Date: Sunday, November 8, 2020
Session Title: Reproductive Issues in Rheumatic Disorders (1497–1501)
Session Type: Abstract Session
Session Time: 3:00PM-3:50PM
Background/Purpose: Axial spondyloarthritis (axSpA) can affect women in their childbearing age. Data on pregnancy in axSpA patients are mainly retrospective and highly heterogeneous . The aim of this analysis was to investigate pregnancy outcomes and health of live born children in women with axSpA in four prospective cohort studies.
 Giovannopoulou E et al. Curr Rheumatol Rev. 2017;13(3):162-9.
Methods: Data of four European pregnancy registries that collect data prospectively and collaborate in the European Network of Pregnancy registries in Rheumatology (EuNeP) were compiled and compared according to a pre-defined study protocol: EGR2 (France), RePreg (Switzerland), RevNatus (Norway) and Rhekiss (Germany). Women with a diagnosis of axSpA enrolled in one of the registries and with a known pregnancy outcome reported until June, August and September 2019, respectively, were eligible for the analysis. Each registry analysed their data descriptively and provided the results to the coordinating centre.
Results: A total of 328 pregnancies in 288 women were investigated. Mean age of patients was comparable between registries ranging from 31 to 33 years. However, disease duration (3-8 years) and proportion of patients with a positive HLA-B27 (64-74%) varied (Table 1). The axSpA diagnosis was either classified by ASAS criteria (fulfilment in EGR2: 93%, RePreg: 65%, RevNatus: 86%) or by ASAS criteria for axial/ peripheral SpA (Rhekiss: 81/ 34%). Preeclampsia occurred in 0-4% and gestational diabetes in 6-9% of patients. Rates for preterm birth were ≤5%, and congenital malformations were reported in 4 out of 287 neonates (Table 2).
Conclusion: Differences in study design and classification criteria result in slightliy different patient populations in each registry. The outcome of pregnancies was favourable. Preterm birth rates are within rates reported by the WHO for the EU general population. However, a selection bias of rather planned and well-controlled pregnancies cannot be ruled out. This is the first collaborative analysis of four European pregnancy registries in rheumatology. Descriptive data were combined, and will be – in a next step – pooled together.
Funding: This work was supported by a research grant from FOREUM Foundation for Research in Rheumatology.
To cite this abstract in AMA style:Meissner Y, Costedoat-Chalumeau N, Foerger F, Goll D, Molto A, Özdemir R, Wallenius M, Strangfeld A, Fischer-Betz R. Pregnancy Outcomes in Patients with Axial Spondyloarthritis – a First Analysis of a European Collaboration of Pregnancy Registries [abstract]. Arthritis Rheumatol. 2020; 72 (suppl 10). https://acrabstracts.org/abstract/pregnancy-outcomes-in-patients-with-axial-spondyloarthritis-a-first-analysis-of-a-european-collaboration-of-pregnancy-registries/. Accessed January 19, 2022.
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