Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Background/Purpose: Identifying populations at risk of SLE is essential to curtail inflammatory damage and select individuals for prevention trials. Blood relatives (Rel) of lupus patients have an increased risk of developing SLE, but no markers which identify individuals at highest risk are known. Using a large resource of SLE patients, lupus relatives, and unrelated controls, this study seeks to identify questionnaire responses and serologic factors that distinguish Rel from SLE patients and unrelated, unaffected individuals.
Methods: This study examined European-American (EA) (n=50) and African-American (AA) (n=50) individuals with medical record-confirmed, classified SLE matched 1:1 by race and gender to unaffected Rel (n=100) and unrelated, unaffected controls (Ctls, n=100). Study participants provided clinical and demographic information, and completed the SLE-specific portion of the CTD Screening Questionnaire (SLE-CSQ). Plasma samples were assessed for autoantibody production by bead-based assays and for 52 soluble mediators (BLyS, APRIL, cytokines, chemokines, and shed TNF receptors) by multiplexed bead-based assays or ELISA.
Results: EA SLE patients had more photosensitivity (p=0.035), with AA SLE patients having more discoid rash (p=0.028) and nephritis (p=0.045). Only 45% of Rel were positive for ANA (by IIF
Conclusion: Lupus Rel are distinguished from SLE patients and Ctls by inflammatory mediators that correlate with SLE-specific CSQ scores, with increased levels of the regulatory mediator, IL-10, compared to SLE patients. Identification of factors which discern unaffected lupus relatives from SLE patients may be beneficial to identify potential treatments to curtail inflammatory damage for prevention trials.
To cite this abstract in AMA style:Munroe ME, Young KA, Norris JM, Aberle T, Roberts VC, Guthridge JM, Kamen DL, Gilkeson GS, Weisman M, Ishimori M, Wallace DJ, Karp D, Sivils KL, Harley JB, James JA. Unaffected Lupus Relatives Are Distinguished from SLE Patients and Unaffected Individuals Not Related to SLE Patients By Lupus-Specific Connective Tissue Disease Questionnaire Scores, Autoantibodies, and Distinct Soluble Mediators [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/unaffected-lupus-relatives-are-distinguished-from-sle-patients-and-unaffected-individuals-not-related-to-sle-patients-by-lupus-specific-connective-tissue-disease-questionnaire-scores-autoantibodies/. Accessed October 18, 2021.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/unaffected-lupus-relatives-are-distinguished-from-sle-patients-and-unaffected-individuals-not-related-to-sle-patients-by-lupus-specific-connective-tissue-disease-questionnaire-scores-autoantibodies/