Abstracts Archive - Page 941 of 2425 - ACR Meeting Abstracts

Abstract Number: 2741 • 2019 ACR/ARP Annual Meeting
Integration of Single Cells from Inflammatory Disease Tissues Reveals Common and Unique Pathogenic Cell States
Fan Zhang¹, Joseph Mears ¹, ilya Korsunsky ¹, Kevin Wei ², Anna Helena Jonsson ², Deepak Rao ¹, Edy Kim ³, Laura Donlin ⁴, Jill Buyon ⁵, Michelle Petri ⁶, Chaim Putterman ⁷, Thomas Tuschl ⁸, Nir Hacohen ⁹, Betty Diamond ¹⁰, Michael Brenner ¹¹ and Soumya Raychaudhuri ¹, ¹Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Brigham and Women's Hospital, Boton, MA, ⁴Hospital For Special Surgery, New York, NY, ⁵New York University School of Medicine, New York, NY, ⁶Johns Hopkins University School of Medicine, Baltimore, MD, ⁷Albert Einstein College of Medicine, New York, NY, ⁸Rockefeller Research Laboratories, New York, ⁹Broad Institute, Cambridge, ¹⁰Feinstein Institutes for Medical Research, Manhasset, ¹¹Brigham and Women’s Hospital:, Boston
Background/Purpose: Different autoimmune diseases can co-exist in an individual and share similar genetic associations, autoimmune signaling pathways, and clinical manifestations. However, autoimmune diseases present varied…
Abstract Number: 2742 • 2019 ACR/ARP Annual Meeting
Toward a Liquid Biopsy for Lupus Nephritis: Urine Proteomic Analysis of SLE Identifies Inflammatory and Macrophage Signatures
Andrea Fava¹, Yuji Zhang ², Jill Buyon ³, H. Michael Belmont ⁴, Peter Izmirly ⁵, Chandra Mohan ⁶, Ting Zhang ⁷, The Accelerating Medicines Partnership ⁸ and Michelle Petri ⁹, ¹Johns Hopkins University, Baltimore, ²University of Maryland, Baltimore, ³NYU School of Medicine, New York, ⁴New York University School of Medicine, Ney York, ⁵New York University School of Medicine, New York, ⁶University of Houston, Houston, ⁷Biomedical Engineering, University of Houston, Houston, TX, ⁸Multiple Organizations, USA, ⁹Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Lupus nephritis (LN) complicates up to 60% of patients with systemic lupus erythematosus (SLE) and carries a high morbidity and mortality. The definitive diagnosis…
Abstract Number: 2743 • 2019 ACR/ARP Annual Meeting
Characterizing the Epigenomic Landscape of Psoriasis Patients Destined to Develop Psoriatic Arthritis
Remy Pollock¹, Rohan Machhar ¹, Vinod Chandran ² and Dafna Gladman ³, ¹Krembil Research Institute, University Health Network, Toronto, Canada, ²University Health Network, University of Toronto, Toronto, Canada, ³Toronto Western Hospital, Toronto, Canada, Toronto, ON, Canada
Background/Purpose: Approximately 30% of psoriasis patients develop psoriatic arthritis (PsA), an inflammatory musculoskeletal disease, usually after psoriasis onset. A large proportion of individuals with PsA…
Abstract Number: 2744 • 2019 ACR/ARP Annual Meeting
Altered Expression of CD52 Facilitates Adhesion of Circulating CD14+ Monocytes in Systemic Sclerosis
Michal Rudnik¹, Mara Stellato ¹, Filip Rolski ², Przemyslaw Blyszczuk ³, Karin Klingel ⁴, Joerg Henes ⁵, Carol Feghali-Bostwick ⁶, Oliver Distler ⁷ and Gabriela Kania ³, ¹Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Clinical Immunology, Jagiellonian University Medical College, Krakow, Poland, ³Centre of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Institute for Pathology and Neuropathology, University Hospital Tuebingen, Tuebingen, Germany, ⁵University Hospital Tuebingen, Department of Internal Medicine II (Oncology, Haematology, Immunology and Rheumatology), Tuebingen, Germany, ⁶Division of Rheumatology & Immunology, Medical University of South Carolina, Charlston, SC, ⁷Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland
Background/Purpose: Infiltration of inflammatory cells, including monocytes, into the organs is a major process leading to fibrosis, remodelling and organ dysfunction in systemic sclerosis (SSc).…
Abstract Number: 2745 • 2019 ACR/ARP Annual Meeting
Iguratimod Treated Scleroderma with Interrupted Egr1/TGF-β Loop
Qingran Yan¹, Lichong Shen ¹, Xiaoxiang Chen ¹ and Liangjing Lu ¹, ¹Department of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of medicine, Shanghai, China (People's Republic)
Background/Purpose: Iguratimod is a novel disease modifying anti-rheumatic drug that has been approved for treating rheumatoid arthritis in East Asia. Transcription factor early growth response…
Abstract Number: 2746 • 2019 ACR/ARP Annual Meeting
Dimethyl Fumarate Ameliorates the GATA6 Deficiency-Induced Pulmonary Hypertension by Normalizing Oxidative and ER Stress
Asako Ichihara¹, Tetsuo Toyama ², Tatiana Kudryashova ³, Yuanjun Shen ³, Dmitry Goncharov ³, Elena Goncharova ³ and Maria Trojanowska ², ¹Arthritis Center, Boston University School of Medicine, Brookline, MA, ²Arthritis Center, Boston University School of Medicine, Boston, ³Pulmonary, Allergy & Critical Care Division, University of Pittsburgh Department of Medicine, Pittsburgh
Background/Purpose: Pulmonary arterial hypertension (PAH) is a leading cause of death in patients with limited form of systemic sclerosis (SSc). We have previously reported that…
Abstract Number: 2747 • 2019 ACR/ARP Annual Meeting
Identification of Naturally Presented Peptides of the Autoantigen Topoisomerase-I Reveals a Common Pathogenic Mechanism in Patients with Systemic Sclerosis
Eleni Tiniakou¹, Andrea Fava ², Zsuzsanna McMahan* ³, Tara Gurh ⁴, Robert O'Meally ⁴, Ami Shah ⁵, Frederick Wigley ³, Robert Cole ⁴, Francesco Boin ⁶ and Erika Darrah ¹, ¹Johns Hopkins University, Baltimore, MD, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³Johns Hopkins University, Division of Rheumatology, Baltimore, ⁴Johns Hopkins University, Baltimore, ⁵Johns Hopkins Hospital, Baltimore, MD, ⁶UCSF, San Francisco, CA
Background/Purpose: Autoimmune responses to DNA topoisomerase-I (TOP1) are found in a subset of patients with scleroderma at high risk for interstitial lung disease (ILD) and…
Abstract Number: 2748 • 2019 ACR/ARP Annual Meeting
Cracking a Novel Profibrotic Molecular Mechanism: lncRNA H19X and DDIT4L Crosstalk
Elena Pachera¹, Shervin Assassi ², Gloria Salazar ³, Mojca Frank-Bertoncelj ⁴, Jörg Distler ⁵, Gabriela Kania ⁶ and Oliver Distler ⁷, ¹Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Zurich, Switzerland, ²Division of Rheumatology and Clinical Immunogenetics, University of Texas McGovern Medical School, Houston, Texas, USA, Houston, TX, ³University of Texas McGovern Medical School, Houston, ⁴University Hospital Zürich, Zürich, Switzerland, ⁵Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany, ⁶Centre of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁷Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland
Background/Purpose: Long noncoding RNAs (lncRNAs) are an emerging class of noncoding transcripts involved in the regulation of gene expression in health and disease. LncRNAs function…
Abstract Number: 2749 • 2019 ACR/ARP Annual Meeting
Long Non-coding RNA HOTAIR Induces Myofibroblast Activation in Systemic Sclerosis Through EZH2 Dependent De-repression of NOTCH Signalling Pathway Activation
Christopher Wasson¹, Giuseppina Abignano ², Rebecca Ross ³, Heidi Hermes ⁴, Sergio Jimenez ⁵ and Francesco Del Galdo ⁶, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²3Rheumatology Institute of Lucania (IReL) and University of Leeds, Leeds, United Kingdom, ³Univesristy of Leeds, Leeds, England, United Kingdom, ⁴Jefferson Institute of Molecular Medicine and Scleroderma Center, Thomas Jefferson University, Philadelphia, ⁵Jefferson Institute of Molecular Medicine and Division of Connective Tissue Diseases, Thomas Jefferson University, Philadelphia, PA, Philadelphia, PA, ⁶University of Leeds and LTHT NIHR Biomedical Research Centre, Leeds, United Kingdom
Background/Purpose: Fibroblasts explanted from affected tissues in Systemic Sclerosis (SSc), conserve their pro-fibrotic phenotype characterised by increased secretion of collagens and other extracellular matrix proteins…
Abstract Number: 2750 • 2019 ACR/ARP Annual Meeting
Development and Preliminary Validation of a Novel Lung Ultrasound Interpretation Criteria for the Detection of Interstitial Lung Disease in Patients with Systemic Sclerosis
Robert Fairchild¹, Diana Yang ², Melody Chung ¹, Laurel Sharpless ¹, Shufeng Li ³ and Lorinda Chung ¹, ¹Stanford University, Palo Alto, CA, ²Santa Clara Valley Medical Center, Palo Alto, CA, ³Division of Immunology and Rheumatology, Department of Medicine, Stanford, Palo Alto, CA
Background/Purpose: Interstitial lung disease (ILD) is a frequent complication of systemic sclerosis (SSc), and screening, characterization, and monitoring of disease activity are important for therapeutic…
Abstract Number: 2751 • 2019 ACR/ARP Annual Meeting
Very Low Prevalence of Ultrasound Determined Tendon Abnormalities in Healthy Subjects Throughout the Age Range: An Outcome Measures in Rheumatology (OMERACT) Ultrasound Minimal Disease Study
Jeanette Trickey¹, Ilfita Sahbudin ², Alessandra Bortoluzzi ³, ANNAMARIA IAGNOCCO ⁴, Carlos Pineda ⁵, Cesar Sifuentes-Cantú ⁶, Coziana Ciurtin ⁷, Cristina Reátegui-Sokolova ⁸, Daniela Fodor ⁹, ESPERANZA NAREDO ¹⁰, Ellen-Margrethe Hauge ¹¹, Florentin Vreju ¹², Garifallia Sakellariou ¹³, George A. W. Bruyn ¹⁴, Georgios Filippou ¹⁵, Giuliana La Paglia ⁶, Gustavo Leon ¹⁶, Hélène Gouze ¹⁷, Helen Keen ¹⁸, Hilde Hammer ¹⁹, Ilaria Tinazzi ²⁰, Irene Azzolin ⁴, Jacek Fliciński ²¹, Kei Ikeda ²², Lene Terslev ²³, Mads Ammitzball Danielsen ²⁴, Mads Nyhuus Bendix Rasch ¹¹, Marcin Milchert ²¹, Maria Stoenoiu ²⁵, Marion Kortekaas ²⁶, Marwin Gutierrez ⁵, Mihaela Maruseac ²⁷, Mohamed Mortada ²⁸, Philippe Carron ²⁹, Rositsa Karalilova ³⁰, Ruth Wittoek ³¹, Sarah Ohrndorf ³², Takeshi Suzuki ³³, Teodora Șerban ³⁴, Maria-Antonietta D’Agostino ³⁵ and Andrew Filer ³⁶, ¹Institute of Inflammation and Ageing, University of Birmingham, Hereford, United Kingdom, ²Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, ³University of Ferrara, Ferrara, Italy, ⁴Academic Rheumatology Centre, Università degli Studi di Torino, TURIN, Italy, ⁵Division of Musculoskeletal and Rheumatic Diseases, Instituto Nacional de Rehabilitación “Luis Guillermo Ibarra Ibarra”, Mexico, Mexico, Mexico, ⁶Department of Rheumatology, Bone and Joint Research Unit. Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain, ⁷Centre for Adolescent Rheumatology, University College London London, UK, Londond, United Kingdom, ⁸Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, ⁹2nd Internal Medicine Department, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Cluj-Napoca, Romania, ¹⁰Rheumatology Department, Joint and Bone Research Unit. Hospital Universitario Fundación Jiménez Díaz, Universidad Autónoma, MADRID, Spain, ¹¹Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ¹²Department of Rheumatology, University of Medicine and Pharmacy Craiova, Craiova, Romania, ¹³Division of Rheumatology, University of Pavia, IRCCS Policlinico San Matteo Foundation, Pavia, Italy, ¹⁴Department of Rheumatology, MC Groep Hospitals., Lelystad, Netherlands, ¹⁵University of Ferrara, Cona, Italy, ¹⁶Instituto Nacional de Rehabilitacion, Mexico City, Lima, Peru, ¹⁷Rheumatology Department, APHP, Ambroise Paré Hospital, Bolougne Billancourt, France, ¹⁸School of Medicine and Pharmacology Fiona Stanley Hospital Unit, University of Western Australia, Perth, Australia, ¹⁹Diakonhjemmet Hospital, Oslo, Norway, ²⁰Sacro Cuore Don Calabria Hospital, Unit of Rheumatology, Verona, Italy, ²¹Department of Rheumatology, Internal Diseases and Geriatrics; Pomeranian Medical University, Szczecin, Poland, ²²Chiba University Hospital, Chiba, Japan, ²³Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Copenhagen, Denmark, ²⁴Copenhagen University Hospital, Copenhagen, Denmark, ²⁵Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique, Bruxelles, Belgium, ²⁶Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²⁷Department of Rheumatology, Cliniques Universitaires Saint-Luc, Institut de recherche expérimentale et clinique (IREC), Université catholique de Louvain, Brussels, Belgium, ²⁸Rheumatology and Rehabilitation Department, Faculty of Medicine, Zagazig University, Egypt, Zagazig, Egypt, ²⁹Ghent University Hospital, Ghent, Belgium, ³⁰Clinic of Rheumatology, Medical University of Plovdiv, University Hospital “Kaspela", Plovdiv, Bulgaria, ³¹Ghent University Hospital, Gent University, Gent, Belgium, ³²Charité Universitätsmedizin Berlin, Berlin, Germany, ³³Division of Allergy and Rheumatology, Japanese Red Cross Medical Center, Tokyo, Japan, ³⁴SC Reumatologia, Ospedale La Colletta, Genoa, Italy, ³⁵Department of Rheumatology, APHP, Hôpital Ambroise Paré, Paris, France, ³⁶Institute of Inflammation and Ageing College of Medical and Dental Sciences University of Birmingham, Birmingham, United Kingdom
Background/Purpose: Tenosynovitis (TS) is a common, often clinically undetectable finding in Rheumatoid Arthritis (RA). Recent data showed TS on ultrasound (US) has a role in…
Abstract Number: 2752 • 2019 ACR/ARP Annual Meeting
Successfull Evaluation of a Predefined Set of Anatomic Sites in the Pelvis of Patients with Polymyalgia Rheumatica Showing Extracapsular Inflammation as Visualized by Contrast Enhanced Magnetic Resonance Imaging
Martin Fruth ¹, Annika Seggewiss ¹, Jessica Kozik ¹, Philipp Martin-Seidel ¹, Xenofon Baraliakos² and Jürgen Braun ³, ¹Radiology Herne, Herne, Germany, ²Rheumazentrum Ruhrgebiet-Ruhr-University Bochum, Herne, Germany, Herne, Germany, ³Rheumazentrum Ruhrgebiet/Ruhr University, Herne, Germany
Background/Purpose: The diagnosis of polymyalgia rheumatica (PMR) is based on a thorough clinical evaluation of the patient - including exclusion of other diseases, since there…
Abstract Number: 2753 • 2019 ACR/ARP Annual Meeting
Major Salivary Gland Ultrasound: Pilot Study of Findings and Feasibility in Childhood-Onset Systemic Lupus Erythematosus (cSLE)
Joseph McDonald¹, Patricia Vega-Fernandez ² and Tracy Ting ¹, ¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Children's Hospital of Atlanta, Atlanta, GA
Background/Purpose: Ultrasonography is becoming an increasingly useful tool in evaluating patients in pediatric rheumatology. It is predominantly used for musculoskeletal assessments, however, major salivary gland…
Abstract Number: 2754 • 2019 ACR/ARP Annual Meeting
AxSpA Patients with Symptom Onset < 30 Years Have More Structural Lesions on MRI of the Sacroiliac Joints When Fulfilling the Modified New York Criteria
Manouk de Hooge¹, Ann-Sophie De Craemer ¹, Thomas Renson ¹, Philippe Carron ¹, Liselotte Deroo ¹, Dirk Elewaut ¹ and Filip Van den Bosch ¹, ¹Ghent University Hospital, Ghent, Belgium
Background/Purpose: The modified New York criteria (mNY) combine clinical symptoms with radiographic sacroiliitis on conventional pelvic radiographs (X-SI) classifying radiographic axial SpA patients (r-axSpA). AxSpA…
Abstract Number: 2755 • 2019 ACR/ARP Annual Meeting
Assessing the Sensitivity to Change of the OMERACT Ultrasound Structural Gout Lesions During Urate-Lowering Therapy
Sara Nysom Christiansen¹, Mikkel Østergaard ², Ole Slot ¹, George A. W. Bruyn ³, Helen Keen ⁴, Maria-Antonietta D’Agostino ⁵ and Lene Terslev ⁶, ¹Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Glostrup, Denmark, ²Copenhagen Center for Arthritis Research, University of Copenhagen, Copenhagen, Denmark, ³Department of Rheumatology, MC Groep Hospitals., Lelystad, Netherlands, ⁴School of Medicine and Pharmacology Fiona Stanley Hospital Unit, University of Western Australia, Perth, Australia, ⁵Department of Rheumatology, Ambroise Pare´ Hospital, and Versailles Saint-Quentin-en-Yvelines University, Boulogne-Billancourt, France, ⁶Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Copenhagen, Denmark
Background/Purpose: To evaluate the sensitivity to change of ultrasound (US) structural gout lesions, as defined by the OMERACT US group, in gout patients during urate…

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