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Abstracts tagged "ACPA"

  • Abstract Number: 8 • 2018 ACR/ARHP Annual Meeting

    Repertoire Studies in Rheumatoid Arthritis Reveal B-Cell Distortions and Baseline Shifts in Unmutated IgG

    Yan Wang1, Katy A. Lloyd2, Sunithi Gunasekera3, Camilla Eriksson3, Daniel Ramsköld2, Karin Lundberg4, Per-Johan Jakobsson1, Ulf Göransson3, Vivianne Malmström1 and Caroline Grönwall5, 1Rheumatology Unit, Dept. of Medicine, Karolinska Institutet, Stockholm, Sweden, 2Rheumatology Unit, Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, 3Division of Pharmacognosy, Dept. of Medicinal Chemistry, Uppsala University, Uppsala, Sweden, 4Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, 5Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: The immunological hallmark of rheumatoid arthritis (RA) is autoreactivity to citrullinated proteins and rheumatoid factor activity. Hence, the adaptive immune system and B cells…
  • Abstract Number: 1470 • 2018 ACR/ARHP Annual Meeting

    Russell Bodies and Serological Status in Rheumatoid Arthritis

    Michael A. McNamara1, Susan M. Goodman2, Laura T. Donlin3, Dana Orange4, Serene Z. Mirza1, Jackie Szymonifka2, Mark P. Figgie5, Vivian P. Bykerk2 and Edward F. DiCarlo6, 1Rheumatology, Hospital for Special Surgery, New York, NY, 2Hospital for Special Surgery, New York, NY, 3Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, 4Rockefeller University, New York, NY, 5Surgery, Hospital for Special Surgery, New York, NY, 6Laboratory Medicine, Hospital for Special Surgery, New York, NY

    Russell Bodies and Serological Status in Rheumatoid Arthritis Background/Purpose: Russell bodies (RBs) are globular aggregates of immunoglobulin produced by plasma cells and identified both within…
  • Abstract Number: 11 • 2018 ACR/ARHP Annual Meeting

    PAD4-Independent Interaction of ACPA with Nuclear Antigens in Apoptotic Cells and Neutrophil Extracellular Traps (NETs) Defines a Subset of Autoantibodies

    Gustaf Wigerblad1, Katy A. Lloyd1, Peter Sahlström2, Karine Chemin2, Johanna Steen2, Philip J. Titcombe2,3, Diana Zhou2, Ragnhild Stålesen1, Bianka Marklein4, Elena Ossipova2, Johan Rönnelid5, Luca Piccoli6, Antonio Lanzavecchia6, Daniel L. Mueller3, Karl Skriner4, Lars Klareskog2, Fredrik Wermeling1, Vivianne Malmström2 and Caroline Grönwall7, 1Rheumatology Unit, Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, 2Rheumatology Unit, Dept. of Medicine, Karolinska Institutet, Stockholm, Sweden, 3The Center for Immunology, Dept. of Medicine, University of Minnesota Medical School, Minneapolis, MN, 4Dept. of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany, 5Dept. of Immunology Genetics and Pathology, Uppsala University, Uppsala, Sweden, 6Università della Svizzera italiana, Institute for Research in Biomedicine, Bellinzona, Switzerland, 7Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Rheumatoid arthritis (RA) associated anti-citrullinated protein autoantibodies (ACPA) bind a wide range of citrullinated proteins with high cross-reactivity. Recent findings suggest that certain, but…
  • Abstract Number: 1481 • 2018 ACR/ARHP Annual Meeting

    Are ACPA Associated with More Bone Loss over Time in Patients with RA?

    Emma de Moel1, Josephine Amkreutz1, Lotte Heimans2, Cornelia F. Allaart3, Tom W.J. Huizinga4 and Diane van der Woude4, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Internal Medicine, Leiden University Medical Center, Leiden, Netherlands, 3Department of Rheumatology, LUMC, Leiden, Netherlands, 4Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Anti-citrullinated protein antibodies (ACPA) are one of the most important serological markers for rheumatoid arthritis (RA) and have been suggested to play a pathophysiologic…
  • Abstract Number: 14 • 2018 ACR/ARHP Annual Meeting

    Individual RA-Derived Monoclonal Anti-Citrullinated Protein Autoantibodies (ACPA) Have Extensive Citrulline Multi-Reactivity Demonstrated By a Large-Scale Protein Array Platform

    Peter Sahlström1, Johanna Steen1, Madeleine Jenning2, Philip J. Titcombe1,3, Ute Nonhoff4,5, Ragnhild Stålesen6, Bianka Marklein2, Daniel L. Mueller3, Zoltan Konthur4, Karin Lundberg7, Anca I. Catrina6, Lars Klareskog1, Vivianne Malmström1, Karl Skriner2 and Caroline Grönwall8, 1Rheumatology Unit, Dept. of Medicine, Karolinska Institutet, Stockholm, Sweden, 2Dept. of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany, 3The Center for Immunology, Dept. of Medicine, University of Minnesota Medical School, Minneapolis, MN, 4Engine GmbH, Hennigsdorf, Germany, 5Max Planck Institute of Colloids and Interfaces, Potsdam, Germany, 6Rheumatology Unit, Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, 7Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, 8Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: The presence of serum IgG anti-citrullinated protein autoantibodies (ACPA) in rheumatoid arthritis (RA), is associated with more aggressive disease progression. Although ACPA have been…
  • Abstract Number: 1487 • 2018 ACR/ARHP Annual Meeting

    Correlation between Cytokine Levels and Power-Doppler Ultrasound Activity Is BMI Dependent, and Different in ACPA Positive and ACPA Negative RA with Wrist Arthritis

    Ottar Gadeholt1, Erin Arnold2, Corinne Gorman3, Tobias Mueller4 and William Arnold2, 1Rheumatology/Immunology, Medical Clinic II, University Clinic Wuerzburg, Wuerzburg, Germany, 2Orthopedics and Rheumatology of the North Shore, Skokie, IL, 3Orthopaedics & Rheumatology of the North Shore, Skokie, IL, 4Department of Bioinformatics, University of Wuerzburg, Wuerzburg, Germany

    Background/Purpose: Multiple cytokines are assumed to be involved in RA pathogenesis. It has been hypothesized that ACPA-negative RA with wrist affection constitutes a separate entity.…
  • Abstract Number: 1250 • 2017 ACR/ARHP Annual Meeting

    Outcomes in Real-World Patients with Early Aggressive Rheumatoid Arthritis

    Keith Knapp1,2, Eric Mueller1,2 and Gary Craig1,2, 1Arthritis Northwest PLLC., Spokane, WA, 2Discus Analytics LLC., Spokane, WA

    Background/Purpose: The window of opportunity to address early rheumatoid arthritis (RA) in patients (pts) is well documented. However early aggressive (agr) RA needs further study…
  • Abstract Number: 1356 • 2017 ACR/ARHP Annual Meeting

    Is ACPA-Positive RA Still a More Severe Disease Than ACPA-Negative RA? a Longitudinal Cohort Study in RA-Patients Treated from 2000 Onwards

    Aleid C. Boer1, Annelies Boonen2 and Annette H.M. van der Helm-van Mil3, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Centre+, Maastricht, The Netherlands, Maastricht, Netherlands, 3Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Anti-citrullinated-protein antibodies (ACPA)-positive rheumatoid arthritis (RA) is considered as more severe than ACPA-negative RA, because of its association with joint destruction. Clinically relevant joint…
  • Abstract Number: 65 • 2017 ACR/ARHP Annual Meeting

    RA-Associated Antibodies Targeting Post Translational Modification Have Different Osteoclastogenetic Potential

    Akilan Krishnamurthy1, Johanna Steen2, Caroline Grönwall3, Gustaf Wigerblad4, Camilla Svensson5,6, Heidi Wähämaa1, Vivianne Malmström1, Bence Rethi1 and Anca I. Catrina1, 1Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, 2Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, 3Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, 4Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, 5Dept. of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden, 6Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Some but not all antibodies against citrullinated modified proteins (ACPA) promote osteoclastogenesis and bone destruction in vitro and in vivo. We aimed to investigate…
  • Abstract Number: 1376 • 2017 ACR/ARHP Annual Meeting

    Diagnostic Performance of 7 Different Anti-Cyclic Citrullinated Peptide Antibody and 6 Rheumatoid Factor Assays in a Primary Diagnostic, Consecutive Rheumatological Population in a Secondary Care Hospital

    Lieve Van Hoovels1, Julie Jacobs1, Bert Vander Cruyssen2, Stefanie Van den Bremt1, Patrick Verschueren3 and Xavier Bossuyt4, 1Laboratory medicine, OLV Hospital, Aalst, Belgium, 2Rheumatology, OLV hospital, Aalst, Belgium, 3Division of Rheumatology, University Hospital Leuven, Leuven, Belgium, 4Laboratory medicine, University Hospital Leuven, Leuven, Belgium

    Background/Purpose: The clinical diagnosis of rheumatoid arthritis (RA) remains a challenge, making serological markers most interesting. The 2010 ACR/EULAR classification criteria for RA take into…
  • Abstract Number: 327 • 2017 ACR/ARHP Annual Meeting

    Association of Anti-Cyclic Citrullinated Peptide Seropositivity and Lean Mass Index with Low Bone Mineral Density in Patients with Rheumatoid Arthritis

    Katherine D. Wysham1, Dolores M. Shoback2, Kashif Jafri1, Sarah L. Patterson3, Gabriela Schmajuk4, John B. Imboden Jr.5 and Patricia P. Katz5, 1University of California, San Francisco, San Francisco, CA, 2Medicine, San Francisco VA Medical Center, University of California, San Francisco, San Francisco, CA, 3Division of Rheumatology, University of California, San Francisco, San Francisco, CA, 4San Francisco VA Medical Center, University of California San Francisco, San Francisco, CA, 5Medicine, University of California, San Francisco, San Francisco, CA

    Background/Purpose:   Osteoporotic fractures are associated with high morbidity and mortality. Persons with rheumatoid arthritis (RA) have twice the risk of osteoporosis-related fracture than age-matched…
  • Abstract Number: 1383 • 2017 ACR/ARHP Annual Meeting

    IMPACT of Smoking in the Expression of Periodontitis and Anticitrullinated Protein Antibodies in Rheumatoid Arthritis

    Jerián González Febles1, Jorge Luis Garnier Rodríguez2, Fernando Sánchez-Alonso3, Sagrario Bustabad4, Federico Díaz-González5, Mariano Sanz Alonso1 and Beatriz Rodriguez Lozano6, 1Periodontology, Universidad Complutense de Madrid, Madrid, Spain, 2Odontology, Dental Clinic Garnier, S/C Tenerife, Spain, 3Unidad de Investigación, Spanish Society of Rheumatology, Madrid, Spain, 4Rheumatology, Servicio de Reumatología. Hospital Universitario de Canarias, La Laguna, Tenerife, Spain, 5Servicio de Reumatología. Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, 6Rheumatology, Hospital de Canarias, S/C Tenerife, Spain

    Background/Purpose: Environmental, genetic and epigenetic factors can induce citrullination of structural peptides by the enzyme PAD, which induce anti-citrullinated protein antibodies (ACPA) preceding RA. Among…
  • Abstract Number: 410 • 2017 ACR/ARHP Annual Meeting

    Association between Anti-Citrullinated Protein Antibody Status and the Incidence of Erosive Disease in Patients with RA

    Leslie R Harrold1, Heather J. Litman2, SE Connolly3, E Alemao3, Sabrina Rebello4, W Hua2 and Joel Kremer5, 1University of Massachusetts Medical School, Worcester, MA, 2Corrona, Southborough, MA, 3Bristol-Myers Squibb, Princeton, NJ, 4Corrona, LLC, Southborough, MA, 5Albany Medical College and The Center for Rheumatology, Albany, NY

    Background/Purpose: RA is characterized by the production of autoantibodies including anti-citrullinated protein antibodies (ACPAs).1 ACPAs are considered a prognostic indicator for more severe RA and…
  • Abstract Number: 1432 • 2017 ACR/ARHP Annual Meeting

    The Prognostic Value of IgA Subtypes of Rheumatoid Factor and Anti-Citrullinated Protein Antibodies (ACPA)  for Prediction of Therapeutic Responses to TNF Inhibitory Therapy in Patients with Rheumatoid Arthritis

    Daniela Sieghart1, Farideh Alasti2, Paul Studenic1 and Günter Steiner2, 1Medical University Vienna, Division of Rheumatology, Department of Internal Medicine III, Vienna, Austria, 2Rheumatology, Medical University of Vienna, Vienna, Austria

    Background/Purpose: Rheumatoid factor (RF) and Anti-Citrullinated Protein antibodies (ACPA) are the most specific diagnostic markers of rheumatoid arthritis (RA). These antibodies are predominantly of the…
  • Abstract Number: 413 • 2017 ACR/ARHP Annual Meeting

    Economic Burden Associated with Anti-Cyclic Citrullinated Peptide Antibody Positivity in Patients Newly Diagnosed with RA

    J An1, Z Bider2, J Kang1, E Alemao3, SE Connolly3 and TC Cheetham1, 1Western University of Health Sciences, Pomona, CA, 2Southern California Permanente Medical Group, Pasadena, CA, 3Bristol-Myers Squibb, Princeton, NJ

    Background/Purpose: Anti-cyclic citrullinated peptide (anti-CCP) antibody positivity has been suggested as a strong predictor of joint erosion as well as a potential biomarker for guiding…
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