ACR Meeting Abstracts

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Abstracts tagged "ACPA"

  • Abstract Number: 1470 • 2018 ACR/ARHP Annual Meeting

    Russell Bodies and Serological Status in Rheumatoid Arthritis

    Michael A. McNamara1, Susan M. Goodman2, Laura T. Donlin3, Dana Orange4, Serene Z. Mirza1, Jackie Szymonifka2, Mark P. Figgie5, Vivian P. Bykerk2 and Edward F. DiCarlo6, 1Rheumatology, Hospital for Special Surgery, New York, NY, 2Hospital for Special Surgery, New York, NY, 3Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, 4Rockefeller University, New York, NY, 5Surgery, Hospital for Special Surgery, New York, NY, 6Laboratory Medicine, Hospital for Special Surgery, New York, NY

    Russell Bodies and Serological Status in Rheumatoid Arthritis Background/Purpose: Russell bodies (RBs) are globular aggregates of immunoglobulin produced by plasma cells and identified both within…
  • Abstract Number: 11 • 2018 ACR/ARHP Annual Meeting

    PAD4-Independent Interaction of ACPA with Nuclear Antigens in Apoptotic Cells and Neutrophil Extracellular Traps (NETs) Defines a Subset of Autoantibodies

    Gustaf Wigerblad1, Katy A. Lloyd1, Peter Sahlström2, Karine Chemin2, Johanna Steen2, Philip J. Titcombe2,3, Diana Zhou2, Ragnhild Stålesen1, Bianka Marklein4, Elena Ossipova2, Johan Rönnelid5, Luca Piccoli6, Antonio Lanzavecchia6, Daniel L. Mueller3, Karl Skriner4, Lars Klareskog2, Fredrik Wermeling1, Vivianne Malmström2 and Caroline Grönwall7, 1Rheumatology Unit, Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, 2Rheumatology Unit, Dept. of Medicine, Karolinska Institutet, Stockholm, Sweden, 3The Center for Immunology, Dept. of Medicine, University of Minnesota Medical School, Minneapolis, MN, 4Dept. of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany, 5Dept. of Immunology Genetics and Pathology, Uppsala University, Uppsala, Sweden, 6Università della Svizzera italiana, Institute for Research in Biomedicine, Bellinzona, Switzerland, 7Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Rheumatoid arthritis (RA) associated anti-citrullinated protein autoantibodies (ACPA) bind a wide range of citrullinated proteins with high cross-reactivity. Recent findings suggest that certain, but…
  • Abstract Number: 1481 • 2018 ACR/ARHP Annual Meeting

    Are ACPA Associated with More Bone Loss over Time in Patients with RA?

    Emma de Moel1, Josephine Amkreutz1, Lotte Heimans2, Cornelia F. Allaart3, Tom W.J. Huizinga4 and Diane van der Woude4, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Internal Medicine, Leiden University Medical Center, Leiden, Netherlands, 3Department of Rheumatology, LUMC, Leiden, Netherlands, 4Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Anti-citrullinated protein antibodies (ACPA) are one of the most important serological markers for rheumatoid arthritis (RA) and have been suggested to play a pathophysiologic…
  • Abstract Number: 14 • 2018 ACR/ARHP Annual Meeting

    Individual RA-Derived Monoclonal Anti-Citrullinated Protein Autoantibodies (ACPA) Have Extensive Citrulline Multi-Reactivity Demonstrated By a Large-Scale Protein Array Platform

    Peter Sahlström1, Johanna Steen1, Madeleine Jenning2, Philip J. Titcombe1,3, Ute Nonhoff4,5, Ragnhild Stålesen6, Bianka Marklein2, Daniel L. Mueller3, Zoltan Konthur4, Karin Lundberg7, Anca I. Catrina6, Lars Klareskog1, Vivianne Malmström1, Karl Skriner2 and Caroline Grönwall8, 1Rheumatology Unit, Dept. of Medicine, Karolinska Institutet, Stockholm, Sweden, 2Dept. of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany, 3The Center for Immunology, Dept. of Medicine, University of Minnesota Medical School, Minneapolis, MN, 4Engine GmbH, Hennigsdorf, Germany, 5Max Planck Institute of Colloids and Interfaces, Potsdam, Germany, 6Rheumatology Unit, Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, 7Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, 8Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: The presence of serum IgG anti-citrullinated protein autoantibodies (ACPA) in rheumatoid arthritis (RA), is associated with more aggressive disease progression. Although ACPA have been…
  • Abstract Number: 1487 • 2018 ACR/ARHP Annual Meeting

    Correlation between Cytokine Levels and Power-Doppler Ultrasound Activity Is BMI Dependent, and Different in ACPA Positive and ACPA Negative RA with Wrist Arthritis

    Ottar Gadeholt1, Erin Arnold2, Corinne Gorman3, Tobias Mueller4 and William Arnold2, 1Rheumatology/Immunology, Medical Clinic II, University Clinic Wuerzburg, Wuerzburg, Germany, 2Orthopedics and Rheumatology of the North Shore, Skokie, IL, 3Orthopaedics & Rheumatology of the North Shore, Skokie, IL, 4Department of Bioinformatics, University of Wuerzburg, Wuerzburg, Germany

    Background/Purpose: Multiple cytokines are assumed to be involved in RA pathogenesis. It has been hypothesized that ACPA-negative RA with wrist affection constitutes a separate entity.…
  • Abstract Number: 22 • 2018 ACR/ARHP Annual Meeting

    Monoclonal Anti-Citrullinated Protein Antibodies Generated from RA-Derived B Cells Recognize Amino Acid Motifs Rather Than Specific Proteins

    Johanna Steen1, Philip J. Titcombe2, Bjorn Forsström3, Caroline Grönwall4, Anca I. Catrina5, Daniel Lightwood6, Peter Nilsson7, Lars Klareskog1 and Vivianne Malmström1, 1Rheumatology Unit, Dept. of Medicine, Karolinska Institutet, Stockholm, Sweden, 2The Center for Immunology, Dept. of Medicine, University of Minnesota Medical School, Minneapolis, MN, 3SciLifeLab, Royal Technology Highschool,, Stockholm, Sweden, 4Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, 5Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 6Antibody-discovery, UCB-Celltech, Slough, United Kingdom, 7Affinity Proteomics, SciLifeLab, School of Biotechnology, KTH - Royal Institute of Technology, Stockholm, Sweden, Stockholm, Sweden

    Background/Purpose: Rheumatoid arthritis (RA) associated anti-citrullinated protein autoantibodies (ACPA) develop before RA diagnosis, at which point a wide range of citrullinated proteins have been shown…
  • Abstract Number: 1504 • 2018 ACR/ARHP Annual Meeting

    Utility of Serial ACPA Measurements in Rheumatoid Arthritis: Results of a Prospective Cohort Study

    Alistair Reid1,2,3, Michael D Wiese4, Robert Metcalf5, Mihir D Wechalekar6,7, Anita Lee8,9, Catherine Hill2,10,11, Cindy Hall8, Leah McWilliams5, Les Cleland8 and Susanna Proudman12, 1Rheumatology, Royal Adelaide Hospital, NORTH ADELAIDE, Australia, 2Medicine, The University of Adelaide, Adelaide, Australia, 3Medicine, University of Wollongong, Wollongong, Australia, 4School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia, 5Rheumatology Unit, Royal Adelaide Hospital, South Australia, Adelaide, Australia, 6Royal Adelaide Hospital, Adelaide, Australia, 7Rheumatology, Flinders University, Adelaide, Australia, 8Rheumatology, Royal Adelaide Hospital, Adelaide, Australia, 9Rheumatology, University of Adelaide, Adelaide, Australia, 10The Queen Elizabeth Hospital, Adelaide, Australia, 11Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia, 12Royal Adelaide Hospital, Rheumatology Unit and University of Adelaide, Discipline of Medicine, Adelaide, Australia

    Background/Purpose: Anti-citrullinated peptide antibody (ACPA) and rheumatoid factor (RF) define “seropositive” rheumatoid arthritis (RA). Both predict disease course, development of extra-articular features and treatment outcomes.…
  • Abstract Number: 54 • 2018 ACR/ARHP Annual Meeting

    In a Macaque Model of RA By Immunization with Citrullinated Peptides, the Valine in the 11 Position of the DRB1 Molecule Has Greater Impacts on T-Cell Response to Citrullinated Peptides Than the 70-74 Position in the Shared Epitope

    Samuel Bitoun1, Pierre Roques2, Roger Le Grand3 and Xavier Mariette4, 1INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, Le Kremlin Bicêtre, France, 2Immunology of viral infections and autoimmune diseases, IDMIT Infrastructure CEA - Université Paris Sud - INSERM U1184, Fontenay-Aux-Roses,, France, 3Immunology of viral infections and autoimmune diseases, IDMIT Infrastructure CEA - Université Paris Sud - INSERM U1184, Fontenay-Aux-Roses, France, 4Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France

    Background/Purpose: Among genetic risk factors of RA, HLA class II molecules confers the highest risk of ACPA positive RA. The shared epitope (SE) hypothesis that…
  • Abstract Number: 1826 • 2018 ACR/ARHP Annual Meeting

    From Cancer to Autoimmunity : A New Model of Rheumatoid Arthritis Emerging from a Constitutional Genetic Approach Used in Low Penetrance Cancers

    Geraldine Falgarone1,2, Morad El Bouchtaoui3, Marcio Do Cruzeiro4, Christophe Leboeuf5,6,7, Irmine Loisel-Ferreira5,6, Carèle Frédonie7, Chrystophe Ferreira8, Rachida Ait El Far5, Marc Espié9, Bruno Cassinat10, Jean-Jacques Kiladjian11, Jean-Paul Feugeas12,13, Anne Janin5,6,14 and Guilhem Bousquet2,5,15, 1HUPSSD, Avicenne Hospital, Rheumatology, APHP, Bobigny, France, 2Paris 13 University, SMBH, Bobigny, France, 3INSERM UMR-S 1165, PARIS, France, 4Plateforme de Recombinaison Homologue, Institut Cochin, INSERM U1016, Paris, France, 5INSERM UMR-S 1165, Paris, France, 6Université Paris Diderot, Paris, France, 7INSERM U944, Paris, France, 8Plateforme ANIMA5, Université Paris Descartes, Paris, France, 9Centre des Maladies du Sein, APHP, Hôpital Saint-Louis, Paris, France, 10Laboratoire de BIologie Cellulaire, APHP, Hôpital Saint-Louis, Paris, France, 11Centre d'Inverstigation Clinique, APHP, Hôpital Saint-Louis, Paris, France, 12INSERM U1137, Paris, France, 13Département de Biologie, Université Franche-Comté, Besançon, France, 14Service de Pathologie, APHP, Hôpital Saint-Louis, Paris, France, 15Service d'Oncologie médicale, APHP, Hôpital Avicenne, Bobigny, France

    Background/Purpose: High-speed technologies for genome sequencing have completely changed the study of disease genetics, but with limited knowledge of the functional value of most genetic…
  • Abstract Number: 67 • 2018 ACR/ARHP Annual Meeting

    Intestinal Inflammation and Netosis Associate with the Presence of Stool IgA ACPA in Subjects at-Risk for RA

    Widian Jubair1, Elizabeth A. Bemis2, Yuko Okamoto3, Marie L. Feser3, Jennifer Seifert3, M. Kristen Demoruelle3, Jill M. Norris4, Kevin D. Deane3, V. Michael Holers5 and Kristine A Kuhn1,6, 1Rheumatology, University of Colorado Denver, Aurora, CO, 2Epidemiology, Colorado School of Public Health, Aurora, CO, 3Division of Rheumatology, University of Colorado Denver, Aurora, CO, 4Department of Epidemiology, Colorado School of Public Health, Aurora, CO, 5Rheumatology Division, University of Colorado Denver, Aurora, CO, 6Mucosal Inflammation Program, University of Colorado Denver, Aurora, CO

    Background/Purpose: Anti-citrullinated protein antibodies (ACPA) and inflammation characterized by neutrophil extracellular trap (NET)osis have been detected at mucosal sites such as the lung and periodontium…
  • Abstract Number: 1976 • 2018 ACR/ARHP Annual Meeting

    Sequencing of the MHC Region Defines HLA-DQA1 As Driven Risk for Anti-Citrullinated Protein Antibodies (ACPA)-Positive Rheumatoid Arthritis in Han Population

    Jianping Guo1, Tao Zhang2, Hongzhi Cao2, Xiaowei Li2, Mengru Liu1, Yundong Zou1 and Zhan-Guo Li1, 1Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, 2Beijing Genomics Institute (BGI)-Shenzhen, Shenzhen, China

    Background/Purpose: The strong genetic contribution of the major histocompatibility complex (MHC) to rheumatoid arthritis (RA) susceptibility has been generally attributed to HLA-DRB1. However, due to…
  • Abstract Number: 72 • 2018 ACR/ARHP Annual Meeting

    Altered Serologic Responses to Epstein Barr Virus Precede Clinical Disease Development in Rheumatoid Arthritis

    Heather M. Berens1, Elizabeth A. Bemis2, M. Kristen Demoruelle1, John B. Harley3, Judith A. James4, Jess Edison5, Kevin D. Deane1, Jill M. Norris6 and V. Michael Holers1, 1Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 2Epidemiology, Colorado School of Public Health, Aurora, CO, 3Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 4University of Oklahoma Health Sciences Center, Oklahoma City, OK, 5Division of Rheumatology, Walter Reed National Military Medical Center, Bethesda, MD, 6Department of Epidemiology, Colorado School of Public Health, Aurora, CO

    Background/Purpose:    EBV infects B cells and is associated with several autoimmune diseases, including RA.  Prior studies have shown that patients with active classified RA…
  • Abstract Number: 2045 • 2018 ACR/ARHP Annual Meeting

    Specific Anti-Citrullinated Protein Antibodies Profiles Are Associated with Rheumatoid Arthritis Related Interstitial Lung Disease

    Pierre-Antoine Juge1, Leonor Nogueira2, Guy Serre2, René-Marc Flipo3, Lidwine Wemeau-Stervinou4, Thierry Schaeverbeke5, Claire Dromer6, Sylvain Adam-Marchand7, Marie-Christophe Boissier8, Hilario Nunes9, Raphaël Borie10, Bruno Crestani10 and Philippe Dieude10, 1Rhumatologie, Hôpital Bichat - Claude Bernard, Paris, France, 2Unité Différenciation Épidermique et Autoimmunité Rhumatoïde, Unité Mixte de Recherche, INSERM, Toulouse, France, 3Hôpital Roger Salengro, Lille, France, 4Pneumologie, CHRU de Lille, Lille, France, 5Department of Rheumatology, Bordeaux University Hospital, BORDEAUX, France, 6Imagerie Thoracique et Cardiovasculaire, CHU Bordeaux, Bordeaux, France, 7Pneumology, Centre Hospitalier Universitaire de Tours, Tours, France, 874 rue Marcel Cachin, INSERM, Bobigny, France, 9Pulmonary diseases department, Avicenne Hospital (AP-HP), Bobigny, France, 10Université Paris-Diderot, Paris, France

    Background/Purpose: The identification of peripheral blood markers of rheumatoid arthritis-associated interstitial lung disease (RA-ILD) may facilitate an earlier diagnosis and provide insight regarding the pathogenesis…
  • Abstract Number: 211 • 2018 ACR/ARHP Annual Meeting

    Excess in Prevalence of Functional Disability in Patients with Rheumatoid Arthritis: Does Serologic Status Matter?

    Elena Myasoedova1, John M. Davis III1, Sara J. Achenbach2, Eric L. Matteson1 and Cynthia S. Crowson2, 1Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, 2Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, MN

    Background/Purpose: Despite the advances in treatment of rheumatoid arthritis (RA) over the recent decades, many patients with RA do not achieve remission or full physical…
  • Abstract Number: 2046 • 2018 ACR/ARHP Annual Meeting

    Serum Immunoglobulin G Targets Citrulline-Containing Immunoglobulin G Peptides in Rheumatoid Arthritis Patients Who Test Positive for Rheumatoid Factor and Anti-Cyclic Citrullinated Peptide Antibodies

    Mandar Bawadekar1, Zihao Zheng2, Alan J. Bridges3,4, Michael A. Newton5 and Miriam A. Shelef1,4, 1Department of Medicine, Division of Rheumatology, University of Wisconsin - Madison, Madison, WI, 2Departments of Statistics, University of Wisconsin - Madison, Madison, WI, 3Medicine, University of Wisconsin - Madison, Madison, WI, 4William S. Middleton Memorial Veterans Hospital, Madison, WI, 5Departments of Statistics and of Biostatistics and Medical Informatics, University of Wisconsin - Madison, Madison, WI

    Background/Purpose: Rheumatoid arthritis patients produce a variety of anti-citrullinated protein antibodies (ACPAs) as well as antibodies that bind homocitrullinated and malondialdehyde-acetaldehyde adducted proteins leading to…
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