Abstract Number: 1469 • 2018 ACR/ARHP Annual Meeting
Measurement of Anti-Amyloid β Autoantibodies in Patients with Rheumatoid Arthritis
Background/Purpose: Amyloid β (Aβ) accumulation in the brain is a risk factor for Alzheimer's disease (AD). The incidence of AD increases with age. Rheumatoid arthritis…Abstract Number: 8 • 2018 ACR/ARHP Annual Meeting
Repertoire Studies in Rheumatoid Arthritis Reveal B-Cell Distortions and Baseline Shifts in Unmutated IgG
Background/Purpose: The immunological hallmark of rheumatoid arthritis (RA) is autoreactivity to citrullinated proteins and rheumatoid factor activity. Hence, the adaptive immune system and B cells…Abstract Number: 1470 • 2018 ACR/ARHP Annual Meeting
Russell Bodies and Serological Status in Rheumatoid Arthritis
Russell Bodies and Serological Status in Rheumatoid Arthritis Background/Purpose: Russell bodies (RBs) are globular aggregates of immunoglobulin produced by plasma cells and identified both within…Abstract Number: 11 • 2018 ACR/ARHP Annual Meeting
PAD4-Independent Interaction of ACPA with Nuclear Antigens in Apoptotic Cells and Neutrophil Extracellular Traps (NETs) Defines a Subset of Autoantibodies
Background/Purpose: Rheumatoid arthritis (RA) associated anti-citrullinated protein autoantibodies (ACPA) bind a wide range of citrullinated proteins with high cross-reactivity. Recent findings suggest that certain, but…Abstract Number: 1481 • 2018 ACR/ARHP Annual Meeting
Are ACPA Associated with More Bone Loss over Time in Patients with RA?
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) are one of the most important serological markers for rheumatoid arthritis (RA) and have been suggested to play a pathophysiologic…Abstract Number: 14 • 2018 ACR/ARHP Annual Meeting
Individual RA-Derived Monoclonal Anti-Citrullinated Protein Autoantibodies (ACPA) Have Extensive Citrulline Multi-Reactivity Demonstrated By a Large-Scale Protein Array Platform
Background/Purpose: The presence of serum IgG anti-citrullinated protein autoantibodies (ACPA) in rheumatoid arthritis (RA), is associated with more aggressive disease progression. Although ACPA have been…Abstract Number: 1487 • 2018 ACR/ARHP Annual Meeting
Correlation between Cytokine Levels and Power-Doppler Ultrasound Activity Is BMI Dependent, and Different in ACPA Positive and ACPA Negative RA with Wrist Arthritis
Background/Purpose: Multiple cytokines are assumed to be involved in RA pathogenesis. It has been hypothesized that ACPA-negative RA with wrist affection constitutes a separate entity.…Abstract Number: 22 • 2018 ACR/ARHP Annual Meeting
Monoclonal Anti-Citrullinated Protein Antibodies Generated from RA-Derived B Cells Recognize Amino Acid Motifs Rather Than Specific Proteins
Background/Purpose: Rheumatoid arthritis (RA) associated anti-citrullinated protein autoantibodies (ACPA) develop before RA diagnosis, at which point a wide range of citrullinated proteins have been shown…Abstract Number: 1504 • 2018 ACR/ARHP Annual Meeting
Utility of Serial ACPA Measurements in Rheumatoid Arthritis: Results of a Prospective Cohort Study
Background/Purpose: Anti-citrullinated peptide antibody (ACPA) and rheumatoid factor (RF) define “seropositive” rheumatoid arthritis (RA). Both predict disease course, development of extra-articular features and treatment outcomes.…Abstract Number: 54 • 2018 ACR/ARHP Annual Meeting
In a Macaque Model of RA By Immunization with Citrullinated Peptides, the Valine in the 11 Position of the DRB1 Molecule Has Greater Impacts on T-Cell Response to Citrullinated Peptides Than the 70-74 Position in the Shared Epitope
Background/Purpose: Among genetic risk factors of RA, HLA class II molecules confers the highest risk of ACPA positive RA. The shared epitope (SE) hypothesis that…Abstract Number: 1826 • 2018 ACR/ARHP Annual Meeting
From Cancer to Autoimmunity : A New Model of Rheumatoid Arthritis Emerging from a Constitutional Genetic Approach Used in Low Penetrance Cancers
Background/Purpose: High-speed technologies for genome sequencing have completely changed the study of disease genetics, but with limited knowledge of the functional value of most genetic…Abstract Number: 67 • 2018 ACR/ARHP Annual Meeting
Intestinal Inflammation and Netosis Associate with the Presence of Stool IgA ACPA in Subjects at-Risk for RA
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) and inflammation characterized by neutrophil extracellular trap (NET)osis have been detected at mucosal sites such as the lung and periodontium…Abstract Number: 1976 • 2018 ACR/ARHP Annual Meeting
Sequencing of the MHC Region Defines HLA-DQA1 As Driven Risk for Anti-Citrullinated Protein Antibodies (ACPA)-Positive Rheumatoid Arthritis in Han Population
Background/Purpose: The strong genetic contribution of the major histocompatibility complex (MHC) to rheumatoid arthritis (RA) susceptibility has been generally attributed to HLA-DRB1. However, due to…Abstract Number: 72 • 2018 ACR/ARHP Annual Meeting
Altered Serologic Responses to Epstein Barr Virus Precede Clinical Disease Development in Rheumatoid Arthritis
Background/Purpose: EBV infects B cells and is associated with several autoimmune diseases, including RA. Prior studies have shown that patients with active classified RA…Abstract Number: 2045 • 2018 ACR/ARHP Annual Meeting
Specific Anti-Citrullinated Protein Antibodies Profiles Are Associated with Rheumatoid Arthritis Related Interstitial Lung Disease
Background/Purpose: The identification of peripheral blood markers of rheumatoid arthritis-associated interstitial lung disease (RA-ILD) may facilitate an earlier diagnosis and provide insight regarding the pathogenesis…
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