ACR Meeting Abstracts

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Abstracts tagged "Cardiovascular"

  • Abstract Number: L06 • ACR Convergence 2022

    Risk of Extended Major Adverse Cardiovascular Event Endpoints with Tofacitinib vs TNF Inhibitors in Patients with Rheumatoid Arthritis: A Post Hoc Analysis of a Phase 3b/4 Randomized Safety Study

    Maya H. Buch1, Deepak L. Bhatt2, Christina Charles-Schoeman3, Jon T. Giles4, Ted R. Mikuls5, Gary Koch6, Steven Ytterberg7, Edward Nagy8, Hyejin Jo9, Kenneth Kwok9, Carol A. Connell10, Karim R. Masri11 and Arne Yndestad12, 1Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester, United Kingdom, 2Division of Cardiovascular Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 3Division of Rheumatology, Department of Medicine, University of California, Los Angeles, CA, 4Division of Rheumatology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, 5Division of Rheumatology, University of Nebraska Medical Center and VA Nebraska-Western Iowa Health Care System, Omaha, NE, 6Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 7Division of Rheumatology, Mayo Clinic, Rochester, MN, 8Pfizer Ltd, Tadworth, Surrey, United Kingdom, 9Pfizer Inc, New York, NY, 10Pfizer Inc, Groton, CT, 11Pfizer Inc, Collegeville, PA, 12Pfizer Inc, Oslo, Norway

    Background/Purpose: ORAL Surveillance (NCT02092467; a post-authorization safety study of tofacitinib 5 and 10 mg twice daily [BID] vs TNF inhibitors [TNFi]) found higher risk of…
  • Abstract Number: 0254 • ACR Convergence 2022

    Lipids and Vascular Inflammation in Patients with RA Using Triple Therapy vs Methotrexate + TNFi: A Secondary Analysis of the TARGET Randomized Active Comparator Trial

    Katherine Liao1, Jon Giles2, Pamela Rist1, Robert Glynn1, Leah Santacroce1, Paul Ridker1, Ahmed Tawakol3, Joan Bathon2 and Daniel Solomon1, 1Brigham and Women's Hospital, Boston, MA, 2Columbia University, New York, NY, 3Massachusetts General Hospital, Boston, MA

    Background/Purpose: Rheumatoid arthritis (RA) treatments are known to cause complex changes in lipids, in part by controlling disease activity. While there are robust data on…
  • Abstract Number: 0626 • ACR Convergence 2022

    Elucidating the Expression and Role of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Human Rheumatoid Arthritis Synovial Fibroblasts and a Rat Adjuvant-induced Arthritis Model

    Meena Afroze Shanta1, Farheen Sultan Shaikh2, Bhanupriya Madarampalli3 and Salahuddin Ahmed2, 1College of Pharmacy and Pharmaceutical Science, Washington State University, Spokane, WA, 2Washington State University, Spokane, WA, 3University of Washington, Bellevue, WA

    Background/Purpose: Proprotein convertase subtilisin/Kexin type-9 (PCSK9) is the most recognized serine protease for its pathological role in cardiovascular diseases, however, its role in inflammatory diseases,…
  • Abstract Number: 0921 • ACR Convergence 2022

    Effects of Methotrexate on the Liver Function and Disease Activity of Newly Diagnosed RA Patients Depending on the Cardiometabolic Profile

    Ivan Arias-de la Rosa1, Miriam Ruiz-Ponce1, Laura Cuesta-Lopez1, Rafaela Ortega-Castro1, Jerusalem Calvo1, lourdes Ladehesa-Pineda2, Carlos Pérez-Sánchez1, Chary López-Pedrera3, Eduardo Collantes1, Alejandro Escudero-Contreras1 and Nuria Barbarroja1, 1IMIBIC/University of Cordoba/Reina Sofia Hospital, Cordoba, Spain, 2Reina Sofia University Hospital/Rheumatology Department/Maimonides Institute for Biomedical Research (IMIBIC), Cordoba, Spain, 3Maimonides Institute for Biomedical Research of Córdoba, Cordoba, Spain

    Background/Purpose: Methotrexate (MTX) is the first-line treatment in Rheumatoid arthritis (RA) patients. To date, the evidence about the liver disease caused by MTX is controversial.…
  • Abstract Number: 1400 • ACR Convergence 2022

    Machine Learning Identifies Molecular Phenotypes That Predict Incident Cardiovascular Disease in Patients with Rheumatoid Arthritis

    Tate Johnson1, Rebekah Gundry2, Merry Lindsey2, Punyasha Roul3, Yangyuna Yang2, Joshua Baker4, Brian Sauer5, Grant Cannon6, Geoffrey Thiele2, Ted Mikuls7 and Bryant England2, 1University of Nebraska Medical Center, Elkhorn, NE, 2University of Nebraska Medical Center, Omaha, NE, 3UNMC, Omaha, NE, 4University of Pennsylvania, Philadelphia, PA, 5Salt Lake City VA/University of Utah, Salt Lake City, UT, 6Retired, Salt Lake City, UT, 7Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Cardiovascular disease (CVD) remains the leading cause of death in patients with rheumatoid arthritis (RA). General population CVD risk calculators underestimate risk in RA,…
  • Abstract Number: 1580 • ACR Convergence 2022

    Poor Serum Urate Control Is a Driver of Excess Cardiovascular Risk in Patients with Gout

    Tate Johnson1, Lindsay Helget2, Harlan Sayles2, Punyasha Roul3, James O'Dell2, Ted Mikuls4 and Bryant England2, 1University of Nebraska Medical Center, Elkhorn, NE, 2University of Nebraska Medical Center, Omaha, NE, 3UNMC, Omaha, NE, 4Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Gout patients suffer from an increased burden of cardiovascular disease (CVD). It remains unclear whether this risk is related to an excess of CVD…
  • Abstract Number: 1846 • ACR Convergence 2022

    Cardiac Sarcoidosis: An Underdiagnosed, Life-threatening yet Treatable Disease

    Patrick Webster1, Yogita Rochlani2 and Konstantinos Loupasakis3, 1Rheumatology Fellow at Montefiore, New York, NY, 2Montefiore Medical Center / Albert Einstein College of Medicine, Bronx, NY, 3Montefiore Medical Center/ Albert Einstein College of Medicine, Bronx, NY

    Background/Purpose: Cardiac sarcoidosis (CS) is potentially life-threatening and it typically causes heart failure, ventricular arrhythmia, AV block or sudden death. CS has been reported to…
  • Abstract Number: 0257 • ACR Convergence 2022

    High Density Lipoprotein Bound miR-1246 Is Enriched in Patients with Rheumatoid Arthritis and Is Proinflammatory

    Qiong Wu, Quanhu Sheng, Danielle Michell, Kasey Vickers and Michelle Ormseth, Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: High density lipoprotein (HDL) is known for its anti-atherogenic cholesterol efflux and antioxidant functions. HDL has additional relevance to rheumatoid arthritis (RA) because of…
  • Abstract Number: 0660 • ACR Convergence 2022

    Serum Proteins and Metabolites Differ in SLE Patients with Coronary Microvascular Dysfunction (CMD) as Determined by Cardiac MRI Compared to SLE Patients Without CMD – a Pilot Study

    Audrey Hagiwara1, Moumita Bose1, Aleksandr Stotland1, Aleksandra Binek1, Koen Raedschelders1, Janet Wei1, C. Noel Bairey Merz1, Sarah Parker1, Jennifer Van Eyk1, Daniel Wallace1, Mariko Ishimori2 and Caroline Jefferies1, 1Cedars-Sinai Medical Center, Los Angeles, CA, 2Cedars-Sinai Health System, Los Angeles, CA

    Background/Purpose: Cardiovascular disease (CVD) is a significant cause of mortality in patients with SLE. While obstructive coronary artery disease (CAD) is a leading cause of…
  • Abstract Number: 0922 • ACR Convergence 2022

    Alteration of the Cardiometabolic and Cardiovascular Proteome in Rheumatoid Arthritis. Modulation by Methotrexate and Tofacitinib

    Nuria Barbarroja1, Carlos Pérez-Sánchez1, Laura Cuesta-Lopez1, Miriam Ruiz-Ponce1, Ivan Arias-de la Rosa1, Antonio Gonzalez2, Eva Perez Pampin3, Chamaida Plasencia-Rodriguez4, Ana Martinez-Feito4, Rafaela Ortega-Castro1, Jerusalem Calvo-Gutierrez5, Alejandro Balsa6, Alejandro Escudero-Contreras1, Eduardo Collantes1 and Chary López-Pedrera7, 1IMIBIC/University of Cordoba/Reina Sofia Hospital, Cordoba, Spain, 2Experimental and Observational Rheumatology and Rheumatology Unit, Instituto de Investigacion Sanitaria-Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain, 3Experimental and Observational Rheumatology and Rheumatology Unit, Instituto de Investigacion Sanitaria-Hospital Clínico Universitario de Santiago, Cordoba, Spain, 4Rheumatology Department, La Paz University Hospital, Madrid, Spain, 5IMIBIC/University of Cordoba/Reina Sofia Hospital, Córdoba, Spain, 6Hospital La Paz Institute for Health Research, Madrid, Spain, 7Maimonides Institute for Biomedical Research of Córdoba, Cordoba, Spain

    Background/Purpose: Patients with rheumatoid arthritis (RA) have a high risk of suffering cardiovascular disease. The analysis of the cardiovascular and cardiometabolic proteome in RA patients…
  • Abstract Number: 1407 • ACR Convergence 2022

    Longitudinal Lipid Profile and NT-proBNP Changes from Pre-clinical to Established Rheumatoid Arthritis: A 12 Years Follow up Explorative Study

    Reinder Raadsen1, Laurette van Boheemen1 and Michael Nurmohamed2, 1Reade Rheumatology Center, Amsterdam, Netherlands, 2Amsterdam University Medical Center, Kortenhoef, Netherlands

    Background/Purpose: Patients with rheumatoid arthritis (RA) have an increased risk for developing cardiovascular diseases (CVD). This is partly due to the systemic inflammation characteristic to…
  • Abstract Number: 1582 • ACR Convergence 2022

    Allopurinol Use and Risk of Acute Coronary Syndrome in Patients with Incident Gout: A Population-based Study in Sweden

    Panagiota Drivelegka1, Lennart Jacobsson2, Karin Bengtsson3 and Mats Dehlin4, 1Department of Rheumatology, Sahlgrenska University Hospital, Gothenburg, Sweden, 2Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden, 3Department of Rheumatology and Inflammation research, University of Gothenburg, Salhgrenska Academy, Gothenburg, Sweden, 4Dept of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: Gout is associated with an increased risk of cardiovascular disease, with accumulated evidence that gout is an independent risk factor. Whether allopurinol use alters…
  • Abstract Number: 1856 • ACR Convergence 2022

    Subclinical Coronary Artery Disease in Patients with Idiopathic Inflammatory Myopathies: A Cross-Sectional Study Evaluation by Computer Tomography Coronary Angiogram

    Tsz Ho Luk1, Weng Nga Lao1, Steve Pang1, Ho So2, Tak Lung Wong3 and Yan Ki Tang4, 1Kwong Wah Hospital, Hong Kong, Hong Kong, 2Chinese University of Hong Kong, Hong Kong, Hong Kong, 3KWH, Kowloon, Hong Kong, 4Kwong Wah Hospital, Hong Kong, China

    Background/Purpose: Idiopathic inflammatory myopathy (IIM) poses elevated risk of cardiovascular event and mortality, similar to other autoimmune rheumatic diseases. With the use of computer tomography…
  • Abstract Number: 0284 • ACR Convergence 2022

    Compared Mortality and Cardiovascular Safety of JAK Inhibitors and Tocilizumab in Patients with RA : A Systematic Review and Network Meta-analysis

    Daniela Chicre1, Alisson Pugliesi1, Manoel Barros Bértolo1, Vani de Abreu Souza Filho1 and Luiz Sérgio F Carvalho2, 1Universidade Estadual de Campinas, Campinas, São Paulo, Brazil, 2Clarity: Inteligência em Saúde, Brasília, Brazil

    Background/Purpose: The ORAL-Surveillance trial showed important data on the comparative safety between Tofacitinib and TNF inhibitors (TNFi) in the treatment of RA, leading to safety…
  • Abstract Number: 0677 • ACR Convergence 2022

    Obstructive Sleep Apnea in Primary Antiphospholipid Syndrome Impacts Damage Accrual

    Gustavo Balbi1, Flavio Victor Signorelli2, Ana Paula Gandara3, Indira Azam3, Dilson Marreiros3, Luciano Drager3 and Danieli Castro Oliveira de Andrade4, 1Universidade de São Paulo, São Paulo, Brazil, 2Universidade do Estado do Rio de Janeiro, Rio De Janeiro, Brazil, 3University of São Paulo, São Paulo, Brazil, 4Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil

    Background/Purpose: Obstructive sleep apnea (OSA) has been associated with an increased risk of thrombotic-related events, such as myocardial infarction and cerebrovascular diseases in the general…
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