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Abstract Number: 0580

Association Between Female Reproductive Factors and Gout: A Nationwide Population-based Cohort Study of 1 Million Postmenopausal Women

Yeonghee Eun1, In Young Kim2, Kyungdo Han3, Kyu Na Lee3, Dong-Yun Lee1, Dong Wook Shin1, Seonyoung Kang1, Seulkee Lee1, Hoon-Suk Cha1, Eun-Mi Koh1, Jaejoon Lee1 and Hyungjin Kim1, 1Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea, 2National Police Hospital, Seoul, Republic of Korea, 3Soongsil University, Seoul, Republic of Korea

Meeting: ACR Convergence 2021

Keywords: Crystal-induced arthritis, Epidemiology, risk factors, sex hormones, Women's health

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Session Information

Date: Sunday, November 7, 2021

Session Title: Epidemiology & Public Health Poster II: Inflammatory Arthritis – RA, SpA, & Gout (0560–0593)

Session Type: Poster Session B

Session Time: 8:30AM-10:30AM

Background/Purpose: Previous studies have shown that the incidence and risk factors of gout differs according to sex. However, little research has been done on the association between reproductive factors and gout. We conducted an analysis of a large nationwide population-based cohort of postmenopausal women to determine whether there is an association between reproductive factors and the incidence of gout.

Methods: A total of 1,076,378 postmenopausal women aged 40–69 years who participated in national health screenings in 2009 were included in the study. The outcome was the occurrence of incident gout, which was defined using the ICD-10 code of gout (M10) in the claim database. Cox proportional hazard models were used for the analyses and stratified analyses according to body mass index (BMI) and the presence/absence of chronic kidney disease (CKD) were performed.

Results: The mean follow-up duration was 8.1 years, and incident cases of gout were 64,052 (incidence rate, 7.31 per 1,000 person-years). Later menarche, earlier menopause, and a shorter reproductive span were associated with a high risk of gout. No association between parity and gout incidence was observed. Use of oral contraceptives (OC) and hormone replacement therapy (HRT) were associated with an increased risk of gout. The association between reproductive factors and gout was not statistical significant in the high BMI group. The effects of OC and HRT usage on gout were not significant in the CKD group.

Conclusion: Shorter exposure to endogenous estrogen was associated with a high risk of gout. Conversely, exposure to exogenous estrogen such as OC and HRT was associated with an increased risk of gout.


Disclosures: Y. Eun, None; I. Kim, None; K. Han, None; K. Lee, None; D. Lee, None; D. Shin, None; S. Kang, None; S. Lee, None; H. Cha, None; E. Koh, None; J. Lee, None; H. Kim, None.

To cite this abstract in AMA style:

Eun Y, Kim I, Han K, Lee K, Lee D, Shin D, Kang S, Lee S, Cha H, Koh E, Lee J, Kim H. Association Between Female Reproductive Factors and Gout: A Nationwide Population-based Cohort Study of 1 Million Postmenopausal Women [abstract]. Arthritis Rheumatol. 2021; 73 (suppl 9). https://acrabstracts.org/abstract/association-between-female-reproductive-factors-and-gout-a-nationwide-population-based-cohort-study-of-1-million-postmenopausal-women/. Accessed February 3, 2023.
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