2012 ACR/ARHP Annual Meeting Archives

Abstract Number: 1518

Damage-Associated Endogenous TLR4 Ligand Fibronectin-EDA Is Overexpressed in Scleroderma and Drives Persistent Fibrosis Via TLR4 and Inhibition of TLR4 Prevents and Reverses Experimental Dermal Fibrosis: Novel Target for Scleroderma Therapy
Abstract Number: 381

DAS Does Not Predict Increasing Treatment in Early Rheumatoid Arthritis: Results From the CATCH Study
Abstract Number: 391

DAS28 Is Not a Sufficient Disease Activity Measure for Obese Rheumatoid Arthritis Patients – Don’t Leave the Feet Behind
Abstract Number: 2440

Decisional Conflict Among Vulnerable Patient Populations with Rheumatoid Arthritis Is Associated with Limited Health Literacy and Non-English Language
Abstract Number: 2297

Decrease Activity of DNA Demethylase in SSc Fibroblast and Microvascular Endothelial Cells: A Possible Mechanism for Persistence of SSc Phenotype
Abstract Number: 1948

Decreased C4A Gene Copy Numbers in Children with Juvenile Dermatomyositis: Association with Decreased C4 Protein and Lower Absolute Number of CD3 Negative CD16/56+ Natural Killer Cells
Abstract Number: 2196

Decreased Expression of TSLP in Labial Salivary Glands of Patients with pSS Is Associated with Local and Systemic Disease Parameters
Abstract Number: 301

Decreased Frequency of Dystrophic Calcifications in Children with Juvenile Dermatomyositis: A 10-Year Study
Abstract Number: 1175

Decreased Frequency of Th17 Cells in Early Rheumatoid Arthritis
Abstract Number: 704

Decreased Number of Endothelial Progenitor Cells in Systemic Sclerosis Patients with Early Disease
Abstract Number: 1217

Decreased Survival in Rheumatoid Arthritis Complicated with Bronchiectasis: A Family-Based Cohort Study
Abstract Number: 393

Defining Criteria for Rheumatoid Arthritis Patient-Derived Disease Activity Score That Corrresponds to Disease Activity Score 28 and Clnical Disease Activity Index Based Statuses and Response Criteria
Abstract Number: 1147

Definition of Improvement Thresholds in Juvenile Idiopathic Arthritis Using the JADAS
Abstract Number: 240

Degenerative Changes in Patients with Knee Pain: A Comparative Study Between Ultrasound and Conventional Radiology
Abstract Number: 1121

Degenerative Medial Meniscal Pathology May Initiate in the Posterior Horn: Data From the Osteoarthritis Initiative
Abstract Number: 2597

Degree of Initial Intracellular Folate Depletion May Predict Methotrexate Response in Juvenile Idiopathic Arthritis
Abstract Number: 1247

Delay in Diagnosis of Rheumatoid Arthritis Increases the Cardiovascular Risk
Abstract Number: 354

Delayed Onset of Hepatitis and/or Neutropenia in Patients with Rheumatoid Arthritis Treated with Combination Therapy of Methotrexate and Leflunomide
Abstract Number: 1624

Deletion of HLA-B27 T Cells Underlies the Immunodominant Response to Influenza Infection On Class I MHC Transgenic Mice
Abstract Number: 900

Deletion of RBP-J in a Murine Model of Inflammatory Arthritis Reveals Differential Pro-Inflammatory Cytokine and FoxP3 Gene Expression
Abstract Number: 1172

Delineating the Role of Multiple Corticosteroid Joint Injections in the Management of Juvenile Idiopathic Arthritis in the Biologic Era
Abstract Number: 1634

Delivering Mesenchymal Stem Cells to Arthritic Joints with Nano-Fiber Scaffold Resulted in Inhibition of Arthritis and Joint Damage in Arthritis Models
Abstract Number: 697

Demographic, Clinical, Serologic and Socioeconomic Measures Each Predict Mortality in Scleroderma
Abstract Number: 2495

Dense Genotyping of Candidate Genes Identifies 16 New Susceptibility Loci in Ankylosing Spondylitis
Abstract Number: 975

Dense Genotyping of Risk Loci in Black South Africans with Rheumatoid Arthritis: An Association Study
Abstract Number: 858

Dense Genotyping, Imputation, and Regression Analysis Identifies Multiple Independent Genetic Susceptibility Loci within the HLA Region in Behcet’s Disease
Abstract Number: 1752

Depletion of CD4-Effector Memory T Cells and Clonally Expanded IgG4 Memory B Cells May Explain the Therapeutic Efficacy of Rituximab in IgG4-Related Disease: Studies Using Flow Cytometry and Single-Cell Sequencing
Abstract Number: 1375

Depression and Anxiety in Psoriatic Disease: Prevalence and Associated Factors
Abstract Number: 871

Depression Predicts Mortality in RA
Abstract Number: 571

Description of Distribution of Active Inflammatory Lesions On Magnetic Resonance Imaging of the Sacroiliac Joints and the Spine in Patients with Early Axial Spondyloarthritis – Analysis of the Esther Trial Baseline Data
Abstract Number: 1587

Despite Low Disease Activity Patients with Poly- and Dermatomyositis Perceive Activity Limitation, Reduced Grip Force and Quality of Life Longitudinally
Abstract Number: 2063

Detection of Inflammatory Arthritis and Musculoskeletal Conditions in a First Nations Community: Results of an Onsite Screening Program
Abstract Number: 123

Detection of Synovitis in Clinically Inactive Juvenile Idiopathic Arthritis Patients by Ultrasonography with POWER Doppler
Abstract Number: 909

Determinants of Patient Preferences for Total Knee Replacement: A Comparison of Whites and African-Americans
Abstract Number: 1525

Determinants of Poor Quality of Life in ANCA Associated Vasculitis (AAV)
Abstract Number: 1572

Developing a Health Literacy Universal Precautions Toolkit for Rheumatology
Abstract Number: 1713

Developing an Index for Disease Activity and Therapeutic Response in Connective Tissue Disease Related Interstitial Lung Disease: Results From A Delphi Exercise: Delivering A Consensus On Domains
Abstract Number: 531

Developmen and Validation of a New Instrument to Asess Health Related Quality of Life in Psoriasis Arthritis: The Vitacora Questionnaire
Abstract Number: 106

Development of a 6 Joint Simplified Ultrasonographic Score to Assess Disease Activity in Patients with Rheumatoid Arthritis
Abstract Number: 1660

Development of a Bruton’s Tyrosine Kinase (Btk) Inhibitor, ONO-4059: Efficacy in a Collagen Induced Arthritis (CIA) Model Indicates Potential Treatment for Rheumatoid Arthritis (RA)
Abstract Number: 1376

Development of A Health Index for Patients with Ankylosing Spondylitis – First Steps of A Global Initiative Based On the ICF Guided by ASAS
Abstract Number: 276

Development of a Longitudinal, Propective Cohort of Young Adults with Childhood-Onset Systemic Lupus Erythematosus
Abstract Number: 37

Development of a Mouse Model of Natural Osteoarthritis of Knee by Induction of obesity and Bipedal Walking
Abstract Number: 32

Development of a Quantitative Model of Endotoxin-Induced Calvarial Bone Erosion Utilizing Micro-Computed Tomography and Pax-It Imaging Analysis Software
Abstract Number: 620

Development of A Quantitative PCR Method to Determine Interferon Signature Metric Status in SLE Patients: Distribution and Clinical & Serological Associations in Two Lupus Clinical Trials
Abstract Number: 1158

Development of Cut-off Values for High Disease Activity in Juvenile Idiopathic Arthritis Based On the Juvenile Arthritis Disease Activity Score
Abstract Number: 1438

Development of Systemic Lupus Erythematosus (SLE) in NZM 2328 Mice in the Absence of Any Single BAFF Receptor
Abstract Number: 2220

Development of the Pulsar (Program to Understand the Longterm Outcomes in Spondyloarthritis) Registry
Abstract Number: 1721

Development of User-Focused Standards of Care for Rheumatoid Arthritis the Www.Eumusc.Net Project – Work Package 5
Abstract Number: 1364

Development, Sensibility and Reliability of a New Case-Finding Questionnaire, the Toronto Axial Spondyloarthritis Questionnaire in Inflammatory Bowel Disease
Abstract Number: 954

Diagnosis of Secondary Fibromyalgia in an Established Rheumatoid Arthritis Cohort
Abstract Number: 1388

Diagnostic Accuracy of Anti-dsDNA Antibodies in Unselected Patients with Recent Onset of Rheumatic Symptoms
Abstract Number: 2111

Diagnostic Performance of the 2010 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Rheumatoid Arthritis: Systematic Literature Review and Meta-Analysis
Abstract Number: 198

Diagnostic Predictors and Clinical Outcomes in Patients Presenting Solely with Lymphadenopathy
Abstract Number: 1921

Diagnostic Utility of Serum IgG4 in IgG4-Related Disease
Abstract Number: 2197

Diagnostic Value of Blood B-Cell Subset Profiling and Autoimmunity Markers in Anti-SSA-Negative Sjögren’s Syndrome Patients
Abstract Number: 1344

Diagnostic Value of High Sensitivity C Reactive Protein for Early Axial Spondyloarthritis: Results From the Devenir Des Spondylarthopathies Indifferenciees Recentes Cohort
Abstract Number: 1116

Diagnostic Value of Internal Rotation Measurement in Patients with Cam- and Pincer-Type Deformities of the Hip
Abstract Number: 1680

Diagnostic Value of the Assessment of Spondyloarthropathy International Society (ASAS) Criteria for Children with Enthesitis Related Arthritis (ERA): A Single Center Study of 124 Patients
Abstract Number: 2129

Dickkopf-1 Is Increased in Rheumatoid Arthritis of Recent Onset and Might Be a New Biomarker of Structural Progression. Data From the Espoir Cohort
Abstract Number: 426

Dickkopf-1 Stimulates Fibroblast-Like Synoviocyte Migration Through Janus Kinase Activation
Abstract Number: 2692

Diet and Other Lifestyle Related Factors and the Risk of Developing Rheumatoid Arthritis
Abstract Number: 2686

Difference in Clinical Features and Mortality Between Pediatric-Onset and Adult-Onset Systemic Lupus Erythematosus
Abstract Number: 339

Differences Between Juvenile and Adult Rodents with Collagen Induced Arthritis
Abstract Number: 1085

Differences in Baseline Characteristics Between TKR and THR Patients: Results From a National Research Consortium
Abstract Number: 521

Differences in Genome-Wide DNA Methylation Profiles Across Multiple Cell and Tissue Types in Sjögren’s Syndrome (SS)
Abstract Number: 2058

Differences in Psychological Characteristics Between Patients with Rheumatoid and Psoriatic Arthritis
Abstract Number: 369

Differences in Short-Term Radiographic Progression Following Early Response to Adalimumab Plus Methotrexate Vs. Methotrexate Alone
Abstract Number: 1514

Differences in the Activation Levels and Expression Patterns of the Molecular Targets of Tyrosine Kinase Inhibitors May Account for the Heterogeneous Treatment Responses
Abstract Number: 550

Differences in the Prevalence of Inflammatory Articular Disease in Psoriatic Patients, Applying Clinical, Ultrasound and/or Radiological Data. Implications in the Classification of Psoriatic Arthritis according to Caspar Criteria
Abstract Number: 671

Differences in the SLE Clinical Phenotype by Age of Diagnosis
Abstract Number: 1791

Different Mechanisms Responsible for IVIG Inhibition of Immune Complex Versus TLR Stimulated Interferon-Alpha
Abstract Number: 1128

Different of Patterns Knee Pain Trajectories: Longitudinal Data From the Osteoarthritis Initiative (OAI)
Abstract Number: 573

Differential Association Between Human Leukocyte Antigen (HLA) Alleles and Joint Subluxation and Ankylosis in Patients with Psoriatic Arthritis
Abstract Number: 2304

Differential Association of IRAK1 and MECP2 with Specific Systemic Sclerosis Phenotypes
Abstract Number: 1329

Differential Effect of 4 and 8 Mg/Kg Tocilizumab in Combination with Methotrexate On Serum Biomarkers of Cartilage, Connective Tissue and Bone Turnover
Abstract Number: 23

Differential Effects of Bone Morphogenetic Protein 2 and 9 On Chondroprotective Transforming Growth Factor β Signaling
Abstract Number: 1471

Differential Expression of Hepatocyte Growth Factor (HGF) in Patients with Systemic Sclerosis-Associated Pulmonary Arterial Hypertension
Abstract Number: 1685

Differential Impact of Cardiac Risk Factors On Coronary Plaque Presence and Features in Asymptomatic Patients with Rheumatoid Arthritis Compared to Controls
Abstract Number: 675

Differential Impairment of Serum Cholesterol Efflux Capacity in Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus
Abstract Number: 878

Differential Regulation of Cytokines by Extracellular-Signal Regulated Kinase and c-Jun N-Terminal Kinase in Map Kinase Kinase-3 and -6 Deficiency
Abstract Number: 1522

Differential Response to Endoplasmic Reticulum Stress Between Alveolar Epithelial Cells and Lung Fibroblasts in Systemic Sclerosis
Abstract Number: 1737

Diffuse Alveolar Hemorrhage Caused by Primary Antiphospholipid Syndrome
Abstract Number: 1348

Diffuse Idiopathic Skeletal Hyperostosis (DISH) in Psoriatic Arthritis
Abstract Number: 1054

Diffusion Tensor and Dynamic Contrast Enhanced Perfusion Imaging Metrics Discriminate Chronic Tubercular Synovitis From Chronic Inflammatory Synovitis of the Knee
Abstract Number: 934

Direct Medical Cost Associated with Organ System Involvement in a Commercially Insured Population with Systemic Lupus Erythematosus in the United States
Abstract Number: 1418

Directed Intuitive Assessment of Lupus (the DIAL system for real world clinics) Correlates Well with BILAG and SLEDAI
Abstract Number: 2386

Disability and Mortality Related to Cerebrovascular Disease in Systemic Vasculitis
Abstract Number: 2254

Discoid Lupus in Patients with Systemic Lupus Erythematosus
Abstract Number: 771

Discontinuation of Adalimumab without Functional and Radiographic Damage Progression After Achieving Sustained Remission in Patients with Rheumatoid Arthritis (the HONOR study): 1-Year Results
Abstract Number: 402

Discordant Inflammatory Markers in Veterans with Rheumatoid Arthritis: Baseline Characteristics and Relationship with Disease Activity
Abstract Number: 2326

Discovery of a Highly Potent, Selective Reversible Covalent Inhibitor of JAK3 Kinase
Abstract Number: 875

Discovery of Pharmacologic MIF Antagonists by Structure-Based Molecular Design
Abstract Number: 588

Discovery of Two Public T Cell Receptor Clonotypes in B27+ Ankylosing Spondylitis by Deep Repertoire Sequence Analysis
Abstract Number: 1570

Discrepancies Between Disease Activity and Disease Burden
Abstract Number: 2109

Discrepancy Between Patient and Physician Global Assessments Over Time in Early Rheumatoid Arthritis
Abstract Number: 2132

Disease Activity and Anti-CCP Status, but Not Sociodemographic Factors or Patient Comorbidities, Affect Time to Diagnosis in Early Rheumatoid Arthritis
Abstract Number: 1842

Disease Activity and Treatment Strategies in Moderate Rheumatoid Arthritis Patient Population: Data From the Consortium of Rheumatology Researchers of North America
Abstract Number: 2661

Disease Activity Score 28-Joint Count: Are Erythrocyte Sedimentation Rate and C-Reactive Protein Versions Comparable?
Abstract Number: 930

Disease Burden and Cost of Illness in SLE During 8 Years Follow up
Abstract Number: 1361

Disease Burden Is Comparable in Patients with Non-Radiographic Axial Spondyloarthritis and Ankylosing Spondylitis
Abstract Number: 171

Disease Modifying Agents Combined with Isoniazid for Latent Tuberculosis in Patients with Rheumatic Diseases
Abstract Number: 730

Disease Modifying Effect of Strontium Ranelate in Experimental Dog Osteoarthritis: Inhibition of Major Catabolic Pathways
Abstract Number: 2480

Disease-Modifying Antirheumatic Drug Use and Toxicities Among Elderly Patients with Rheumatoid Arthritis
Abstract Number: 202

Diseases Associated with Markedly Elevated Ferritin Levels
Abstract Number: 108

Disparity Between Sonographic and Clinical Criteria of Remission in Psoriasis Arthritis
Abstract Number: 1754

Disruption of Dominant B-Cell and Plasma Cell Clones in Rheumatoid Arthritis Synovium by Rituximab Correlates with Treatment Response
Abstract Number: 212

Distinctive Characteristics of Anti-Mi-2 and –p155/140 Autoantibody Production in Two Cohorts of Mexican Patients with Dermatomyositis
Abstract Number: 279

Distribution of Vasculitides in Childhood Arthritis and Rheumatology Research Alliance-Affiliated Pediatric Rheumatology Centers in the United States
Abstract Number: 492

Divergent Toxicity of TNF Inhibitors On Demyelinating Disorders and Neurological Events
Abstract Number: 593

DKK1 Serum Level Is Increased in Recent Spondyloarthritis and Is Associated with Higher Prevalence of Syndesmophytes. Sclerostin Is Highly Correlated with Age. Data From the DESIR Cohort
Abstract Number: 380

DMARD and Biologic Use During Pregnancy Among Rheumatoid and Psoriatic Arthritis Patients in the Corrona Registry
Abstract Number: 2611

Do Patients with Psoriatic Arthritis Fall Into Distinct Clinical Sub-Groups- a Cluster Analysis?
Abstract Number: 840

Do Serum Hepcidin 25 Levels Predict SLE Renal or Non-Renal Flares?
Abstract Number: 1824

Do Statins Reduce the Incidence of Connective Tissue Disease? A Retrospective Cohort Study
Abstract Number: 2004

Do We Need a Minimum Standards in Care for Children with Localized Scleroderma- Result of the Consensus Meeting in Hamburg Germany On the 11th of December 2011. Part I. Diagnosis and Assessment of the Disease
Abstract Number: 1087

Do Younger TKR Patients Have Similar Disability At Time of Surgery As Older Adults?
Abstract Number: 2043

Documentation of Improvement Over 2 Months in Osteoarthritis, Systemic Lupus Erythematosus, Spondyloarthropathy and Gout Similarly to Rheumatoid Arthritis According to Function, Pain, Patient Global Estimate and RAPID3 On a Multidimensional Health Assessment Questionnaire (MDHAQ)
Abstract Number: 382

Does Biased Risk Perception Explain the Underuse of Disease Modifying Anti-Rheumatic Drugs?
Abstract Number: 2009

Does Breastfeeding Influence the Presentation of Juvenile Idiopathic Arthritis? Results From the Childhood Arthritis Prospective Study
Abstract Number: 2415

Does Interleukin-6 Mediate the Relation Between Estrogen and Bone? an Epidemiologic Approach in the Framingham Osteoporosis Study
Abstract Number: 109

Does Joint Sonography Really Add Clinically Important Information Beyond Clinical Joint Examination?
Abstract Number: 1541

Does Leflunomide Have a Place As Remission Maintenance Therapy in ANCA-Associated Vasculitis? A Bayesian Network Meta-Analysis with Hypothesis Driven Sensitivity Analyses to Adjust for Potential Biases
Abstract Number: 1475

Does Skin Gene Expression Profile Predict Response to Imatinib?
Abstract Number: 2470

Does Structural Progression of Knee Osteoarthritis Measured with Magnetic Resonance Imaging or Radiography Predict Knee Replacement? – Data From the Osteoarthritis Initiative
Abstract Number: 728

Does the Use of Angiotensin Converting Enzyme Inhibitors Prior to Scleroderma Renal Crisis Affect Prognosis ? – Results of the International Scleroderma Renal Crisis Survey
Abstract Number: 799

Does Unpredictable Intermittent Knee Pain Limit Functional Ability and Walking Frequency in Knee OA?
Abstract Number: 2632

Doing Is Believing: Health Beliefs Before and After an Exercised-Based Rehabilitation Programme for Chronic Knee Pain
Abstract Number: 474

Dose Reduction in Rituximab Retreatment May Delay Achievement of Optimal Responses
Abstract Number: 1365

Double-Blind, Placebo-Controlled, 28-Week Trial of Efficacy and Safety of Infliximab Plus Naproxen Vs Naproxen Alone: Results From the Infliximab As First Line Therapy in Patients with Early, Active Axial Spondyloarthritis Trial, Part I
Abstract Number: 1496

Downregulated Expression of Metallothionein Genes in Response to the Gadolinium Contrast Agent Omniscan in Normal Human Differentiated Macrophages and Dermal Fibroblasts
Abstract Number: 463

Drug Survival, Efficacy and Predictors for Survival On Tocilizumab in Real-Life Patients with Rheumatoid Arthritis; Results From the Swedish Biologics Register
Abstract Number: 1830

Drugs Are the Major Cost Driver of Rheumatoid Arthritis As Soon As the First Year of the Disease: An Economic Analysis Based On the Espoir Cohort Data
Abstract Number: 2460

Dual Antiplatelet Therapy As Prophylaxis of Recurrent Arterial Thrombosis in Patients with　antiphospholipid Syndrome
Abstract Number: 1782

Dual Effects of Soluble FasL and Membrane Bound FasL On Fibroblast-Like Synoviocytes Cells (FLS) From Rheumatoid Arthritis (RA) Patients
Abstract Number: 1784

Dual Function of Interleukin-33 in Fibroblast-Like Synoviocytes in Patients with Rheumatoid Arthritis
Abstract Number: 154

Dual-Energy Computed Tomography As a Diagnostic Tool for Gout During Intercritical Periods
Abstract Number: 481

Duration of Sustained Remission and Differences in Responce Between Medications, in Tumor Necrosis factor inhibitor Treated Rheumatoid Arthritis Patients
Abstract Number: 1045

Dynamic Contrast-Enhanced Magnetic Resonance Imaging of the Wrist in Rheumatoid Arthritis Patients Treated with Methotrexate, Intra-Articular Glucocorticoid and Adalimumab/Placebo
Abstract Number: 1006

Dynamic Gene Expression of Wnt Signaling Pathway During Osteogenic Stimulation in Vitro of Osteoarthritis Mesenchymal Stem Cells
Abstract Number: 726

Dynamic in Vivo Imaging of Th17-Mediated Osteoclastic Bone Resorption in Live Bones by Using Intravital Multiphoton Microscopy
Abstract Number: 2322

Dynamic Regulation of T Follicular Helper Cell Differentiation Through STAT Signaling
Abstract Number: 1127

Dynamic Stereo X-Ray Evaluation of Knee Joint Mechanics During Downhill Walking in Subject with Knee Osteoarthritis
Abstract Number: 1063

Dysfunction of Natural Killer and Natural Killer T Cells in Patients with Adult Onset Still’s Disease
Abstract Number: 416

Dyslipidaemia in Early Rheumatoid Arthritis Patients Is Common and Not Influenced by Two Years of Effective DMARD Therapy. the Opera Study
Abstract Number: 277

Dyslipidemia in Juvenile Dermatomyositis: The Role of Disease Activity
Abstract Number: 2286

Dysregulated Discoidin Domain Receptor 2-Microrna 196a-Mediated Negative Feedback Against Excess Type I Collagen Expression in Scleroderma Dermal Fibroblasts
Abstract Number: 1490

Dysregulation of Angiogenic Homeostasis in Systemic Sclerosis
Abstract Number: 2223

Dysregulation of Chromatin Modification Enzymes in Psoriatic Arthritis