Date: Monday, October 22, 2018
Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: Hyperuricemia is increasing worldwide, and is emerging as a potential biomarker and predictor for metabolic syndrome and related complications. We aimed this study to investigate the association between hyperuricemia and metabolic syndrome with or without obesity.
Methods: We performed multivariate logistic regression analyses using the 2016 Korea National Health and Nutrition Examination Survey (KNHANES) data collected in a representative sample of Korean adults (defined by age ≥ 20 years). Hyperuricemia was defined by serum uric acid level ≥7.0 mg/dl for men and ≥6.0 mg/dl for women. Obesity was based on body mass index (BMI) ≥ 25 kg/m2.
Results: Among a total of 5,591 Korean adult participants, 685 (12.3%) individuals were classified as having hyperuricemia. Hyperuricemia was significantly associated with metabolic syndrome in both men (Odd ratio (OR) = 1.74, 95% CI: 1.29-2.34) and women (OR = 2.47, 95% CI: 1.55-3.93) after adjustments for age, sex, smoking, alcohol, exercise, BMI and estimated glomerular filtration rate (eGFR). Obesity was also independently related to hyperuricemia in both sex (OR = 1.70, 95% CI: 1.31-2.19 in men, OR = 3.73, 95% CI: 2.57-5.41 in women). Among the components of metabolic syndrome, elevated blood pressure, elevated triglyceride and reduced high-density lipoprotein (HLD)-cholesterol in men, and increased waist circumference, hyperglycemia, elevated triglyceride in women were risk factors for hyperuricemia. In subgroup analyses, individuals who had metabolic syndrome with obesity were at the highest risk of hyperuricemia, followed by those with metabolic syndrome without obesity in overall population (OR = 3.91, 95% CI: 3.00-5.09, OR = 3.21, 95% CI: 2.28-4.52, respectively). In population with metabolic syndrome, the presence of obesity posed higher risk for hyperuricemia in women compared with men (OR = 7.24, 95% CI: 4.56-11.50 versus OR = 2.90, 95% CI: 2.12-3.96).
Conclusion: Our results indicate that hyperuricemia is independently associated with metabolic syndrome and obesity in both sex. The effect of obesity in increasing the risk of hyperuricemia was more pronounced in women compared to men.
To cite this abstract in AMA style:Kim IY, Eun YH, Park EJ, Ahn JK, Jeon CH, Lee J, Cha HS, Koh EM, Han K, Kim H. Association between Hyperuricemia and Metabolic Syndrome with or without Obesity: Results from the 2016 Korea National Health and Nutrition Examination Survey [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 10). https://acrabstracts.org/abstract/association-between-hyperuricemia-and-metabolic-syndrome-with-or-without-obesity-results-from-the-2016-korea-national-health-and-nutrition-examination-survey/. Accessed April 8, 2020.
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