Session Type: Poster Session C
Session Time: 9:00AM-11:00AM
Background/Purpose: To identify if biochemical markers s-Coll2-1, a peptide of type collagen and its nitrated from, s-Coll2-1NO2 are associated to knee osteoarthritis (OA), focusing on pain, function as well as structural features assessed by MRI and to assess their ability at predicting knee OA worsening.
Methods: 116 subjects with knee OA were followed during one year with pain, function and MRI evaluation (PRODIGE study, NCT02070224). Type II collagen-specific biomarker Coll2-1 and its nitrated form Coll2-1NO2 were directly measured in serum using immunoassays at baseline and after three, six and twelve months follow-up.
Results: S-Coll2-1 was significantly correlated with bursitis (r=0.29, P< 0.01), bone attrition (r=0.25, P=0.01), cysts (r=0.24, P=0.02) and cartilage (r=0.23, P=0.03) WORMS sub-scores for the whole joint as well as with the medial femorotibial joint sum score (r=0.26, P=0.01) and medial femorotibial joint cartilage (r=0.23, P=0.02). s-Coll2-1NO2 was correlated with WORMS total score (r=0.23, P=0.02), WORMS scores in the patellofemoral (r=0.23, P=0.02) and medial femorotibial compartments (r=0.21, P=0.03) and with osteophytes scores (r=0.27, P< 0.01). Baseline s-Coll2-1NO2 was higher in subjects with a pain worsening (426.4 pg/mL [278.04-566.95]) as compared to non-progressors (306.84 [200.37-427.84]) over one year (AUC=0.655, P=0.015).
Conclusion: Cartilage biomarkers s-Coll2-1 and s-Coll2-1NO2 are associated to several knee OA features quantified with WORMS scoring system on MRI. Serum values of Coll2-1NO2 are also associated to a worsening of target knee pain over one year. Coll2-1 and Coll2-1NO2, in association with other structural features, pain and function, could help at identifying OA phenotypes and patients at risk of OA worsening.
To cite this abstract in AMA style:Henrotin Y, Hick A, Costes B, Labasse A, Conrozier T, Malaise M, Maugars Y, Pelousse F, Lemaire J, Tits C, Helleputte T, Loeuille D. Cartilage Biomarkers s-Coll2-1 and s-Coll2-1NO2 Are Associated with Knee Osteoarthritis MRI Features and Predict Disease Worsening [abstract]. Arthritis Rheumatol. 2020; 72 (suppl 10). https://acrabstracts.org/abstract/cartilage-biomarkers-s-coll2-1-and-s-coll2-1no2-are-associated-with-knee-osteoarthritis-mri-features-and-predict-disease-worsening/. Accessed January 23, 2022.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/cartilage-biomarkers-s-coll2-1-and-s-coll2-1no2-are-associated-with-knee-osteoarthritis-mri-features-and-predict-disease-worsening/