ACR Meeting Abstracts

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Abstracts tagged "Inflammation"

  • Abstract Number: 0055 • ACR Convergence 2022

    Protective Role for Mast Cells in TNF-induced Inflammatory-Erosive Arthritis and Its Associated Lymphatic Dysfunction in Mice

    Yue Peng1, H. Mark Kenney2, Karen Bentley3, Lianping Xing4, Christopher Ritchlin5 and Edward Schwarz1, 1University of Rochester Medical Center, Rochester, NY, 2University of Rochester Medical Center, Henrietta, NY, 3University of Rochester, Rochester, 4University of Rochester Medical Center, Webster, NY, 5Allergy, Immunology and Rheumatology Division, University of Rochester Medical School, Canandaigua, NY

    Background/Purpose: Inflammatory-erosive arthritis is exacerbated by lymphatic dysfunction (1). Mast cells (MCs) regulate lymphatic vessels by releasing inflammatory and vasoactive mediators (e.g. histamine) (2). Previous…
  • Abstract Number: 0548 • ACR Convergence 2022

    Postural Orthostatic Tachycardia Syndrome, Small Fiber Neuropathy, and Systemic Inflammation: Are They Related?

    Elizabeth Bettini, Carolyn Ramwell, Sangeeta Sule and Jeffery Moak, Children's National Hospital, Washington, DC

    Background/Purpose: Postural Orthostatic Tachycardia Syndrome (POTS) is a dysautonomia associated with chronic autonomic and neuropathic symptoms, including pain in multiple body regions, paresthesia, fatigue, brain…
  • Abstract Number: 0659 • ACR Convergence 2022

    Comprehensive Proteomic Screen of Murine Lupus Serum and Cerebrospinal Fluid Uncovers Diagnostic and Therapeutic Targets

    Joshua Reynolds1, Chandra Mohan2, Yaxi Li2 and Chaim Putterman1, 1Albert Einstein College of Medicine, Bronx, NY, 2University of Houston, Houston, TX

    Background/Purpose: Up to 50% of SLE patients experience neuropsychiatric involvement (neuropsychiatric lupus, or NPLSE) through an unknown mechanism. Diagnosis currently relies on clinical criteria and…
  • Abstract Number: 1151 • ACR Convergence 2022

    Colonic Organoids to Study the Role of HLA-B27 in Gastrointestinal Epithelial Biology

    Alec Furst1, John Davis1, Manuel Rodriguez1, Kimberly Ogle1, James T. Rosenbaum2 and Tejpal Gill1, 1OHSU, Portland, OR, 2Legacy Devers Eye Institute, Portland, OR

    Background/Purpose: Axial spondyloarthritis (axSpA) is defined clinically as inflammatory back pain along with peripheral arthritis, and extra-articular manifestations involving the eye, gut, and skin. Even…
  • Abstract Number: 1610 • ACR Convergence 2022

    Are Serological Protease-mediated Peptides of Tissue Remodeling and Inflammation the New Disease Activity Biomarkers in Psoriatic Arthritis Patients?

    Solveig S. Groen1, Signe Holm Nielsen2, Anne-Christine Bay-Jensen2, Mozhgan Rasti3, Darshini Ganatra3, Katerina Oikonomopoulou3 and Vinod Chandran4, 1Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark, 2Nordic Bioscience, Herlev, Denmark, 3Schroeder Arthritis Institute, Krembil Research Institute, Toronto, ON, Canada, 4Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto/ Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada

    Background/Purpose: Inflammatory and degenerative processes in the joint tissues are hallmarks of patients with psoriatic arthritis (PsA). Here, proteases play a major role in remodeling…
  • Abstract Number: 1833 • ACR Convergence 2022

    Intraarticular Morphine in Knee-arthritis – Results of a Randomized Placebo-controlled Trial

    Hildrun Haibel1, Joachim Sieper1, Denis Poddubnyy2, valeria Rios-Rodriguez3, Fabian Proft2, Mikhail Protopopov4, Judith Rademacher4, Sabrina Igel5, Peter Martus6 and Christoph Stein5, 1Charité - Universitätsmedizin, Berlin, Berlin, Germany, 2Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité – Universitätsmedizin Berlin, Berlin, Germany, 3Charité-Universitätsmedizin Berlin, Berlin, Germany, 4Charité Universitätsmedizin Berlin, Berlin, Germany, 5Charité University Medicine Berlin, Berlin, Germany, 6University Hospital Tübingen, Tübingen, Germany

    Background/Purpose: The current standard of intraarticular therapy in patients with inflammatory arthritis (e.g. rheumatoid arthritis; RA) or inflammatory exacerbations of osteoarthritis (OA) is the injection…
  • Abstract Number: 2143 • ACR Convergence 2022

    Effect of Upadacitinib and Adalimumab on Residual Pain Among Patients with Psoriatic Arthritis Whose Inflammation Was Attenuated After Three and Six Months of Treatment

    Louis Bessette1, Georg Pongratz2, Luca Navarini3, Rodrigo Garcia Salinas4, Tianming Gao5, Marie-Claude Laliberté6, Ralph Lippe7 and Philip J Mease8, 1Centre de l'Ostoporose et de Rhumatologie de Québec, Québec, QC, Canada, 2Asklepios Clinic Bad Abbach, University of Regensburg, Regensburg, Germany, 3Rheumatology, Immunology, and Clinical Medicine, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy, 4Hospital Italiano de La Plata, La Plata, Argentina, 5AbbVie, Inc., North Chicago, IL, 6AbbVie, Québec, QC, Canada, 7AbbVie, Inc, Wiesbaden, Germany, 8Swedish Medical Center/Providence St. Joseph Health, Seattle, WA

    Background/Purpose: Managing pain, a predominant symptom of psoriatic arthritis (PsA), is a priority for patients and healthcare providers. Upadacitinib (UPA), a Janus kinase (JAK) inhibitor,…
  • Abstract Number: 0133 • ACR Convergence 2022

    Retention Rate of Targeted Therapies in Erdheim-Chester Disease

    Corrado Campochiaro1, alessandro tomelleri1, Francesco Pegoraro2, Giovanni Galardi3, Nicola Farina4, Martina Mazzariol5, Francesco Catamerò6, Giacomo De Luca4, Giulio Cavalli4, Augusto Vaglio7 and Lorenzo Dagna8, 1IRCCS San Raffaele Hospital. Vita-Salute San Raffaele University, Milano, Italy, 2Department of Health Sciences, University of Florence, Firenze, Italy, 3Department of Health Sciences, University of Florence, Florence, Italy, 4IRCCS San Raffaele Hospital - Vita-Salute San Raffaele University, Milano, Italy, 5University of Turin, Torino, Italy, 6Vita-Salute San Raffaele University, Milano, Italy, 7Azienda Ospedaliero Universitaria Meyer, Parna, Italy, 8IRCCS San Raffaele Hospital and Vita-Salute San Raffaele University, Milano, Italy

    Background/Purpose: Erdheim-Chester disease (ECD) is a rare non-Langerhans histiocytosis with a broad clinical spectrum. The therapeutic landscape of ECD has remarkably changed over the last…
  • Abstract Number: 0557 • ACR Convergence 2022

    VEXAS Syndrome Is Characterized by Blood and Tissues Inflammasome Pathway Activation and Monocyte Dysregulation

    Benjamin Terrier1, Celine Posseme2, Marie Temple3, Aurélien Corneau4, Francesco Carbone5, Eugénie Duroyon3, camille Gobeaux3, Estibaliz Lazaro6, Roderau Outh7, Guillaume Le Guenno8, Francois Lifermann9, Marie Berleur10, Thierry Weitten11, Vivien Guillotin12, Cédric Lenormand13, Hang-Korng Ea14, Mickael Ménager5, Darragh Duffy2 and Olivier Kosmider3, 1National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France, 2Institut Pasteur, Paris, France, 3Cochin Hospital, Paris, France, 4Pitié Salpêtrière Hospital, Paris, France, 5Institut Imagine, Paris, France, 6Bordeaux Hospital University, Bordeaux, France, 7CH, Perpignan, France, 8CHU, Clermont-Ferrand, France, 9Dax Hospital, Dax, France, 10CH, Versailles, France, 11CHIGAS, Gap, France, 12CHU Bordeaux, Bordeaux, France, 13CHRU, Strasbourg, France, 14Lariboisière Hospital, Paris, France

    Background/Purpose: Acquired mutations in the UBA1 gene, occurring in myeloid cells and resulting in expression of a catalytically impaired isoform of the enzyme E1, were…
  • Abstract Number: 0693 • ACR Convergence 2022

    Low Neutrophil Ectonucleotidase Activity Drives Neutrophil-Platelet Aggregation and Platelet Activation in Antiphospholipid Syndrome (APS)

    Naveen Kumar S K1, Claire Hoy1, Srilakshmi Yalavarthi1, Cyrus Sarosh2, Kaitlyn Sabb1, Christine Rysenga1, Jacqueline Madison1, Yu Zuo1 and Jason S Knight3, 1University of Michigan, Ann Arbor, MI, 2University of Michigan, Temperance, MI, 3University of Michigan, Division of Rheumatology, Ann Arbor, MI

    Background/Purpose: By converting extracellular ATP into homeostatic adenosine, the ectonucleotidases CD39 (ATP to AMP) and CD73 (AMP to adenosine) dictate extracellular purinergic gradients and as…
  • Abstract Number: 1154 • ACR Convergence 2022

    Axial Spondyloarthritis: Profiling of MiRNAs in Peripheral Blood Mononuclear Cells

    Aneta Pekčcová1, Kristýna Bubová2, Monika Gregova3, Šárka Forejtová2, Jana Hořínková2, Markéta Hušáková2, Michal Tomcik4, Jindřiška Gatterová2, Jiří Vencovský5, Karel Pavelka6, Ladislav Šenolt5 and Jiří Baloun2, 1Institue of Rheumatology, Prague, Prague, Czech Republic, 2Institue of Rheumatology, Prague, Czech Republic, 3Institue of Rheumatology, Prague, 4Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 5Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 6Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Praha, Czech Republic

    Background/Purpose: microRNAs (miRNAs) are small non-coding RNAs, which are essential for correct gene expression. The dysregulation in miRNA expression is accompanied by various diseases and…
  • Abstract Number: 1614 • ACR Convergence 2022

    Females with Non-Radiographic but Not with Radiographic Axial Spondyloarthritis Are Less Likely to Achieve Inactive Disease State Than Males: Results from a Multicountry Prospective Observational Study

    Denis Poddubnyy1, Joachim Sieper2, Servet Akar3, Santiago Muñoz-Fernández4, Hildrun Haibel2, Torsten Diekhoff5, Mikhail Protopopov6, Elisabeth Altmaier7, Fabiana Ganz8 and Robert Inman9, 1Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité – Universitätsmedizin Berlin, Berlin, Germany, 2Charité - Universitätsmedizin, Berlin, Berlin, Germany, 3Izmir Katip Celebi University School of Medicine, Izmir, Turkey, 4Servicio de Reumatología, Hospital Universitario Infanta Sofía, Universidad Europea, Madrid, Spain, 5Department of Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany, 6Charité Universitätsmedizin Berlin, Berlin, Germany, 7GKM Gesellschaft für Therapieforschung mbH, Munich, Germany, 8AbbVie, Inc., Luzern, Switzerland, 9University Health Network, Toronto, ON, Canada

    Background/Purpose: Emerging evidence suggests that men and women experience axial spondyloarthritis (axSpA) differently. Some studies suggested that the probability of treatment response was lower in…
  • Abstract Number: 1846 • ACR Convergence 2022

    Cardiac Sarcoidosis: An Underdiagnosed, Life-threatening yet Treatable Disease

    Patrick Webster1, Yogita Rochlani2 and Konstantinos Loupasakis3, 1Rheumatology Fellow at Montefiore, New York, NY, 2Montefiore Medical Center / Albert Einstein College of Medicine, Bronx, NY, 3Montefiore Medical Center/ Albert Einstein College of Medicine, Bronx, NY

    Background/Purpose: Cardiac sarcoidosis (CS) is potentially life-threatening and it typically causes heart failure, ventricular arrhythmia, AV block or sudden death. CS has been reported to…
  • Abstract Number: 2161 • ACR Convergence 2022

    Alterations of Nutritional Status of Scleroderma Patients and Associations with Disease-specific Features

    Sabína Oreská1, Hana Storkanova1, Maja Spiritovic2, Barbora Hermankova2, Michal Vrablík3, Karel Pavelka4, Jiří Vencovský5, Ladislav Šenolt5, Radim Becvar1 and Michal Tomcik1, 1Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 2Institute of Rheumatology, Department of Physiotherapy, Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, Prague, Czech Republic, 33rd Department of Internal Medicine, General University Hospital and 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 4Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Praha, Czech Republic, 5Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic

    Background/Purpose: Systemic sclerosis (SSc) is characterized by skin and organ involvement and chronic disease course. In particular, involvement of the gastrointestinal tract and systemic inflammation…
  • Abstract Number: 0137 • ACR Convergence 2022

    Polyarticular Arthritis and Osteolysis Caused by Mutations in the ASAH1 Gene: Farber Disease Clinical Presentations in the First-ever Natural History Study

    Alexander Solyom1, Kathleen Crosby2, Nils Confer2 and Jaime Lopez Valdez3, 1Aceragen, Basel, Switzerland, 2Aceragen, Durham, NC, 3Centenario Hospital Miguel Hidalgo, Aguascalientes, Mexico

    Background/Purpose: Farber disease is frequently misdiagnosed as polyarticular juvenile idiopathic arthritis or seronegative rheumatoid arthritis which leads to a delay in diagnosis for many patients.…
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