010 was used…Abstract Number: 44 • 2014 ACR/ARHP Annual Meeting
Physical Function, Hyperuricemia and Gout in Older Adults
Background/Purpose: The prevalence of gout is higher in older adults than in younger adults and these patients are at risk of physical disability. We sought…Abstract Number: 45 • 2014 ACR/ARHP Annual Meeting
Body Mass Index Across the Lifespan and Lifetime Incidence of Gout in Men
Background/Purpose: Gout is the leading cause of inflammatory arthritis in men and is linked to higher levels of body weight and obesity in mid-adult life.…Abstract Number: 2949 • 2014 ACR/ARHP Annual Meeting
Activation of AMP-Activated Protein Kinase (AMPK) By Berberine Limits Both Surgical Knee Instability-Induced and Aging-Related Osteoarthritis in Mice
Background/Purpose Human knee OA articular cartilage chondrocytes and aged mouse knee cartilage chondrocytes demonstrate decreased activation of master cellular energy bio-sensor AMPK. Moreover, inflammatory stimuli…Abstract Number: 2909 • 2013 ACR/ARHP Annual Meeting
2010 Medical Care Expenditures Among US Adults With Arthritis
Background/Purpose: Using data from the 2010 Medical Expenditure Panel Survey (MEPS), we estimated total and arthritis-attributable medical care expenditures among US adults age 18 years…Abstract Number: 2854 • 2013 ACR/ARHP Annual Meeting
Restricting Back Pain and Subsequent Mobility Disability In Community-Living Older Persons
Background/Purpose: Although back pain is common and costly, few longitudinal studies have evaluated the association between back pain, severe enough to restrict activity (hereafter referred…Abstract Number: 2710 • 2013 ACR/ARHP Annual Meeting
Deficiency Of The Protein Kinase Ataxia Telangiectasia Mutated Accelerates T Cell Aging In Rheumatoid Arthritis
Background/Purpose: T lymphocytes hold a pinnacle position in the pathogenesis of rheumatoid arthritis (RA) and through their longevity contribute to disease chronicity. The protein kinase…Abstract Number: 2331 • 2013 ACR/ARHP Annual Meeting
Efficacy and Safety Of Tofacitinib In Older and Younger Patients With Rheumatoid Arthritis
Background/Purpose: Tofacitinib is a novel, oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). The clinical development program for tofacitinib in RA enrolled ˃500…Abstract Number: 2162 • 2013 ACR/ARHP Annual Meeting
Physical, Psychological, and Social Impacts Of Restricting Back Pain: The Older Person’s Perspective
Background/Purpose: Although back pain is the most common type of pain reported by older adults, we have a limited understanding of its impact on the…Abstract Number: 1787 • 2013 ACR/ARHP Annual Meeting
Does Age At Disease Onset Influence Disease Activity and Function In Rheumatoid Arthritis Patients? Results From The Ontario Best Practices Research Initiative (OBRI) Registry
Background/Purpose: The population of elderly individuals with rheumatoid arthritis (RA) is increasing. The aim of this study was to assess whether age at disease onset…