Abstracts tagged "Rheumatoid arthritis (RA)"

Abstract Number: 490 • 2018 ACR/ARHP Annual Meeting
Catastrophizing in Rheumatoid Arthritis
Soraya Benamar¹, Charlotte Hua², Jacques Morel³, Françoise Barchechath-Flaisler⁴, Bernard Combe³, Cédric Lukas³ and Cécile Gaujoux-Viala⁵, ¹Rheumatology, Department of Rheumatology, Nîmes University Hospital and Montpellier University EA 2415, Nîmes, France, ²Department of Rheumatology, Nîmes University Hospital and Montpellier University EA 2415, Montpellier, France, ³University Hospital Lapeyronie, Department of Rheumatology, Montpellier, France, ⁴Rheumatology, Department of Rheumatology, Nîmes University Hospital and Montpellier University EA 2415, Nîmes, France, ⁵Department of Rheumatology, Nîmes University Hospital and Montpellier University EA 2415, Nîmes, France
Background/Purpose: Several studies pay a particular attention to catastrophizing. Catastrophizing is a negative cognitive and affective response based on inadequate expression of pain. The objective…
Abstract Number: 1072 • 2018 ACR/ARHP Annual Meeting
Fibrin-Triggered Chondrosynovial Adhesion As a Novel Mechanism of Cartilage Damage in Rheumatoid Arthritis
Sonia Nasi¹, Jay Degen², Nathalie Busso³, Alexander So⁴ and Thomas Hügle⁵, ¹1 Service of Rheumatology, DAL, Lausanne University Hospital (CHUV), University of Lausanne, Switzerland., epalinges, Switzerland, ²Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Rheumatology, University Hospital Lausanne (CHUV), epalinges, Switzerland, ⁴University of Lausanne, Lausanne, Switzerland, ⁵Rheumatology, University Hospital Lausanne (CHUV), Lausanne, Switzerland
Background/Purpose: Pannus infiltration and inflammatory cytokines are the main responsible factors for cartilage damage in rheumatoid arthritis (RA). Moreover, the crosstalk between inflammation and coagulation…
Abstract Number: 1926 • 2018 ACR/ARHP Annual Meeting
Effects of Social Networking on Chronic Disease Management in Rheumatoid Arthritis
Maria A. Lopez-Olivo¹, Jessica Foreman², Heather Lin³, Cheuk Hong Leung⁴, Tiffany Westrich-Robertson⁵, Catherine Hofstetter⁶, Susan K. Peterson⁷, Anne Lyddiatt⁸, Amye L. Leong⁹, Irmgard U. Willcockson¹⁰ and Maria Suarez-Almazor¹, ¹Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, ²Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA, Houston, TX, ³Biostatistics, Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, Houston, TX, ⁴Department of Biostatistics, Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, Houston, TX, ⁵International Foundation for Autoimmune and Autoinflammatory Arthritis, Saint Louis, Missouri, USA, St Louis, MO, ⁶OMERACT patient research partner group, Ottawa, ON, Canada, ⁷Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston Texas, USA, Houston, TX, ⁸Musculoskeletal Group, Cochrane Collaboration, Hamilton, ON, Canada, ⁹Spokesperson; Strategic Relations, Bone and Joint Decade, Santa Barbara, CA, ¹⁰School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX
Background/Purpose: We evaluated a social networking intervention to help patients with rheumatoid arthritis become active partners in their own care. We developed a closed independent…
Abstract Number: 2503 • 2018 ACR/ARHP Annual Meeting
Impact of Tobacco Smoking on 1-Year Mortality Following Total Hip and Total Knee Arthroplasty Among Rheumatoid Arthritis Patients – a Danish Cohort Study Using Nationwide Health Care Registers
René Cordtz^1,2, Laerke Bech-Illum³, Daniel Prieto-Alhambra⁴, Pil Hoejgaard^3,5, Kristian Zobbe^3,6, Nina Imbæk³ and Lene Dreyer⁷, ¹Center for Rheumatology and Spine Diseases, Gentofte-Rigshospitalet, Hellerup, Denmark, ²The Parker Institute, Bispebjerg and Frederiksberg Hospital, The Capital Region of Denmark, Copenhagen, Denmark, ³Center for Rheumatology and Spine Diseases - Gentofte, Rigshospitalet, Hellerup, Denmark, ⁴Internal Medicine and Primary Care, URFOA-IMIM, Parc de Salut Mar; Idiap Jordi Gol i Gurina-Institut Català de la Salut; Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK, Barcelona, Spain, ⁵The Parker Institute, Bispebjerg and Frederiksberg Hospital, The Capital Region of Denmark, Denmark, ⁶The Parker Institute, Bispebjerg and Frederiksberg Hospital, Capital Region of Denmark, Copenhagen, Denmark, ⁷Departments of Rheumatology and Clinical Medicine, Aalborg University Hospital and Aalborg University, 9000 Aalborg, Denmark
Background/Purpose: Tobacco smoking and rheumatoid arthritis (RA) are independent risk factors for short-term complications following total hip and total knee arthroplasty (THA/TKA). We aimed to…
Abstract Number: 493 • 2018 ACR/ARHP Annual Meeting
Trends in the Incidence of SOLID Tumors in Patients with Rheumatoid Arthritis in Spain. a National Observational Cohort Study
Virginia Villaverde García¹, Manuel Fernández², Ramon Mazzucchelli³, Cristina Macia-Villa⁴, Gloria Candelas⁵, Javier Quirós³, M Peña³, E Perez-Fernandez³, Natalia Crespí⁶, Alberto Garcia-Vadillo⁷, Carmen Barbadillo⁸, J.L Morell-Hita⁹, Hilda Godoy⁸, Maria Espinosa¹⁰, C Morado-Quiñoa⁵, Cristina Martinez-Prada⁵, María Galindo¹¹, O Guzon-Illescas³ and Angela Herranz¹², ¹Rheumatology, Hospital Universitario de Móstoles, Móstoles, Spain, ²Hospital Universitario de Guadalajara, Guadalajara, Spain, ³H.U.Fundación Alcorcón, Madrid, Spain, ⁴Hospital Universitario Severo Ochoa, Madrid, Spain, ⁵H.U. Clínico San Carlos, Madrid, Spain, ⁶C.S. La Rivota, Madrid, Spain, ⁷Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, ⁸H.U. Puerta de Hierro, Madrid, Spain, ⁹H.U.Ramón y Cajal, Madrid, Spain, ¹⁰Rheumatology, H.U. Puerta de Hierro, Madrid, Spain, ¹¹Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain, ¹²H.U. del Henares, Madrid, Spain
Background/Purpose: During the last 20 years, the treatment in rheumatoid arthritis (RA) has changed. Considering the increasing use of biological immunomodulators to treat chronic inflammatory…
Abstract Number: 1198 • 2018 ACR/ARHP Annual Meeting
Ultrasound-Detected Joint Erosions in Rheumatoid Arthritis: What Every Sonographer Should Know
York Kiat Tan^1,2,3, HuiHua Li⁴, John Carson Allen Jr⁵ and Julian Thumboo^1,2,3, ¹Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore, ²Duke-NUS Medical School, Singapore, Singapore, ³Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, ⁴Health Services Research, Singapore General Hospital, Singapore, Singapore, ⁵Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore
Background/Purpose: Previous work in rheumatoid arthritis (RA) on bone erosion(s) using ultrasound (US) focused mostly on small joints of the fingers and toes. We aim…
Abstract Number: 1966 • 2018 ACR/ARHP Annual Meeting
Transcriptome and Methylome Integrative Molecular Analysis Uncovers a New Systemic Autoimmune Disease Classification
Guillermo Barturen¹, Sepideh Babaei², Francesc Catala-Moll³, Zuzanna Makowska², Antonio García-Gómez³, Anne Buttgereit⁴, Elena Carnero-Montoro¹, Sikander Hayat⁴, Martin Kerick⁵, Thomas Charlon⁶, David C Gemperline⁷, Lucas Le Lann⁸, Rosa Quirantes-PIné⁹, Isabel Borrás-Linares¹⁰, Brian Muchmore¹, Jorge Kageyama⁴, Javier Rodríguez-Ubreva³, Alvaro Fernández-Ochoa⁹, Pedro Carmona Sanz¹¹, Christophe Jamin⁸, Ralf Lesche², Robert J. Benschop⁷, Chris Chamberlain¹², Ernst R. Dow⁷, Tania Gomes¹, Maria Juárez¹³, Laurence Laigle¹⁴, Jacqueline Marovac¹², Fiona MacDonald¹⁵, Jerome Wojcik⁶, Esteban Ballestar¹⁶, Lorenzo Beretta¹⁷, Maria Orietta Borghi¹⁸, Johan Frostegård¹⁹, Maria Luisa Garcia²⁰, Javier Martín⁵, Jacques-Olivier Pers⁸, Yves Renadineau²¹, Antonio Segura Carretero⁹ and Marta Alarcón-Riquelme^1,19, ¹Medical Genomics, Center for Genomics and Oncological Research (GENYO), Granada, Spain, ²Pharmaceuticals Division, Bayer Pharma Aktiengesellschaft, Berlin, Germany, ³Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain, ⁴Bayer Pharma Aktiengesellschaft, Berlin, Germany, ⁵Institute of Parasitology and Biomedicine López Neyra, Spanish National Research Council, Granada, Spain, ⁶QuartzBIO, SA, Geneva, Switzerland, ⁷Eli Lilly and Company, Indianapolis, IN, ⁸U1227, Université de Brest, Inserm, Labex IGO, CHU de Brest, Brest, France, ⁹Department of Analytical Chemistry, University of Granada, Granada, Spain, ¹⁰Analytical Chemistry, University of Granada, Granada, Spain, ¹¹Unit of Bioinformatics, Center for Genomics and Oncological Research (GENYO), Pfizer-University of Granada-Andalusian Regional Government, Health Sciences Technology Park, Granada, Spain, ¹²UCB Pharma, Slough, United Kingdom, ¹³UCB, Slough, United Kingdom, ¹⁴Institut de Recherches Internationales Servier, Suresnes, France, ¹⁵Bayer Pharma G, Berlin, Germany, ¹⁶Cancer Epigenetics and Biology Programme (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain, ¹⁷Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ¹⁸University of Milan, IRCCS Istituto Auxologico Italiano, Milan, Italy, ¹⁹Unit for Chronic Inflammatory Diseases, Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ²⁰Nano-Imaging, BIONAND. Centro Andaluz de Nanotecnología y Biomedicina, Malaga, Spain, ²¹U1227, Université de Brest, inserm, Labex IGO, CHU de brest, Brest, France
Background/Purpose: Systemic autoimmune diseases (SADs) are chronic inflammatory conditions with autoimmune aetiology and many common clinical features, difficulting diagnosis and adequate treatment decisions. Finding new…
Abstract Number: 2542 • 2018 ACR/ARHP Annual Meeting
Integrated Exposure-Response Analyses for Upadacitinib Efficacy and Effects on Laboratory Parameters in Rheumatoid Arthritis – Analyses of Phase 2b Studies
Mohamed-Eslam Mohamed¹, Insa Winzenborg², Eva Doelger², Peter Noertersheuser³, Heidi S. Camp¹, Sebastian Meerwein³ and Ahmed A. Othman¹, ¹AbbVie Inc., North Chicago, IL, ²AbbVie Deutschland GmbH & Co. KG, Ludwigshafen am Rhein, Germany, ³AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany
Background/Purpose: Upadacitinib is an oral, selective inhibitor of Janus kinase 1 (JAK1) which is currently being evaluated for the treatment of several autoimmune disorders, including…
Abstract Number: 498 • 2018 ACR/ARHP Annual Meeting
Trends in the Incidence of Cardiovascular Diseases in Patients with Rheumatoid Arthritis in Spain: A National Observational Cohort Study of Hospital Discharges
Cristina Macia-Villa¹, Ramon Mazzucchelli², E Perez-Fernandez², Javier Quirós², J.L Morell-Hita³, Natalia Crespí⁴, M Peña², Carmen Barbadillo⁵, Maria Espinosa⁶, Hilda Godoy⁵, Manuel Fernández⁷, María Galindo⁸, Alberto Garcia-Vadillo⁹, O Guzon-Illescas², Angela Herranz¹⁰, Cristina Martinez-Prada¹¹, C Morado-Quiñoa¹¹ and Virginia Villaverde García¹², ¹Hospital Universitario Severo Ochoa, Madrid, Spain, ²H.U.Fundación Alcorcón, Madrid, Spain, ³H.U.Ramón y Cajal, Madrid, Spain, ⁴C.S. La Rivota, Madrid, Spain, ⁵H.U. Puerta de Hierro, Madrid, Spain, ⁶Rheumatology, H.U. Puerta de Hierro, Madrid, Spain, ⁷Hospital Universitario de Guadalajara. Spain, Guadalajara, Spain, ⁸Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain, ⁹Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, ¹⁰H.U. del Henares, Madrid, Spain, ¹¹H.U. Clínico San Carlos, Madrid, Spain, ¹²Rheumatology, Hospital Universitario de Móstoles, Móstoles, Spain
Background/Purpose: Cardiovascular diseases (CVDs) are a worldwide health problem, with an increased risk in Rheumatoid Arthritis (RA) due to its inflammatory context, comorbidities and the…
Abstract Number: 1199 • 2018 ACR/ARHP Annual Meeting
The Use of Musculoskeletal Ultrasound to Assess Remission in Patients with Rheumatoid Arthritis
Myriam Allen¹, Maggie Larche² and Karen A. Beattie², ¹Rheumatology, McMaster University, Hamilton, ON, Canada, ²Medicine, McMaster University, Hamilton, ON, Canada
Background/Purpose: Patients with rheumatoid arthritis (RA) should achieve remission rapidly to avoid irreversible joint sequela. Studies have shown that patients with apparent clinical remission have…
Abstract Number: 1979 • 2018 ACR/ARHP Annual Meeting
Rheumatoid Arthritis-Associated Genetic Alteration Defines a New Promoter for Peptydil Arginine Deiminase 4 Gene
Daniel M. Tóth¹, Timea Ocskó², Tibor T. Glant¹ and Tibor A. Rauch¹, ¹Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Orthopedic Surgery, Rush University Medical Center, Chicago, IL
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) are frequently detected in Rheumatoid Arthritis (RA) patients and used as diagnostic biomarkers at a very early stage of the…
Abstract Number: 2548 • 2018 ACR/ARHP Annual Meeting
The Impact of Rheumatoid Arthritis on Patient-Reported Outcomes: Comparison between Sarilumab Clinical Trials and Real-World Patient Data
Vibeke Strand¹, Colleen M. Carpinella², Lulu K. Lee², Susan Boklage³ and Matthew Reaney⁴, ¹Stanford University School of Medicine, Palo Alto, CA, ²Kantar Health, San Mateo, CA, ³Regeneron Pharmaceuticals, Inc., Tarrytown, NY, ⁴Sanofi, Guildford, United Kingdom
Background/Purpose: Rheumatoid arthritis (RA) and its treatment have significant impacts on health-related quality of life (HRQoL), work productivity (WP) and activity participation. Data are limited…
Abstract Number: 506 • 2018 ACR/ARHP Annual Meeting
Clinical and Sonographic Characteristics of Carotid Intima-Media Thickness in Rheumatoid Arthritis Patients
José R. Azpiri-López¹, Iris J. Colunga-Pedraza², Estefania E. Abundis-Marquez³, Jose A. Davila-Jimenez³, Andres H. Guillen-Lozoya³, Raymundo Vera-Pineda³, Jesus A. Cardenas-de la Garza³, Adrián Martínez-Moreno³, Rosa I. Arvizu-Rivera³, Francisco J. Torres-Quintanilla³, Aldo Valdovinos-Bañuelos³, Ray Ramos-Cázares³, Cinthia Y. Guillen-Gutierrez³, Guillermo Elizondo-Riojas³, Dionisio Castillo-Ortiz⁴ and Dionicio A. Galarza-Delgado⁵, ¹Cardiology, Hospital Universitario, UANL, Monterrey, Mexico, ²Rheumatology, Hospital Universitario, UANL, Monterrey, Mexico, ³Hospital Universitario, UANL, Monterrey, Mexico, ⁴Unidad de Investigacion en Enfermedades Cronico-Degenerativas, Guadalajara, Mexico, ⁵Chief of Rheumatology, Hospital Universitario, UANL, Monterrey, Mexico
Clinical and Sonographic Characteristics of Carotid Intima-media Thickness in Rheumatoid arthritis patientsBackground/Purpose: Rheumatoid arthritis (RA) is a chronic and systemic disease with high cardiovascular (CV)…
Abstract Number: 1203 • 2018 ACR/ARHP Annual Meeting
Tenosynovitis Detected By Ultrasound Predicts Arthritis Onset in Individuals at Risk of Developing Rheumatoid Arthritis
Yogan Kisten¹, Hamed Rezaei¹, Erik af Klint¹, Guozhong Fei^1,2, Aleksandra Antovic^1,2, Aase Hensvold^1,2 and Anca I. Catrina^1,2, ¹Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ²Stockholm Health Services, Academic Specialist Center, Center for Rheumatology, Stockholm, Sweden
Background/Purpose: The urgent need for identifying imaging and serological markers that early predicts rheumatoid arthritis (RA) is clinically important. We aim to identify ultrasound findings…
Abstract Number: 2164 • 2018 ACR/ARHP Annual Meeting
IMPACT of a Systematic Screening of Multimorbidities in Patients with Chronic Inflammatory Rheumatic Diseases
Mégane Beurai-Weber Jr.¹, Audrey Jaussent², Guilhem du Cailar³, Marie-Christine Picot², François Roubille Sr.⁴, Jean-David Cohen⁵, Jacques Morel⁶, Jean Bousquet⁷, Pierre Fesler⁸, Bernard Combe⁹ and Claire Daien¹⁰, ¹Rheumatology Department, Lapeyronie Hospital and Montpellier University, MONTPELLIER, France, ²Department of medical information, Lapeyronie Hospital and Montpellier University, MONTPELLIER, France, ³Internal Medicine and Hypertension, Hopital Lapeyronie, Montpellier, France, ⁴Department of cardiology, Arnaud de Villeneuve Hospital and Montpellier University, MONTPELLIER, France, ⁵IMMUNO-RHEUMATOLOGY, CHU LAPEYRONIE, MONTPELLIER, France, ⁶Department of Rheumatology, University Hospital Lapeyronie, Montpellier, Montpellier, France, ⁷MACVIA-France, Lapeyronie Hospital and Montpellier University, MONTPELLIER, France, ⁸Internal medicine and hypertension, Lapeyronie Hospital and Montpellier University, Montpellier, France, ⁹University Hospital Lapeyronie, Department of Rheumatology, Montpellier, France, ¹⁰Rheumatology, University Hospital Lapeyronie, Montpellier, Montpellier, France
Background/Purpose: EULAR proposes to screen multimorbidities in chronic inflammatory rheumatic diseases. The aim of the study was to assess i) multimorbidities in patients with chronic…

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