Session Type: Poster Session A
Session Time: 8:30AM-10:30AM
Background/Purpose: To evaluate the prevalence of scleroderma (SSc) specific and anti-Ro52 autoantibodies in seropositive rheumatoid arthritis (RA) patients with lung involvement.
Methods: Sera from 67 seropositive RA patients with available high-resolution computed tomography scans (HRCTs) were tested for the presence of SSc-specific and anti-Ro52 antibodies. According to the band intensity, samples were classified in those with medium and strong positive titers. Demographic, clinical, laboratory, imaging and pulmonary function data were recorded. 26 patients suffered from interstitial lung disease (ILD group), 25 had some other type of lung involvement (non-ILD group) and 16 had normal HRCTs (no-lung group).
Results: Autoantibody testing revealed a significantly higher prevalence of positive SSc-specific antibodies in patients with lung involvement compared to the no-lung group (45.1% vs 12.5%, p=0.02) (Figure 1A). Lung involvement was also associated with older age, male sex, heavier smoking, and increased white blood cell counts, CRP and RF values (Table 1). Prevalence of anti-Ro52 positivity was also higher in these patients, but no statistical significance was reached. ILD and non-ILD groups displayed a similar frequency (Figure 1B) but a distinct non-overlapping pattern of SSc-specific antibodies (in strong titers) against RP155, Th/To, fibrillarin and NOR90 autoantigens in the ILD group (Figure 1C) and towards Ku, Pm/Scl100, CENP-A/B in the non-ILD group (Figure 1D)
Conclusion: Seropositive RA patients with lung involvement display several demographic, clinical and laboratory characteristics along with increased rates of SSc-specific autoantibodies. These data imply that seropositive RA patients with lung involvement probably represent a distinct overlap entity, requiring tailored diagnostic and therapeutic approaches.
To cite this abstract in AMA style:Koulouri V, Tavernaraki K, Giannelou M, Mavragani C. Increased Prevalence of Scleroderma Specific Autoantibodies in Seropositive Rheumatoid Arthritis with Lung Involvement [abstract]. Arthritis Rheumatol. 2021; 73 (suppl 10). https://acrabstracts.org/abstract/increased-prevalence-of-scleroderma-specific-autoantibodies-in-seropositive-rheumatoid-arthritis-with-lung-involvement/. Accessed December 3, 2021.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/increased-prevalence-of-scleroderma-specific-autoantibodies-in-seropositive-rheumatoid-arthritis-with-lung-involvement/