Abstract Number: 0048 • ACR Convergence 2022
Combination of Repetitive Inhalant Endotoxin Exposure and Collagen-induced Arthritis Interact in a Testosterone-dependent Manner to Drive Inflammatory Lung Disease Processes and Arthritis Severity in Mice
Background/Purpose: Respiratory-related diseases are among the most common causes of death in rheumatoid arthritis (RA). Although autoimmune diseases are reported in higher frequency in females,…Abstract Number: 0052 • ACR Convergence 2022
Elucidating Androgen Effects on Focal Erosions in TNF-Induced Inflammatory Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is characterized by chronic joint disease and is female predominant. The TNF-transgenic (TNF-Tg) mouse model of RA develops inflammatory-erosive arthritis and…Abstract Number: 1904 • ACR Convergence 2022
Is Treating Painful Hand Osteoarthritis with Hormone Replacement Therapy Feasible? Primary Results from a Randomised Controlled Trial in Post-menopausal Women
Background/Purpose: Hand osteoarthritis (OA) is more common in females and relative risk increases further around the age of menopause, potentially implicating sex hormone deficiency. There…Abstract Number: 0299 • ACR Convergence 2021
Sex Hormones and Risk of Sjögren’s Syndrome: Hypothesis Generating Findings Implicating Androgen and Estrogen Ratios
Background/Purpose: Sjӧgren’s syndrome (SS) is the most female predominant systemic autoimmune disease, with peak onset around perimenopause. Estrogen appears to protect against SS, but prior…Abstract Number: 0580 • ACR Convergence 2021
Association Between Female Reproductive Factors and Gout: A Nationwide Population-based Cohort Study of 1 Million Postmenopausal Women
Background/Purpose: Previous studies have shown that the incidence and risk factors of gout differs according to sex. However, little research has been done on the…Abstract Number: 1052 • ACR Convergence 2021
Female Reproductive Factors and Risk of Joint Replacement Arthroplasty of the Knee and Hip Due to Osteoarthritis in Postmenopausal Women: A Nationwide Cohort Study of 1.36 Million Women
Background/Purpose: Previous studies of the relationships between female reproductive factors and osteoarthritis (OA) have shown conflicting results. In this study, we aimed to explore the…Abstract Number: 1891 • ACR Convergence 2021
Variable Effects of Testosterone on Male versus Female Derived Macrophages in Inflammatory Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that is female predominant. The TNF-transgenic (TNF-Tg) mouse model of RA also develops a sexually…Abstract Number: 0081 • ACR Convergence 2020
Prevalence of Systemic Autoimmune Diseases in Polycystic Ovary Syndrome
Background/Purpose: Polycystic ovary syndrome (PCOS) is characterized by hormonal abnormality, chronic anovulation, hyperandrogenism, and obesity. Due to the hormonal imbalance, we hypothesize that patients with…Abstract Number: 0421 • ACR Convergence 2020
Polymyalgia Rheumatica Is Associated with Later Menopause: An Observational Study
Background/Purpose: Oestrogen exposure leads to an increase in peak bone mass whereas menopause is associated with rapid bone loss. Numerous studies have linked rheumatoid arthritis…Abstract Number: 2289 • 2019 ACR/ARP Annual Meeting
Progesterone Decreases Gut Permeability Through Upregulating Occludin Expression in Primary Human Gut Tissues and Caco-2 Cells
Background/Purpose: Progesterone plays a protective role in preventing inflammation and preterm delivery during pregnancy. However, the mechanism involved is unknown. Microbial product translocation from a…
ACR Meeting Abstracts