ACR Meeting Abstracts

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Abstracts tagged "Cardiovascular"

  • Abstract Number: L08 • ACR Convergence 2020

    Long Term Cardiovascular Safety of Febuxostat and Allopurinol in Patients with Chronic Gout: The Febuxostat versus Allopurinol Streamlined Trial (on Behalf of the FAST Investigators)

    Thomas MacDonald1, Isla Mackenzie1, George Nuki2 and Ian Ford3, 1University of Dundee, Dundee, Scotland, United Kingdom, 2University of Edinburgh, Edinburgh, Scotland, United Kingdom, 3University of Glasgow, Glasgow, Scotland, United Kingdom

    Background/Purpose: Febuxostat and allopurinol are uric acid lowering agents. Following concerns about the cardiovascular safety of febuxostat, the European Medicines Agency (EMA) recommended a post-authorization…
  • Abstract Number: 0059 • ACR Convergence 2020

    EHR-Supported Staff Protocol Improves Smoking Cessation in a Diverse Rheumatology Clinic: Results of Quit Connect Dissemination Project

    Jennifer Brandt1, S. Sam Lim1, Edmond Ramly2, Monica Messina3 and Christie Bartels4, 1Emory University, Atlanta, GA, 2University of Wisconsin School of Medicine and Public Health, Department of Family Medicine and Community Health;, Madison, 3University of Wisconsin School of Medicine and Public Health, Department of Medicine, Rheumatology Division, Madison, WI, 4University of Wisconsin School of Medicine and Public Health, Department of Medicine, Division of Rheumatology, Madison, WI

    Background/Purpose: Smoking is a key risk factor for rheumatologic conditions such as rheumatoid arthritis and lupus that disproportionately impacts disadvantaged patients and predicts worse outcomes.…
  • Abstract Number: 0786 • ACR Convergence 2020

    A Combination of Dimensionality Reduction Techniques Reveals Novel HLA-DR+ ‘Candidate’ Antigen-Presenting Cell Subsets (cAPC) in Patients with Rheumatoid Arthritis (RA)

    Christian Geier1, Jon Giles1, Samantha Gaines2, Christopher Depender1, Joan Bathon1 and Robert Winchester1, 1Division of Rheumatology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, 2Division of Rheumatology, Columbia University Vagelos College of Physicians and Surgeons, New York

    Background/Purpose: The presentation of MHC-peptide complexes to T lymphocytes via antigen-presenting cells (APC) is a crucial step in the initiation of immune responses. Dendritic cells…
  • Abstract Number: 1190 • ACR Convergence 2020

    Sex Differences in Cardiovascular Disease Prevention in Patients with Rheumatoid Arthritis: World-wide Data from the SURF-RA

    Elena Myasoedova1, Cynthia Crowson2, Joseph Sexton3, Silvia Rollefstad3 and Anne Grete Semb4, 1Mayo Clinic, Rochester, MN, 2Mayo Clinic, Rochester, Minnesota, USA, Rochester, MN, 3Diakonhjemmet Hospital, Oslo, Norway, 4Preventive Cardio-Rheuma clinic, Dept Rheum, Diakonhjemmet Hospital, Oslo, Norway, Oslo, Norway

    Background/Purpose: Rheumatoid arthritis (RA) is associated with 2-fold increase in risk of cardiovascular (CV) disease. Extensive evidence from the general population suggests that control of…
  • Abstract Number: 1474 • ACR Convergence 2020

    Early Peak of Cardiovascular Events Occurs Equally in Caucasians and African-American SLE but Is Attributed to Different Risk Factors

    Michelle Petri1, Jessica Li2 and Daniel Goldman1, 1Johns Hopkins University School of Medicine, Timonium, MD, 2Johns Hopkins University, Baltimore, MD

    Background/Purpose: The classic bimodal pattern of morbidity/mortality in SLE highlighted that cardiovascular events occurred later in the natural history of SLE (Urowitz & Gladman. J…
  • Abstract Number: 1937 • ACR Convergence 2020

    Aortic Aneurysm in Giant Cell Arteritis: A Nationwide Analysis

    Jiayi Zheng1, Ruoning Ni2, Yan Tang3 and Liangjing Lu4, 1Department of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, China (People's Republic), 2St. Agnes Hospital, Baltimore, MD, 3Department of Stomatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, China (People's Republic), 4Department of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (People's Republic)

    Background/Purpose: Giant cell arteritis (GCA) is an inflammatory vasculopathy affecting primarily medium and large sized arteries. Previous studies have demonstrated a higher prevalence of aortic…
  • Abstract Number: 0239 • ACR Convergence 2020

    Adjudicated MACE and VTE in the Filgotinib RA Program: Integrated Analysis from Phase 2 and 3 Clinical Trials

    Christina Charles-Schoeman1, Sang-Cheol Bae2, Arvind Chopra3, Stanley Cohen4, Jeffrey R Curtis5, Jacques-Eric Gottenberg6, Edward C Keystone7, Kunihiro Yamaoka8, Peter Nash9, J-Abraham Simon-Campos10, William Stohl11, Michael Weinblatt12, Rene Westhovens13, Jeff Siegel14, Iyabode Tiamiyu14, Lei Ye14, Deyuan Jiang14, Franziska Matzkies14, Angelika Jahreis14, John S. Sundy14 and Jon Giles15, 1University of California, Los Angeles, Los Angeles, CA, 2Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, 3Center for Rheumatic Diseases, Pune, India, 4University of Texas Southwestern Medical School at Dallas, and Metroplex Clinical Research Center, Dallas, TX, 5Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 6Strasbourg University Hospital, Strasbourg, France, 7Mount Sinai Hospital, Toronto, ON, Canada, 8Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan, 9School of Medicine Griffith University, Brisbane, Queensland, Australia, 10Köhler & Milstein Research, Mérida, Mexico, 11University of Southern California Keck School of Medicine, Los Angeles, CA, 12Brigham and Women's Hospital, Boston, MA, 13University Hospitals Leuven, Belgium, Leuven, Belgium, 14Gilead Sciences, Inc., Foster City, CA, 15Columbia University, New York, NY

    Background/Purpose: Filgotinib (FIL)—an oral, selective Janus kinase 1 inhibitor (JAKi)—improved RA signs and symptoms in three phase 3 trials. Despite the efficacy of FIL and…
  • Abstract Number: 0789 • ACR Convergence 2020

    Matrix Gla Protein (MGP) Modified with Malondialdehyde/Acetaldehyde Is Increased in Rheumatoid Arthritis and Cardiovascular Patients

    Xiarepati Tieliwaerdi1, Nozima Aripova1, Michael Duryee1, Xiaoting Jiang1, Lynell Klassen2, James O'Dell1, Bryant England1, Daniel Anderson1, Ted Mikuls1 and Geoffrey Thiele1, 1University of Nebraska Medical Center, Omaha, NE, 2Univerisity of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Rheumatoid arthritis (RA) is associated with an increased cardiovascular disease (CVD) burden, dramatically increasing the risk of mortality. Circulating antibodies to Malondialdehyde-Acetaldehyde (MAA) modified…
  • Abstract Number: 1191 • ACR Convergence 2020

    Specificity for Inflammatory Pathways Associated with Coronary Microvascular Dysfunction in Rheumatoid Arthritis

    Brittany Weber1, Zeling He1, Sicong Huang1, Daniel H. Solomon2, Elena Massarotti1, Charlotte Golnik1, Thany Seyok1, Seth Brownmiller1, Laurel Martell1, Leann Barrett1, Courtney Bibbo1, Marcy Bolster3, Marcelo DiCarli1 and Katherine Liao1, 1Brigham and Women's Hospital, Boston, MA, 2Brigham & Women's Hospital and Harvard Medical School, Boston, MA, 3Massachusetts General Hospital, Concord, MA

    Background/Purpose: Coronary microvascular disease (CMD) is associated with increased mortality in RA independent of traditional cardiovascular (CV) risk factors. Inflammation likely plays an important role…
  • Abstract Number: 1510 • ACR Convergence 2020

    Platelet-bound C4d Is Associated with Platelet Activation and Arterial Thrombotic Events

    Yevgeniya Gartshteyn1, Adam Mor2, Daichi Shimbo2, Leila Khalili3, Teja Kapoor4, Laura Geraldino-Pardilla5, Roberta Vezza Alexander6, Thierry Dervieux7 and Anca Askanase2, 1Columbia University College of Physicians and Surgeons, Glen Rock, NJ, 2Columbia University College of Physicians and Surgeons, New York, NY, 3Columbia University Medical Center, New Haven, CT, 4Columbia University College of Physicians and Surgeons, Leonia, NJ, 5Division of Rheumatology, Columbia University Vagelos College of Physicians and Surgeons, New York, 6Exagen Inc, Vista, CA, 7Prometheus Biosciences Inc, Irvine, CA

    Background/Purpose: Platelets have a well-defined role in arterial thrombosis, and platelet-bound complement activation products (PC4d) correlate with vascular thromboses in patients with Systemic Lupus Erythematosus…
  • Abstract Number: 1993 • ACR Convergence 2020

    Cardiovascular Risk in Rheumatoid Arthritis Patients Treated with Methotrexate versus Hydroxychloroquine

    Mengdong He1, Ajinkya Pawar1, Rishi Desai1, Robert Glynn1, Hemin Lee1, Michael Weinblatt1, Daniel H Solomon1 and Seoyoung Kim1, 1Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Rheumatoid arthritis (RA) is a known risk factor for cardiovascular (CV) events. While most RA patients use conventional disease-modifying antirheumatic drugs (DMARDs) such as…
  • Abstract Number: 0431 • ACR Convergence 2020

    Hydroxychloroquine Use Was Not Associated with QTc Length in a Large Cohort of SLE and RA Patients

    Elizabeth Park1, Jon Giles2, Thania Perez-Recio1, Paloma Pina3, Christopher Depender1, Joan Bathon1 and Laura Geraldino-Pardilla4, 1Division of Rheumatology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, 2Columbia University, New York, NY, 3Cardiac Electrophysiology, Northwestern Medicine, Chicago, IL, 4Division of Rheumatology, Columbia University Vagelos College of Physicians and Surgeons, New York

    Background/Purpose: Hydroxychloroquine (HCQ) is a cornerstone therapy for systemic lupus erythematosus (SLE), and is used as monotherapy and combined with other DMARDs in rheumatoid arthritis…
  • Abstract Number: 0864 • ACR Convergence 2020

    Effect of Cumulative Hydroxychloroquine Dose on Prevention of Damage Progression in Patients with Systemic Lupus Erythematosus

    Lisa Zhu1, Manpreet Singh2, Caroline Siegel3, Lori Sahakian2, Jennifer Grossman4 and Maureen McMahon5, 1University of California, Los Angeles, Van Nuys, CA, 2University of California, Los Angeles, Los Angeles, CA, 3Hospital for Special Surgery, New York, NY, 4University of California, Los Angeles, Sherman Oaks, CA, 5University of California Los Angeles, Los Angeles, CA

    Background/Purpose: Hydroxychloroquine (HCQ) has demonstrated a wide array of beneficial effects in patients with systemic lupus erythematosus (SLE), with regard to disease activity, flare rates,…
  • Abstract Number: 1192 • ACR Convergence 2020

    Subclinical Coronary Calcification Associated with Long-term Cardiovascular Outcomes in Rheumatoid Arthritis

    George Karpouzas1, Sarah Ormseth1, Elizabeth Hernandez1 and Matthew Budoff1, 1Harbor-UCLA Medical Center and the Lundquist Institute, Torrance, CA

    Background/Purpose: Large, multicenter studies established the strong prognostic value of coronary artery calcium (CAC) scoring in asymptomatic individuals. Increasing CAC score is an independent predictor…
  • Abstract Number: 1514 • ACR Convergence 2020

    The Impact of Renal Transplantation on Cardiovascular Events Among Patients with End-State Kidney Disease Due to Lupus Nephritis: A Nationwide Cohort Study

    April Jorge1, Xiaoqing Fu2, Yuqing Zhang3, Hyon Choi4 and Zachary Wallace5, 1Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital, Boston, 3Massachusetts General Hospital, Harvard Medical School, Boston, 4Massachusetts General Hospital, Department of Medicine, Division of Rheumatology, Lexington, MA, 5Harvard Medical School, Boston

    Background/Purpose:A major complication of systemic lupus erythematosus (SLE) is the progression of lupus nephritis (LN) to end-stage kidney disease (ESKD). Both SLE and ESKD are…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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