Abstracts Archive - Page 841 of 2425 - ACR Meeting Abstracts

Abstract Number: 1239 • 2019 ACR/ARP Annual Meeting
The Association Between Urate and CSF Markers of Alzheimer’s Disease in a Population-Based Sample of 70-Year-Olds
Tahzeeb Fatima¹, Lennart Jacobsson ², Lena Johansson ³, Mats Dehlin ⁴ and Ingmar Skoog ³, ¹Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Gothenburg, Sweden, ²Dept of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden,, Gothenburg, Sweden, ³Department of Psychiatry and Neurochemistry at Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Gothenburg, Sweden, ⁴Dept of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden, Gothenburg, Sweden
Background/Purpose: Urate is a powerful antioxidant that accounts for approximately 60% of free-radical scavenging capacity in the human body. The diagnosis of Alzheimer’s dementia (AD)…
Abstract Number: 1240 • 2019 ACR/ARP Annual Meeting
A Randomized, Phase 2 Study Evaluating the Efficacy and Safety of Anakinra in Difficult-To-Treat Acute Gouty Arthritis: The anaGO Study
Kenneth Saag¹, Alexander So ², Puja Khanna ³, Robert Keenan ⁴, Sven Ohlman ⁵, Torbjörn Kullenberg ⁵, Lisa Osterling Koskinen ⁵, Michael Pillinger ⁶ and Robert Terkeltaub ⁷, ¹University of Alabama at Birmingham, Birmingham, AL, ²Université de Lausanne, Lausanne, Switzerland, ³University of Michigan Medical School, Ann Arbor, ⁴Duke University School of Medicine, Durham, ⁵Sobi, Stockholm, Sweden, ⁶New York University School of Medicine, New York, ⁷San Diego VA/UCSD, San Diego, CA
Background/Purpose: In gout, urate crystals deposited in and around joints trigger episodes of acute arthritis, mediated by the proinflammatory cytokine IL-1β. In uncontrolled studies, the…
Abstract Number: 1241 • 2019 ACR/ARP Annual Meeting
Further Characterizing Morphea Subsets Using a Multi-center, Prospective, Cross-sectional Analysis of Morphea in Adults and Children
Smriti Prasad¹, Kaila L. Schollaert ², Robert Haley ¹, Kathryn Torok ³ and Heidi Jacobe ¹, ¹University of Texas Southwestern Medical Center, Dallas, ²University of Pittsburgh, Pittsburgh, ³UPMC Children's Hospital of Pittsburgh, Pittsburgh
Background/Purpose: There have been few large, prospective cohort studies performed on morphea, or localized scleroderma. Most that exist focus exclusively on either pediatric or adult…
Abstract Number: 1242 • 2019 ACR/ARP Annual Meeting
Impact of Smoking Status on Remission in Hidradenitis Suppurativa
Amil Agarwal ¹, Marissa Mangini ¹, Derek Jones ¹, Catherine Hood ¹, Richard Amdur ¹ and Victoria Shanmugam², ¹The George Washington University School of Medicine and Health Sciences, Washington, DC, ²George Washington University, Georgetown, DC
Background/Purpose: Hidradenitis Suppurativa (HS) is an inflammatory disease of the apocrine sweat glands characterized by recurrent abscessing inflammation. The molecular drivers of HS are poorly…
Abstract Number: 1243 • 2019 ACR/ARP Annual Meeting
Anakinra Treatment in Recurrent Pericarditis: Single Center Experience
Zeynep Toker Dincer¹, Osman Corbali ², Serdal Ugurlu ¹ and Huri Ozdogan ¹, ¹Istanbul University - Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, ISTANBUL, Turkey, ²Istanbul University - Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, ISTANBUL
Background/Purpose: Recurrent pericarditis (RP), however the etiology is unknown in the majority, may be observed in autoinflammatory diseases such as familial Mediterranean fever (FMF) and…
Abstract Number: 1244 • 2019 ACR/ARP Annual Meeting
Tocilizumab – An Effective Rescue Therapy for Refractory Unclassified Autoinflammatory Diseases in Children
Jasmin B. Kuemmerle-Deschner¹, Daniel Sturm ¹ and Susanne Benseler ², ¹University Hospital Tuebingen, Tuebingen, Germany, ²Alberta Childrens Hospital Research Institute, Calgary, Canada
Background/Purpose: Evidence based treatment options for children and adults with unclassified autoinflammatory diseases (AID) are limited. Frequently, IL-1-inhibition is primarily tried to control the severe…
Abstract Number: 1245 • 2019 ACR/ARP Annual Meeting
Efficacy of Canakinumab Treatment in Adult-onset Still’s Disease
Corrado Campochiaro¹, Alessandro Tomelleri ², De Luca Giacomo ³, Nicola Farina ², Elena Baldissera ², Giulio Cavalli ² and Lorenzo Dagna ², ¹Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy, ²Unit of Immunology, Rheumatology, Allergy and Rare Diseases. IRCCS San Raffaele Hospital. Vita-Salute San Raffaele University., Milan, Italy, ³Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Milan, Italy
Background/Purpose: Adult-onset Still’s disease (AOSD) is a rare auto-inflammatory condition characterized by fever, arthritis, skin rash, and multi-organ inflammation. The pathogenesis of AOSD is centrally…
Abstract Number: 1246 • 2019 ACR/ARP Annual Meeting
Using PROMIS Data to Assess Activity of Inflammatory Eye Disease
Joshua Hedrick¹, Rula Hajj-ali ², Yuxuan Jin ³ and Sunil Srivastava ¹, ¹Cleveland Clinic, Cleveland, OH, ²Rheumatologic and Immunologic Disease/Cleveland Clinic, Cleveland, OH, ³Quantitative Health Science, Cleveland Clinic, Cleveland, OH
Background/Purpose: Diagnosing and managing patients with inflammatory eye disease (IED) requires close interdisciplinary care with rheumatologists adjusting systemic, potentially toxic, therapies based on exam findings…
Abstract Number: 1247 • 2019 ACR/ARP Annual Meeting
Adult-Onset Still’s Disease and Spondyloarthritis: Overlapping Syndrome or Incidental Association? A Series of 5 Cases
Aly Kamissoko ¹, Nolan Hassold ², Alexis Mathian ³, Edouard Pertuiset ⁴, Gaetane Nocturne ², Bruno Fautrel ⁵ and Stéphane Mitrovic⁶, ¹AP-HP, Department of Rheumatology, Pitié-Salpêtrière University Hospital, Paris, France, Paris, France, ²Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France., Paris, France, ³AP-HP, Service de Médecine Interne 2, Hôpital Universitaire Pitié-Salpêtrière, Paris, France, Paris, France, ⁴Rheumatology Department, Pontoise Hospital, Pontoise, France, Pontoise, France, ⁵Pitié-Salpêtrière Hospital, Department of Rheumatology, AP-HP, Sorbonne University, UPMC university, Paris, Ile-de-France, France, ⁶AP-HP, Department of Rheumatology, Pitié-Salpêtrière University Hospital, Sorbonne Université, GRC 08, Pierre Louis Institute of Epidemiology and Public Health, Paris, France - Centre d’Etude et de Référence sur les Maladies AutoInflammatoires et les Amyloses (CEREMAIA), FAI2R network, Paris, France - Institut Mutualiste Montsouris, Paris, France, Paris, France
Background/Purpose: Some forms of spondyloarthritis (SpA) such as SAPHO syndrome are classified as auto-inflammatory disorders. Association with adult onset Still’s disease (AoSD) has never been…
Abstract Number: 1248 • 2019 ACR/ARP Annual Meeting
Clinical Manifestations and Management of US Patients with SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis) Syndrome, a Retrospective Study
Delamo Bekele¹, Paras Karmacharya ², Kerry Wright ² and Clement Michet ¹, ¹Mayo Clinic Rochester, Rochester, MN, ²Mayo Clinic, Rochester, MN
Background/Purpose: The SAPHO syndrome is a rare inflammatory disorder of bones, joints and skin first coined by Chamot in 1987 characterized by synovitis, acne, pustulosis,…
Abstract Number: 1249 • 2019 ACR/ARP Annual Meeting
Pelvic Congestion Syndrome, an Uncommon Cause of Osteoarticular Pain
Mireia Castillo-Vilella¹, Jose Luis Tandaipan ², Laura Berbel ³, Lluís Moga ³, Georgina Salvador ³, Silvia Martínez-Pardo ³ and Nuria Giménez ³, ¹Hospital Universitari Sagrat Cor, Barcelona, Spain, ²Hospital Universitari Mutua Terrassa, Terrassa, Spain, ³Hospital Universitari Mútua Terrassa, Terrassa
Background/Purpose: Background: The pelvic congestion syndrome (PCS) is an under and often misdiagnosed entity that appears more frequently in premenopausal age and multiparous women. The…
Abstract Number: 1250 • 2019 ACR/ARP Annual Meeting
Can Patient-Reported Outcomes and Disease Activity Scores Predict Patient Acceptable Symptom State in Adult-Onset Still’s Disease?
Emre Bilgin ¹, Timuçin Kaşifoğlu ², Ahmet Omma ³, Cemal Bes ⁴, Muhammet Çınar ⁵, Hakan Emmungil ⁶, Orhan Küçükşahin ⁷, Servet Akar ⁸, Kenan Aksu ⁹, Fatih Yıldız ¹⁰, Nilüfer Kanıtez ¹¹, Abdulsamet Erden ¹², Sezin Turan ¹³, Ediz Dalkılıç ¹⁴, Selime Ermurat ¹⁵, Mutlu Hayran ¹⁶ and Umut Kalyoncu¹⁷, ¹Hacettepe University Vasculitis Centre, Ankara, Turkey, Ankara, Turkey, ²Eskişehir Osmangazi University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Eskişehir, Turkey, ³Ankara Numune Education and Research Hospital, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey, ⁴University of Medical Sciences, İstanbul, Turkey, ⁵University of Medical Sciences, Ankara, Turkey, ⁶Trakya University, Edirne, Turkey, ⁷Liv Hospital, Ankara, Turkey, ⁸Izmir Katip Celebi University, Faculty of Medicine, Division of Rheumatology, İzmir, Turkey, ⁹Ege University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, İzmir, Turkey, ¹⁰Kahramanmaraş Sütçü İmam University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Kahramanmaraş, Turkey, ¹¹Koç University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, İstanbul, Turkey, ¹²Ministry of Health Ankara City Hospital, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey, ¹³Trakya University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Edirne, Turkey, ¹⁴Uludağ University, Bursa, Turkey, ¹⁵Uludağ University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Bursa, Turkey, ¹⁶Hacettepe University, Faculty of Medicine, Department of Preventive Oncology, Ankara, Turkey, ¹⁷Hacettepe University Department of Rheumatology, Ankara, Turkey
Background/Purpose: Adult-onset Still’s disease (AOSD) is a rare, chronic and auto-inflammatory disorder with multisystemic involvement. Patient Acceptable Symptom State (PASS) is the highest level of…
Abstract Number: 1251 • 2019 ACR/ARP Annual Meeting
The Impact of Aging on Familial Mediterranean Fever Patients
Serdal Ugurlu ¹, Okan Aydin ², Bugra Han Egeli³, Asli Ece Soykut ², Deniz Demir ² and Huri Ozdogan ², ¹Istanbul University - Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, istanbul, Turkey, ²Istanul University-Cerrahpasa, istanbul, Turkey, ³İstanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey
Background/Purpose: Familial Mediterranean Fever (FMF) is a monogenic autoinflammatory disorder with innate immune activation with an onset before age 20 in approximately 90% of the…
Abstract Number: 1252 • 2019 ACR/ARP Annual Meeting
Pattern of Arthropathy in Patients with Cystic Fibrosis
Daniel Pham ¹, Mehrdad Maz ², Michael Crosser ¹ and Megan Krause¹, ¹University of Kansas, Kansas City, KS, ²The University of Kansas Medical Center, KANSAS CITY, KS
Background/Purpose: Arthropathy is a rare but debilitating manifestation of cystic fibrosis (CF) that has no formal definition. This study attempts to characterize the spectrum of…
Abstract Number: 1253 • 2019 ACR/ARP Annual Meeting
Novel Nonsense Variant and Entire Deletion of TNFAIP3 Cause Haploinsufficiency of A20 Clinically Distinct from Behçet’s Disease
Naomi Tsuchida¹, Yohei Kirino ¹, Yutaro Soejima ¹, Hideaki Nakajima ¹, Satoko Miyatake ² and Naomichi Matsumoto ², ¹Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ²Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan
Background/Purpose: Haploinsufficiency of A20 (HA20) is caused by loss-of-function TNFAIP3 variants. Phenotypic and genetic features of HA20 remain uncertain; therefore, clinical distinction between HA20 and…

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