ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 0293

Increased Prevalence of Scleroderma Specific Autoantibodies in Seropositive Rheumatoid Arthritis with Lung Involvement

Vasiliki Koulouri1, Kyriaki Tavernaraki2, Mayra Giannelou3 and Clio Mavragani1, 1National and Kapodistrian University of Athens, Athens, Greece, 2Imaging and Interventional Radiology, Sotiria General and Chest Diseases Hospital, Athens, Greece, 3Department of Rheumatology, General Hospital of Athens "G. Gennimatas", Athens, Greece

Meeting: ACR Convergence 2021

Keywords: , ,

Session Information

Date: Saturday, November 6, 2021

Title: RA – Diagnosis, Manifestations, & Outcomes Poster I: Cardiovascular Pulmonary Disease (0268–0295)

Session Type: Poster Session A

Session Time: 8:30AM-10:30AM

Background/Purpose: To evaluate the prevalence of scleroderma (SSc) specific and anti-Ro52 autoantibodies in seropositive rheumatoid arthritis (RA) patients with lung involvement.

Methods: Sera from 67 seropositive RA patients with available high-resolution computed tomography scans (HRCTs) were tested for the presence of SSc-specific and anti-Ro52 antibodies. According to the band intensity, samples were classified in those with medium and strong positive titers. Demographic, clinical, laboratory, imaging and pulmonary function data were recorded. 26 patients suffered from interstitial lung disease (ILD group), 25 had some other type of lung involvement (non-ILD group) and 16 had normal HRCTs (no-lung group).

Results: Autoantibody testing revealed a significantly higher prevalence of positive SSc-specific antibodies in patients with lung involvement compared to the no-lung group (45.1% vs 12.5%, p=0.02) (Figure 1A). Lung involvement was also associated with older age, male sex, heavier smoking, and increased white blood cell counts, CRP and RF values (Table 1). Prevalence of anti-Ro52 positivity was also higher in these patients, but no statistical significance was reached. ILD and non-ILD groups displayed a similar frequency (Figure 1B) but a distinct non-overlapping pattern of SSc-specific antibodies (in strong titers) against RP155, Th/To, fibrillarin and NOR90 autoantigens in the ILD group (Figure 1C) and towards Ku, Pm/Scl100, CENP-A/B in the non-ILD group (Figure 1D)

Conclusion: Seropositive RA patients with lung involvement display several demographic, clinical and laboratory characteristics along with increased rates of SSc-specific autoantibodies. These data imply that seropositive RA patients with lung involvement probably represent a distinct overlap entity, requiring tailored diagnostic and therapeutic approaches.

Figure1. SSc-specific and anti-Ro52 antibodies in seropositive RA patients with different types of lung involvement

Table 1. Demographic, clinical, serological and laboratory features of seropositive RA patients with and without lung involvement

Disclosures: V. Koulouri, None; K. Tavernaraki, None; M. Giannelou, None; C. Mavragani, None.

To cite this abstract in AMA style:

Koulouri V, Tavernaraki K, Giannelou M, Mavragani C. Increased Prevalence of Scleroderma Specific Autoantibodies in Seropositive Rheumatoid Arthritis with Lung Involvement [abstract]. Arthritis Rheumatol. 2021; 73 (suppl 9). https://acrabstracts.org/abstract/increased-prevalence-of-scleroderma-specific-autoantibodies-in-seropositive-rheumatoid-arthritis-with-lung-involvement/. Accessed .

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