ACR Meeting Abstracts

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Abstracts tagged "ACPA"

  • Abstract Number: 1454 • 2017 ACR/ARHP Annual Meeting

    Association of Poor Prognostic Factors with Medication Persistence Among Adult RA Patients within a Community of Rheumatology Clinics

    Damemarie Paul1, Laura McDonald2, Aarti Rao3, Ruthwik Anupindi4 and Keith Knapp5,6, 1HEOR, Bristol Myers Squibb, Lawrence Township, NJ, 2CORDS, Bristol Myers Squibb, Uxbridge, United Kingdom, 3Analytics, Mu-Sigma, Bengaluru, India, 4Analytics, Mu-Sigma, Lawrence Township, NJ, 5Arthritis Northwest PLLC., Spokane, WA, 6Discus Analytics LLC., Spokane, WA

    Background/Purpose: A fixed treatment paradigm often exists for Rheumatoid Arthritis(RA) patient(pts)1. However, RA is a heterogeneous disease and differences in pts’ serostatus affect disease progression.…
  • Abstract Number: 432 • 2017 ACR/ARHP Annual Meeting

    ACPA and RF As Predictors of Sustained Clinical Remission in Rheumatoid Arthritis Patients: Data from a Rheumatoid Arthritis Cohort

    Janet E. Pope1, Emmanouil Rampakakis2, Mohammad Movahedi3, Angela Cesta3, John S. Sampalis4 and Claire Bombardier3, 1Department of Medicine, Division of Rheumatology, University of Western Ontario, St Joseph's Health Care, London, ON, Canada, 2JSS Medical Research, Montreal, QC, Canada, 3Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, 4McGill University, Montreal, QC, Canada

    ACPA and RF as Predictors of Sustained Clinical Remission in Rheumatoid Arthritis Patients: Data From a Rheumatoid Arthritis CohortBackground/Purpose: Positive serology for anti-citrullinated protein antibody…
  • Abstract Number: 2012 • 2017 ACR/ARHP Annual Meeting

    First Description of Tenosynovitis Prevalence in a Large Cohort of ACPA-Positive Patients

    Gisela Eugénio1,2,3, Kulveer Mankia3,4, Peta Pentony2,3, Jackie L. Nam2,3, Laura Hunt2,3, Hanna Gul2,3, Richard J. Wakefield2,3 and Paul Emery3,5, 1Rheumatology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal, 2Leeds Teaching Hospitals NHS Trust, NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, 3University of Leeds, Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, United Kingdom, 4Rheumatology, Leeds Teaching Hospitals NHS Trust, NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, 5NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

    Background/Purpose: Tenosynovitis has been regarded as a feature of RA, although its true prevalence in early stages has not been firmly established. The aim of…
  • Abstract Number: 459 • 2017 ACR/ARHP Annual Meeting

    Disease Course in Seronegative RA Patients Classified According to the 2010 ACR/EULAR Criteria

    Lena Bugge Nordberg1, Siri Lillegraven2, Anna-Birgitte Aga2, Inge C Olsen3, Elisabeth Lie4, Hilde B Hammer2, Till Uhlig2, Désirée van der Heijde5, Tore Kvien6 and Espen A. Haavardsholm2, 1Departement of Rheumatology, Diakonhjemmet hospital, oslo, Norway, 2Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 3Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 4Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 5Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 6Diakonhjemmet Hospital, Oslo, Norway

    Background/Purpose: The development of the 2010 classification criteria for rheumatoid arthritis (RA) has led to a redefinition of the patient population, including classification of seropositive…
  • Abstract Number: 2016 • 2017 ACR/ARHP Annual Meeting

    Favourable Changes in Power Doppler Scores in the Feet over 1-Year in an Early Rheumatoid Arthritis Cohort: The Role of Rheumatoid Factor and Anti–Citrullinated Protein Antibody

    Karen A. Beattie1, Hanyan Zou2, George Ioannidis3 and Maggie Larche1, 1Medicine, McMaster University, Hamilton, ON, Canada, 2McMaster University, Hamilton, ON, Canada, 3St Joseph's Healthcare Hamilton, Hamilton, ON, Canada

    Background/Purpose : MTP joints are seldom examined in routine clinical visits. As such, it is important to understand how the standard treatment of patients with…
  • Abstract Number: 478 • 2017 ACR/ARHP Annual Meeting

    Ectopic Lymphoid Tissue in the Lung Is Uniquely Associated with the ACPA IgA Isotype Even in Absence of Classifiable RA

    Lindsay B. Kelmenson1, M. Kristen Demoruelle1, Carlyne D. Cool2 and Kevin D. Deane1, 1Rheumatology Division, University of Colorado Denver, Aurora, CO, 2Pathology, University of Colorado Denver, Aurora, CO

    Background/Purpose: Antibodies to citrullinated protein antigens (ACPA) precede the development of rheumatoid arthritis (RA) and may be generated in the lung of established and preclinical…
  • Abstract Number: 2375 • 2017 ACR/ARHP Annual Meeting

    Does the Body Mass Index Have Any Influence in the Characteristics of Early Arthritis Patients?

    Pablo Moreno Fresneda1, Lola Martínez-Quintanilla Jiménez1, Ana M. Ortiz Garcia2, Eva Tomero3, Rosario García-Vicuña4 and Isidoro Gonzalez-Alvaro2, 1Rheumatology, Rheumatology Division, Hospital Universitario La Princesa, IIS-IP, Madrid, Spain, 2Rheumatology, Rheumatology Service, Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain, 3Hospital La Princesa. Madrid., Madrid, Spain, 4Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain

    Background/Purpose: Obesity has been proposed as a risk factor to develop rheumatoid arthritis (RA) and it has been associated with a worse response to several…
  • Abstract Number: 482 • 2017 ACR/ARHP Annual Meeting

    The Link between ACPA and Erosion Development: Is ACPA Sufficient? an Association Study in Clinically Suspect Arthralgia

    Robin M ten Brinck1, REM Toes2 and Annette H.M. van der Helm-van Mil1, 1Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Anti-citrullinated protein antibodies (ACPA) associate with more severe joint erosions in rheumatoid arthritis (RA), but the underlying mechanism is unclear. Recent in vitro and…
  • Abstract Number: 2406 • 2017 ACR/ARHP Annual Meeting

    Increased Cartilage Damage in Metacarpophalangeal Joints of ACPA Positive Rheumatoid Arthritis (RA) Patients Using T2 Mapping in 3 Tesla Magnetresonance Imaging (MRI)

    Nina Renner1, Arnd Kleyer2, David Simon2, Gerhard Krönke3, Juergen Rech2, Georg Schett2, Goetz Welsch4 and Milena L. Pachowsky1, 1Department of Trauma and Orthopedic Surgery, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany, 2Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Germany, 3Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Austria, 4UKE Athleticum, University Hospital Hamburg-Eppendorf, Hamburg, Germany

    Background/Purpose: T2 mapping is a non-invasive MRI approach to measure cartilage quality, reflecting cartilage hydration and collagen integrity without using contrast enhancement. It has been…
  • Abstract Number: 484 • 2017 ACR/ARHP Annual Meeting

    Sputum Neutrophils Demonstrate Increased Neutrophil Extracellular Trap Formation in RA-Free Subjects at-Risk of Future RA

    Yuko Okamoto1, Michael P. Mohning2, Stacey M. Thomas2, Ashley Visser1, Lindsay B. Kelmenson3, Jill M. Norris4, Mariana J. Kaplan5, William J. Janssen2, V. Michael Holers1, Kevin D. Deane1 and M. Kristen Demoruelle1, 1Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 2Division of Pulmonary Disease and Critical Care Medicine, National Jewish Health, Denver, CO, 3Division of Rheumatoloty, University of Colorado School of Medicine, Aurora, CO, 4Department of Epidemiology, Colorado School of Public Health, Aurora, CO, 5Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, MD

    Background/Purpose: Data support that ACPAs are generated in the lung in RA-free subjects At-Risk of future RA. Our group previously demonstrated a significant positive correlation…
  • Abstract Number: 2450 • 2017 ACR/ARHP Annual Meeting

    Comparative Effectiveness of Abatacept Versus TNFi in Patients with RA Who Are CCP+ in the United States Corrona Registry

    Leslie R Harrold1, Heather J. Litman2, SE Connolly3, E Alemao3, K Price3, S Kelly3, Sabrina Rebello4, W Hua2 and Joel Kremer5, 1University of Massachusetts, Worcester, MA, 2Corrona, Southborough, MA, 3Bristol-Myers Squibb, Princeton, NJ, 4Corrona, LLC, Southborough, MA, 5Albany Medical College and The Center for Rheumatology, Albany, NY

    Background/Purpose: Anti-cyclic citrullinated peptide positivity (CCP+) is associated with a better response to abatacept than anti-CCP negativity in patients with RA1,2; however, there are no…
  • Abstract Number: 487 • 2017 ACR/ARHP Annual Meeting

    ARE ANTI-Citrullinated Protein Antibody Levels Associated with Periodontal Disease in Rheumatoid Arthritis?

    Jerián González Febles1, Fernando Sánchez-Alonso2, Jorge Luis Garnier Rodríguez3, Mariano Sanz Alonso1, Federico Díaz-González4 and Beatriz Rodriguez Lozano5,6, 1Periodontology, Universidad Complutense de Madrid, Madrid, Spain, 2Unidad de Investigación, Spanish Society of Rheumatology, Madrid, Spain, 3Odontology, Dental Clinic Garnier, S/C Tenerife, Spain, 4Servicio de Reumatología. Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, 5Rheumatology, Rheumatology Department. Hospital Universitario de Canarias, S/C TENERIFE, Spain, 6Rheumatology, Hospital de Canarias, S/C Tenerife, Spain

    Background/Purpose: Positivity of anti-citrullinated peptides antibodies (ACPA) indicates severity in Rheumatoid Arthritis (RA). There is evidence for chronic periodontitis (PD) in RA autoimmune response by…
  • Abstract Number: 2791 • 2017 ACR/ARHP Annual Meeting

    Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) and Marginal Jawbone Loss Predates the Onset of Rheumatoid Arthritis

    Elin Kindstedt1, Linda Johansson2, Py Palmqvist3, Cecilia Koskinen Holm1, Heidi Kokkonen4, Ingegerd Johansson3, Pernilla Lundberg3 and Solbritt Rantapaa-Dahlqvist5, 11Department of Odontology/Molecular Periodontology, Umeå University, Umeå, Sweden, 2Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden, 3Department of Odontology/Molecular Periodontology, Umeå University, Umeå, Sweden, 4Public Health and Clinical Medicine/ Rheumatology, Umeå University, Umeå, Sweden, 5Dept of Public Health and Clinical Medicine/Rheumatology, Umeå University, Sweden, Umeå, Sweden

    Background/Purpose: Previous studies have shown a higher incidence of alveolar bone loss in patients with rheumatoid arthritis (RA) and that patients with periodontitis are at…
  • Abstract Number: 492 • 2017 ACR/ARHP Annual Meeting

    Is Leukotoxin_A Produced By Aggregatibacter Actynomycetemcomitans Important for Initiating Autoimmune Responses Underlying Rheumatoid Arthritis?

    Mikhail Volkov1, Jacqueline Dekkers1, Bruno G. Loos2, Sergio Bizzarro2, Tom W.J. Huizinga3, Helle A. Praetorius4, Rene E.M. Toes5 and Diane van der Woude1, 1Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Department of Periodontology, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit, Amsterdam, Netherlands, 3Department of Rheumatology, LUMC, Leiden, Netherlands, Leiden, Netherlands, 4Department of Biomedicine, Aarhus University, Aarhus, Denmark, 5Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: In a recent publication in Science Translational Medicine, Konig et al. (2016) describe a potential explanation for the link between periodontal infection and RA.…
  • Abstract Number: 2919 • 2017 ACR/ARHP Annual Meeting

    Number and Type of ACPA Fine Specificities Are Correlated to High Resolution Computed Tomography Parenchymal Lungs Changes in Patients with Early Untreated Rheumatoid Arthritis

    Vijay Joshua1, Aase Hensvold1, Gudrun Reynisdottir1, Monika Hansson1, Guy Serre2, Johan Grunewald3, Katerina Chatzidionysiou1 and Anca I. Catrina1, 1Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, 2Unité Différenciation Épidermique et Autoimmunité Rhumatoïde, Unité Mixte de Recherche, INSERM, Toulouse, France, 3Division of Respiratory Medicine, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Airways abnormalities that are consistent with inflammation are common in anti-CCP2 positive subjects without inflammatory arthritis. Anti-CCP2 antibodies are associated with HRCT parenchymal lung…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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