ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 1123

Plasmacytoid Dendritic Cells in Bronchoalveolar Lavage Correlate with Pulmonary Artery Diameter and Infiltrate Perivascular Areas in the Lungs from Patients with Systemic Sclerosis Associated Pulmonary Hypertension

Isela Valera1, Anagha Divekar2, Dinesh Khanna3, Fereidoun Abtin4, Rajan Saggar4 and Ram R. Singh4, 1Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, UCLA, Los Angeles, CA, 2Biolegend, Sa Diego, CA, 3Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, 4UCLA, Los Angeles, CA

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: dendritic cells and systemic sclerosis, Lung Disease, Pulmonary Involvement

  • Tweet
  • Email
  • Print
Session Information

Date: Monday, October 22, 2018

Session Title: Systemic Sclerosis and Related Disorders – Basic Science Poster II

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose: In patients with systemic sclerosis (SSc), plasmacytoid dendritic cells (pDCs) increase in the bronchoalveolar lavage (BAL) and lung tissues (Kafaja S, et al, JCI Insight 2018). Importantly, the frequency of pDCs in the lungs of patients with SSc correlated with the severity of interstitial lung disease, and with the frequency of CD4+ and IL-4+ T-cells in the lung. A pivotal role of pDCs was shown in animal studies, where the depletion of pDCs ameliorated fibrosis in the bleomycin model. These data suggest a role of pDCs in the pathogenesis of fibrosis. Fibroblast proliferation and accumulation around pulmonary vessels is also an early and important event during the development of pulmonary arterial hypertension (PAH). Here, we explore a possible relationship between pDCs and pulmonary hypertension.

Methods: Previous studies have suggested the utility of HRCT-determined pulmonary artery diameters in predicting pulmonary hypertension. In one study, right pulmonary artery diameter of more than 18.7±2.8 mm was considered abnormal, and main pulmonary artery diameter of >29 mm was predictive of pulmonary hypertension. Hence, to begin to investigate a relation between immune cell subsets and subclinical pulmonary arterial hypertension, we analyzed correlation between diameters (mm) of main or right pulmonary arteries and frequencies (% of total) of cell types in BAL. Frequencies of cellular subsets from RML and RLL were averaged. Next, we stained lung tissue slides from patients with SSc-PAH using markers for pDCs and blood vessels (alpha-smooth muscle cells and endothelial cells).

Results: The frequencies of pDCs correlated with the diameters of both main (r = 0.45) and right pulmonary arteries (r = 0.57). There was no correlation between the frequencies of T-cells (CD4+, CD8+, Th2 and Tc2) and pulmonary artery diameters. We further found increased pDCs around blood vessels and other areas of lungs from patients with SSc-PAH as compared to control lungs.

Conclusion: These data argue for a possible role of pDCs in SSc-associated pulmonary vascular disease.


Disclosure: I. Valera, None; A. Divekar, None; D. Khanna, None; F. Abtin, None; R. Saggar, None; R. R. Singh, None.

To cite this abstract in AMA style:

Valera I, Divekar A, Khanna D, Abtin F, Saggar R, Singh RR. Plasmacytoid Dendritic Cells in Bronchoalveolar Lavage Correlate with Pulmonary Artery Diameter and Infiltrate Perivascular Areas in the Lungs from Patients with Systemic Sclerosis Associated Pulmonary Hypertension [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/plasmacytoid-dendritic-cells-in-bronchoalveolar-lavage-correlate-with-pulmonary-artery-diameter-and-infiltrate-perivascular-areas-in-the-lungs-from-patients-with-systemic-sclerosis-associated-pulmonar/. Accessed February 6, 2023.
  • Tweet
  • Email
  • Print

« Back to 2018 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/plasmacytoid-dendritic-cells-in-bronchoalveolar-lavage-correlate-with-pulmonary-artery-diameter-and-infiltrate-perivascular-areas-in-the-lungs-from-patients-with-systemic-sclerosis-associated-pulmonar/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2023 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences