Date: Monday, November 8, 2021
Session Type: Poster Session C
Session Time: 8:30AM-10:30AM
Background/Purpose: Epidemiological information on Giant Cell Arteritis (GCA) comes mainly from the Scandinavian countries of northern Europe, which show a higher incidence than the countries of southern Europe. GCA clinical manifestations can be divided into cranial, extracranial, and general syndrome.
In a large series of GCA from Spain, we studied a) the incidence of GCA, b) clinical manifestations, and c) comorbidities at the time of disease diagnosis.
Methods: ARTESER is a retrospective epidemiological observational study of GCA promoted by the Spanish Society of Rheumatology in which 26 hospitals participate. The inclusion criteria were: all new patients diagnosed with GCA by a) ACR criteria, b) positive diagnostic test (temporal artery biopsy, temporal artery ultrasound or other relevant imaging techniques) and/or c) investigator’s clinical judgment. The patient recruitment period ranged from June 1, 2013 to March 29, 2019. The overall incidence of GCA per 100,000 people ≥50 years for the whole period and the mean annual incidence were evaluated. The clinical variables were collected by reviewing the patient’s medical history.
Results: 1675 patients were included. The average annual incidence rate was 7.42 (95% CI: 6.57-8.27). All the cases were older than 50 years, and the age group with the highest incidence was that of 80 to 84 years, where it reached a value of 130.12 (95% CI: 126.71-133.54). The mean annual incidence is higher in women than in men 10.06 (95% CI: 8.7-11.5) vs 4.83 (95% CI 3.8- 5.9) (Table 1).
The description of the population is shown in Table 2, the mean age at diagnosis was 76.9±8.1 years, 1178 (70.3%) were women. ACR criteria were met by 1400 (83.6%) patients and an objective diagnostic test by 1258 (75.1%). The more frequent comorbidity was arterial hypertension (n=1079; 64.6%), followed by dyslipidemia (n=801, 48%). The predominant cranial manifestation was headache, (n= 1337; 79.9%) and 605 patients experienced visual symptoms (36.1%). Polymyalgia rheumatica (n=699; 41.8%) and asthenia (n=837; 52.2%) were the most frequent extracranial and general syndrome manifestation, respectively. Regarding laboratory parameters, the most characteristic data was the increase of ESR (75.9±33.6 mm/1st h).
Conclusion: The mean annual incidence of GCA in Spain, 7.42 (95% CI: 6.57-8.27), is lower than that of the Scandinavian countries. It is higher in people older than 80 years. Cranial manifestations constituted the most clinical features. The most frequent clinical manifestations are cranial. Up to a third of patients had visual manifestations.
To cite this abstract in AMA style:Sánchez-Costa J, Melero-González R, Fernández-Fernández E, Silva-Diaz M, Belzunegui J, Moriano C, Sánchez J, Lluch J, Calvo I, Aldasoro V, Abasolo L, Loricera J, Ruíz-Román A, Castañeda S, Moya P, Garcia-Villanueva M, Navarro-Angeles V, Galisteo C, Riveros-Frutos A, Román-Ivorra J, Labrada-Arrabal S, Vasques-Rocha M, Iñiguez-Ubiaga C, García-González M, Molina-Almela C, Alcalde-Villar M, Juan Mas A, De Miguel E, Narvaez J, gonzalez-Gay M, Garrido-Puñal N, Estrada-Alarcon P, Blanco R. Incidence and General Clinical Features of Giant Cell Arteritis in the ARTESER Multicenter Study [abstract]. Arthritis Rheumatol. 2021; 73 (suppl 9). https://acrabstracts.org/abstract/incidence-and-general-clinical-features-of-giant-cell-arteritis-in-the-arteser-multicenter-study/. Accessed January 30, 2023.
« Back to ACR Convergence 2021
ACR Meeting Abstracts - https://acrabstracts.org/abstract/incidence-and-general-clinical-features-of-giant-cell-arteritis-in-the-arteser-multicenter-study/