ACR Meeting Abstracts

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Abstracts tagged "Aging"

  • Abstract Number: 1737 • 2014 ACR/ARHP Annual Meeting

    Altered Phenotype and Function of Senescent Regulatory T Cells in Rheumatoid Arthritis

    Johannes Fessler1, Chrsitine Schwarz1, Anja C. Ficjan1, Rusmir Husic2, Evelyne Höller3, Angelika Lackner1, Winfried B. Graninger4 and Christian Dejaco1,5, 1Rheumatology and Immunology, Medical University Graz, Graz, Austria, 2Rheumatology, Medical University Graz, Graz, Austria, 3Endocrinology, Medical University Graz, Graz, Austria, 4Internal medicine/Rheumatology and Immunology, Medical University Graz, Graz, Austria, 5Department of Rheumatology and Immunology, Medical University Graz, Graz A-8036, Austria

    Background/Purpose Immunosenescence accompanied by accumulation of senescent T cells  is a hallmark feature in the pathogenesis of rheumatoid arthritis (RA). Here we characterize a novel senescent…
  • Abstract Number: 1379 • 2014 ACR/ARHP Annual Meeting

    Studies on Ageing and the Severity of Radiographic Joint Damage in Rheumatoid Arthritis

    L. Mangnus1, H.W. van Steenbergen1, E. Brouwer2, E. Lindqvist3, M. Reijnierse4, P.K. Gregersen5, S. M. Rantapää-Dahlqvist6, D. M. van der Heijde1 and A. H. M. van der Helm- van Mil1, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Dept. of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 3Rheumatology, Lund University, Lund, Sweden, 4Radiology, Leiden University Medical Center, Leiden, Netherlands, 5The Feinstein Institute for Medical Research, Manhasset, NY, 6Department for Public Health and Clinical Medicine/ Rheumatology, Umeå University, Umeå, Sweden

    Background/Purpose: The Western population is getting older; consequently the proportion of elderly persons presenting with Rheumatoid Arthritis (RA) is increasing. We studied whether age is…
  • Abstract Number: 1220 • 2014 ACR/ARHP Annual Meeting

    Higher Inflammatory Response in Elderly Patients during Gout Attack

    Ji Ae Yang1, Jae Hyun Lee1, Eun Young Lee2, Eun Bong Lee1, Yeong Wook Song3 and Jin Kyun Park1, 1Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, 2Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, 3Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea

    Higher inflammatory response in elderly patients during gout attack Background/Purpose Clinical experiences suggest that gout attacks in elderly patients are accompanied by stronger systemic inflammatory…
  • Abstract Number: 757 • 2014 ACR/ARHP Annual Meeting

    Distinctive Patterns of Telomere Shortening and Apoptosis in Limited and Diffuse cutaneous  Systemic Sclerosis

    Jasper Broen1, Liane McGlynn2, Dagmara McGuinness2, Rina Wichers3, Jacqueline Thomson2, Rajan Madhok4, Robert Lafyatis5, Carol A. Feghali-Bostwick6, Paul Shiels2 and T.R.D.J. Radstake1, 1Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2University of Glasgow, Glasgow, United Kingdom, 3UMC Utrecht, Utrecht, Netherlands, 4Glasgow Royal Infirmary, Glasgow, United Kingdom, 5Arthritis Center, Boston University, Boston, MA, 6Medicine, Medical University of South Carolina, Charleston, SC

    Background/Purpose: Aberrant telomere shortening and DNA damage-responses have been previously described in SSc, here we aim to validate these observations and incorporate them in a…
  • Abstract Number: 221 • 2014 ACR/ARHP Annual Meeting

    An Analysis of Age-Related Loss of Skeletal Muscle Mass and Its Significance on Osteoarthritis in a Korean Population

    Hyunje Kim1, Minjung Kim1, Choong Ki Lee2 and Young Hoon Hong3, 1Internal medicine, School of medicine, Yeungnam University, Daegu, South Korea, 2Internal medicine, school of medicine, Yeungnam University, Daegu, South Korea, 3Department of Internal medicine, School of Medicine,, Yeungnam University, Daegu, South Korea

    Background/Purpose This study was conducted in order to analyze the effects of sarcopenia and sarcopenic obesity on age-related OA of the knee in a Korean…
  • Abstract Number: 191 • 2014 ACR/ARHP Annual Meeting

    Utilization and Outcomes Following Total Shoulder Arthroplasty in Elderly and Non-Elderly Patients

    Jasvinder A. Singh1 and Rekha Ramachandaran2, 1University of Alabama and VA Medical Center, Birmingham, AL, 2University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: To assess the age-related differences in total shoulder arthroplasty (TSA) outcomes and utilization and associated time-trends.Methods: Nationwide Inpatient Sample (NIS) from 1998-2010 was used…
  • Abstract Number: 44 • 2014 ACR/ARHP Annual Meeting

    Physical Function, Hyperuricemia and Gout in Older Adults

    Mara McAdams-DeMarco1, Bridget Burke2, Andrew Law3, Anna Kottgen4, Alan N. Baer5 and Josef Coresh1, 1Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 2Johns Hopkins University, Baltimore, MD, 3Epidemiology, Johns Hopkins, Baltimore, MD, 4Renal Division, University Hospital Freiburg, Freiburg, Germany, 5Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: The prevalence of gout is higher in older adults than in younger adults and these patients are at risk of physical disability. We sought…
  • Abstract Number: 45 • 2014 ACR/ARHP Annual Meeting

    Body Mass Index Across the Lifespan and Lifetime Incidence of Gout in Men

    Allan C. Gelber1, Lucy Meoni2, Michael Klag2 and Joseph Gallo2, 1Medicine/ Rheumatology, Johns Hopkins University, Baltimore, MD, 2Medicine, Johns Hopkins University, Baltimore, MD

    Background/Purpose: Gout is the leading cause of inflammatory arthritis in men and is linked to higher levels of body weight and obesity in mid-adult life.…
  • Abstract Number: 2949 • 2014 ACR/ARHP Annual Meeting

    Activation of AMP-Activated Protein Kinase (AMPK) By Berberine Limits Both Surgical Knee Instability-Induced and Aging-Related Osteoarthritis in Mice

    Ru Bryan1, Xianling Zhao2, Yun Wang3, Han Sol Lee2, Hyunje Kim4, Alifah Akasdi2 and Robert Terkeltaub5, 1Medicine-Rheumatology, VA Medical Center/University of California San Diego, San Diego, CA, 2VAMC, San Diego, CA, 3Medicine-Rheumatology, VA Medical Ctr/UCSD, San Diego, CA, 4Internal medicine, School of medicine, Yeungnam University, Daegu, South Korea, 5Medicine-Rheumatology, VA Medical Ctr/University of California San Diego, San Diego, CA

    Background/Purpose Human knee OA articular cartilage chondrocytes and aged mouse knee cartilage chondrocytes demonstrate decreased activation of master cellular energy bio-sensor AMPK. Moreover, inflammatory stimuli…
  • Abstract Number: 2909 • 2013 ACR/ARHP Annual Meeting

    2010 Medical Care Expenditures Among US Adults With Arthritis

    Miriam Cisternas1, Louise Murphy2, David Pasta3, Edward H. Yelin4 and Charles G. Helmick5, 1MGC Data Services, Carlsbad, CA, 2Division of Population Health, CDC, Atlanta, GA, 3DMA Corporation, Palo Alto, CA, 4Medicine, UC San Francisco, San Francisco, CA, 5National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA

    Background/Purpose: Using data from the 2010 Medical Expenditure Panel Survey (MEPS), we estimated total and arthritis-attributable medical care expenditures among US adults age 18 years…
  • Abstract Number: 2854 • 2013 ACR/ARHP Annual Meeting

    Restricting Back Pain and Subsequent Mobility Disability In Community-Living Older Persons

    Una E. Makris1, Liana Fraenkel2, Ling Han3, Linda Leo-Summers3 and Thomas M. Gill4, 1Rheumatology, UT Southwestern Medical Center, VA Medical Center, Dallas, TX, 2Medicine, Section of Rheumatology, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, New Haven, CT, 3Internal Medicine, Department of Medicine, New Haven, CT, 4Internal Medicine, Section of Geriatrics, Yale University, New Haven, CT

    Background/Purpose: Although back pain is common and costly, few longitudinal studies have evaluated the association between back pain, severe enough to restrict activity (hereafter referred…
  • Abstract Number: 2710 • 2013 ACR/ARHP Annual Meeting

    Deficiency Of The Protein Kinase Ataxia Telangiectasia Mutated Accelerates T Cell Aging In Rheumatoid Arthritis

    Zhen Yang1, Hiroshi Fujii2, Eric L. Matteson3, Jorg J. Goronzy1 and Cornelia M. Weyand4, 1Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, 2Department of Hematology and Rheumatology, Tohoku University, Sendai, Japan, 3Rheumatology, Mayo Clinic, Rochester, MN, 4Medicine, Stanford University School of Medicine, Stanford, CA

    Background/Purpose: T lymphocytes hold a pinnacle position in the pathogenesis of rheumatoid arthritis (RA) and through their longevity contribute to disease chronicity. The protein kinase…
  • Abstract Number: 2331 • 2013 ACR/ARHP Annual Meeting

    Efficacy and Safety Of Tofacitinib In Older and Younger Patients With Rheumatoid Arthritis

    J. R. Curtis1, H. Schulze-Koops2, L Takiya3, C. A. Mebus4, K. Terry4, R. Chew4 and T. V. Jones3, 1Rheumatology & Immunology, University of Alabama at Birmingham, Birmingham, AL, 2University of Munich, Munich, Germany, 3Pfizer Inc, Collegeville, PA, 4Pfizer Inc, Groton, CT

    Background/Purpose: Tofacitinib is a novel, oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). The clinical development program for tofacitinib in RA enrolled ˃500…
  • Abstract Number: 2162 • 2013 ACR/ARHP Annual Meeting

    Physical, Psychological, and Social Impacts Of Restricting Back Pain: The Older Person’s Perspective

    Una E. Makris1, Trisha V. Melhado2, Simon C. Lee3, Heidi A. Hamann2, Lisa M. Walke4, Thomas M. Gill4 and Liana Fraenkel5, 1Rheumatology, UT Southwestern Medical Center, VA Medical Center, Dallas, TX, 2Clinical Sciences, UT Southwestern Medical Center, Dallas, TX, 3UT Southwestern Medical Center, Dallas, TX, 4Internal Medicine, Section of Geriatrics, Yale University, New Haven, CT, 5Medicine, Section of Rheumatology, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, New Haven, CT

    Background/Purpose: Although back pain is the most common type of pain reported by older adults, we have a limited understanding of its impact on the…
  • Abstract Number: 1787 • 2013 ACR/ARHP Annual Meeting

    Does Age At Disease Onset Influence Disease Activity and Function In Rheumatoid Arthritis Patients? Results From The Ontario Best Practices Research Initiative (OBRI) Registry

    Thanu Nadarajah1, Binu Jacob2, Pooneh Akhavan3, Bindee Kuriya4, Edward C. Keystone5 and Claire Bombardier6, 1Department of Medicine, University of Toronto, Toronto, ON, Canada, 2University Health Network, Toronto General Research Institute, Toronto, ON, Canada, 3Medicine, Mount Sinai Hospital/University of Toronto, Toronto, ON, Canada, 4Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 5Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 6Rheumatology, University of Toronto, Toronto, ON, Canada

    Background/Purpose: The population of elderly individuals with rheumatoid arthritis (RA) is increasing. The aim of this study was to assess whether age at disease onset…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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