ACR Meeting Abstracts

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  • Abstract Number: 2665 • 2019 ACR/ARP Annual Meeting

    Clinical Outcomes of Patients with Giant Cell Arteritis and Polymyalgia Rheumatica Symptoms Treated with Tocilizumab in Routine Clinical Practice

    Sebastian Unizony1, Robert Spiera 2, Jinglan Pei 3, Páris Sidiropoulos 3, Jennie Best 4 and John Stone 1, 1Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, 2Hospital for Special Surgery, New York, NY, 3Genentech, South San Francisco, CA, 4Genentech, Inc., South San Francisco, CA

    Background/Purpose: Approximately 50% of patients with giant cell arteritis (GCA) also have polymyalgia rheumatica (PMR) symptoms.1 The purpose of this study was to determine whether…
  • Abstract Number: 2666 • 2019 ACR/ARP Annual Meeting

    Development and Outcome of Aortic Complications During Tocilizumab (TCZ) Treatment of GCA and Histopathologic Evidence of Residual Inflammation

    Andrea Rubbert-Roth1, Peter Karl Bode 2, Thomas Langenegger 3, Claudia Pfofe 4, Thomas Neumann 5, Olaf Chan-Hi Kim 6 and Johannes von Kempis 7, 1Division of Rheumatology, Kantonsspital St. Gallen, St. Gallen, Sankt Gallen, Switzerland, 2Institute of Pathology and Molecular Pathology, University Hospital of Zurich, Zuerich, Switzerland, 3Rheumatology Clinic Zug, Zug, Switzerland, 4Pathology Institute Triemli, Zurich, Zuerich, Switzerland, 5Division of Rheumatology and Immunolog, Kantonsspital St. Gallen, St. Gallen, Sankt Gallen, Switzerland, 6Department of Radiology, Kantonsspital St Gallen, St.Gallen, Switzerland, 7Division of Rheumatology, Kantonsspital St Gallen, St.Gallen, Switzerland

    Background/Purpose: GCA may affect the aorta and lead to dissections and aortic aneurysms. TCZ treatment may control aortic inflammation as demonstrated by CRP normalization and…
  • Abstract Number: 2667 • 2019 ACR/ARP Annual Meeting

    Efficacy and Safety of Tocilizumab in Giant Cell Arteritis: A Monocentric Real-life Experience

    Elena Baldissera1, Alessandro Tomelleri 1, Corrado Campochiaro 2, Silvia Sartorelli 3 and Lorenzo Dagna 1, 1Unit of Immunology, Rheumatology, Allergy and Rare Diseases. IRCCS San Raffaele Hospital. Vita-Salute San Raffaele University., Milan, Italy, 2Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy, 3Vita-Salute San Raffaele University, IRCCS San Raffaele Hospital, Milan, Italy

    Background/Purpose: Tocilizumab (TCZ) has recently been shown to be effective and safe for the treatment of patients with giant cell arteritis (GCA). Here we describe…
  • Abstract Number: 2668 • 2019 ACR/ARP Annual Meeting

    Pharmacokinetics and Pharmacodynamics of Tocilizumab in Combination with Prednisone Tapering in Patients with Giant Cell Arteritis: 3-Year Results from a Randomized Controlled Phase 3 Trial

    Navita Malallieu1, Min Bao 2 and John Stone 3, 1Roche Innovation Center, New York, NY, 2Genentech, South San Francisco, CA, 3Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA

    Background/Purpose: Tocilizumab (TCZ) administered subcutaneously weekly or every 2 weeks with a 26-week prednisone taper (TCZ-QW or TCZ-Q2W) was superior to placebo given with a…
  • Abstract Number: 2669 • 2019 ACR/ARP Annual Meeting

    Survival Trends in Giant Cell Arteritis: A Population-based Cohort Study

    Thomas Garvey1, Cynthia Crowson 1, Matthew Koster 2, Eric Matteson 3 and Kenneth Warrington 2, 1Mayo Clinic Rochester, Rochester, 2Mayo Clinic Rochester, Rochester, MN, 3Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA, Rochester

    Background/Purpose: To investigate survival trends in patients with giant cell arteritis (GCA) diagnosed over a 60-year period.Methods: We assembled a population-based incidence cohort of patients…
  • Abstract Number: 2670 • 2019 ACR/ARP Annual Meeting

    Giant Cell Arteritis with Intracranial Vasculitis: A Case Series

    Catalina Sanchez-Alvarez1, Alexander Hawkins 1, Matthew Koster 2, Vance T. Lehman 3, Cynthia Crowson 1 and Kenneth Warrington 2, 1Mayo Clinic, Rochester, MN, 2Mayo Clinic Rochester, Rochester, MN, 3Mayo Clinic, Rochester

    Background/Purpose: Giant cell arteritis (GCA) is a large vessel vasculitis that primarily affects the aorta and its branches. Extracranial branches of the carotid artery are…
  • Abstract Number: 2671 • 2019 ACR/ARP Annual Meeting

    PET/CT Vascular Findings at Baseline and Six Months in Patients with Newly Diagnosed Giant Cell Arteritis

    Anthony Sammel1, Edward Hsiao 1, Geoff Schembri 1, Elizabeth Bailey 1, Katherine Nguyen 1, Janice Brewer 1, Beatrice Janssen 1, Leslie Schrieber 1, Peter Youssef 2, Clare Fraser 3 and Rodger Laurent 1, 1Royal North Shore Hospital, Sydney, Australia, 2Royal Prince Alfred Hospital, Sydney, Australia, 3Save Sight Institute, Sydney, Australia

    Background/Purpose: PET/CT is a useful modality to diagnose GCA but there is limited knowledge as to how inflammatory vascular findings evolve on follow-up scans. This…
  • Abstract Number: 2672 • 2019 ACR/ARP Annual Meeting

    Ultrasonography in the Diagnosis of Giant Cell Arteritis

    ROK JESE 1, Ziga Rotar 1, Matija Tomšič 2 and Alojzija Hocevar3, 1UMC LJUBLJANA, DPT. OF RHEUMATOLOGY, LJUBLJANA, Slovenia, 2Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, LJUBLJANA, Slovenia, 3Department of Rheumatology, University Medical Center Ljubljana, Slovenia, LJUBLJANA, Slovenia

    Background/Purpose: Imaging has been recently recognized as a tool equivalent to the temporal artery biopsy in diagnosing giant cell arteritis (GCA). Amongst a variety of…
  • Abstract Number: 2673 • 2019 ACR/ARP Annual Meeting

    Presentation and Management of Giant Cell Arteritis in a Real-World Setting (Artemis Study)

    Alfred Mahr1, Eric Hachulla 2, Hubert de BOYSSON 3, Nassim Guerroui 4, Emmanuel Héron 5, Stéphane Vinzio 6, Jonathan Broner 7, François-Xavier Lapebie 8, Martin Michaud 9, Laurent Sailler 8, Thierry Zenone 10, Mohamed Djerad 11, Mathieu Jouvray 12, Emilie Shipley 13, Nathalie Tieulie 14, Isabelle Idier 15, Marc Paccalin 16 and Valérie Devauchelle Pensec 17, 1Hospital Saint-Louis, University Paris Diderot, Paris, France, 2Dept. of Internal Medicine and Clinical Immunology, Hôpital Claude Huriez, University of Lille, Lille, France, Lille, France, 3University Hospital of Caen, Caen, France, 4European Hospital of Marseille, Marseille, France, 5Quinze-Vingt Hospital, Paris, France, 6GHM Grenoble, Grenoble, France, 7University Hospital of Nîmes, Nîmes, France, 8University Hospital of Toulouse, Toulouse, France, 9Joseph Ducuing Hospital, Toulouse, France, 10Hospital of Valence, Valence, France, 11Hospital of Nevers, Nevers, France, 12Hospital of Arras, Arras, France, 13Hospital of Dax, Dax, France, 14University Hospital of Nice, Nice, France, 15Chugai Pharma France, Paris La Défense, France, 16University Hospital of Poitiers, Poitiers, France, 17University Hospital of Brest, Brest, France

    Background/Purpose: We have few real-world data on the natural history and care of patients with giant cell arteritis (GCA). The objective of this observational study…
  • Abstract Number: 2674 • 2019 ACR/ARP Annual Meeting

    Clinical Symptoms and Associated Vascular Imaging Findings in Takayasu’s Arteritis Compared to Giant Cell Arteritis

    Despina Michailidou1, Joel S. Rosenblum 2, Casey A. Rimland 3, Jamie Marko 4, Mark A. Ahlman 4 and Peter C. Grayson 5, 1National Institute of Arthritis, Musculoskeletal and Skin Disease (NIAMS), Bethesda, MD, Division of Rheumatology, University of Washington, Seattle, WA, Seattle, WA, 2National Institute of Arthritis, Musculoskeletal and Skin Disease (NIAMS), Bethesda, MD, Bethesda, MD, 3National Institute of Arthritis, Musculoskeletal and Skin Disease (NIAMS), Bethesda, MD, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, Chapel Hill, NC, 4Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, Bethesda, MD, 5National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institutes of Health, Bethesda, MD, Bethesda, MD

    Background/Purpose: Takayasu’s arteritis (TAK) and giant cell arteritis (GCA) are the two major forms of large vessel vasculitis. The study objectives were to compare clinical…
  • Abstract Number: 2675 • 2019 ACR/ARP Annual Meeting

    Risk of Potential Glucocorticoid-Related Adverse Events in Patients with Giant Cell Arteritis: Results from a US-based Electronic Health Records Database

    Jennie Best1, Amanda M. Kong 2, Oth Tran 2 and Margaret Michalska 1, 1Genentech, Inc., South San Francisco, CA, 2IBM Watson Health, Cambridge, MA

    Background/Purpose: Oral glucocorticoids (OGC) have been the mainstay of treatment for giant cell arteritis (GCA). However, OGCs are associated with several adverse events (AEs). The…
  • Abstract Number: 2676 • 2019 ACR/ARP Annual Meeting

    Cardiovascular Treatment and the Incidence of Giant Cell Arteritis (GCA) – a Population-Based Case-Control Study

    Aladdin Mohammad1, Pavlos Stamatis 1 and Aleksandra Turkiewicz 2, 1Lund University, Lund, Skane Lan, Sweden, 2Lund University, Lund, Sweden

    Background/Purpose: The aetiology of giant cell arteritis (GCA) is largely unknown. We aimed to evaluate ACE-inhibitors (ACE-i), angiotensin II receptor blockers (ARBs), beta-blocking agents, calcium…
  • Abstract Number: 2677 • 2019 ACR/ARP Annual Meeting

    Healthcare Resources Utilization in Giant Cell Arteritis – a Population-Based Study

    Aladdin Mohammad1, Aleksandra Turkiewicz 2, Pavlos Stamatis 1, Carl Turesson 3, Martin Englund 2 and Ali Kiadaliri 2, 1Lund University, Lund, Skane Lan, Sweden, 2Lund University, Lund, Sweden, 3Lund University, Malmö, Sweden

    Background/Purpose: To study the healthcare resource utilization (HRU) in patients with giant cell arteritis (GCA) compared with the background population in southern Sweden.Methods: The study…
  • Abstract Number: 2678 • 2019 ACR/ARP Annual Meeting

    Response to Tocilizumab in Patients with Giant Cell Arteritis, According to Ischemic vs Systemic Symptoms

    Mónica Calderón-Goercke1, Javier Loricera 2, DIANA PRIETO- PENA 3, Santos Castañeda 4, Vicente Aldasoro Caceres 5, Ignacio Villa 6, Alicia Humbría 7, Clara Moriano 8, Susana Romero-Yuste 9, Javier Narváez 10, Catalina Gómez-Arango 11, Eva Perez Pampín 12, Rafael Melero 13, Elena Becerra-Fernández 14, Marcelino Revenga 15, Noelia Álvarez-Rivas 16, Carles Galisteo 17, Francisca Sivera 18, Alejandro Olivé-Marqués 19, María Álvarez del buergo 20, Luisa Marena-Rojas 21, Carlos Fernández-López 22, Francisco Navarro 23, E. Raya 24, Eva Galindez-Agirregoikoa 25, Beatriz Arca 26, Roser Solans-Laqué 27, Arantxa Conesa 28, Cristina Hidalgo 29, Carlos Vazquez 30, Jose Andrés Román-Ivorra 31, Pau Lluch 32, Sara Manrique 33, P. Vela 34, Eugenio de Miguel 35, Carmen Torres-Martín 36, Juan Carlos Nieto 37, Carmen Ordas-Calvo 38, Eva salgado-Pérez 39, Cristina Luna-Gómez 40, F. Javier Toyos-Sáenz De Miera 41, Nagore Fernández-Llanio 42, Antonio García 43, Carmen Larena 44, María Varela-García 5, Raquel Dos Santos 45, Norberto Ortego 46, Jose Luis Hernández 1, Miguel Angel González-Gay 47 and Ricardo Blanco 48, 1Hospital Marqués de Valdecilla, Santander, Cantabria, Spain, 2Rheumatology Department. Hospital Marqués de Valdecilla, Santander, Cantabria, Spain, 3Rheumatology, Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain, 4Rheumatology Department, Hospital Universitario de la Princesa, IIS-Princesa, Madrid, Spain, Madrid, Spain, 5Complejo Hospitalario de Navarra, Navarra, Navarra, Spain, 6Hospital de Sierrallana, Torrelavega, Cantabria, Spain, 7Hospital de La Princesa, Madrid, Madrid, Spain, 8Complejo Asistencial Universitario de León, León, Castilla y Leon, Spain, 9Complejo Hospitalario Universitario Pontevedra, Pontevedra, Galicia, Spain, 10Rheumatology Department, Hospital Universitario de Bellvitge, Barcelona, Spain, Barcelona, Catalonia, Spain, 11Hospital Alto Deba, Mondragon, Pais Vasco, Spain, 12Division of Rheumatology, Instituto de Investigación Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, Santiago de Compostela, Spain, 13Complexo Hospitalario Universitario de Vigo, Vigo, Galicia, Spain, 14Hospital de Torrevieja, Alicante, Comunidad Valenciana, Spain, 15Hospital Ramón y Cajal, Madrid, Madrid, Spain, 16Hospital Universitario Lucus Augusti, Lugo, Galicia, Spain, 17Hospital Parc Taulí, Barcelona, Catalonia, Spain, 18Hospital General Universitario de Elda, Elda, Spain, 19Hospital Universitari Germans Trias i Pujol, Badalona, Catalonia, Spain, 20Hospital Río Carrión, Palencia, Castilla y Leon, Spain, 21Hospital La Mancha Centro, Alcázar de San Juan, Castilla-La Mancha, Spain, 22Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, 23Hospital General Universitario de Elche, Alicante, Comunidad Valenciana, Spain, 24Hospital San Cecilio, Granada, Andalucia, Spain, 25Hospital de Basurto, Bilbao, Pais Vasco, Spain, 26Hospital Universitario San Agustín, Avilés, Asturias, Spain, 27Department of Internal Medicine, Hospital Vall d'Hebron, Barcelona, Spain., Barcelona, Catalonia, Spain, 28Hospital General Universitario de Castellón, Castellón, Comunidad Valenciana, Spain, 29Hospital Clínico Universitario de Salamanca, Salamanca, Castilla y Leon, Spain, 30Hospital Miguel Servet, Zaragoza, Aragon, Spain, 31Hospital Universitario y Politécnico La Fe, Valencia, Comunidad Valenciana, Spain, 32Hospital Mateu Orfila, Menorca, Islas Baleares, Spain, 33Hospital Regional de Málaga, Málaga, Andalucia, Spain, 34Hospital General Universitario de Alicante, Alicante, Comunidad Valenciana, Spain, 35Rheumatology Department, Hospital Universitario La Paz, Madrid, Spain, 36Complejo Asistencial de Ávila, Ávila, Castilla y Leon, Spain, 37Rheumatology Department. Hospital Gregorio Marañón, Madrid, Madrid, Spain, 38Hospital Cabueñes, Gijón, Asturias, Spain, 39Complejo Hospitalario Universitario de Ourense, Ourense, Galicia, Spain, 40Hospital Universitario Nuestra Señora de la Candelaria, Tenerife, Canarias, Spain, 41Hospital Universitario Virgen Macarena, Sevilla, Andalucia, Spain, 42Hospital Arnau de Vilanova, Lérida, Catalonia, Spain, 43Hospital Virgen de las Nieves, Granada, Andalucia, Spain, 44Hospital Universitario Ramón y Cajal, Madrid, Madrid, Spain, 45Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Galicia, Spain, 46Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, Granada, Spain, 47Universidad de Cantabria and IDIVAL, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 48Rheumatology, Hospital Universitario Marques de Valdecilla, Santander, Spain

    Background/Purpose: In Giant Cell Arteritis (GCA) two dominant cytokine clusters have been linked to disease activity, IL-6 – IL-17 axis (Th17) and IL-12 – IFN…
  • Abstract Number: 2679 • 2019 ACR/ARP Annual Meeting

    Tocilizumab in Giant Cell Arteritis: Route of Administration: Intravenous or Subcutaneous

    Mónica Calderón-Goercke1, Javier Loricera 2, DIANA PRIETO- PENA 3, Santos Castañeda 4, Vicente Aldasoro Caceres 5, Ignacio Villa 6, Alicia Humbría 7, Clara Moriano 8, Susana Romero-Yuste 9, Javier Narváez 10, Catalina Gómez-Arango 11, Eva Perez Pampín 12, Rafael Melero 13, Elena Becerra-Fernández 14, Marcelino Revenga 15, Noelia Álvarez-Rivas 16, Carles Galisteo 17, Francisca Sivera 18, Alejandro Olivé-Marqués 19, María Álvarez del buergo 20, Luisa Marena-Rojas 21, Carlos Fernández-López 22, Francisco Navarro 23, E. Raya 24, Eva Galindez-Agirregoikoa 25, Beatriz Arca 26, Roser Solans-Laqué 27, Arantxa Conesa 28, Cristina Hidalgo 29, Carlos Vazquez 30, Jose Andrés Román-Ivorra 31, Pau Lluch 32, Sara Manrique 33, P. Vela 34, Eugenio de Miguel 35, Carmen Torres-Martín 36, Juan Carlos Nieto 37, Carmen Ordas-Calvo 38, Eva salgado-Pérez 39, Cristina Luna-Gómez 40, F. Javier Toyos-Sáenz De Miera 41, Nagore Fernández-Llanio 42, Antonio García 43, Carmen Larena 44, María Varela-García 5, Elena Aurrecoechea 6, Francisco Ortiz-Sanjuán 31, Jose Luis Hernández 1, Miguel Angel González-Gay 45 and Ricardo Blanco 46, 1Hospital Marqués de Valdecilla, Santander, Cantabria, Spain, 2Rheumatology Department. Hospital Marqués de Valdecilla, Santander, Cantabria, Spain, 3Rheumatology, Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain, 4Rheumatology Department, Hospital Universitario de la Princesa, IIS-Princesa, Madrid, Spain, Madrid, Spain, 5Complejo Hospitalario de Navarra, Navarra, Navarra, Spain, 6Hospital de Sierrallana, Torrelavega, Cantabria, Spain, 7Hospital de La Princesa, Madrid, Madrid, Spain, 8Complejo Asistencial Universitario de León, León, Castilla y Leon, Spain, 9Complejo Hospitalario Universitario Pontevedra, Pontevedra, Galicia, Spain, 10Rheumatology Department, Hospital Universitario de Bellvitge, Barcelona, Spain, Barcelona, Catalonia, Spain, 11Hospital Alto Deba, Mondragon, Pais Vasco, Spain, 12Division of Rheumatology, Instituto de Investigación Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, Santiago de Compostela, Spain, 13Complexo Hospitalario Universitario de Vigo, Vigo, Galicia, Spain, 14Hospital de Torrevieja, Alicante, Comunidad Valenciana, Spain, 15Hospital Ramón y Cajal, Madrid, Madrid, Spain, 16Hospital Universitario Lucus Augusti, Lugo, Galicia, Spain, 17Hospital Parc Taulí, Barcelona, Catalonia, Spain, 18Hospital General Universitario de Elda, Elda, Spain, 19Hospital Universitari Germans Trias i Pujol, Badalona, Catalonia, Spain, 20Hospital Río Carrión, Palencia, Castilla y Leon, Spain, 21Hospital La Mancha Centro, Alcázar de San Juan, Castilla-La Mancha, Spain, 22Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, 23Hospital General Universitario de Elche, Alicante, Comunidad Valenciana, Spain, 24Hospital San Cecilio, Granada, Andalucia, Spain, 25Hospital de Basurto, Bilbao, Pais Vasco, Spain, 26Hospital Universitario San Agustín, Avilés, Asturias, Spain, 27Department of Internal Medicine, Hospital Vall d'Hebron, Barcelona, Spain., Barcelona, Catalonia, Spain, 28Hospital General Universitario de Castellón, Castellón, Comunidad Valenciana, Spain, 29Hospital Clínico Universitario de Salamanca, Salamanca, Castilla y Leon, Spain, 30Hospital Miguel Servet, Zaragoza, Aragon, Spain, 31Hospital Universitario y Politécnico La Fe, Valencia, Comunidad Valenciana, Spain, 32Hospital Mateu Orfila, Menorca, Islas Baleares, Spain, 33Hospital Regional de Málaga, Málaga, Andalucia, Spain, 34Hospital General Universitario de Alicante, Alicante, Comunidad Valenciana, Spain, 35Rheumatology Department, Hospital Universitario La Paz, Madrid, Spain, 36Complejo Asistencial de Ávila, Ávila, Castilla y Leon, Spain, 37Rheumatology Department. Hospital Gregorio Marañón, Madrid, Madrid, Spain, 38Hospital Cabueñes, Gijón, Asturias, Spain, 39Complejo Hospitalario Universitario de Ourense, Ourense, Galicia, Spain, 40Hospital Universitario Nuestra Señora de la Candelaria, Tenerife, Canarias, Spain, 41Hospital Universitario Virgen Macarena, Sevilla, Andalucia, Spain, 42Hospital Arnau de Vilanova, Lérida, Catalonia, Spain, 43Hospital Virgen de las Nieves, Granada, Andalucia, Spain, 44Hospital Universitario Ramón y Cajal, Madrid, Madrid, Spain, 45Universidad de Cantabria and IDIVAL, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 46Rheumatology, Hospital Universitario Marques de Valdecilla, Santander, Spain

    Background/Purpose: Recently, based on the GiACTA trial results, weekly subcutaneous Tocilizumab (TCZ) has been approved for the treatment of Giant Cell Arteritis (GCA). It has…
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