Abstracts Archive - Page 1261 of 2425 - ACR Meeting Abstracts

Abstract Number: 832 • 2017 ACR/ARHP Annual Meeting
Single Cell Analysis Reveals Heterogeneity of Type I IFN Gene Expression in Developing Autoreactive B Cells
Jennie Hamilton¹, PingAr Yang², Qi Wu³, Bao Luo⁴, Shanrun Liu⁵, Jun Li⁶, Mark Walter⁷, Eleanor Fish⁸, Hui-Chen Hsu³ and John D. Mountz⁹, ¹Medicine/Division of Clinical Immunology and Rhematology, University of Alabama at Birmingham, Birmingham, AL, ²Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁴Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁵Biochemistry & Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL, ⁶Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁷Microbiology, University of Alabama at Birmingham, Birmingham, AL, ⁸University Health Network & Department of Immunology, University of Toronto, Toronto General Research Institute, Toronto, ON, Canada, ⁹University of Alabama at Birmingham, Department of Medicine, Birmingham, AL
Background/Purpose: B cell development involves passage through a formative transitional B cell stage in the spleen. In SLE, self-nucleic acid reactive B cells fail to…
Abstract Number: 833 • 2017 ACR/ARHP Annual Meeting
Chronic Cutaneous Lupus Erythematosus Patients Have a Breakdown in Autoreactive VH4.34 Antibody Tolerance While Maintaining Tolerance to dsDNA and Chromatin
Scott Jenks¹, Regina Bugrovsky¹, Xiaoqian Wang^1,2, Aisha Hill³, Chungwen Wei⁴, S. Sam Lim⁵, Ignacio Sanz⁶ and Cristina Drenkard⁵, ¹Emory University School of Medicine and Lowance Center for Human Immunology, Atlanta, GA, ²Division of Rheumatology and Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA, ³Medicine, Emory University School of Medicine, atlanta, GA, ⁴Medicine, Emory University School of Medicine, Atlanta, GA, ⁵Division of Rheumatology, Emory University School of Medicine, Atlanta, GA, ⁶Rheumatology and Lowance Center for Human Immunology, Emory University School of Medicine and Lowance Center for Human Immunology, Atlanta, GA
Background/Purpose: While the contribution of humoral immunity to SLE is well established, the role it plays in chronic cutaneous lupus erythematosus (CCLE) is less clear.…
Abstract Number: 834 • 2017 ACR/ARHP Annual Meeting
Citrulline-Polyspecific B Cell Antigen Receptors Arising from Somatic Hypermutation within Clades Demonstrate Pathogenicity in Rheumatoid Arthritis
Philip J. Titcombe^1,2, Gustaf Wigerblad³, Natalie Sippl³, Na Zhang¹, Anna K. Shmagel⁴, Peter Sahlström⁵, Yue Jack Zhang¹, Laura Barsness Motschenbacher¹, Yogita Ghodke-Puranik⁶, Monika Hansson⁷, Lena Israelsson⁵, Timothy B. Niewold⁸, Lars Klareskog⁹, Camilla Svensson¹⁰, Khaled Amara⁷, Vivianne Malmström¹¹ and Daniel L. Mueller¹, ¹Medicine/Rheumatic and Autoimmune Diseases, University of Minnesota Medical School, Minneapolis, MN, ²Rheumatology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, ³Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, ⁴Rheumatic & Autoimmune Diseases, University of Minnesota Medical School, Minneapolis, MN, ⁵Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ⁶Colton Center for Autoimmunity, New York University, New York, NY, ⁷Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ⁸Rheumatology and Immunology, Mayo Clinic, Rochester, MN, ⁹Rheumatology unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ¹⁰Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden, ¹¹Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Citrulline–modified proteins arising from the post-translational modification of arginine residues are recognized as primary rheumatoid arthritis (RA) autoantigen targets based on the strong association…
Abstract Number: 835 • 2017 ACR/ARHP Annual Meeting
Generation of an Efficient CRISPR-Cas9 Editing Technique in Human Primary B Cells for the Targeted Study of Autoimmune Susceptibility Genes
Yuriy Baglaenko¹, Dario Ferri², Juan Carlos Zuniga-Pflucker³ and Joan E. Wither^2,4,5, ¹Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ²Immunology, University of Toronto, Toronto, ON, Canada, ³Biological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ⁴Krembil Research Institute, University Health Network, Toronto, ON, Canada, ⁵Genetics and Development, Toronto Western Research Institute, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Autoimmunity is a complex, poly-genic disorder that culminates in multi-organ damage. In systemic lupus erythematosus (SLE), the prototypic autoimmune disorder, a breakdown of tolerance…
Abstract Number: 836 • 2017 ACR/ARHP Annual Meeting
B Cell Receptor Sequencing of Anti-Citrullinated Protein Antibody Expressing B Cells Indicates a Selective Advantage for the Introduction of N-Glycosylation Sites during Somatic Hypermutation
Rochelle D. Vergroesen¹, Linda Slot¹, Lise Hafkenscheid¹, Marvyn T. Koning², Ellen I.H. van der Voort³, Christine A. Grooff¹, George Zervakis², Tom W.J. Huizinga¹, Theo Rispens⁴, Hendrik Veelken², Rene E.M. Toes¹ and Hans U. Scherer³, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Hematology, Leiden University Medical Center, Leiden, Netherlands, ³Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Immunopathology, Sanquin Research, Amsterdam, Netherlands
Background/Purpose: The vast majority (>90%) of anti-citrullinated protein antibodies (ACPA) of the IgG isotype in serum and synovial fluid of patients with rheumatoid arthritis carry…
Abstract Number: 837 • 2017 ACR/ARHP Annual Meeting
Rheumatoid Arthritis and Risk for Chronic Obstructive Pulmonary Disease or Asthma Among Women during 38 Years of Prospective Follow-up
Jeffrey A. Sparks¹, Tzu-Chieh Lin², Carlos Camargo³, Medha Barbhaiya⁴, Sara K. Tedeschi⁵, Karen H. Costenbader², Benjamin Raby⁶, Hyon K. Choi⁷ and Elizabeth Karlson⁴, ¹Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Emergency Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ⁴Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁵Division of Rheumatology, Immunology and Allergy,, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁶Pulmonary Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁷Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose : Rheumatoid arthritis (RA) has been associated with increased risk for chronic obstructive pulmonary disease (COPD) and asthma, but these findings may have been…
Abstract Number: 838 • 2017 ACR/ARHP Annual Meeting
Rates of New-Onset Pulmonary Disease Among Patients with Systemic Lupus Erythematosus in Sweden
Lindsy J. Forbess¹, Michael Weisman² and Julia F Simard³, ¹Medicine, Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ²Cedars-Sinai Medical Center Division of Rheumatology, Los Angeles, CA, ³Division of Epidemiology, Health Research and Policy Department, Stanford School of Medicine, Stanford, CA
Background/Purpose: Our goal was to examine lung disease and types of pulmonary manifestations observed in patients with SLE. We studied population-based register data from Sweden…
Abstract Number: 839 • 2017 ACR/ARHP Annual Meeting
Use of Bisphosphonate and Risk of Incident Atrial Fibrillation in a Population-Based Study
Shanshan Sheehy¹, Christine Peloquin² and Tuhina Neogi³, ¹Clinical Epidemiology Research & Training Unit, Boston University, Boston, MA, ²Boston University School of Medicine, Boston, MA, ³Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Bisphosphonates remain the first-line agent prescribed medication for the prevention and treatment of osteoporosis. Apart from concern about atypical fractures, another concern about risk…
Abstract Number: 840 • 2017 ACR/ARHP Annual Meeting
Mortality Post Hip Fracture in Rheumatoid Arthritis Compared to General Population Controls, a Population-Based Study
C. Allyson Jones¹, Pierre Guy², Hui Xie³, Eric C. Sayre⁴ and Diane Lacaille^5,6, ¹Physical Therapy, University of Alberta, Edmonton, AB, Canada, ²Department of Orthopaedics, University of British Columbia / Centre for Hip Health and Mobility, Vancouver, BC, Canada, ³Biostatistics, Faculty of Health Sciences, Simon Fraser University / Arthritis Research Canada, Burnaby, BC, Canada, ⁴Arthritis Research Canada, Richmond, BC, Canada, ⁵University of British Columbia, Arthritis Research Canada, Richmond, BC, Canada, ⁶Arthritis Research Canada/ University of British Columbia, Vancouver, BC, Canada
Background/Purpose: In prior work, we found a higher incidence of hip fractures in RA than age and sex matched general population controls (4.1 vs. 2.9…
Abstract Number: 841 • 2017 ACR/ARHP Annual Meeting
Optimal Regimens of Sulfamethoxazole-Trimethoprim for Chemoprophylaxis of Pneumocystis Pneumonia in Patients with Systemic Rheumatic Diseases: 52-Week Follow-up of a Non-Blinded, Randomized Controlled Trial
Masayoshi Harigai^1,2, Masako Utsunomiya^2,3,4, Hiroaki Dobashi⁵, Toshio Odani^6,7, Kazuyoshi Saito^8,9, Naoto Yokogawa¹⁰, Kenji Nagasaka^11,12, Kenchi Takenaka^3,11, Makoto Soejima^11,13, Takahiko Sugihara¹⁴, Hiroyuki Hagiyama¹⁵, Shinya Hirata¹⁶, Kazuo Matsui^17,18, Yoshinori Nonomura¹⁹, Masahiro Kondo²⁰, Fumihito Suzuki^13,21, Makoto Tomita²², Mari Kihara²³, Waka Yokoyama³, Fumio Hirano²⁴, Hayato Yamazaki³, Ryoko Sakai^2,25, Toshihiro Nanki^2,26, Ryuji Koike^2,3, Hitoshi Kohsaka³ and Nobuyuki Miyasaka³, ¹Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, ³Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, ⁴Department of Rheumatology, Musashino Red Cross Hospital, Tokyo, Japan, ⁵Internal Medicine Division of Hematology, Rheumatology, and Respiratory Medicine, Kagawa University, Kagawa, Japan, ⁶Third Department of Internal Medicine, Obihiro-Kosei General Hospital, Hokkaido, Japan, ⁷Molecular Physiology and Therapeutics Branch/Adeno-Associated Virus Biology Section, National Institute of Dental and Craniofacial Research (NIDCR)/ National Institutes of Health (NIH), Bethesda, MD, ⁸Tobata General Hospital, Fukuoka, Japan, ⁹The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, ¹⁰Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan, ¹¹Department of Rheumatology, Ome Municipal General Hospital, Tokyo, Japan, ¹²Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences,, Tokyo Medical and Dental University, Tokyo, Japan, ¹³Department of Rheumatology, Soka Municipal Hospital, Saitama, Japan, ¹⁴Department of Medicine and Rheumatology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan, ¹⁵Department of Rheumatology, Yokohama City Minato Red Cross Hospital, Kanagawa, Japan, ¹⁶Department of Hematology, Rheumatology, and Infectious Disease, Kumamoto University, Kumamoto, Japan, ¹⁷Department of Rheumatology, Kameda Medical Center, Chiba, Japan, ¹⁸Department of Internal Medicine, Takikawa Municipal Hospital, Hokkaido, Japan, ¹⁹Department of Rheumatology, Tokyo Kyosai Hospital, Tokyo, Japan, ²⁰Department of Rheumatology, Faculty of Medicine, Shimane University, Shimane, Japan, ²¹Department of Rheumatology, JA Toride Medical Center, Ibaraki, Japan, ²²Clinical Research Center, Tokyo Medical and Dental University, Tokyo, Japan, ²³Department of Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan, ²⁴Departments of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, ²⁵Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases, Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan, ²⁶Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan
Background/Purpose: Sulfamethoxazole-trimethoprim (SMX/TMP) is a standard drug for the prophylaxis of Pneumocystis pneumonia (PCP), but is sometimes discontinued due to adverse events (AEs). We have…
Abstract Number: 842 • 2017 ACR/ARHP Annual Meeting
Risk of Serious Infection in Patients with Rheumatoid Arthritis Treated with Biologic Vs. Non-Biologic Dmards
Gulsen Ozen¹, Sofia Pedro², Bryant R. England³, Bella Mehta⁴, Frederick Wolfe² and Kaleb Michaud¹, ¹Rheumatology, University of Nebraska Medical Center, Omaha, NE, ²National Data Bank for Rheumatic Diseases, Wichita, KS, ³Division of Rheumatology & Immunology, Department of Internal Medicine, Nebraska-Western IA VA Health Care System & University of Nebraska Medical Center, Omaha, NE, ⁴Rheumatology, Hospital for Special Surgery/Weill Cornell Medical College, New York, NY
Background/Purpose: Serious infections (SIs) are a major concern in RA patients, significantly contributing to increased mortality. We examined the SI risk associated with bDMARDs compared…
Abstract Number: 843 • 2017 ACR/ARHP Annual Meeting
The Role of Personality in Patients with Fibromyalgia
Andrew Seto¹, Teresa Wu¹, Lori Lyn Price^2,3,4,5, Xingyi Han⁶, William F. Harvey¹ and Chenchen Wang⁷, ¹Tufts Medical Center, Boston, MA, ²Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ³Clinical Care Research, Tufts Medical Center, Boston, MA, ⁴Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ⁵Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, ⁶Public Health and Community Medicine, Tufts University, Boston, MA, ⁷Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Previous studies investigating the potential associations between personality and clinical symptoms in fibromyalgia (FM) patients have found mixed results. The purpose of this study…
Abstract Number: 844 • 2017 ACR/ARHP Annual Meeting
Social Support, Stress and Health Outcomes in Systemic Lupus Erythematosus: Georgians Organized Against Lupus (GOAL) Cohort
Charmayne M. Dunlop-Thomas, S. Sam Lim, Gaobin Bao and Cristina Drenkard, Division of Rheumatology, Emory University School of Medicine, Atlanta, GA
Background/Purpose: Stress can influence immune and neuroendocrine processes, and may lead to poor outcomes in people with systemic lupus erythematosus (SLE). Social support can potentially…
Abstract Number: 845 • 2017 ACR/ARHP Annual Meeting
Effectiveness of Brief Group Psychoanalytic Psychotherapy in Patients with Systemic Lupus Erythematosus and Follow-up
Emilia Sato^1,2, Céu Conceiçao³, Ivone Meinão⁴ and Sergio Blay⁵, ¹Rheumatology Division. Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, ²Rheumatology Div/Dept of Med, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil, ³Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, Sao Paulo, Brazil, ⁴Medicine, Universidade Federal de São Paulo, Sao Paulo, Brazil, ⁵Psychiatry, Escola Paulista de Medicina, Universidade Federal de São Paulo, Sao Paulo, Brazil
Background/Purpose: There are few studies evaluating the effectiveness of psychotherapy in Systemic Lupus Erythematosus (SLE) patients. Objectives: To evaluate the effectiveness of brief group psychoanalytic…
Abstract Number: 846 • 2017 ACR/ARHP Annual Meeting
Social Support in Couples-Focused Physical Activity Interventions for People with Hip or Knee Osteoarthritis: What Kinds of Partner Support Are Associated with Increases in Physical Activity and Reductions in Sedentary Behavior?
Christine Rini¹, Liubov Arbeeva², Stephanie Bahorski², Cynthia Khan³, Rebekah Layton², Derek Hales², Julie Upchurch², Shelby Rimmler², Ida Griesemer², Mary Altpeter², Dana Carthron⁴, Todd Schwartz² and Leigh F. Callahan⁵, ¹Biomedical Research, Hackensack University Medical Center, Hackensack, NJ, ²University of North Carolina at Chapel Hill, Chapel Hill, NC, ³Econometrica, Inc., Bethesda, MD, ⁴Michigan State University, East Lansing, MI, ⁵Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Physical activity (PA) reduces joint symptoms in people with osteoarthritis (PWOA), but most PWOA get insufficient PA. They would benefit from small but sustained…

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