ACR Meeting Abstracts

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Abstracts tagged "Inflammation"

  • Abstract Number: L03 • ACR Convergence 2020

    Efficacy and Safety of Deucravacitinib (BMS-986165), an Oral, Selective Tyrosine Kinase 2 Inhibitor, in Patients with Active Psoriatic Arthritis: Results from a Phase 2, Randomized, Double-Blind, Placebo-Controlled Trial

    Philip Mease1, Atul Deodhar2, Désirée van der Heijde3, Frank Behrens4, Alan Kivitz5, Jonghyeon Kim6, Shalabh Singhal6, Miroslawa Nowak6 and Subhashis Banerjee6, 1Swedish Medical Center/Providence St. Joseph Health and University of Washington, Seattle, WA, 2Oregon Health & Science University, Portland, OR, 3Leiden University Medical Center, Leiden, Netherlands, 4CIRI/Rheumatology and Fraunhofer Institute IME, Translational Medicine and Pharmacology, Goethe University, Frankfurt, Germany, 5Department of Rheumatology, Altoona Center for Clinical Research, Duncansville, PA, 6Bristol Myers Squibb, Princeton, NJ

    Background/Purpose: Tyrosine kinase 2 (TYK2) is an intracellular kinase that mediates signaling by key cytokines involved in psoriatic arthritis (PsA) pathophysiology. Deucravacitinib (BMS-986165) is a…
  • Abstract Number: L06 • ACR Convergence 2020

    Mavrilimumab (anti GM-CSF Receptor α Monoclonal Antibody) Reduces Time to Flare and Increases Sustained Remission in a Phase 2 Trial of Patients with Giant Cell Arteritis

    Maria C. Cid1, Sebastian Unizony2, Lara Pupim3, Fang Fang4, Joseph Pirrello3, Ai Ren4, Manoj Samant4, Teresa Zhou4 and John F Paolini4, 1Hospital Clinic Barcelona, Barcelona, Spain, 2Massachusetts General Hospital, Boston, MA, 3Kiniksa Pharmaceuticals, Lexington, MA, 4Kiniksa Pharmaceuticals, Lexington

    Background/Purpose: T helper (Th)1 and Th17 lymphocytes play a role in the pathogenesis of giant cell arteritis (GCA). Current treatments (e.g., corticosteroids and tocilizumab) target…
  • Abstract Number: 0015 • ACR Convergence 2020

    COVID -19 Lung Inflammation – What Have We Learnt so Far ?

    Sriya Gokaraju1, Maria Darda2, Vinod Vijayaraghavan Nalini Warrier3, Irina Duta3, Fiona Hayes3, Yasser Ahmed4 and Gouri Koduri3, 1Southend University Hospital NHS Trust, Essex, United Kingdom, 2Southend University Hospital NHS Trust, Essex, United Kingdom, 3Southend University Hospital NHS Trust, Essex, United Kingdom, 4Southend University Hospital, Essex, United Kingdom

    Background/Purpose: The SARS CoV-2 pandemic has inspired new interest in understanding the fundamental pathology of pneumonia and Acute Respiratory Distress Syndrome (ARDS). SARS CoV-2 in…
  • Abstract Number: 0410 • ACR Convergence 2020

    Exploring Gene Expression Profile of Primary Central Nervous System Vasculitis

    Carlo Salvarani1, Robert Brown2, Jonas Paludo2, Stefania Croci3, Stephen Ansell4, Caterina Giannini2, Joseph Parisi2, Kenneth Warrington2 and Gene Hunder2, 1Azienda USL-IRCCS di Reggio Emilia e Università di Modena e Reggio Emilia, Reggio Emilia, Italy, 2Mayo Clinic, Rochester, MN, 3Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy, 4Mayo Clinic, Rochester

    Background/Purpose: Primary CNS vasculitis (PCNSV) is an uncommon and poorly understood disease that affects the brain and spinal cord. It includes heterogeneous  histopathological patterns,  clinical…
  • Abstract Number: 0706 • ACR Convergence 2020

    Adenosine A2A Receptor Activation Reduces Markers of Chondrocyte Senescence and Cartilage Inflammation Associated with Osteoarthritis

    Benjamin Friedman1 and Bruce Cronstein2, 1NYU Rheumatology, New York, NY, 2NYU Grossman School of Medicine, New York, NY

    Background/Purpose: Osteoarthritis is an aging-associated disorder linked to dysfunctional metabolism, chronic inflammation, oxidative stress, and cellular senescence. Cellular senescence is associated with stable cell cycle…
  • Abstract Number: 0953 • ACR Convergence 2020

    Long-term Xanthine Oxidase Inhibitor Treat to Target Urate Lowering Therapy Coordinately Re-wires the Mononuclear Leukocyte Mitochondrial and Inflammatory Proteome in Gout

    Jacob Wozniak1, Ru Bryan2, David Gonzalez3 and Robert Terkeltaub4, 1UC San Diego, San Diego, CA, 2UCSD, San Diego, CA, 3UC San Diego, San Diego, CO, 4VA Medical Center/UC San Diego, San Diego, CA

    Background/Purpose: In gout, long-term xanthine oxidase inhibitor treat to target urate lowering therapy (XOIT2T) markedly reduces flares and synovitis, despite delayed resolution of tissue crystal…
  • Abstract Number: 1309 • ACR Convergence 2020

    Prevalence of Undiagnosed Axial Spondyloarthritis Among Patients with Inflammatory Bowel Disease: A Secondary Care Cross-Sectional Study

    Chong Seng Edwin Lim1, Mark Tremelling1, Louise Hamilton1, Alexander MacGregor1, Tom Turmezei1, Matthew Kim1 and Karl Gaffney2, 1Norfolk and Norwich University Hospital, Norwich, United Kingdom, 2Norfolk and Norwich University Hospital NHS Foundation Trust, Norfolk, United Kingdom

    Background/Purpose: Axial spondyloarthritis (axSpA) is closely related to inflammatory bowel disease (IBD), however contemporary data on the burden of hidden disease in the IBD population…
  • Abstract Number: 1648 • ACR Convergence 2020

    Comparison of Methotrexate and Glucosamine in Primary Knee Osteoarthritis with Inflammation

    Biswadip Ghosh1, Subhankar Haldar2 and Meghna Saha2, 1IPGME&R, Kolkata, Kolkata, West Bengal, India, 2IPGME&R, Kolkata, KOLKATA, India

    Background/Purpose: Many patients suffering from knee OA show swelling, warmth along with pain which are features of inflammation. There are no accepted pharmacological therapy for osteoarthritis…
  • Abstract Number: PP06 • ACR Convergence 2020

    Only in My Dreams Can I Do the Things I Used to Do: Where There Is Research, There Is Hope

    Dan Smith1, Robert Smith1 and Jillian Covault1, 1Canton, MI

    Background/Purpose: In Mach 2020, I was diagnosed with relapsing polychondritis ("RP"), a multisystem, rheumatologic disease characterized by inflammation of cartilaginous structures including the ear, nose,…
  • Abstract Number: 0065 • ACR Convergence 2020

    The Energy-dependent Hierarchy of Immune Functions in Human Monocytes

    Pierre-Louis Krauß1, Thomas Buttgereit2, Yuling Chen1, Moritz Pfeiffenberger1, Timo Gaber1 and Frank Buttgereit3, 1Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Berlin, Germany, 2Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Dermatology, Venerology, and Allergology, Berlin, Germany, 3Charité University Medicine, Berlin, Germany

    Background/Purpose: At sites of inflammation, monocytes carry out specific immunological functions while facing challenging bioenergetic restrictions. Here, we investigated the potential of human monocytes to…
  • Abstract Number: 0447 • ACR Convergence 2020

    Magnetic Resonance Imaging Characteristics in Patients with Spondyloarthritis and Clinical Diagnosis of Heel Enthesitis: Screening Data from a Phase 3 Trial

    Xenofon Baraliakos1, Philipp Sewerin2, Eugenio De Miguel3, Christine Kleinmond4, Ankita Shekhawat5, Claudia Jentzsch6, Annette Wiedon7 and Frank Behrens8, 1Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Bochum, Germany, 2Department of Rheumatology & Hiller Research Unit, University Hospital Düsseldorf, Duesseldorf, Germany, 3Rheumatology Department, Hospital Universitario La Paz, Madrid, Spain, 4ClinProject GmbH, Eurasburg, Germany, 5Novartis Healthcare Private Limited, Hyderabad, Telangana, India, 6Novartis Pharma GmbH, Nuremberg, Germany, 7Novartis Pharma GmbH, Nurnberg, Germany, 8CIRI/Rheumatology & Fraunhofer TMP, Goethe University, Frankfurt, Germany

    Background/Purpose: Inflammation and pain at entheseal sites are the key clinical signs in patients (pts) with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA).1 Magnetic resonance…
  • Abstract Number: 0738 • ACR Convergence 2020

    Systemic Administration of Novel Hydroxyl Dendrimers to Target Inflammation in Arthritic Tissues

    Jeffrey Cleland1, Rishi Sharma2, Minghao Sun3, Santiago Appiani La Rosa3 and Rangaramanujam M. Kannan4, 1Ashvattha Therapeutics, Inc, Redwood City, CA, 2Ashvattha Therapeutics, Baltimore, MD, 3Ashvattha Therapeutics, Inc, Baltimore, MD, 4Johns Hopkins School of Medicine, Baltimore, MD

    Background/Purpose: Chronic inflammation observed in arthritis and other autoimmune disorders is mediated primarily by pro-inflammatory reactive macrophages.  Systemic administration of anti-inflammatory agents does not selectively…
  • Abstract Number: 0956 • ACR Convergence 2020

    An IL-18-Containing Five-Gene Signature Distinguishes Histologically Identical Dermatomyositis and Lupus Erythematosus Skin Lesions

    Alex Tsoi1, Mehrnaz Gharaee-Kermani2, Celine Berthier1, Tori Nault3, Grace Hile2, Shannon Estadt4, Matthew Patrick1, Rachael Wasikowski1, Allison Billi1, Lori Lowe1, Tamra Reed1, Johann Gudjonsson5 and J. Michelle Kahlenberg6, 1University of Michigan, Ann Arbor, 2University of Michigan, Ann Arbor, MI, 3University of Michigan, Canton, MI, 4University of Michigan, Ypsilanti, MI, 5University of Michigan, Ann ArborUniversity of Michigan, 6Division of Rheumatology, University of Michigan, Ann Arbor, MI

    Background/Purpose: Skin lesions in dermatomyositis (DM) patients are common, frequently refractory, and have prognostic significance.  Histologically, DM lesions appear similar to cutaneous lupus erythematosus (CLE)…
  • Abstract Number: 1333 • ACR Convergence 2020

    Ankylosing Spondylitis Patients at Risk of Developing Aortic Valve Regurgitation, Need for Mandatory Echocardiography?

    Milad Baniaamam1, Sjoerd C. Heslinga2, Laura Boekel1, M. Louis Handoko3, Thelma C. Konings3, Otto Kamp3, Vokko P. van Halm4, J. Christiaan van Denderen1, Irene van der Horst-Bruinsma2 and Mike Nurmohamed5, 1Reade, Amsterdam, Netherlands, 2Department of Rheumatology, Amsterdam UMC, location VU University Medical Centre, Amsterdam, Netherlands, 3Department of Cardiology, Amsterdam UMC, location VU University Medical Centre, Amsterdam, Netherlands, 4Department of Cardiology, Amsterdam UMC, location VU University Medical Centre, Amsterdam, 5Amsterdam Rheumatology and immunology Center, location Reade and Amsterdam UMC, VU medical center, Amsterdam, Netherlands

    Background/Purpose: The overall mortality rate in ankylosing spondylitis (AS) patients is increased by 60–90% compared with the general population. This higher mortality rate is predominately…
  • Abstract Number: 1649 • ACR Convergence 2020

    Effect of Knee Aspiration and Intra-articular Corticosteroid Injection on Gait Biomechanics and Strength Impairment in Patients with Signs of Inflammation Due to Knee Osteoarthritis

    Ryan Pinto1, Trevor Birmingham1, Holly Philpott2, Dominique Arsenault1, Codie Primeau1 and Tom Appleton3, 1Western University, London, Canada, 2Western University, London, ON, Canada, 3The University of Western Ontario, LONDON, ON, Canada

    Background/Purpose: Synovial inflammation in knees with OA can be measured with musculoskeletal ultrasound (MSK US), is associated with increased pain and disease progression, and may…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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