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Abstract Number: 0558

Statin Use Pattern in Patients with Inflammatory Joint Disease in a Single Site VA Medical Center

Lenche Kostadinova1, Sofi Damjanovska2, Angela Gupta3, Ibtissam Gad4, Sameena Syed4, Alyssa Lange5, Corinne Kowal6, Carey Shive7, Christopher Burant4, Brigid Wilson4, David Canaday4, David Zidar8, Donald Anthony9 and Maya Mattar10, 1(1) Department of Medicine, VA Medical Center and VA GRECC, Case Western Reserve University, Cleveland OH, Highland Heights, OH, 2(1) Department of Medicine, VA Medical Center and VA GRECC, Case Western Reserve University, Cleveland OH, Cleveland, OH, 3(1) Department of Medicine, VA Medical Center and VA GRECC, Case Western Reserve University, Cleveland OH, Cleveland, 4(1) Department of Medicine, VA Medical Center and VA GRECC, Case Western Reserve University, Cleveland OH, ohio, 5Case Western Reserve University, Cleveland, 6Case western reserve university/Cleveland VA Medical Center, ohio, 7(2) Department of Pathology, Case Western Reserve University, ohio, 8Case Western Reserve University/Cleveland VA Medical Center, Cleveland, 9Case Western Reserve University/Cleveland VA Medical Center/MetroHealth Medical Center, Cleveland, OH, 10Department of Medicine, VA Medical Center and VA GRECC, Case Western Reserve University, Cleveland OH, Cleveland, OH

Meeting: ACR Convergence 2020

Keywords: autoimmune diseases, Cardiovascular, Comorbidity, Inflammation, risk assessment

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Session Information

Date: Saturday, November 7, 2020

Title: Epidemiology & Public Health Poster II: OA, Osteoporosis, & Other Rheumatic Disease

Session Type: Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose: Patients with inflammatory joint disease, including rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) carry increased risk of cardiovascular disease (CVD). Mechanisms underlying this increased risk are thought to be attributable to a combination of traditional and novel CVD risk factors (engaged pathogenic inflammatory pathways). Lipid lowering statin therapy is one of the most commonly used CVD preventive medications. We explored statin use patterns in patients with inflammatory joint disease (RA, PsA and AS) accounting for traditional CVD risk factors. 

Methods: This was a retrospective chart review study conducted at the Cleveland VA Medical Center. ICD 10 diagnoses for RA, AS and PsA identified local populations of these patients. Medical charts of 200 RA (all seropositive for either RF or CCP in this sample set), 41 AS, 94 PsA and 19 patients with no inflammatory joint disease (general medical clinic patients) were reviewed. Diagnoses were verified using rheumatology clinic visit information and ACR, ASAS, or CASPAR criteria. Records were reviewed for ASCVD risk score components (age, gender, race, presence of hypertension or diabetes, lipid profile, and smoking status). We examined patient race, body mass index (BMI), and treatment history. When calculating ASCVD Risk Score, if age or lipid levels were above or below the limitations of the calculator, either the upper or lower limit values were used, respectively.

Results: Clinical characteristics are shown in Table 1. Most of the patients were male, consistent with the VA patient population. Patients with RA had higher ASCVD scores compared to patients with AS and PsA. In the subgroups with ASCVD score above or equal to 7.5, RA and PsA patients more commonly had diabetes mellitus, while RA patients were older and more commonly had hypertension. Only 51.8% of RA, 37% of AS and 68% or PsA patients with ASCVD score at or above 7.5 were prescribed statin compared to 81.8% of patients with no inflammatory joint disease (p=0.06). Chart review for reasons patients were not on statin included: 1) undergoing a trial of dietary change and weight loss; 2) patient declining recommended medication; and 3) other.

Conclusion: Patients with inflammatory joint disease and traditional CVD risk factor with indication for statin may benefit of provider education and improvement of CVD risk assessment and initiation of proper preventive measures in these high risk inflammatory joint disease patient populations.


Disclosure: L. Kostadinova, None; S. Damjanovska, None; A. Gupta, None; I. Gad, None; S. Syed, None; A. Lange, None; C. Kowal, None; C. Shive, None; C. Burant, None; B. Wilson, None; D. Canaday, None; D. Zidar, None; D. Anthony, None; M. Mattar, None.

To cite this abstract in AMA style:

Kostadinova L, Damjanovska S, Gupta A, Gad I, Syed S, Lange A, Kowal C, Shive C, Burant C, Wilson B, Canaday D, Zidar D, Anthony D, Mattar M. Statin Use Pattern in Patients with Inflammatory Joint Disease in a Single Site VA Medical Center [abstract]. Arthritis Rheumatol. 2020; 72 (suppl 10). https://acrabstracts.org/abstract/statin-use-pattern-in-patients-with-inflammatory-joint-disease-in-a-single-site-va-medical-center/. Accessed .
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