Abstracts Archive - Page 602 of 2607 - ACR Meeting Abstracts

Abstract Number: 1790 • ACR Convergence 2022
Ultrasound Diagnosis of Calcium Pyrophosphate Crystal Deposition: Which Sites Should Be Scanned?
Edoardo Cipolletta¹, Erica Moscioni², Silvia Sirotti³, Georgios Filippou⁴ and Emilio Filippucci⁵, ¹Polytechnic University of Marche, Ancona, Italy, ²Polytechnic University of Marche, Jesi, Italy, ³Università degli Studi di Milano, Milano, Italy, ⁴Rheumatology Department, Luigi Sacco University Hospital, Siena, Italy, ⁵Polytechnic University of Marche, Rheumatology Unit, Department of Clinical and Molecular Sciences, "Carlo Urbani" Hospital, Jesi, Italy
Background/Purpose: In recent years, ultrasonography (US) has emerged as an accurate and reliable tool for the diagnosis of calcium pyrophosphate (CPP) deposition disease (CPPD) in…
Abstract Number: 1780 • ACR Convergence 2022
Improved Overall Survival in Patients with Lung Cancer and Autoimmune Rheumatic Diseases
Paola Ghanem¹, Joseph C. Murray¹, Christopher Mecoli², Ami Shah³, Benjamin Levy¹, Kristen A. Marrone¹, David Ettinger¹, Valsamo Anagnostou¹, Vincent K. Lam¹, Julie R. Brahmer¹ and Laura C. Cappelli⁴, ¹Johns Hopkins University, Baltimore, MD, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³Johns Hopkins Rheumatology, Baltimore, MD, ⁴Johns Hopkins School of Medicine, Baltimore, MD
Background/Purpose: Lung cancer remains the leading cause of cancer-related death. Concomitant autoimmune diseases (AD) can add morbidity and complicate treatment decisions. We evaluated the tumor…
Abstract Number: 1788 • ACR Convergence 2022
Pulmonary Vascular Dysfunction Occurs in Association with Hyperuricaemia: Assessment by a Novel Non-Invasive Measurement of Pulmonary Pulse Wave Transit Time
Rachael Flood¹, Nicole Fagan², Diarmuid O'Brien¹, Colm Kirby¹, David Kane¹ and Ronan Mullan¹, ¹Tallaght University Hospital, Dublin, Ireland, ²St James' Hospital, Dublin, Ireland
Background/Purpose: Hyperuricaemia is common in pulmonary hypertension (PH) occurring in up to 80% of patients with serum uric acid levels(sUA) correlating with poor PH outcomes.…
Abstract Number: 1801 • ACR Convergence 2022
High Frequency of Structural Damage in the Lower Spine of Patients with Chondrocalcinosis
Kalliopi Klavdianou¹, Jona Kasfeld², Martin Fruth³, Styliani Tsiami⁴, Juergen Braun⁵, Philipp Sewerin⁶, David Kiefer⁵ and Xenofon Baraliakos⁷, ¹'Asklepieion' General Hospital, Department of Rheumatology, Voula, Athens, Greece, ²Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, ³Blikk, Radiologie, Herne, Germany, ⁴Rheumazentrum Ruhrgebiet, Herne, Ruhr-University Bochum, Herne, Germany, ⁵Rheumazentrum Ruhrgebiet, Herne, Germany, ⁶Rheumazentrum Ruhrgebiet, Ruhr-Universität-Bochum, Herne, Germany, ⁷Rheumazentrum Ruhrgebiet Herne, Herne, Germany
Background/Purpose: Calcium pyrophosphate dihydrate crystal deposition disease (CPPD, chondrocalcinosis) is known to affect fibrocartilaginous tissue in the large and smaller peripheral joints. The affection of…
Abstract Number: 1795 • ACR Convergence 2022
Therapeutic Strategies for Patients with Chronic Manifestations of Calcium Pyrophosphate Deposition Disease
Julien Damart¹, Silvia Sirotti², Mariano Andrès³, Edoardo Cipolletta⁴, Georgios Filippou⁵, Davide Carboni⁶, Emilio Filippucci⁷, Pilar Diez⁸, Abhishek Abhishek⁹, Augustin Latourte¹⁰, Hang-Korng Ea¹¹, Sebastien Ottaviani¹², Jean-Guillaume Letarouilly¹³, Renaud Desbarbieux¹⁴, Sahara Graf¹, Laurène Norberciak¹, Pascal Richette¹⁵ and Tristan Pascart¹⁶, ¹Hôpital Saint-Philibert, Lomme, France, ²Università degli Studi di Milano, Milano, Italy, ³Dr Balmis Alicante General University Hospital-ISABIAL, Alicante, Spain, ⁴Polytechnic University of Marche, Ancona, Italy, ⁵Rheumatology Department, Luigi Sacco University Hospital, Siena, Italy, ⁶Luigi Sacco University, Milano, Italy, ⁷Polytechnic University of Marche, Rheumatology Unit, Department of Clinical and Molecular Sciences, "Carlo Urbani" Hospital, Jesi, Italy, ⁸Alicante University, Alicante, Spain, ⁹University of Nottingham, Nottingham, United Kingdom, ¹⁰Université de Paris, Paris, France, ¹¹Lariboisière Hospital, Paris, France, ¹²Hopital Bichat-Claude Bernard, Paris, France, ¹³CHU Lille, Lille, France, ¹⁴Ch Boulogne-sur-Mer, Boulogne-sur-Mer, France, ¹⁵Department of Rheumatology, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France, ¹⁶Groupement Hospitalier de l'Institut Catholique de Lille, Lomme, France
Background/Purpose: Calcium pyrophosphate deposition (CPPD) disease lacks recommendations on treatment strategies. This study reports on treatment modalities used in European tertiary hospitals for the management…
Abstract Number: 1797 • ACR Convergence 2022
Factors Driving Opioid Use in United States Veterans with Gout
Lindsay Helget¹, Bryant England¹, Punyasha Roul², Harlan Sayles¹, Alison Petro¹, Tuhina Neogi³, James O'Dell¹ and Ted Mikuls⁴, ¹University of Nebraska Medical Center, Omaha, NE, ²UNMC, Omaha, NE, ³Boston University School of Medicine, Boston, MA, ⁴Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Patients with gout often seek care for painful flares and nearly one-third are prescribed opioids during acute ambulatory visits. Unfortunately, opioids do not address…
Abstract Number: 1793 • ACR Convergence 2022
Prevalence of HLA B*5801 Allele Among African American Patients with Gout in an Academic Health Center
Namitha Nair, Dipanjan Debnath and FLORINA CONSTANTINESCU, MedStar Washington Hospital Center, Washington, DC
Background/Purpose: The presence of the HLA-B*5801 allele is strongly associated with Allopurinol Hypersensitivity Syndrome (AHS) manifesting as severe cutaneous adverse reactions (SCARs) like Drug rash…
Abstract Number: 1804 • ACR Convergence 2022
Raman Spectroscopy Integrated with Polarized Light Microscopy for Diagnosis of Crystallopathies
Tom Niessink¹, Matthijs Janssen², Cees Otto¹ and Tim Jansen³, ¹Medical Cell Biophysics group, University of Twente, Enschede, Netherlands, ²Rijnstate Hospital, Bennekom, Netherlands, ³Department of Rheumatology, VieCuri Medical Centre, Venlo, Netherlands
Background/Purpose: The current golden standard in diagnosing gout and calcium pyrophosphate deposition is polarized light microscopy (PLM). However, small crystal sizes, the presence of other…
Abstract Number: 1806 • ACR Convergence 2022
Characteristics and Comorbidity Burden of Phase 3 Clinical Trial Participants Who Did and Did Not Experience Acute Gout Flares During Biweekly Pegloticase Dosing
Naomi Schlesinger¹, Lissa Padnick-Silver², Katie Obermeyer² and Brian LaMoreaux², ¹Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, ²Horizon Therapeutics plc, Deerfield, IL
Background/Purpose: Acute gout flare often accompanies urate-lowering therapy initiation and is the most common adverse event associated with pegloticase, a recombinant pegylated uricase that rapidly…
Abstract Number: 1803 • ACR Convergence 2022
Neutrophil-to-lymphocyte Ratio Among Flaring and Non-flaring Uncontrolled Gout Patients Undergoing Pegloticase Therapy as Part of the Phase 3 Pivotal Trials
Michael Pillinger¹, Katie Obermeyer², Lissa Padnick-Silver² and Brian LaMoreaux², ¹NYU Grossman School of Medicine, New York, NY, ²Horizon Therapeutics plc, Deerfield, IL
Background/Purpose: Gout flares result from an innate immune response against monosodium urate crystal deposits, resulting in macrophage crystal phagocytosis and cellular activation.1 NLRP3 inflammasome activation…
Abstract Number: 1805 • ACR Convergence 2022
Effect of Short-Term Fruit Juice and Sugared Beverage Intake on Risk of Recurrent Gout Flares
Natalie McCormick¹, Chio Yokose², Minna Kohler³, Janeth Yinh¹, Clara Chen⁴, Tuhina Neogi⁵, Tony Merriman⁶, kenneth saag⁷, Yuqing Zhang⁸ and Hyon Choi⁹, ¹Massachusetts General Hospital, Boston, MA, ²Massachusetts General Hospital, Waltham, MA, ³Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Boston University School of Public Health, Boston, MA, ⁵Boston University School of Medicine, Boston, MA, ⁶University of Otago, Dunedin, New Zealand, ⁷University of Alabama at Birmingham, Birmingham, AL, ⁸Massachusetts General Hospital, Quincy, MA, ⁹MASSACHUSETTS GENERAL HOSPITAL, Lexington, MA
Background/Purpose: Habitual fructose-rich beverage intake has been associated with increased serum urate (SU) levels and prevalent and incident gout. This is likely because fructose induces…
Abstract Number: 1301 • ACR Convergence 2022
Reliable Transition Policy Distribution and Transition Readiness Assessment Questionnaire Completion Using a Digital Intervention in a Pediatric Rheumatology Clinic
Emily Smitherman¹, Livie Huie¹, John Bridges², Randy Cron¹, Victoria Gennaro³, Kim Jerkins¹, Julie Mauldin¹, Linda McAllister⁴, Annelle Reed³, Daniel Reiff¹, Erica Reynolds³, Isabella Sanchez³, Carolyn Smith³, Matthew Stoll¹, Tana Webb¹, Peter Weiser¹, JoAnne Zech¹ and Melissa Mannion¹, ¹University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham/Children's of Alabama, Birmingham, AL, ³Children's of Alabama, Birmingham, AL, ⁴Children's of Alabama, Trussville, AL
Background/Purpose: The process of transition from pediatric- to adult-based care should be well-timed, coordinated, and planned to educate and encourage the adolescent towards an adult…
Abstract Number: 1746 • ACR Convergence 2022
Increased CD39+FoxP3+CD4+ Regulatory T Cells in Early Rheumatoid Arthritis Provide a Slot for Prompt Initiation of Methotrexate and Serve as Early Biomarkers of Clinical Response
María-Eugenia Miranda-Carús¹, Alejandro Villalba¹, Laura Nuño¹, Marta Benito-Miguel², Irene Monjo¹, Marta Novella-Navarro¹, Diana Peiteado¹, Sara Garcia-Carazo¹ and Alejandro Balsa³, ¹Hospital Universitario La Paz - IdiPAZ, Madrid, Spain, ²Universidad Nebrija, Physiology, Madrid, Spain, ³Hospital La Paz Institute for Health Research, Madrid, Spain
Background/Purpose: FoxP3+ regulatory CD4+ T cells (Tregs) are key to the homeostasis of the immune system. Stressed cells at inflammatory foci release adenine nucleotides to…
Abstract Number: 1696 • ACR Convergence 2022
Single Cell RNA-seq Identifies Major Shifts in Myeloid Cells in Dermatomyositis Skin and Peripheral Blood Compared to Systemic Lupus
Grace Hile, Feiyang Ma, Amanda Victory, Bin Xu, Mehrnaz Gharaee-Kermani, Elisabeth Pedersen, Rachael Wasikowski, Celine Berthier, Vladimir Ognenovski, Allison Billi, Johann Gudjonsson and J. Michelle Kahlenberg, University of Michigan, Ann Arbor, MI
Background/Purpose: Skin disease in dermatomyositis (DM) is relapsing and often refractory to treatment, reflecting a lack of understanding of the mechanisms driving skin inflammation. DM…
Abstract Number: 1553 • ACR Convergence 2022
Effectiveness and Safety of Adalimumab versus Leflunomide in Patients with Takayasu Arteritis – a Retrospective Cohort Study
Faustino Peron Filho¹, Andressa de Souza Moreira², Anna Larissa Janes² and Alexandre Wagner de Souza², ¹UNIFESP-EPM, Mogi das Cruzes, São Paulo, Brazil, ²UNIFESP-EPM, São Paulo, Brazil
Background/Purpose: Therapy for Takayasu arteritis (TAK) is based on the combination of high-dose glucocorticoids and immunosuppressive and/or biologic agents. Patients presenting severe disease manifestations are…

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